Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain

Journal of Biological Chemistry

Volumn 283, Issue 28, 2008, Pages 19410-19421

  Kroschewski, Helga ^a   Siew, Pheng Lim ^b   Butcher, Rebecca E ^c   Thai, Leong Yap ^b,d   Lescar, Julien ^d   Wright, Peter J ^c   Vasudevan, Subhash G ^b,e   Davidson, Andrew D ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^c MONASH UNIVERSITY   (Australia)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^e DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINATION; AMINES; AMINO ACIDS; BINDING SITES; CLONING; METHYLATION; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC ACIDS; POSITIVE IONS; RNA; VIRUSES;

ACTIVE SITE RESIDUES; BINDING POCKETS; BIOCHEMICAL ASSAYS; CAP METHYLATIONS; CAP STRUCTURES; CDNA CLONES; DENGUE VIRUSES; DO-MAINS; IN-VIVO; METHYL TRANSFERASES; METHYLTRANSFERASE ACTIVITIES; RNA GENOMES; SEQUENTIAL METHYLATIONS; THRESHOLD LEVELS; VIRAL REPLICATIONS; VIRUS REPLICATIONS; WILD TYPES;

ENZYMES;

COMPLEMENTARY DNA; METHYLTRANSFERASE; MUTANT PROTEIN; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5; S ADENOSYLMETHIONINE; VIRUS PROTEIN; VIRUS RNA; NS5 PROTEIN, FLAVIVIRUS;

AMINO ACID SUBSTITUTION; AMINO ACID SYNTHESIS; ARTICLE; BACTERIUM; BINDING SITE; BIOASSAY; CATALYSIS; CONTROLLED STUDY; DENGUE; DENGUE VIRUS; DENGUE VIRUS 2; ENZYME ACTIVITY; ENZYME BINDING; FLAVIVIRUS; GENE MUTATION; GENE TARGETING; IN VIVO STUDY; METHYLATION; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; RNA METHYLATION; VIRUS GENOME; VIRUS INFECTION; VIRUS MUTANT; VIRUS REPLICATION; WASTE; WILD TYPE; AEDES; ANIMAL; CERCOPITHECUS; ENZYME STABILITY; ENZYMOLOGY; GENETICS; METABOLISM; MISSENSE MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; VERO CELL;

DENGUE VIRUS TYPE 2; FLAVIVIRUS;

AEDES; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CATALYSIS; CERCOPITHECUS AETHIOPS; DENGUE VIRUS; ENZYME STABILITY; GENOME, VIRAL; METHYLTRANSFERASES; MUTAGENESIS; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; RNA, VIRAL; S-ADENOSYLMETHIONINE; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 50349097265     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800613200     Document Type: Article

References (54)

1. Shuman, S. (2001) Prog. Nucleic Acid Res. Mol. Biol. 66, 1-40
2. Shuman, S. (2002) Nat. Rev. Mol. Cell Biol. 3, 619-625
3. Furuichi, Y., and Shatkin, A. J. (2000) Adv. Virus Res. 55, 135-184
4. Shuman, S. (1995) Prog. Nucleic Acid Res. Mol. Biol. 50, 101-129
5. Hercyk, N., Horikami, S. M., and Moyer, S. A. (1988) Virology 163, 222-225
6. Ramadevi, N., Burroughs, N. J., Mertens, P. P., Jones, I. M., and Roy, P. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13537-13542
7. Ogino, T., Kobayashi, M., Iwama, M., and Mizumoto, K. (2005) J. Biol. Chem. 280, 4429-4435
8. Reinisch, K. M., Nibert, M. L., and Harrison, S. C. (2000) Nature 404, 960-967
9. Sutton, G., Grimes, J. M., Stuart, D. I., and Roy, P. (2007) Nat. Struct. Mol. Biol. 14, 449-451
10. Li, J., Fontaine-Rodriguez, E. C., and Whelan, S. P. (2005) J. Virol. 79, 13373-13384
11. Ray, D., Shah, A., Tilgner, M., Guo, Y., Zhao, Y., Dong, H., Deas, T. S., Zhou, Y., Li, H., and Shi, P. Y. (2006) J. Virol. 80, 8362-8370
12. Egloff, M. P., Benarroch, D., Selisko, B., Romette, J. L., and Canard, B. (2002) EMBO J. 21, 2757-2768
13. Gubler, D. J. (2002) Trends Microbiol. 10, 100-103
14. Benarroch, D., Egloff, M. P., Mulard, L., Guerreiro, C., Romette, J. L., and Canard, B. (2004) J. Biol. Chem. 279, 35638-35643
15. Li, J., Chorba, J. S., and Whelan, S. P. (2007) J. Virol. 81, 4104-4115
16. Luzhkov, V. B., Selisko, B., Nordqvist, A., Peyrane, F., Decroly, E., Alvarez, K., Karlen, A., Canard, B., and Qvist, J. (2007) Bioorg. Med. Chem. 15, 7795-7802
17. Lindenbach, B. D., and Rice, C. M. (2001) in Fields Virology (Knipe, D. M., and Howley, P. M., eds) 4th Ed., pp. 991-1042, Lippincott Williams & Wilkins, Philadelphia
18. Li, H. T., Clum, S., You, S. H., Ebner, K. E., and Padmanabhan, R. (1999) J. Virol. 73, 3108-3116
19. Wengler, G. (1993) Virology 197, 265-273
20. Koonin, E. V. (1993) J. Gen. Virol. 74, 733-740
21. Koonin, E. V., and Dolja, V. V. (1993) Crit. Rev. Biochem. Mol. Biol. 28, 375-430
22. Ackermann, M., and Padmanabhan, R. (2001) J. Biol. Chem. 276, 39926-39937
23. Guyatt, K. J., Westaway, E. G., and Khromykh, A. A. (2001) J. Virol. Method. 92, 37-44
24. Selisko, B., Dutartre, H., Guillemot, J. C., Debarnot, C., Benarroch, D., Khromykh, A., Despres, P., Egloff, M. P., and Canard, B. (2006) Virology 351, 145-158
25. Tan, B. H., Fu, J., Sugrue, R. J., Yap, E. H., Chan, Y. C., and Tan, Y. H. (1996) Virology 216, 317-325
26. Yap, T. L., Xu, T., Chen, Y. L., Malet, H., Egloff, M. P., Canard, B., Vasudevan, S. G., and Lescar, J. (2007) J. Virol. 81, 4753-4765
27. Zhou, Y., Ray, D., Zhao, Y., Dong, H., Ren, S., Li, Z., Guo, Y., Bernard, K. A., Shi, P. Y., and Li, H. (2007) J. Virol. 81, 3891-3903
28. Assenberg, R., Ren, J., Verma, A., Walter, T. S., Alderton, D., Hurrelbrink, R. J., Fuller, S. D., Bressanelli, S., Owens, R. J., Stuart, D. I., and Grimes, J. M. (2007) J. Gen. Virol. 88, 2228-2236
29. Mastrangelo, E., Bollati, M., Milani, M., Selisko, B., Peyrane, F., Canard, B., Grard, G., de Lamballerie, X., and Bolognesi, M. (2007) Protein Sci. 16, 1133-1145
30. Egloff, M. P., Decroly, E., Malet, H., Selisko, B., Benarroch, D., Ferron, F., and Canard, B. (2007) J. Mol. Biol. 372, 723-736
31. Malet, H., Egloff, M. P., Selisko, B., Butcher, R. E., Wright, P. J., Roberts, M., Gruez, A., Sulzenbacher, G., Vonrhein, C., Bricogne, G., Mackenzie, J. M., Khromykh, A. A., Davidson, A. D., and Canard, B. (2007) J. Biol. Chem. 282, 10678-10689
32. Gualano, R. C., Pryor, M. J., Cauchi, M. R., Wright, P. J., and Davidson, A. D. (1998) J. Gen. Virol. 79, 437-446
33. Pryor, M. J., Carr, J. M., Hocking, H., Davidson, A. D., Li, P., and Wright, P. J. (2001) Am. J. Trop. Med. Hyg. 65, 427-434
34. Reed, L. J., and Muench, H. (1938) Am. J. Hyg. 27, 493-497
35. Kagan, R. M., and Clarke, S. (1994) Arch. Biochem. Biophys. 310, 417-427
36. Malone, T., Blumenthal, R. M., and Cheng, X. (1995) J. Mol. Biol. 253, 618-632
37. Cheng, X., Kumar, S., Posfai, J., Pflugrath, J. W., and Roberts, R. J. (1993) Cell 74, 299-307
38. Wu, S., and Liu, B. (2005) BioDrugs 19, 383-392
39. Dong, H., Ren, S., Zhang, B., Zhou, Y., Puig-Basagoiti, F., Li, H., and Shi, P. Y. (2008) J. Virol. 82, 4295-4307
40. Li, J., Wang, J. T., and Whelan, S. P. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 8493-8498
41. Dong, H., Ray, D., Ren, S., Zhang, B., Puig-Basagoiti, F., Takagi, Y., Ho, C. K., Li, H., and Shi, P. Y. (2007) J. Virol. 81, 4412-4421
42. Luongo, C. L., Contreras, C. M., Farsetta, D. L., and Nibert, M. L. (1998) J. Biol. Chem. 273, 23773-23780
43. Mao, X., Schwer, B., and Shuman, S. (1996) Mol. Cell. Biol. 16, 475-480
44. Mao, X., and Shuman, S. (1996) Biochemistry 35, 6900-6910
45. Mao, X., and Shuman, S. (1994) J. Biol. Chem. 269, 24472-24479
46. Fabrega, C., Hausmann, S., Shen, V., Shuman, S., and Lima, C. D. (2004) Mol. Cell 13, 77-89
47. Hausmann, S., Zheng, S., Fabrega, C., Schneller, S. W., Lima, C. D., and Shuman, S. (2005) J. Biol. Chem. 280, 20404-20412
48. Kapoor, M., Zhang, L., Ramachandra, M., Kusukawa, J., Ebner, K. E., and Padmanabhan, R. (1995) J. Biol. Chem. 270, 19100-19106
49. Johansson, M., Brooks, A. J., Jans, D. A., and Vasudevan, S. G. (2001) J. Gen. Virol. 82, 735-745
50. Khromykh, A. A., Sedlak, P. L., and Westaway, E. G. (1999) J. Virol. 73, 9247-9255
51. Liu, W. J., Sedlak, P. L., Kondratieva, N., and Khromykh, A. A. (2002) J. Virol. 76, 10766-10775
52. Hanley, K. A., Lee, J. J., Blaney, J. E., Jr., Murphy, B. R., and Whitehead, S. S. (2002) J. Virol. 76, 525-531
53. Luo, D., Xu, T., Hunke, C., Gruber, G., Vasudevan, S. G., and Lescar, J. (2008) J. Virol. 82, 173-183
54. DeLano, W. L. (2002) DeLano Scientific, Palo Alto, CA