A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication

Virus Research

Volumn 165, Issue 1, 2012, Pages 103-106

  Nag, Dilip K ^a,b   Finley, Daniel ^c  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Antiviral drug; Deubiquitinase; Deubiquitinase inhibitor; Flaviviruses; Proteasome; Protein degradation

Indexed keywords

ANTIVIRUS AGENT; ENZYME INHIBITOR; IU 1; UNCLASSIFIED DRUG; USP 14 ENZYME; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CHIKUNGUNYA ALPHAVIRUS; DENGUE; DENGUE VIRUS 2; HUMAN; HUMAN CELL; LA CROSSE VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; UBIQUITINATION; VIRUS ENTRY; VIRUS RELEASE; VIRUS REPLICATION; VIRUS TRANSCRIPTION; WEST NILE FLAVIVIRUS; YELLOW FEVER FLAVIVIRUS;

CELL LINE; DENGUE; DENGUE VIRUS; DOWN-REGULATION; ENZYME INHIBITORS; HUMANS; SMALL MOLECULE LIBRARIES; UBIQUITIN; UBIQUITIN THIOLESTERASE; VIRUS REPLICATION;

DENGUE VIRUS; FLAVIVIRUS;

EID: 84858865470     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2012.01.009     Document Type: Article

References (32)

1. Banks L., Pim D., Thomas M. Viruses and the 26S proteasome: hacking into destruction. Trends Biochem. Sci. 2003, 228:452-459.
2. Bedford L., Lowe J., Dick L.R., Mayer R.J., Brownell J.E. Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets. Nat. Rev. Drug Discov. 2011, 10:29-46.
3. Clague M.J., Urbé S. Ubiquitin: same molecule, different degradation pathways. Cell 2010, 143:682-685.
4. Colland F. The therapeutic potential of deubiquitinating enzyme inhibitors. Biochem. Soc. Trans. 2010, 38:137-143.
5. Colpitts T.M., Cox J., Nguyen A., Feitosa F., Krishnan M.N., Fikrig E. Use of a tandem affinity purification assay to detect interactions between West Nile and Dengue viral proteins of the mosquito vector. Virology 2011, 417:179-187.
6. Daviet L., Colland F. Targeting ubiquitin specific proteases for drug discovery. Biochimie 2008, 90:270-283.
7. Fernandez-Garcia M-D., Meertens L., Bonazzi M., Cossart P., Arenzana-Seisdedos F., Amara A. Appraising the roles of CBLL1 and the ubiquitin-proteasome system for flavivirus entry and replication. J. Virol. 2011, 85:2980-2989.
8. Fink J., Gu F., Ling L., Tolfvenstam T., Olfat F., Chin K.C., Aw P., George J., Kuznetsov V.A., Schreiber M., Vasudevan S.G., Hibberd M.L. Host gene expression profiling of dengue virus infection in cell lines and patients. PLos Negl. Trop. Dis. 2007, 1:e86.
9. Finley D. Recognition and processing of ubiquitin-protein conjugates by the proteasome. Ann. Rev. Biochem. 2009, 78:477-513.
10. Fischl W., Bartenschlager R. Exploitation of cellular pathways by Dengue virus. Curr. Opin. Microbiol. 2011, 14:1-6.
11. Gao G., Luo H. The ubiquitin-proteasome pathway in viral infections. Can. J. Physiol. Pharmcol. 2006, 84:5-14.
12. Gilfoy F., Fayzulin R., Mason P.W. West Nile virus genome amplification requires the functional activities of the proteasome. Virology 2009, 385:74-84.
13. Gubler D.J., Kuno G., Markoff L. Flaviviruses. Fields Virology 2007, 1153-1252. Lippincott Williams & Wilkins, Philadelphia, PA. 5th ed. D.M. Knipe, P.M. Howley, D.E. Griffin, R.A. Lamb, M.A. Martin, B. Roizman, S.E. Straus (Eds.).
14. Guzman M.G., Halstead S.B., Artsob H., Buchy P., Farrar J., Gubler D.J., Hunsperger E., Kroeger A., Margolis H.S., Martínez E., Nathan M.B., Pelegrino J.L., Simmons C., Yoksan S., Peeling R.W. Dengue: a continuing global threat. Nat. Rev. Microbiol. 2010, S7-S16.
15. Kanlaya R., Pattanakikitsakul S.-N., Sinchaikul S., Chen S.-T., Thongboonkerd V. The ubiquitin-proteasome pathway is important for dengue virus infection in primary human endothelial cells. J. Proteome Res. 2010, 9:4960-4971.
16. Khor R., McElroy L.J., Whittaker G.R. The ubiquitin-vacuolar protein sorting system is selectively required during entry of influenza virus into host cells. Traffic 2003, 4:857-868.
17. Kikkert M., Hassink G., Barel M., Hirsch C., van der wal F.J., Wiertz E. Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the cytoplasmic reticulum to the cytosol. Biochem. J. 2001, 358:369-377.
18. Kramer L., Li J., Shi P.-Y. West Nile virus. Lancet Neurol. 2007, 6:171-182.
19. Krishnan M.N., Ng A., Sukumaran B., Gilfoy F.D., Uchil P.D., Sultana H., Brass A.L., Adametz R., Tsui M., Qian F., Montgomery R.R., Lev S., Mason P.W., Koski R.A., Elledge S.J., Xavier R.J., Agaisse H., Fikrig E. RNA interference screen for human genes associated with West Nile virus infection. Nature 2008, 455:242-245.
20. Lee B.H., Lee M.J., Park S., Oh D.C., Elsasser S., Chen P.C., Gartner C., Dimova N., Hanna J., Gygi S.P., Wilson S.M., King R.W., Finley D. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 2010, 467:179-184.
21. Levitskaya J., Shapiro A., Leonchiks A., Ciechanover A., Msucci M.G. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:12616-12621.
22. Luo H., Zhang J., Cheung C., Suarez A., McManus B.M., Yang D. Proteasome inhibition reduces coxsackievirus B3 replication in murine cardiomyocytes. Am. J. Pathol. 2003, 163:381-385.
23. Pastorino B., Boucomont-Chapeaublanc E., Peyrefitte C.N., Belghazi M., Fusai T., Rogier C., Tolou H.J., Almeras L. Identification of cellular proteome modifications in response to West Nile virus infection. Mol. Cell. Proteomics 2009, 8:1623-1637.
24. Patnaik A., Chau V., Wills J.W. Ubiquitin is part of the retrovirus budding machinery. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:13069-13074.
25. Scheffner M., Huibregtse J.M., Vierstra R.D., Howley P.M. The HPV-16E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993, 75:495-505.
26. Schrader E.K., Harstad K.G., Matouschek A. Targeting proteins for degradation. Nat. Chem. Biol. 2009, 5:815-822.
27. Schubert U., Ott D.E., Chertova E.N., Welker R., Tessmer U., Princiotta M.F., Bennink J.R., Krausslich H.G., Yewdell J.W. Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:13057-13062.
28. Sessions O.M., Barrows N.J., Souza-Neto J.A., Robinson T.J., Hershey C.L., Rodgers M.A., Ramirez J.L., Dimopoulos G., Yang P.L., Pearson J.L., Garcia-Blanco M.A. Discovery of insect and human dengue virus host factors. Nature 2009, 458:1047-1050.
29. Shackelford J., Pagano J.S. Targeting of host-cell ubiquitin pathways by viruses. Essays Biochem. 2005, 41:139-156.
30. Shamu C.E., Flierman D., Ploegh H.L., Rapoport T.A., Chau V. Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Mol. Biol. Cell. 2001, 12:2546-2555.
31. Strack B., Calistri A., Accola M.A., Palu G., Gottlinger H.G. A role for ubiquitin ligase recruitment in retrovirus release. Proc. Natl. Acad. Sci. 2000, 97:13063-13068.
32. Zhu Q., Yao J., Wani G., Chen J., Wang Q.E., Wani A.A. The ubiquitin proteasome pathway is required for the function of the viral VP16 transcriptional activation domain. FEBS Lett. 2004, 556:19-25.