-
4
-
-
0030961006
-
Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22642-22647
-
-
Salceda, S.1
Caro, J.2
-
7
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
Nicholls, L.G.4
Harris, A.L.5
Stratford, I.J.6
Hankinson, O.7
Pugh, C.W.8
Ratcliffe, P.J.9
-
11
-
-
85007624247
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation, and tumor angiogenesis
-
(1998)
Nature (Lond.)
, vol.394
, pp. 435-439
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.-M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neemann, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshet, E.16
-
13
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
14
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
Ratcliffe, P.J.6
Harris, A.L.7
-
16
-
-
0029785838
-
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10589-10594
-
-
Gnarra, J.R.1
Zhou, S.2
Merrill, M.J.3
Wagner, J.R.4
Krumm, A.5
Papavassiliou, E.6
Oldfield, E.H.7
Klausner, R.D.8
Linehan, W.M.9
-
17
-
-
0033587146
-
The turnout suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
(1999)
Nature (Lond.)
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.-W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
21
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel-Lindau protein
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
Hoffman, M.A.4
Kim, T.Y.5
Huang, L.E.6
Pavletich, N.7
Chau, V.8
Kaelin, W.G.9
-
23
-
-
0034682783
-
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25733-25741
-
-
Cockman, M.E.1
Masson, N.2
Mole, D.R.3
Jaakola, P.4
Chang, G.W.5
Clifford, S.C.6
Maher, E.R.7
Pugh, C.W.8
Ratcliffe, P.J.9
Maxwell, P.H.10
-
25
-
-
0032189844
-
Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1α
-
(1998)
Blood
, vol.92
, pp. 2260-2268
-
-
Wiesener, M.S.1
Turley, H.2
Allen, W.E.3
Willam, C.4
Eckardt, K.-U.5
Talks, K.L.6
Wood, S.M.7
Gatter, K.C.8
Harris, A.L.9
Pugh, C.W.10
Ratcliffe, P.J.11
Maxwell, P.H.12
-
26
-
-
0027367661
-
Identification of the renal erythropoietin-producing cells using transgenic mice
-
(1993)
Kidney Int.
, vol.44
, pp. 1149-1162
-
-
Maxwell, P.H.1
Osmond, M.K.2
Pugh, C.W.3
Heryet, A.4
Nicholls, L.G.5
Tan, C.C.6
Doe, B.G.7
Ferguson, D.J.P.8
Johnson, M.H.9
Ratcliffe, P.J.10
-
27
-
-
0028091126
-
Molecular genetic investigation of sporadic renal cell carcinoma: Analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22
-
(1994)
Br. J. Cancer
, vol.69
, pp. 230-234
-
-
Foster, K.1
Crossey, P.A.2
Cairns, P.3
Hetherington, J.W.4
Richards, F.M.5
Jones, M.H.6
Bentley, E.7
Affara, N.A.8
Ferguson-Smith, M.A.9
Maher, E.R.10
-
32
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
(1994)
Nat. Genet.
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
Schmidt, L.4
Wei, M.H.5
Li, H.6
Latif, F.7
Liu, S.8
Chen, F.9
Duh, F.-M.10
Lubensky, I.11
Duan, D.R.12
Florence, C.13
Pozzatti, R.14
Walther, M.M.15
Bander, N.H.16
Grossman, H.B.17
Brauch, H.18
Pomer, S.19
Brooks, J.D.20
Isaacs, W.B.21
Lerman, M.I.22
Zbar, B.23
Linehan, W.M.24
more..
-
35
-
-
0027938458
-
Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas
-
(1994)
Cancer Res.
, vol.54
, pp. 4845-4847
-
-
Kanno, H.1
Kondo, K.2
Ito, S.3
Yamamoto, I.4
Fujii, S.5
Torigoe, S.6
Sakai, N.7
Hosaka, M.8
Shuin, T.9
Yao, M.10
-
36
-
-
18844474899
-
Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas
-
(1998)
Cancer Res.
, vol.58
, pp. 504-508
-
-
Lee, J.-Y.1
Dong, S.M.2
Park, W.-S.3
Yoo, N.-J.4
Kim, C.-S.5
Jang, J.-J.6
Chi, J.-G.7
Zbar, B.8
Lubensky, I.A.9
Linehan, W.M.10
Vortmeyer, A.O.11
Zhuang, Z.12
-
37
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
40
-
-
0034101808
-
Expression of vascular endothelial growth factor in renal cell carcinomas
-
(2000)
Virchows Arch.
, vol.436
, pp. 351-356
-
-
Paradis, V.1
Ben Lagha, N.2
Zeimoura, L.3
Blanchet, P.4
Eschwege, P.5
Ba, N.6
Benoit, G.7
Jardin, A.8
Bedossa, P.9
-
41
-
-
0033061154
-
Expression pattern of vascular endothelial growth factor isoform is closely correlated with tumour stage and vascularisation in renal cell carcinoma
-
(1999)
Eur. J. Cancer
, vol.35
, pp. 133-137
-
-
Tomisawa, M.1
Tokunaga, T.2
Oshika, Y.3
Tsuchida, T.4
Fukushima, Y.5
Sato, H.6
Kijima, H.7
Yamazaki, H.8
Ueyama, Y.9
Tamaoki, N.10
Nakamura, M.11
-
42
-
-
0027933191
-
Markedly increased amounts of messenger RNAs for vascular endothelial growth factor and placenta growth factor in renal cell carcinoma associated with angiogenesis
-
(1994)
Cancer Res.
, vol.54
, pp. 4233-4237
-
-
Takahashi, A.1
Sasaki, H.2
Kim, S.J.3
Tobisu, K.-I.4
Kakizoe, T.5
Tsukamato, T.6
Kumamoto, Y.7
Sugimura, T.8
Terada, M.9
-
47
-
-
0031870653
-
Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2α
-
(1998)
Am. J. Pathol.
, vol.153
, pp. 25-29
-
-
Flamme, I.1
Krieg, M.2
Plate, K.H.3
-
49
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
(2000)
Cancer Res.
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
Cozens, R.4
Ferrari, S.5
Frei, J.6
Hofmann, F.7
Mestan, J.8
Mett, H.9
O'Reilly, T.10
Persohn, E.11
Rosel, J.12
Schnell, C.13
Stover, D.14
Theuer, A.15
Towbin, H.16
Wenger, F.17
Woods-Cook, K.18
Menrad, A.19
Siemeister, G.20
Schirner, M.21
Thierauch, K.H.22
Schneider, M.R.23
Drevs, J.24
Martiny-Baron, G.25
Totzke, F.26
more..
-
50
-
-
0034733953
-
Suppression of facilitative glucose transporter 1 mRNA can suppress tumor growth
-
(2000)
Cancer Lett.
, vol.154
, pp. 175-182
-
-
Noguchi, Y.1
Saito, A.2
Miyagi, Y.3
Yamanka, S.4
Marat, D.5
Doi, C.6
Yoshikawa, T.7
Tsuburaya, A.8
Ito, T.9
Satoh, S.10
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