The kinase inhibitor sfv785 dislocates dengue virus envelope protein from the replication complex and blocks virus assembly

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Anwar, Azlinda ^a   Hosoya, Takamitsu ^b   Leong, Kok Mun ^a   Onogi, Hiroshi ^b,c   Okuno, Yukiko ^b   Hiramatsu, Toshiyuki ^b   Koyama, Hiroko ^d   Suzuki, Masaaki ^e   Hagiwara, Masatoshi ^b,f   Garcia Blanco, Mariano A ^a,g  

^a DUKE NUS MEDICAL SCHOOL   (Singapore)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c KinoPharma   (Japan)

^d GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e RIKEN   (Japan)

^f KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^g DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (1 AZACYCLOOCTANYL) 5 (TRIFLUOROMETHYL)]PHENYL 3 NICOTINOYLTHIOUREA; ANTIVIRUS AGENT; CALNEXIN; NONSTRUCTURAL PROTEIN 3; PHOSPHOTRANSFERASE INHIBITOR; RIBAVIRIN; SERINE ARGININE RICH PROTEIN; SFV 785; SMALL INTERFERING RNA; SRPIN 340; SRPIN 785; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; 1 (2 (1 AZACYCLOOCTANYL) 5 (TRIFLUOROMETHYL))PHENYL 3 NICOTINOYLTHIOUREA; 1-(2-(1-AZACYCLOOCTANYL)-5-(TRIFLUOROMETHYL))PHENYL-3-NICOTINOYLTHIOUREA; AZOCINE DERIVATIVE; DRUG DERIVATIVE; PROTEIN KINASE INHIBITOR; THIOUREA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DENGUE; DENGUE VIRUS; DOSE RESPONSE; DRUG SYNTHESIS; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; FLAVIVIRUS; LIFE CYCLE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPLICON; RNA SYNTHESIS; RNA TRANSLATION; STRUCTURE ACTIVITY RELATION; VIRION; VIRUS ASSEMBLY; VIRUS NUCLEOCAPSID; VIRUS PARTICLE; VIRUS REPLICATION; ANIMAL; BODY WEIGHT; CELL LINE; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETICS; HEPATITIS C VIRUS; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MOUSE; TUMOR CELL LINE; ULTRASTRUCTURE; VERO CELL; VIROLOGY;

DENGUE VIRUS; HEPATITIS C VIRUS; MIRIDAE; YELLOW FEVER VIRUS GROUP;

ANIMALS; ANTIVIRAL AGENTS; AZOCINES; BODY WEIGHT; CELL LINE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; DENGUE VIRUS; ENDOPLASMIC RETICULUM; HEPACIVIRUS; HUMANS; MICE; MICE, INBRED ICR; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; NUCLEOCAPSID; PROTEIN KINASE INHIBITORS; THIOUREA; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRION; VIRUS ASSEMBLY; VIRUS REPLICATION;

EID: 80051731938     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023246     Document Type: Article

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