Gene expression profiling of dengue infected human primary cells identifies secreted mediators in vivo

Journal of Medical Virology

Volumn 81, Issue 8, 2009, Pages 1403-1411

  Becerra, Aniuska ^a   Warke, Rajas V ^a   Martin, Katherine ^a,b   Xhaja, Kris ^a   De Bosch, Norma ^c   Rothman, Alan L ^a   Bosch, Irene ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Bioarray Consulting   (United States)

^c Banco Metropolitano de Sangre del Distrito Capital   (Venezuela)

Author keywords

Affymetrix; Dengue virus; Global gene expression; IP 10; MCP 2; MIP 1 ; TRAIL

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 2; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ADULT; ARTICLE; BLOOD CULTURE; CLINICAL ARTICLE; CLINICAL EXAMINATION; COHORT ANALYSIS; COMPARATIVE STUDY; DENDRITIC CELL; DENGUE; DENGUE VIRUS; DNA FINGERPRINTING; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; INFLAMMATION; MALE; PRIMARY INFECTION; PROSPECTIVE STUDY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SYSTEMATIC REVIEW; UPREGULATION; VENEZUELA;

ADOLESCENT; ADULT; B-LYMPHOCYTES; CELLS, CULTURED; CHEMOKINE CCL8; CHEMOKINE CXCL10; CHILD; COHORT STUDIES; DENDRITIC CELLS; DENGUE; DENGUE VIRUS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; MONOCYTES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; VENEZUELA; YOUNG ADULT;

DENGUE VIRUS;

EID: 68049083654     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21538     Document Type: Article

References (38)

1. Ashkenazi A, Pai RC, Fong S, Leung S, Lawrence DA, Marsters SA, Blackie C, Chang L, McMurtrey AE, Hebert A, DeForge L, Koumenis IL, Lewis D,Harris L, Bussiere J, KoeppenH, Shahrokh Z, Schwall RH. 1999. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 104:155-162.
2. Avirutnan P, Malasit P, Seliger B, Bhakdi S, Husmann M. 1998. Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis. J Immunol 161:6338-6346. (Pubitemid 28536010)
3. Becerra A, Warke RV, de Bosch N, Rothman AL, Bosch I. 2008. Elevated levels of soluble ST2 protein in dengue virus infected patients. Cytokine 41:114-120.
4. Bozza FA, Cruz OG, Zagne SM, Azeredo EL, Nogueira RM, Assis EF, Bozza PT, Kubelka CF. 2008. Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity. BMC Infect Dis 8:86.
5. Chaturvedi U, Nagar R, Shrivastava R. 2006. Dengue and dengue haemorrhagic fever: Implications of host genetics. FEMS Immunol Med Microbiol 47:155-166. (Pubitemid 43881735)
6. Chen YC, Wang SY. 2002. Activation of terminally differentiated human monocytes/macrophages by dengue virus: Productive infection, hierarchical production of innate cytokines and chemokines, and the synergistic effect of lipopolysaccharide. J Virol 76: 9877-9887.
7. Chen JP, Lu HL, Lai SL, Campanella GS, Sung JM, Lu MY, Wu-Hsieh BA, Lin YL, Lane TE, Luster AD, Liao F. 2006. Dengue virus induces expression of CXC chemokine ligand 10/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate. J Immunol 177:3185-3192. (Pubitemid 44304270)
8. Diago M, Castellano G, Garcia-Samaniego J, Perez C, Fernandez I, Romero M, Iacono OL, Garcia-Monzon C. 2006. Association of pretreatment serum interferon gamma inducible protein 10 levels with sustained virological response to peginterferon plus ribavirin therapy in genotype 1 infected patients with chronic hepatitis C. Gut 55:374-379. (Pubitemid 43268277)
9. Diehl GE, Yue HH, Hsieh K, Kuang AA, Ho M, Morici LA, Lenz LL, Cado D, Riley LW, Winoto A. 2004. TRAIL-R as a negative regulator of innate immune cell responses. Immunity 21:877-889. (Pubitemid 39626676)
10. Farber JM. 1997. Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol 61:246-257.
11. Fink J, Gu F, Ling L, Tolfvenstam T, Olfat F, Chin KC, Aw P, George J, Kuznetsov VA, Schreiber M, Vasudevan SG, Hibberd ML. 2007. Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Negl Trop Dis 1:e86. (Pubitemid 352024655)
12. Guzman MG, Kouri GP, Bravo J, Soler M, Vazquez S, Morier L. 1990. Dengue hemorrhagic fever in Cuba, 1981: A retrospective seroepidemiologic study. Am J Trop Med Hyg 42:179-184. (Pubitemid 20093452)
13. Halstead SB, Nimmannitya S, Cohen SN. 1970. Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale J Biol Med 42:311-328.
14. Hsieh MF, Lai SL, Chen JP, Sung JM, Lin YL, Wu-Hsieh BA, Gerard C, Luster A, Liao F. 2006. Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus. J Immunol 177:1855-1863. (Pubitemid 44092524)
15. Huang YH, Lei HY, Liu HS, Lin YS, Liu CC, Yeh TM. 2000. Dengue virus infects human endothelial cells and induces IL-6 and IL-8 production. Am J Trop Med Hyg 63:71-75.
16. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP. 2003. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31:e15.
17. Juffrie M, van Der Meer GM, Hack CE, Haasnoot K, Sutaryo J, Veerman AJ, Thijs LG. 2000. Inflammatory mediators in dengue virus infection in children: Interleukin-8 and its relationship to neutrophil degranulation. Infect Immun 68:702-707. (Pubitemid 30056526)
18. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA. 1997. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis 176:313-321. (Pubitemid 27328752)
19. King CA, Anderson R, Marshall JS. 2002. Dengue virus selectively induces human mast cell chemokine production. J Virol 76:8408-8419. (Pubitemid 34809093)
20. Laine PS, Schwartz EA, Wang Y, Zhang WY, Karnik SK, Musi N, Reaven PD. 2007. Palmitic acid induces IP-10 expression in human macrophages via NF-kappaB activation. Biochem Biophys Res Commun 358:150-155. (Pubitemid 46719095)
21. Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV. 1992. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30:545-551.
22. Lee YR, Liu MT, Lei HY, Liu CC, Wu JM, Tung YC, Lin YS, Yeh TM, Chen SH, Liu HS. 2006. MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J Gen Virol 87:3623-3630.
23. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408. (Pubitemid 34164012)
24. Maurer M, von Stebut E. 2004. Macrophage inflammatory protein-1. Int J Biochem Cell Biol 36:1882-1886.
25. Monath TP. 1994. Dengue: The risk to developed and developing countries. Proc Natl Acad Sci USA 91:2395-2400.
26. O'Boyle G, Brain JG, Kirby JA, Ali S. 2007. Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2. Mol Immunol 44:1944-1953.
27. Proost P, Wuyts A, Van Damme J. 1996. Humanmonocyte chemotactic proteins-2 and -3: Structural and functional comparison with MCP-1. J Leukoc Biol 59:67-74. (Pubitemid 26054592)
28. Raghupathy R, Chaturvedi UC, Al-Sayer H, Elbishbishi EA, Agarwal R, Nagar R, Kapoor S, Misra A, Mathur A, Nusrat H, Azizieh F, Khan MA, Mustafa AS. 1998. Elevated levels of IL-8 in dengue hemorrhagic fever. J Med Virol 56:280-285. (Pubitemid 28458099)
29. Roe B, Coughlan S, Hassan J, Grogan A, Farrell G, Norris S, Bergin C, Hall WW. 2007. Elevated serum levels of interferon-gamma-inducible protein-10 in patients coinfected with hepatitis C virus and HIV. J Infect Dis 196:1053-1057. (Pubitemid 47580300)
30. Rothman AL, Ennis FA. 1999. Immunopathogenesis of dengue hemorrhagic fever. Virology 257:1-6.
31. Secchiero P, Corallini F, di Iasio MG, Gonelli A, Barbarotto E, Zauli G. 2005. TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release. Blood 105:3413-3419. (Pubitemid 40628180)
32. Song K, Chen Y, Goke R,Wilmen A, Seidel C, Goke A, Hilliard B, Chen Y. 2000. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression. J Exp Med 191:1095-1104. (Pubitemid 30207673)
33. Spain-Santana TA, Marglin S, Ennis FA, Rothman AL. 2001. MIP-1 alpha and MIP-1 beta induction by dengue virus. J Med Virol 65:324-330.
34. Suksanpaisan L, Cabrera-Hernandez A, Smith DR. 2007. Infection of human primary hepatocytes with dengue virus serotype 2. J Med Virol 79:300-307. (Pubitemid 46213194)
35. Vassina E, Leverkus M, Yousefi S, Braathen LR, Simon HU, Simon D. 2005. Increased expression and a potential anti-inflammatory role of TRAIL in atopic dermatitis. J Invest Dermatol 125:746-752.
36. Warke RV, Xhaja K, Martin KJ, Fournier MF, Shaw SK, BrizuelaN, de Bosch N, Lapointe D, Ennis FA, Rothman AL, Bosch I. 2003. Dengue virus induces novel changes in gene expression of human umbilical vein endothelial cells. J Virol 77:11822-11832. (Pubitemid 37271679)
37. Warke RV, Martin KJ, Giaya K, Shaw SK, Rothman AL, Bosch I. 2007. TRAIL is a novel anti-viral protein against dengue virus. J Virol 82:555-564. (Pubitemid 350309170)
38. WHO. 2003. HQ/SEAROP/WPRO meeting on Dengue Net implementation in South-East Asia and the Western Pacific, Kuala Lumpur, 11-13 December 2003. Wkly Epidemiol Rec 78:346-347.