Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumours

Journal of Hepatology

Volumn 35, Issue 5, 2001, Pages 643-649

  Saarnio, Juha ^a   Parkkila, Seppo ^a   Parkkila, Anna Kaisa ^a   Pastoreková, Silvia ^b   Haukipuro, Kari ^a   Pastorek, Jaromir ^b   Juvonen, Tatu ^a   Karttunen, Tuomo J ^a  

^a UNIVERSITY OF OULU   (Finland)

^b INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

Biliary epithelium; Biomarker; Carbonic anhydrase; Gallbladder; Hepatobiliary tumor; Liver

Indexed keywords

BIOLOGICAL MARKER; BIOTIN; CARBONATE DEHYDRATASE; CARBONIC ANHYDRASE ISOENZYME IX; ISOENZYME; STREPTAVIDIN; UNCLASSIFIED DRUG;

ARTICLE; BILE DUCT CARCINOMA; BILIARY TRACT TUMOR; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYME LOCALIZATION; EPITHELIUM TUMOR; GALLBLADDER TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, NEOPLASM; BILIARY TRACT NEOPLASMS; CARBONIC ANHYDRASES; CARCINOMA, HEPATOCELLULAR; EPITHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; KI-67 ANTIGEN; LIVER NEOPLASMS; MEMBRANE PROTEINS; NEOPLASM PROTEINS; REFERENCE VALUES; TUMOR MARKERS, BIOLOGICAL;

EID: 0035164633     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(01)00193-3     Document Type: Article

References (38)

1. Amount and distribution of carbonic anhydrases CA I and CA II in the gastrointestinal tract
2. Human carbonic anhydrases and carbonic anhydrase deficiencies
3. Carbonic anhydrase in the alimentary tract. Roles of the different isozymes and salivary factors in the maintenance of optimal conditions in the gastrointestinal canal
4. Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cancers
5. Isolation and characterization of CA XIV, a novel membrane-bound carbonic anhydrase from mouse kidney
6. Distribution of carbonic anhydrase isoenzymes I, II and VI in the human alimentary tract
7. Carbonic anhydrase IV expression in rat and human gastrointestinal tract: Regional, cellular and subcellular localization
8. Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gall-bladder epithelium
9. Immunohistochemical demonstration of MN/CA IX, carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts
10. Mitochondrial carbonic anhydrase (isozyme V) in mouse and rat: cDNA cloning, expression, subcellular localization, processing, and tissue distribution
11. Mitochondrial carbonic anhydrase CA VB: Differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles
12. Expression of MaTu-MN protein in human tumor cultures and in clinical specimens
13. Study of in vitro conditions modulating expression of MN/CA IX protein in human cell lines derived from cervical carcinoma
14. Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas
15. Expression of the MN antigen in cervical Papanicolau smears is an diagnostic biomarker of cervical dysplasia
16. NM antigen expression in normal, preneoplastic, and neoplastic esophagus
17. Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
18. Expression of tumor-associated antigen MN/G250 in urologic carcinoma: Potential therapeutic target
19. Expression of the tumor-associated gene MN: A potential biomarker for human renal cell carcinoma
20. Identification of the MN/CA9 protein as a reliable diagnostic biomarker of clear cell carcinoma of the kidney
21. MN/CA9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships
22. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment
23. Immunohistochemistry of carbonic anhydrase isoenzyme IX (MN/CA IX) in human gut reveals polarized expression in the epithelial cells with the highest proliferative capacity
24. A novel quasi-viral agent, MaTu, is a two-component system
25. Location of the carbonic anhydrase isoenzymes VI and II in human salivary glands by immunohistochemistry
26. Salivary carbonic anhydrase protects gastroesophageal mucosa from acid injury
27. Cell proliferation in colorectal tumor progression: An immunohistochemica approach to intermediate biomarkers
28. Differences in cell proliferation and prognostic significance of proliferating cell nuclear antigen and Ki-67 antigen immunoreactivity in in situ and invasive carcinomas of the extrahepatic biliary tract
29. Is Ki-67 a better proliferative marker in the colon than proliferating cell nuclear antigen?
30. Keratin polypeptides in malignant epithelial liver tumors
31. Immunohistochemistry in the differential diagnosis of liver carcinomas
32. Combined hepatocellular and cholangiocarcinoma: Proposed criteria according to cytokeratin expression and analysis of clinicopathologic features
33. Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications
34. Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors
35. Down regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
36. Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma
37. Is there a liver stem cell?
38. Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6