메뉴 건너뛰기




Volumn , Issue , 2009, Pages 193-222

Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII

Author keywords

Carbonic anhydrase inhibitors targeting cancer; Carbonic anhydrases CA IX and XII interesting molecules from research and clinical view points; Tissue distribution of CA IX and CA XII

Indexed keywords


EID: 84889331040     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470508169.ch8     Document Type: Chapter
Times cited : (12)

References (174)
  • 1
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
    • Supuran, C. T. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat. Rev. Drug Discov. 2008, 7, 168-181.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 2
    • 0009125899 scopus 로고    scopus 로고
    • An overview of the distribution and function of carbonic anhydrase in mammals
    • In The Carbonic Anhydrases: New Horizons; Chegwidden,W. R.; Carter, N.; Edwards, Y., Eds.; Birkhauser Verlag: Basil
    • Parkkila, S. An overview of the distribution and function of carbonic anhydrase in mammals, In The Carbonic Anhydrases: New Horizons; Chegwidden,W. R.; Carter, N.; Edwards, Y., Eds.; Birkhauser Verlag: Basil, 2000; pp 76-93.
    • (2000) , pp. 76-93
    • Parkkila, S.1
  • 3
    • 34249750070 scopus 로고    scopus 로고
    • Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV
    • Hilvo, M.; Supuran, C. T.; Parkkila, S. Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV. Curr. Top. Med. Chem. 2007, 7, 893-899.
    • (2007) Curr. Top. Med. Chem. , vol.7 , pp. 893-899
    • Hilvo, M.1    Supuran, C.T.2    Parkkila, S.3
  • 4
    • 3442883664 scopus 로고    scopus 로고
    • Carbonic anhydrases: current state of the art, therapeutic applications and future prospects
    • Pastorekova, S.; Parkkila, S.; Pastorek, J.; Supuran, C. T. Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J. Enzyme Inhib. Med. Chem. 2004, 19, 199-229.
    • (2004) J. Enzyme Inhib. Med. Chem. , vol.19 , pp. 199-229
    • Pastorekova, S.1    Parkkila, S.2    Pastorek, J.3    Supuran, C.T.4
  • 5
    • 35248828654 scopus 로고    scopus 로고
    • Hypoxia in cancer cell metabolism and pH regulation
    • Brahimi-Horn, M. C.; Pouysségur, J. Hypoxia in cancer cell metabolism and pH regulation. Essays Biochem. 2007, 43, 165-178.
    • (2007) Essays Biochem. , vol.43 , pp. 165-178
    • Brahimi-Horn, M.C.1    Pouysségur, J.2
  • 6
    • 33748079158 scopus 로고    scopus 로고
    • Tumor-associated carbonic anhydrases and their clinical significance
    • Pastorekova, S.; Parkkila, S.; Zavada, J. Tumor-associated carbonic anhydrases and their clinical significance. Adv. Clin. Chem. 2006, 42, 167-216.
    • (2006) Adv. Clin. Chem. , vol.42 , pp. 167-216
    • Pastorekova, S.1    Parkkila, S.2    Zavada, J.3
  • 11
    • 0030076314 scopus 로고    scopus 로고
    • Functional diversity, conservation and convergence in the evolution of the alpha, beta and gamma carbonic anhydrase gene families
    • Hewett-Emmett, D.; Tashian, R. E. Functional diversity, conservation and convergence in the evolution of the alpha, beta and gamma carbonic anhydrase gene families. Mol. Phylogenet. Evol. 1996, 5, 50-77.
    • (1996) Mol. Phylogenet. Evol. , vol.5 , pp. 50-77
    • Hewett-Emmett, D.1    Tashian, R.E.2
  • 12
    • 44449089520 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: historical and future perspectives
    • Oosterwijk, E. Carbonic anhydrase IX: historical and future perspectives. BJU Int. 2008, 101 (Suppl. 4), 2-7.
    • (2008) BJU Int. , vol.101 , Issue.SUPPL. 4 , pp. 2-7
    • Oosterwijk, E.1
  • 14
    • 28244451574 scopus 로고    scopus 로고
    • Biological significance of overexpression of carbonic anhydrase IX in renal cell carcinoma:EGF-induced phosphorylation of carbonic anhydrase IX leads to activation of PI-3-kinase pathway in renal cell carcinoma
    • Dorai, T.; Sawczuk, I. S.; Pastorek, J.; Wiernik, P. H.; Dutcher, J. P. Biological significance of overexpression of carbonic anhydrase IX in renal cell carcinoma:EGF-induced phosphorylation of carbonic anhydrase IX leads to activation of PI-3-kinase pathway in renal cell carcinoma. Eur. J. Cancer 2005, 41, 2935-2947.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2935-2947
    • Dorai, T.1    Sawczuk, I.S.2    Pastorek, J.3    Wiernik, P.H.4    Dutcher, J.P.5
  • 16
    • 1842790839 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorinecontaining sulfonamides. The first subnanomolar CA IX inhibitor discovered
    • Vullo, D.; Scozzafava, A.; Pastorekova, S.; Pastorek, J.; Supuran, C. T. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorinecontaining sulfonamides. The first subnanomolar CA IX inhibitor discovered. Bioorg. Med. Chem. Lett. 2004, 14, 2351-2356.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2351-2356
    • Vullo, D.1    Scozzafava, A.2    Pastorekova, S.3    Pastorek, J.4    Supuran, C.T.5
  • 17
    • 0038587356 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors
    • Winum, J. Y.; Vullo, D.; Casini, A.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors. J. Med. Chem. 2003, 46, 2197-2204.
    • (2003) J. Med. Chem. , vol.46 , pp. 2197-2204
    • Winum, J.Y.1    Vullo, D.2    Casini, A.3    Montero, J.L.4    Scozzafava, A.5    Supuran, C.T.6
  • 19
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov, S.V.;Kuzmin, I.;Wei, M. H.; Pack, S.; Geil, L.; Johnson, B. E.; Stanbridge, E. J.; Lerman, M. I. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc. Natl. Acad. Sci. USA 1998, 95, 12596-12601.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 12596-12601
    • Ivanov, S.V.1    Kuzmin, I.2    Wei, M.H.3    Pack, S.4    Geil, L.5    Johnson, B.E.6    Stanbridge, E.J.7    Lerman, M.I.8
  • 20
    • 0034687801 scopus 로고    scopus 로고
    • Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers
    • Ulmasov,B.;Waheed, A.; Shah, G.N.; Grubb, J.H.; Sly, W. S.; Tu, C.; Silverman,D. N. Purification and kinetic analysis of recombinant CA XII, a membrane carbonic anhydrase overexpressed in certain cancers. Proc. Natl. Acad. Sci. USA 2000, 97, 14212-14217.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 14212-14217
    • Ulmasov, B.1    Waheed, A.2    Shah, G.N.3    Grubb, J.H.4    Sly, W.S.5    Tu, C.6    Silverman, D.N.7
  • 21
    • 0031040821 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts
    • Pastorekova, S.; Parkkila, S.; Parkkila, A. K.; Opavsky, R.; Zelník, V.; Saarnio, J.; Pastorek, J. Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Gastroenterology 1997, 112, 398-408.
    • (1997) Gastroenterology , vol.112 , pp. 398-408
    • Pastorekova, S.1    Parkkila, S.2    Parkkila, A.K.3    Opavsky, R.4    Zelník, V.5    Saarnio, J.6    Pastorek, J.7
  • 26
    • 0027981949 scopus 로고
    • Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas
    • Liao, S. Y.; Brewer, C.; Zavada, J.; Pastorek, J.; Pastorekova, S.; Manetta, A.; Berman, M. L.; DiSaia, P. J.; Stanbridge, E. J. Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas. Am. J. Pathol. 1994, 145, 598-609.
    • (1994) Am. J. Pathol. , vol.145 , pp. 598-609
    • Liao, S.Y.1    Brewer, C.2    Zavada, J.3    Pastorek, J.4    Pastorekova, S.5    Manetta, A.6    Berman, M.L.7    DiSaia, P.J.8    Stanbridge, E.J.9
  • 27
    • 0030972193 scopus 로고    scopus 로고
    • MNantigen expression in normal, preneoplastic and neoplastic esophagus: a clinicopathological study of a new cancerassociated biomarker
    • Turner, J. R.; Odze, R. D.; Crum, C. P.; Resnick, M. B. MNantigen expression in normal, preneoplastic and neoplastic esophagus: a clinicopathological study of a new cancerassociated biomarker. Hum. Pathol. 1997, 28, 740-744.
    • (1997) Hum. Pathol. , vol.28 , pp. 740-744
    • Turner, J.R.1    Odze, R.D.2    Crum, C.P.3    Resnick, M.B.4
  • 28
    • 0030835515 scopus 로고    scopus 로고
    • Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney
    • Liao, S.Y.; Aurelio, O. N.; Jan, K.; Zavada, J.; Stanbridge, E. J. Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney. Cancer Res. 1997, 57, 2827-2831.
    • (1997) Cancer Res. , vol.57 , pp. 2827-2831
    • Liao, S.Y.1    Aurelio, O.N.2    Jan, K.3    Zavada, J.4    Stanbridge, E.J.5
  • 30
  • 35
    • 0031819881 scopus 로고    scopus 로고
    • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
    • Saarnio, J.; Parkkila, S.; Parkkila, A. K.; Haukipuro, K.; Pastorekova, S.; Pastorek, J.; Kairaluoma, M. I.; Karttunen, T. J. Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am. J. Pathol. 1998, 153, 279-285.
    • (1998) Am. J. Pathol. , vol.153 , pp. 279-285
    • Saarnio, J.1    Parkkila, S.2    Parkkila, A.K.3    Haukipuro, K.4    Pastorekova, S.5    Pastorek, J.6    Kairaluoma, M.I.7    Karttunen, T.J.8
  • 36
    • 0030057305 scopus 로고    scopus 로고
    • Expression of the MN antigen in cervical papanicolaou smears is an early diagnostic biomarker of cervical dysplasia
    • Liao, S. Y.; Stanbridge, E. J. Expression of the MN antigen in cervical papanicolaou smears is an early diagnostic biomarker of cervical dysplasia. Cancer Epidemiol. Biomarkers Prev. 1996, 5, 549-557.
    • (1996) Cancer Epidemiol. Biomarkers Prev. , vol.5 , pp. 549-557
    • Liao, S.Y.1    Stanbridge, E.J.2
  • 37
    • 0034162457 scopus 로고    scopus 로고
    • Expression of MN/CA9 protein in Papanicolaou smears containing atypical glandular cells of undetermined significance is a diagnostic biomarker of cervical dysplasia and neoplasia
    • Liao, S. Y.; Stanbridge, E. J. Expression of MN/CA9 protein in Papanicolaou smears containing atypical glandular cells of undetermined significance is a diagnostic biomarker of cervical dysplasia and neoplasia. Cancer 2000, 88, 1108-1121.
    • (2000) Cancer , vol.88 , pp. 1108-1121
    • Liao, S.Y.1    Stanbridge, E.J.2
  • 46
    • 0037374846 scopus 로고    scopus 로고
    • Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma
    • Liao, S.Y.; Ivanov, S.; Ivanova, A.; Ghosh, S.; Cote, M. A.;Keefe, K.; Coca-Prados, M.; Stanbridge, E. J.; Lerman, M. I. Expression of cell surface transmembrane carbonic anhydrase genes CA9 and CA12 in the human eye: overexpression of CA12 (CAXII) in glaucoma. J. Med. Genet. 2003, 40, 257-261.
    • (2003) J. Med. Genet. , vol.40 , pp. 257-261
    • Liao, S.Y.1    Ivanov, S.2    Ivanova, A.3    Ghosh, S.4    Cote, M.A.5    Keefe, K.6    Coca-Prados, M.7    Stanbridge, E.J.8    Lerman, M.I.9
  • 49
    • 0032731194 scopus 로고    scopus 로고
    • Transcriptional regulation of the MN/CA9 gene coding for the tumor-associated carbonic anhydrase IX. Identification and characterization of a proximal silencer element
    • Kaluz, S.; Kaluzova, M.; Opavsky, R.; Pastorekova, S.; Gibadulinova, A.; Dequiedt, F.; Kettmann, R.; Pastorek, J. Transcriptional regulation of the MN/CA9 gene coding for the tumor-associated carbonic anhydrase IX. Identification and characterization of a proximal silencer element. J. Biol. Chem. 1999, 274, 32588-32595.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32588-32595
    • Kaluz, S.1    Kaluzova, M.2    Opavsky, R.3    Pastorekova, S.4    Gibadulinova, A.5    Dequiedt, F.6    Kettmann, R.7    Pastorek, J.8
  • 52
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway
    • Kaelin,W. G., Jr.; Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell. 2008, 30, 393-402.
    • (2008) Mol. Cell. , vol.30 , pp. 393-402
    • Kaelin Jr, W.G.1    Ratcliffe, P.J.2
  • 53
    • 35248824187 scopus 로고    scopus 로고
    • Oxygen sensing and hypoxia-induced responses
    • Coleman, M. L.; Ratcliffe, P. J. Oxygen sensing and hypoxia-induced responses. Essays Biochem. 2007, 43, 1-15.
    • (2007) Essays Biochem. , vol.43 , pp. 1-15
    • Coleman, M.L.1    Ratcliffe, P.J.2
  • 54
    • 24344443670 scopus 로고    scopus 로고
    • Hypoxia-dependent activation of HIF into a transcriptional regulator
    • Ruas, J. L.; Poellinger, L. Hypoxia-dependent activation of HIF into a transcriptional regulator. Semin. Cell Dev. Biol. 2005, 16, 514-522.
    • (2005) Semin. Cell Dev. Biol. , vol.16 , pp. 514-522
    • Ruas, J.L.1    Poellinger, L.2
  • 55
    • 0036682009 scopus 로고    scopus 로고
    • Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1a stabilization: a role for phosphatidylinositol 30-kinase
    • Kaluz, S.; Kaluzova, M.; Chrastina, A.; Olive, P. L.; Pastorekova, S.; Pastorek, J.; Lerman, M. I.; Stanbridge, E. J. Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1a stabilization: a role for phosphatidylinositol 30-kinase. Cancer Res. 2002, 62, 4469-4477.
    • (2002) Cancer Res. , vol.62 , pp. 4469-4477
    • Kaluz, S.1    Kaluzova, M.2    Chrastina, A.3    Olive, P.L.4    Pastorekova, S.5    Pastorek, J.6    Lerman, M.I.7    Stanbridge, E.J.8
  • 59
  • 60
    • 22844444398 scopus 로고    scopus 로고
    • Methylation of the CA9 promoter can modulate expression of the tumor-associated carbonic anhydrase IX in dense carcinoma cell lines
    • Jakubickova, L.; Biesova, Z.; Pastorekova, S.; Kettmann, R.; Pastorek, J. Methylation of the CA9 promoter can modulate expression of the tumor-associated carbonic anhydrase IX in dense carcinoma cell lines. Int. J. Oncol. 2005, 26, 1121-1127.
    • (2005) Int. J. Oncol. , vol.26 , pp. 1121-1127
    • Jakubickova, L.1    Biesova, Z.2    Pastorekova, S.3    Kettmann, R.4    Pastorek, J.5
  • 63
    • 1842852597 scopus 로고    scopus 로고
    • Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells
    • Rafajova, M.; Zatovicova, M.; Kettmann, R.; Pastorek, J.; Pastorekova, S. Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells. Int. J. Oncol. 2004, 24, 995-1004.
    • (2004) Int. J. Oncol. , vol.24 , pp. 995-1004
    • Rafajova, M.1    Zatovicova, M.2    Kettmann, R.3    Pastorek, J.4    Pastorekova, S.5
  • 64
    • 27944500753 scopus 로고    scopus 로고
    • Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
    • Zatovicova, M.; Sedlakova, O.; Svastova, E.; Ohradanova, A.; Ciampor, F.; Arribas, J.; Pastorek, J.; Pastorekova, S. Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17. Br. J. Cancer 2005, 93, 1267-1276.
    • (2005) Br. J. Cancer , vol.93 , pp. 1267-1276
    • Zatovicova, M.1    Sedlakova, O.2    Svastova, E.3    Ohradanova, A.4    Ciampor, F.5    Arribas, J.6    Pastorek, J.7    Pastorekova, S.8
  • 65
    • 0141887319 scopus 로고    scopus 로고
    • Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients
    • Zavada, J.; Zavadova, Z.; Zatovicova, M.; Hyrsl, L.; Kawaciuk, I. Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. Br. J. Cancer 2003, 89, 1067-1071.
    • (2003) Br. J. Cancer , vol.89 , pp. 1067-1071
    • Zavada, J.1    Zavadova, Z.2    Zatovicova, M.3    Hyrsl, L.4    Kawaciuk, I.5
  • 66
    • 46449104314 scopus 로고    scopus 로고
    • Serum carbonic anhydrase 9 level is associated with postoperative recurrence of conventional renal cell cancer
    • Li, G.; Feng, G.; Gentil-Perret, A.; Genin, C.; Tostain, J. Serum carbonic anhydrase 9 level is associated with postoperative recurrence of conventional renal cell cancer. J. Urol. 2008, 180, 510-513.
    • (2008) J. Urol. , vol.180 , pp. 510-513
    • Li, G.1    Feng, G.2    Gentil-Perret, A.3    Genin, C.4    Tostain, J.5
  • 67
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: significance and impact on clinical outcome
    • Vaupel, P.; Mayer, A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 2007, 26, 225-239.
    • (2007) Cancer Metastasis Rev. , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 68
    • 34447503754 scopus 로고    scopus 로고
    • The potential role of intrinsic hypoxia markers as prognostic variables in cancer
    • Moon,E. J.; Brizel,D. M.;Chi, J.T.;Dewhirst,M.W. The potential role of intrinsic hypoxia markers as prognostic variables in cancer. Antioxid. Redox Signal. 2007, 9, 1237-1294.
    • (2007) Antioxid. Redox Signal. , vol.9 , pp. 1237-1294
    • Moon, E.J.1    Brizel, D.M.2    Chi, J.T.3    Dewhirst, M.W.4
  • 69
    • 0035392959 scopus 로고    scopus 로고
    • Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis and microvessel density
    • Beasley, N. J.;Wykoff, C. C.;Watson, P. H.; Leek, R.; Turley, H.; Gatter, K.; Pastorek, J.; Cox, G. J.; Ratcliffe, P.; Harris, A. L. Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis and microvessel density. Cancer Res. 2001, 61, 5262-5267.
    • (2001) Cancer Res. , vol.61 , pp. 5262-5267
    • Beasley, N.J.1    Wykoff, C.C.2    Watson, P.H.3    Leek, R.4    Turley, H.5    Gatter, K.6    Pastorek, J.7    Cox, G.J.8    Ratcliffe, P.9    Harris, A.L.10
  • 71
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    • Swinson, D. E.; Jones, J. L.; Richardson, D.;Wykoff, C.; Turley, H.; Pastorek, J.; Taub, N.; Harris, A. L.; O'Byrne, K. J. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J. Clin. Oncol. 2003, 21, 473-482.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 473-482
    • Swinson, D.E.1    Jones, J.L.2    Richardson, D.3    Wykoff, C.4    Turley, H.5    Pastorek, J.6    Taub, N.7    Harris, A.L.8    O'Byrne, K.J.9
  • 76
    • 0035503362 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
    • Giatromanolaki, A.;Koukourakis, M. I.; Sivridis, E.; Pastorek, J.;Wykoff, C. C.; Gatter, K. C.; Harris, A. L. Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer. Cancer Res. 2001, 61, 7992-7998.
    • (2001) Cancer Res. , vol.61 , pp. 7992-7998
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3    Pastorek, J.4    Wykoff, C.C.5    Gatter, K.C.6    Harris, A.L.7
  • 78
    • 33751277287 scopus 로고    scopus 로고
    • CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance
    • Brennan, D. J.; Jirstrom, K.; Kronblad, A.; Millikan, R. C.; Landberg, G.; Duffy, M. J.; Rydén, L.; Gallagher, W. M.; O'Brien, S. L. CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance. Clin. Cancer Res. 2006, 12, 6421-6431.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6421-6431
    • Brennan, D.J.1    Jirstrom, K.2    Kronblad, A.3    Millikan, R.C.4    Landberg, G.5    Duffy, M.J.6    Rydén, L.7    Gallagher, W.M.8    O'Brien, S.L.9
  • 85
    • 33644638219 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas
    • Driessen,A.; Landuyt, W.; Pastorekova, S.;Moons, J.;Goethals, L.;Haustermans, K.; Nafteux, P.; Penninckx, F.; Geboes, K.; Lerut, T.; Ectors, N. Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas. Ann. Surg. 2006, 243, 334-340.
    • (2006) Ann. Surg. , vol.243 , pp. 334-340
    • Driessen, A.1    Landuyt, W.2    Pastorekova, S.3    Moons, J.4    Goethals, L.5    Haustermans, K.6    Nafteux, P.7    Penninckx, F.8    Geboes, K.9    Lerut, T.10    Ectors, N.11
  • 86
    • 25144464638 scopus 로고    scopus 로고
    • Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer
    • Ord, J. J.; Streeter, E. H.; Roberts, I. S.; Cranston, D.; Harris, A. L. Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer. Br. J. Cancer 2005, 93, 346-354.
    • (2005) Br. J. Cancer , vol.93 , pp. 346-354
    • Ord, J.J.1    Streeter, E.H.2    Roberts, I.S.3    Cranston, D.4    Harris, A.L.5
  • 88
    • 33846879810 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma
    • Kaelin W. G., Jr. The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin. Cancer Res. 2007, 13, 680s-684s.
    • (2007) Clin. Cancer Res. , vol.13
    • Kaelin Jr, W.G.1
  • 95
    • 46449100409 scopus 로고    scopus 로고
    • Carbonic anhydrase IX as a predictive biomarker for clear cell renal cell carcinoma
    • Pantuck, A. J.; Klatte, T.; Seligson, D.; Atkins, M.; Belldegrun, A. Carbonic anhydrase IX as a predictive biomarker for clear cell renal cell carcinoma. J. Clin. Oncol. 2008, 26, 3105-3107.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3105-3107
    • Pantuck, A.J.1    Klatte, T.2    Seligson, D.3    Atkins, M.4    Belldegrun, A.5
  • 96
    • 0041836180 scopus 로고    scopus 로고
    • Interferons can upregulate the expression of the tumor associated antigen G250-MN/CA IX, a potential target for (radio)immunotherapy of renal cell carcinoma
    • Brouwers, A. H.; Frielink, C.; Oosterwijk, E.; Oyen, W. J.; Corstens, F. H.; Boerman, O. C. Interferons can upregulate the expression of the tumor associated antigen G250-MN/CA IX, a potential target for (radio)immunotherapy of renal cell carcinoma. Cancer Biother. Radiopharm. 2003, 18, 539-547.
    • (2003) Cancer Biother. Radiopharm. , vol.18 , pp. 539-547
    • Brouwers, A.H.1    Frielink, C.2    Oosterwijk, E.3    Oyen, W.J.4    Corstens, F.H.5    Boerman, O.C.6
  • 98
    • 44449143994 scopus 로고    scopus 로고
    • Carbonic anhydrase IX and renal cell carcinoma:prognosis, response to systemic therapy, and future vaccine strategies
    • Shuch, B.; Li, Z.; Belldegrun, A. S. Carbonic anhydrase IX and renal cell carcinoma:prognosis, response to systemic therapy, and future vaccine strategies. BJU Int. 2008, 101 (Suppl. 4), 25-30.
    • (2008) BJU Int. , vol.101 , Issue.SUPPL. 4 , pp. 25-30
    • Shuch, B.1    Li, Z.2    Belldegrun, A.S.3
  • 99
    • 0142219359 scopus 로고    scopus 로고
    • Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway
    • Pantuck, A. J.; Zeng, G.; Belldegrun, A. S.; Figlin, R. A. Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway. Clin. Cancer Res. 2003, 9, 4641-4652.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4641-4652
    • Pantuck, A.J.1    Zeng, G.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 100
    • 43049109844 scopus 로고    scopus 로고
    • Diagnostic and prognostic molecular markers in renal cell carcinoma
    • Tunuguntla, H. S.; Jorda, M. Diagnostic and prognostic molecular markers in renal cell carcinoma. J. Urol. 2008, 179, 2096-2102.
    • (2008) J. Urol. , vol.179 , pp. 2096-2102
    • Tunuguntla, H.S.1    Jorda, M.2
  • 101
    • 3042816190 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways
    • Swinson, D. E.; Jones, J. L.; Cox, G.; Richardson, D.; Harris, A. L.; O'Byrne, K. J. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. Int. J. Cancer 2004, 111, 43-50.
    • (2004) Int. J. Cancer , vol.111 , pp. 43-50
    • Swinson, D.E.1    Jones, J.L.2    Cox, G.3    Richardson, D.4    Harris, A.L.5    O'Byrne, K.J.6
  • 103
    • 33746071114 scopus 로고    scopus 로고
    • P300 and p53 levels determine activation of HIF-1 downstream targets in invasive breast cancer
    • Vleugel, M. M.; Shvarts, D.; van der Wall, E.; van Diest, P. J. p300 and p53 levels determine activation of HIF-1 downstream targets in invasive breast cancer. Hum. Pathol. 2006, 37, 1085-1092.
    • (2006) Hum. Pathol. , vol.37 , pp. 1085-1092
    • Vleugel, M.M.1    Shvarts, D.2    Van Der Wall, E.3    Van Diest, P.J.4
  • 109
    • 4344699403 scopus 로고    scopus 로고
    • Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion
    • Robertson, N.; Potter, C.; Harris, A. L. Role of carbonic anhydrase IX in human tumor cell growth, survival, and invasion. Cancer Res. 2004, 64, 6160-6165.
    • (2004) Cancer Res. , vol.64 , pp. 6160-6165
    • Robertson, N.1    Potter, C.2    Harris, A.L.3
  • 110
    • 50649105780 scopus 로고    scopus 로고
    • Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths
    • Swietach, P.; Wigfield, S.; Cobden, P.; Supuran, C. T.; Harris, A. L.; Vaughan-Jones, R. D. Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellular growths. J. Biol. Chem. 2008, 283, 20473-20483.
    • (2008) J. Biol. Chem. , vol.283 , pp. 20473-20483
    • Swietach, P.1    Wigfield, S.2    Cobden, P.3    Supuran, C.T.4    Harris, A.L.5    Vaughan-Jones, R.D.6
  • 111
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase I.X. and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche, J.; Ilc, K.; Laferrière, J.; Trottier, E.; Dayan, F.; Mazure, N. M.; Brahimi-Horn, M. C.; Pouysségur, J. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res. 2009, 69, 358-368.
    • (2009) Cancer Res. , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferrière, J.3    Trottier, E.4    Dayan, F.5    Mazure, N.M.6    Brahimi-Horn, M.C.7    Pouysségur, J.8
  • 113
    • 0036554644 scopus 로고    scopus 로고
    • Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
    • Helmlinger, G.; Sckell, A.; Dellian, M.; Forbes, N. S.; Jain, R. K. Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin. Cancer Res. 2002, 8, 1284-1291.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1284-1291
    • Helmlinger, G.1    Sckell, A.2    Dellian, M.3    Forbes, N.S.4    Jain, R.K.5
  • 114
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize
    • Fukumura, D.; Jain, R. K. Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J. Cell. Biochem. 2007, 101, 937-949.
    • (2007) J. Cell. Biochem. , vol.101 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 115
    • 0035795336 scopus 로고    scopus 로고
    • VHL tumor suppressor regulates Cl-/HCO3-exchange and Na{thorn}/H{thorn} exchange activities in renal carcinoma cells
    • Karumanchi, S. A.; Jiang, L.; Knebelmann, B.; Stuart-Tilley, A. K.; Alper, S. L.; Sukhatme, V. P. VHL tumor suppressor regulates Cl-/HCO3-exchange and Na{thorn}/H{thorn} exchange activities in renal carcinoma cells. Physiol. Genomics 2001, 5, 119-128.
    • (2001) Physiol. Genomics , vol.5 , pp. 119-128
    • Karumanchi, S.A.1    Jiang, L.2    Knebelmann, B.3    Stuart-Tilley, A.K.4    Alper, S.L.5    Sukhatme, V.P.6
  • 116
    • 33751117499 scopus 로고    scopus 로고
    • HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
    • Shimoda, L. A.; Fallon, M.; Pisarcik, S.; Wang, J.; Semenza, G. L. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006, 291, L941-L949.
    • (2006) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.291
    • Shimoda, L.A.1    Fallon, M.2    Pisarcik, S.3    Wang, J.4    Semenza, G.L.5
  • 117
    • 33646917296 scopus 로고    scopus 로고
    • The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism
    • Ullah, M. S.; Davies, A. J.; Halestrap, A. P. The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. J. Biol. Chem. 2006, 281, 9030-9037.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9030-9037
    • Ullah, M.S.1    Davies, A.J.2    Halestrap, A.P.3
  • 118
    • 33947423405 scopus 로고    scopus 로고
    • Why bicarbonate? Biochem
    • Casey, J. R. Why bicarbonate? Biochem. Cell Biol. 2006, 84, 930-939.
    • (2006) Cell Biol. , vol.84 , pp. 930-939
    • Casey, J.R.1
  • 119
    • 12444339728 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates
    • Innocenti, A.;Vullo, D.; Scozzafava, A.; Casey, J. R.; Supuran, C. T. Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg. Med. Chem. Lett. 2005, 15, 573-578.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 573-578
    • Innocenti, A.1    Vullo, D.2    Scozzafava, A.3    Casey, J.R.4    Supuran, C.T.5
  • 121
    • 35748970483 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
    • Fukumura, D.; Jain, R. K. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc. Res. 2007, 74, 72-84.
    • (2007) Microvasc. Res. , vol.74 , pp. 72-84
    • Fukumura, D.1    Jain, R.K.2
  • 122
    • 8844224030 scopus 로고    scopus 로고
    • Microenvironmental and cellular consequences of altered blood flow in tumours
    • Raghunand, N.; Gatenby, R. A.; Gillies, R. J. Microenvironmental and cellular consequences of altered blood flow in tumours. Br. J. Radiol. 2003, 76, S11-22.
    • (2003) Br. J. Radiol. , vol.76
    • Raghunand, N.1    Gatenby, R.A.2    Gillies, R.J.3
  • 123
    • 0034024783 scopus 로고    scopus 로고
    • Human tumourassociated cell adhesion protein MN/CA IX: identification of M75 epitope and of the region mediating cell adhesion
    • Zävada, J.; Zävadovä, Z.; Pastorek, J.; Biesovä, Z.; Jezek, J.; Velek, J. Human tumourassociated cell adhesion protein MN/CA IX: identification of M75 epitope and of the region mediating cell adhesion. Br. J. Cancer 2000, 82, 1808-1813.
    • (2000) Br. J. Cancer , vol.82 , pp. 1808-1813
    • Zävada, J.1    Zävadovä, Z.2    Pastorek, J.3    Biesovä, Z.4    Jezek, J.5    Velek, J.6
  • 124
    • 25144484490 scopus 로고    scopus 로고
    • Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment
    • Zavadova, Z.; Zavada, J. Carbonic anhydrase IX (CA IX) mediates tumor cell interactions with microenvironment. Oncol. Rep. 2005, 13, 977-982.
    • (2005) Oncol. Rep. , vol.13 , pp. 977-982
    • Zavadova, Z.1    Zavada, J.2
  • 128
    • 34248995010 scopus 로고    scopus 로고
    • Circulating oncoproteins HER2/neu, EGFR and CAIX (MN) as novel cancer biomarkers
    • Carney, W. P. Circulating oncoproteins HER2/neu, EGFR and CAIX (MN) as novel cancer biomarkers. Expert Rev. Mol. Diagn. 2007, 7, 309-319.
    • (2007) Expert Rev. Mol. Diagn. , vol.7 , pp. 309-319
    • Carney, W.P.1
  • 130
    • 44449147064 scopus 로고    scopus 로고
    • The use of positron-emission tomography in the diagnosis of tumour phenotype
    • Divgi, C. The use of positron-emission tomography in the diagnosis of tumour phenotype. BJU Int. 2008, 101, 36-38.
    • (2008) BJU Int. , vol.101 , pp. 36-38
    • Divgi, C.1
  • 131
    • 84889289995 scopus 로고    scopus 로고
    • Characterization of G250 monoclonal antibody binding to human cancer-associated carbonic anhydrase IX
    • In Abstract booklet from International CA IX Symposium: Functional and Clinical Aspects, November 14, Abstract No. 3
    • Supalova, L.; Hulikova, A.; Barathova, M.; Gibadulinova, A.; Parkkila, S.; Supuran, C. T.; Pastorek, J.; Pastorekova, S.; Zatovicova, M. Characterization of G250 monoclonal antibody binding to human cancer-associated carbonic anhydrase IX. In Abstract booklet from International CA IX Symposium: Functional and Clinical Aspects, November 14, 2007, Abstract No. 3.
    • (2007)
    • Supalova, L.1    Hulikova, A.2    Barathova, M.3    Gibadulinova, A.4    Parkkila, S.5    Supuran, C.T.6    Pastorek, J.7    Pastorekova, S.8    Zatovicova, M.9
  • 132
    • 26844517863 scopus 로고    scopus 로고
    • Carbonic anhydrase IX (CA IX) as a potential target for cancer therapy
    • Online
    • Pastorekova, S.; Zavada, J. Carbonic anhydrase IX (CA IX) as a potential target for cancer therapy. Cancer Ther. 2004, 2, 245-262. Online: www.cancer-therapy.org.
    • (2004) Cancer Ther. , vol.2 , pp. 245-262
    • Pastorekova, S.1    Zavada, J.2
  • 133
    • 0034018870 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors and their therapeutic potential
    • Supuran, C.T.; Scozzafava, A. Carbonic anhydrase inhibitors and their therapeutic potential. Expert Opin. Ther. Pat. 2000, 10, 575-600.
    • (2000) Expert Opin. Ther. Pat. , vol.10 , pp. 575-600
    • Supuran, C.T.1    Scozzafava, A.2
  • 135
    • 0037463790 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides
    • Vullo, D.; Franchi, M.; Gallori, E.; Pastorek, J.; Scozzafava, A.; Pastorekova, S.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides. Bioorg. Med. Chem. Lett. 2003, 13, 1005-1009.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 1005-1009
    • Vullo, D.1    Franchi, M.2    Gallori, E.3    Pastorek, J.4    Scozzafava, A.5    Pastorekova, S.6    Supuran, C.T.7
  • 136
    • 2442428176 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors:the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides
    • Jaiswal,M.;Khadikar, P.V.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors:the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides. Bioorg. Med. Chem. Lett. 2004, 14, 3283-3290.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 3283-3290
    • Jaiswal, M.1    Khadikar, P.V.2    Scozzafava, A.3    Supuran, C.T.4
  • 137
    • 25144498040 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: inhibition of the tumor-associated isoenzymes IX and XII with a library of aromatic and heteroaromatic sulfonamides
    • Ozensoy, O.; Pucetti, L.; Fasolis, G.; Arslan, O.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: inhibition of the tumor-associated isoenzymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg. Med. Chem. Lett. 2005, 15, 4862-4866.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4862-4866
    • Ozensoy, O.1    Pucetti, L.2    Fasolis, G.3    Arslan, O.4    Scozzafava, A.5    Supuran, C.T.6
  • 138
    • 0037911231 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives
    • Ilies, M. A.;Vullo, D.; Pastorek, J.; Scozzafava, A.; Ilies, M.; Caproiu, M. T.; Pastorekova, S.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. J. Med. Chem. 2003, 46, 2187-2196.
    • (2003) J. Med. Chem. , vol.46 , pp. 2187-2196
    • Ilies, M.A.1    Vullo, D.2    Pastorek, J.3    Scozzafava, A.4    Ilies, M.5    Caproiu, M.T.6    Pastorekova, S.7    Supuran, C.T.8
  • 139
    • 0043198462 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides
    • Franchi, M.;Vullo, D.; Gallori, E.; Pastorek, J.; Russo, A.; Scozzafava, A.; Pastorekova, S.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with lipophilic sulfonamides. J. Enzyme Inhib. Med. Chem. 2003, 18, 333-338.
    • (2003) J. Enzyme Inhib. Med. Chem. , vol.18 , pp. 333-338
    • Franchi, M.1    Vullo, D.2    Gallori, E.3    Pastorek, J.4    Russo, A.5    Scozzafava, A.6    Pastorekova, S.7    Supuran, C.T.8
  • 141
    • 5344225272 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties
    • Garaj,V.; Pucetti, L.; Fasolis, G.;Winum, J.Y.; Montero, J. L.; Scozzafava, A.;Vullo, D.; Innocenti, A.; Supuran, C. T. Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. Bioorg. Med. Chem. Lett. 2004, 14, 5427-5433.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 5427-5433
    • Garaj, V.1    Pucetti, L.2    Fasolis, G.3    Winum, J.Y.4    Montero, J.L.5    Scozzafava, A.6    Vullo, D.7    Innocenti, A.8    Supuran, C.T.9
  • 142
    • 19944401083 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX
    • Garaj,V.; Pucetti, L.; Fasolis, G.;Winum, J.Y.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX. Bioorg. Med. Chem. Lett. 2005, 15, 3102-3108.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3102-3108
    • Garaj, V.1    Pucetti, L.2    Fasolis, G.3    Winum, J.Y.4    Montero, J.L.5    Scozzafava, A.6    Supuran, C.T.7
  • 143
    • 7044241041 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide
    • Cecchi, A.; Winum, J. Y.; Innocenti, A.; Vullo, D.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide. Bioorg. Med. Chem. Lett. 2004, 14, 5775-5780.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 5775-5780
    • Cecchi, A.1    Winum, J.Y.2    Innocenti, A.3    Vullo, D.4    Montero, J.L.5    Scozzafava, A.6    Supuran, C.T.7
  • 144
    • 0348147633 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX
    • Abbate, F.; Casini, A.; Owa, T.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg. Med. Chem. Lett. 2004, 14, 225-229.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 225-229
    • Abbate, F.1    Casini, A.2    Owa, T.3    Scozzafava, A.4    Supuran, C.T.5
  • 145
    • 17144387904 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds
    • Pucetti, L.; Fasolis, G.; Cecchi, A.; Winum, J. Y.; Gamberi, A.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg. Med. Chem. Lett. 2005, 15, 2359-2364.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 2359-2364
    • Pucetti, L.1    Fasolis, G.2    Cecchi, A.3    Winum, J.Y.4    Gamberi, A.5    Montero, J.L.6    Scozzafava, A.7    Supuran, C.T.8
  • 146
    • 10644254283 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II and the tumor-associated isozymes IX
    • Turkmen, H.; Dugrun, M.; Yilmaztekin, S.; Emul, M.; Innocenti, A.; Vullo, D.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II and the tumor-associated isozymes IX. Bioorg. Med. Chem. Lett. 2005, 17, 367-372.
    • (2005) Bioorg. Med. Chem. Lett. , vol.17 , pp. 367-372
    • Turkmen, H.1    Dugrun, M.2    Yilmaztekin, S.3    Emul, M.4    Innocenti, A.5    Vullo, D.6    Scozzafava, A.7    Supuran, C.T.8
  • 147
    • 15444377021 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating hydrazine moieties
    • Winum, J. Y.; Dogne, J. M.; Casini, A.; de Leval, X.; Montero, J. L.; Scozzafava, A.; Vullo, D.; Innocenti, A.; Supuran, C. T. Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with sulfonamides incorporating hydrazine moieties. J. Med. Chem. 2005, 48, 2121-2125.
    • (2005) J. Med. Chem. , vol.48 , pp. 2121-2125
    • Winum, J.Y.1    Dogne, J.M.2    Casini, A.3    de Leval, X.4    Montero, J.L.5    Scozzafava, A.6    Vullo, D.7    Innocenti, A.8    Supuran, C.T.9
  • 148
    • 17144398878 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with a series of 1,3,4-thiadiazole-and 1,2,4-triazole-thiols
    • Almajan, G. L.; Innocenti, A.; Pucetti, L.; Manole, G.; Berbuceanu, S.; Saramet, I.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with a series of 1,3,4-thiadiazole-and 1,2,4-triazole-thiols. Bioorg. Med. Chem. Lett. 2005, 15, 2347-2352.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 2347-2352
    • Almajan, G.L.1    Innocenti, A.2    Pucetti, L.3    Manole, G.4    Berbuceanu, S.5    Saramet, I.6    Scozzafava, A.7    Supuran, C.T.8
  • 149
    • 17244376080 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumorassociated carbonic anhydrase isozymes I, II and IX with N-hydroxysulfamides: a new zinc-binding function in the design of inhibitors
    • Winum, J.Y.; Innocenti, A.; Nasr, J.; Montero, J. L.; Scozzafava, A.;Vullo, D.; Supuran, C. T. Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumorassociated carbonic anhydrase isozymes I, II and IX with N-hydroxysulfamides: a new zinc-binding function in the design of inhibitors. Bioorg. Med. Chem. Lett. 2005, 15, 2353-2358.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 2353-2358
    • Winum, J.Y.1    Innocenti, A.2    Nasr, J.3    Montero, J.L.4    Scozzafava, A.5    Vullo, D.6    Supuran, C.T.7
  • 150
    • 22544439682 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: synthesis and inhibition of the tumorassociated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides
    • Pastorekova, S.; Vullo, D.; Casini, A.; Scozzafava, A.; Pastorek, J.; Nishimori, I.; Supuran, C. T. Carbonic anhydrase inhibitors: synthesis and inhibition of the tumorassociated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides. J. Enzyme Inhib. Med. Chem. 2005, 20, 211-217.
    • (2005) J. Enzyme Inhib. Med. Chem. , vol.20 , pp. 211-217
    • Pastorekova, S.1    Vullo, D.2    Casini, A.3    Scozzafava, A.4    Pastorek, J.5    Nishimori, I.6    Supuran, C.T.7
  • 151
    • 25144469687 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with benzo[b]thiophene 1,1 dioxide sulfonamides
    • Innocenti, A.; Villar, R.; Martinez-Merino, V.; Gil, M. J.; Scozzafava, A.; Vullo, D.; Supuran, C. T. Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with benzo[b]thiophene 1,1 dioxide sulfonamides. Bioorg. Med. Chem. Lett. 2005, 15, 4872-4876.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 4872-4876
    • Innocenti, A.1    Villar, R.2    Martinez-Merino, V.3    Gil, M.J.4    Scozzafava, A.5    Vullo, D.6    Supuran, C.T.7
  • 152
    • 26844469638 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA and IX with a library of substituted difluoromethanesulfinamides
    • Cecchi, A.; Taylor, S. D.; Liu, Y.; Hill, B.; Vullo, D.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA and IX with a library of substituted difluoromethanesulfinamides. Bioorg. Med. Chem. Lett. 2005, 15, 5192-5196.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 5192-5196
    • Cecchi, A.1    Taylor, S.D.2    Liu, Y.3    Hill, B.4    Vullo, D.5    Scozzafava, A.6    Supuran, C.T.7
  • 153
    • 33646446585 scopus 로고    scopus 로고
    • Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX
    • Thiry, A.; Ledecq, M.; Cecchi, A.; Dogne, J. M.;Wouters, J.; Supuran, C. T.; Masereel, B. Indanesulfonamides as carbonic anhydrase inhibitors. Toward structure-based design of selective inhibitors of the tumor-associated isozyme CA IX. J. Med. Chem. 2006, 49, 2743-2749.
    • (2006) J. Med. Chem. , vol.49 , pp. 2743-2749
    • Thiry, A.1    Ledecq, M.2    Cecchi, A.3    Dogne, J.M.4    Wouters, J.5    Supuran, C.T.6    Masereel, B.7
  • 154
    • 38349169561 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII
    • Rami, M.;Winum, J. Y.; Innocenti, A.; Montero, J. L.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII. Bioorg. Med. Chem. Lett. 2008, 18, 836-841.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 836-841
    • Rami, M.1    Winum, J.Y.2    Innocenti, A.3    Montero, J.L.4    Scozzafava, A.5    Supuran, C.T.6
  • 155
    • 1642540579 scopus 로고    scopus 로고
    • Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib:newpharmacological opportunities due to related binding site recognition
    • Weber, A.; Casini, A.; Heine, A.; Kuhn, D.; Supuran, C. T.; Scozzafava, A.; Klebe, G. Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib:newpharmacological opportunities due to related binding site recognition. J. Med. Chem. 2004, 47, 550-557.
    • (2004) J. Med. Chem. , vol.47 , pp. 550-557
    • Weber, A.1    Casini, A.2    Heine, A.3    Kuhn, D.4    Supuran, C.T.5    Scozzafava, A.6    Klebe, G.7
  • 157
    • 34547585390 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies
    • Temperini, C.; Innocenti, A.; Mastrolorenzo, A.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies. Bioorg. Med. Chem. Lett. 2007, 17, 4866-4872.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 4866-4872
    • Temperini, C.1    Innocenti, A.2    Mastrolorenzo, A.3    Scozzafava, A.4    Supuran, C.T.5
  • 158
    • 2542592581 scopus 로고    scopus 로고
    • Modulation of carbonic anhydrase activity and its applications in therapy
    • Scozzafava, A.; Mastrolorenzo, A.; Supuran, C.T. Modulation of carbonic anhydrase activity and its applications in therapy. Expert Opin. Ther. Pat. 2004, 14, 667-702.
    • (2004) Expert Opin. Ther. Pat. , vol.14 , pp. 667-702
    • Scozzafava, A.1    Mastrolorenzo, A.2    Supuran, C.T.3
  • 159
    • 42149127006 scopus 로고    scopus 로고
    • Design of zinc binding functions for carbonic anhydrase inhibitors
    • Winum, J. Y.; Scozzafava, A.; Montero, J. L.; Supuran, C. T. Design of zinc binding functions for carbonic anhydrase inhibitors. Curr. Pharm. Des. 2008, 14, 615-621.
    • (2008) Curr. Pharm. Des. , vol.14 , pp. 615-621
    • Winum, J.Y.1    Scozzafava, A.2    Montero, J.L.3    Supuran, C.T.4
  • 160
    • 1842628633 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX
    • Casey, J. R.; Morgan, P. E.; Vullo, D.; Scozzafava, A.; Mastrolorenzo, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Design of selective, membrane-impermeant inhibitors targeting the human tumor-associated isozyme IX. J. Med. Chem. 2004, 47, 2337-2347.
    • (2004) J. Med. Chem. , vol.47 , pp. 2337-2347
    • Casey, J.R.1    Morgan, P.E.2    Vullo, D.3    Scozzafava, A.4    Mastrolorenzo, A.5    Supuran, C.T.6
  • 161
    • 0842281270 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX
    • Pastorekova, S.; Casini, A.; Scozzafava, A.; Vullo, D.; Pastorek, J.; Supuran, C. T. Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX. Bioorg. Med. Chem. Lett. 2004, 14, 869-873.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 869-873
    • Pastorekova, S.1    Casini, A.2    Scozzafava, A.3    Vullo, D.4    Pastorek, J.5    Supuran, C.T.6
  • 162
    • 34547905000 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureidosulfonamides
    • Smaine, F. Z.; Winum, J. Y.; Montero, J. L.; Regainia, Z.; Vullo, D.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors: selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureidosulfonamides. Bioorg. Med. Chem. Lett. 2007, 17, 5096-5100.
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 5096-5100
    • Smaine, F.Z.1    Winum, J.Y.2    Montero, J.L.3    Regainia, Z.4    Vullo, D.5    Scozzafava, A.6    Supuran, C.T.7
  • 163
    • 33746836508 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors
    • Saczewski, F.; Sławiński, J.; Kornicka, A.; Brzozowski, Z.; Pomarnacka, E.; Innocenti, A.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors. Bioorg. Med. Chem. Lett. 2006, 16, 4846-4851.
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 4846-4851
    • Saczewski, F.1    Sławiński, J.2    Kornicka, A.3    Brzozowski, Z.4    Pomarnacka, E.5    Innocenti, A.6    Scozzafava, A.7    Supuran, C.T.8
  • 164
    • 22744446294 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
    • Cecchi, A.; Hulikova, A.; Pastorek, J.; Pastorekova, S.; Scozzafava, A.;Winum, J. Y.; Montero, J. L.; Supuran, C. T. Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. J. Med. Chem. 2005, 48, 4834-4841.
    • (2005) J. Med. Chem. , vol.48 , pp. 4834-4841
    • Cecchi, A.1    Hulikova, A.2    Pastorek, J.3    Pastorekova, S.4    Scozzafava, A.5    Winum, J.Y.6    Montero, J.L.7    Supuran, C.T.8
  • 166
    • 33745644458 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX
    • Alterio, V.; Vitale, R. M.; Monti, S. M.; Pedone, C.; Scozzafava, A.; Cecchi, A.; De Simone, G.; Supuran, C. T. Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX. J. Am. Chem. Soc. 2006, 128, 8329-8335.
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 8329-8335
    • Alterio, V.1    Vitale, R.M.2    Monti, S.M.3    Pedone, C.4    Scozzafava, A.5    Cecchi, A.6    De Simone, G.7    Supuran, C.T.8
  • 167
    • 44849090972 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes
    • Cecchi, A.; Ciani, L.;Winum, J.Y.; Montero, J. L.; Scozzafava, A.; Ristori, S.; Supuran, C. T. Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes. Bioorg. Med. Chem. Lett. 2008, 18, 3475-3480.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 3475-3480
    • Cecchi, A.1    Ciani, L.2    Winum, J.Y.3    Montero, J.L.4    Scozzafava, A.5    Ristori, S.6    Supuran, C.T.7
  • 168
    • 0030942009 scopus 로고    scopus 로고
    • Influence of the pH on cytotoxicity of paclitaxel, mitoxanthrone and topotecan
    • Vukovic, V.; Tannock, I. F. Influence of the pH on cytotoxicity of paclitaxel, mitoxanthrone and topotecan. Br. J. Cancer 1997, 75, 1167-1172.
    • (1997) Br. J. Cancer , vol.75 , pp. 1167-1172
    • Vukovic, V.1    Tannock, I.F.2
  • 169
    • 0035874951 scopus 로고    scopus 로고
    • The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics
    • Kozin, S. V.; Shkarin, P.; Gerweck, L. E. The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics. Cancer Res. 2001, 61, 4740-4743.
    • (2001) Cancer Res. , vol.61 , pp. 4740-4743
    • Kozin, S.V.1    Shkarin, P.2    Gerweck, L.E.3
  • 170
    • 0027367258 scopus 로고
    • A carbonic anhydrase inhibitor is potential modulator of cancer therapies
    • Teicher, B. A.; Liu, S. D.; Liu, J. T.; Holden, S. A.; Herman, T. S. A carbonic anhydrase inhibitor is potential modulator of cancer therapies. Anticancer Res. 1993, 13, 1549-1556.
    • (1993) Anticancer Res. , vol.13 , pp. 1549-1556
    • Teicher, B.A.1    Liu, S.D.2    Liu, J.T.3    Holden, S.A.4    Herman, T.S.5
  • 171
    • 20444409690 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with boron-containing sulfonamides, sulfamides and sulfamates: towards agents for boron neutron capture therapy of hypoxic tumors
    • Winum, J. Y.; Cecchi, A.; Montero, J. L.; Innocenti, A.; Scozzafava, A.; Supuran, C. T. Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II and IX with boron-containing sulfonamides, sulfamides and sulfamates: towards agents for boron neutron capture therapy of hypoxic tumors. Bioorg. Med. Chem. Lett. 2005, 15, 3302-3306.
    • (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 3302-3306
    • Winum, J.Y.1    Cecchi, A.2    Montero, J.L.3    Innocenti, A.4    Scozzafava, A.5    Supuran, C.T.6
  • 172
    • 44449091556 scopus 로고    scopus 로고
    • Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia
    • Pastorekova, S.; Ratcliffe, P. J.; Pastorek, J. Molecular mechanisms of carbonic anhydrase IX-mediated pH regulation under hypoxia. BJU Int. 2008, 101 (Suppl. 4), 8-15.
    • (2008) BJU Int. , vol.101 , Issue.SUPPL. 4 , pp. 8-15
    • Pastorekova, S.1    Ratcliffe, P.J.2    Pastorek, J.3
  • 173
    • 44949190364 scopus 로고    scopus 로고
    • Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs
    • Thiry, A.; Supuran, C. T.; Masereel, B.; Dogné, J. M. Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J. Med. Chem. 2008, 51, 3051-3056.
    • (2008) J. Med. Chem. , vol.51 , pp. 3051-3056
    • Thiry, A.1    Supuran, C.T.2    Masereel, B.3    Dogné, J.M.4
  • 174
    • 0042847064 scopus 로고    scopus 로고
    • Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer
    • Potter, C. P.; Harris, A. L. Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Br. J. Cancer 2003, 89, 2-7.
    • (2003) Br. J. Cancer , vol.89 , pp. 2-7
    • Potter, C.P.1    Harris, A.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.