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Volumn 123, Issue 2, 2008, Pages 395-400

Low CAIX expression and absence of VHL gene mutation are associated with tumor aggressiveness and poor survival of clear cell renal cell carcinoma

Author keywords

CAIX; Prognosis; Renal cell carcinoma; Survival; VHL

Indexed keywords

GENOMIC DNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY M75; PROTEIN; PROTEIN CAIX; VON HIPPEL LINDAU PROTEIN; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE; TUMOR ANTIGEN; VHL PROTEIN, HUMAN;

EID: 44949119410     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23496     Document Type: Article
Times cited : (164)

References (49)
  • 6
    • 0242608613 scopus 로고    scopus 로고
    • The genetic basis of cancer of the kidney
    • Linehan WM, Walther MM, Zbar B. The genetic basis of cancer of the kidney. J Urol 2003;170:2163-72.
    • (2003) J Urol , vol.170 , pp. 2163-2172
    • Linehan, W.M.1    Walther, M.M.2    Zbar, B.3
  • 8
    • 0028235907 scopus 로고
    • Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas
    • Shuin T, Kondo K, Torigoe S, Kishida T, Kubota Y, Hosaka M, Nagashima Y, Kitamura H, Latif F, Zbar B. Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 1994;54:2852-5.
    • (1994) Cancer Res , vol.54 , pp. 2852-2855
    • Shuin, T.1    Kondo, K.2    Torigoe, S.3    Kishida, T.4    Kubota, Y.5    Hosaka, M.6    Nagashima, Y.7    Kitamura, H.8    Latif, F.9    Zbar, B.10
  • 9
    • 0032578357 scopus 로고    scopus 로고
    • pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation
    • Iliopoulos O, Ohh M, Kaelin WG, Jr. pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation. Proc Natl Acad Sci USA 1998;95:11661-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11661-11666
    • Iliopoulos, O.1    Ohh, M.2    Kaelin Jr, W.G.3
  • 10
    • 0033602089 scopus 로고    scopus 로고
    • Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity
    • Blankenship C, Naglich JG, Whaley JM, Seizinger B, Kley N. Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity. Oncogene 1999;18:1529-35.
    • (1999) Oncogene , vol.18 , pp. 1529-1535
    • Blankenship, C.1    Naglich, J.G.2    Whaley, J.M.3    Seizinger, B.4    Kley, N.5
  • 12
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim WY, Kaelin WG. Role of VHL gene mutation in human cancer. J Clin Oncol 2004;22:4991-5004.
    • (2004) J Clin Oncol , vol.22 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 18
    • 33845654683 scopus 로고    scopus 로고
    • Role of carbonic anhydrases in the progression of renal cell carcinoma subtypes: Proposal of a unified hypothesis
    • Dorai T, Sawczuk I, Pastorek J, Wiernik PH, Dutcher JP. Role of carbonic anhydrases in the progression of renal cell carcinoma subtypes: proposal of a unified hypothesis. Cancer Invest 2006;24:754-79.
    • (2006) Cancer Invest , vol.24 , pp. 754-779
    • Dorai, T.1    Sawczuk, I.2    Pastorek, J.3    Wiernik, P.H.4    Dutcher, J.P.5
  • 19
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer
    • Swinson DE, Jones JL, Richardson D, Wykoff C, Turley H, Pastorek J, Taub N, Harris AL, O'Byrne KJ. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poor prognosis in non-small-cell lung cancer. J Clin Oncol 2003;21:473-82.
    • (2003) J Clin Oncol , vol.21 , pp. 473-482
    • Swinson, D.E.1    Jones, J.L.2    Richardson, D.3    Wykoff, C.4    Turley, H.5    Pastorek, J.6    Taub, N.7    Harris, A.L.8    O'Byrne, K.J.9
  • 21
    • 0043123069 scopus 로고    scopus 로고
    • Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: Association with treatment outcome
    • Span PN, Bussink J, Manders P, Beex LV, Sweep CG. Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. Br J Cancer 2003;89:271-6.
    • (2003) Br J Cancer , vol.89 , pp. 271-276
    • Span, P.N.1    Bussink, J.2    Manders, P.3    Beex, L.V.4    Sweep, C.G.5
  • 23
    • 33644638219 scopus 로고    scopus 로고
    • Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas
    • Driessen A, Landuyt W, Pastorekova S, Moons J, Goethals L, Haustermans K, Nafteux P, Penninckx F, Geboes K, Lerut T, Ectors N. Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas. Ann Surg 2006;243:334-40.
    • (2006) Ann Surg , vol.243 , pp. 334-340
    • Driessen, A.1    Landuyt, W.2    Pastorekova, S.3    Moons, J.4    Goethals, L.5    Haustermans, K.6    Nafteux, P.7    Penninckx, F.8    Geboes, K.9    Lerut, T.10    Ectors, N.11
  • 27
    • 0002387316 scopus 로고    scopus 로고
    • UICC International Union Against Cancer, eds
    • 6th edn. New York: Willey-Liss
    • Sobin LH, Wittekind C. Kidney. In: UICC International Union Against Cancer, eds. TNM classification of malignant tumors, 6th edn. New York: Willey-Liss, 2003.193-5.
    • (2003) TNM classification of malignant tumors , pp. 193-195
    • Sobin, L.H.1    Kidney, W.C.2
  • 29
    • 0020376310 scopus 로고
    • Prognostic significance of morphologic parameters in renal cell carcinoma
    • Fuhrman SA, Lasky LC, Limas C. Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 1982;6:655-63.
    • (1982) Am J Surg Pathol , vol.6 , pp. 655-663
    • Fuhrman, S.A.1    Lasky, L.C.2    Limas, C.3
  • 31
  • 32
    • 0142219359 scopus 로고    scopus 로고
    • Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway
    • Pantuck AJ, Zeng G, Belldegrun AS, Figlin RA. Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway. Clin Cancer Res 2003;9:4641-52.
    • (2003) Clin Cancer Res , vol.9 , pp. 4641-4652
    • Pantuck, A.J.1    Zeng, G.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 33
    • 20444433599 scopus 로고    scopus 로고
    • Loss of expression of von Hippel-Lindau tumor suppressor protein associated with improved survival in patients with early-stage clear cell renal cell carcinoma
    • Parker AS, Cheville JC, Lohse CM, Igel T, Leibovich BC, Blute ML. Loss of expression of von Hippel-Lindau tumor suppressor protein associated with improved survival in patients with early-stage clear cell renal cell carcinoma. Urology 2005;65:1090-5.
    • (2005) Urology , vol.65 , pp. 1090-1095
    • Parker, A.S.1    Cheville, J.C.2    Lohse, C.M.3    Igel, T.4    Leibovich, B.C.5    Blute, M.L.6
  • 34
    • 0036154040 scopus 로고    scopus 로고
    • VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma
    • Schraml P, Struckmann K, Hatz F, Sonnet S, Kully C, Gasser T, Sauter G, Mihatsch MJ, Moch H. VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma. J Pathol 2002;196:186-93.
    • (2002) J Pathol , vol.196 , pp. 186-193
    • Schraml, P.1    Struckmann, K.2    Hatz, F.3    Sonnet, S.4    Kully, C.5    Gasser, T.6    Sauter, G.7    Mihatsch, M.J.8    Moch, H.9
  • 36
    • 0034676331 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
    • Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH. Up-regulation of hypoxia-inducible factors HIF-1α and HIF-2α under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000:19:5435-43.
    • (2000) Oncogene , vol.19 , pp. 5435-5443
    • Krieg, M.1    Haas, R.2    Brauch, H.3    Acker, T.4    Flamme, I.5    Plate, K.H.6
  • 37
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Hockel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001;93:266-76.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 38
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, Simons JW, Semenza GL. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-5.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 39
    • 1842852597 scopus 로고    scopus 로고
    • Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells
    • Rafajova M, Zatovicova M, Kettmann R, Pastorek J, Pastorekova S. Induction by hypoxia combined with low glucose or low bicarbonate and high posttranslational stability upon reoxygenation contribute to carbonic anhydrase IX expression in cancer cells. Int J Oncol 2004;24:995-1004.
    • (2004) Int J Oncol , vol.24 , pp. 995-1004
    • Rafajova, M.1    Zatovicova, M.2    Kettmann, R.3    Pastorek, J.4    Pastorekova, S.5
  • 40
    • 33749642343 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors in renal cell carcinoma: Current status and future applications
    • Pantuck AJ, Thomas G, Belldegrun AS, Figlin RA. Mammalian target of rapamycin inhibitors in renal cell carcinoma: current status and future applications. Semin Oncol 2006;33:607-13.
    • (2006) Semin Oncol , vol.33 , pp. 607-613
    • Pantuck, A.J.1    Thomas, G.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 41
    • 25144458219 scopus 로고    scopus 로고
    • Expression of the vacular endothelial growth factor family in tumor dissemination and disease free survival in clear cell renal cell carcinoma
    • Lam JS, Leppert JT, Yu H, Seligson DB, Dong J, Horvath S, Pantuck AJ, Figlin RA, Belldegrun AS. Expression of the vacular endothelial growth factor family in tumor dissemination and disease free survival in clear cell renal cell carcinoma. J Clin Oncol 2005;23:4538.
    • (2005) J Clin Oncol , vol.23 , pp. 4538
    • Lam, J.S.1    Leppert, J.T.2    Yu, H.3    Seligson, D.B.4    Dong, J.5    Horvath, S.6    Pantuck, A.J.7    Figlin, R.A.8    Belldegrun, A.S.9
  • 44
    • 0035418586 scopus 로고    scopus 로고
    • Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: Correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix
    • Loncaster JA, Harris AL, Davidson SE, Logue JP, Hunter RD, Wycoff CC, Pastorek J, Ratcliffe PJ, Stratford IJ, West CM. Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix. Cancer Res 2001;61:6394-9.
    • (2001) Cancer Res , vol.61 , pp. 6394-6399
    • Loncaster, J.A.1    Harris, A.L.2    Davidson, S.E.3    Logue, J.P.4    Hunter, R.D.5    Wycoff, C.C.6    Pastorek, J.7    Ratcliffe, P.J.8    Stratford, I.J.9    West, C.M.10
  • 45
    • 33846661210 scopus 로고    scopus 로고
    • Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer
    • Lee S, Shin HJ, Han IO, Hong EK, Park SY, Roh JW, Shin KH, Kim TH, Kim JY. Tumor carbonic anhydrase 9 expression is associated with the presence of lymph node metastases in uterine cervical cancer. Cancer Sci 2007;98:329-33.
    • (2007) Cancer Sci , vol.98 , pp. 329-333
    • Lee, S.1    Shin, H.J.2    Han, I.O.3    Hong, E.K.4    Park, S.Y.5    Roh, J.W.6    Shin, K.H.7    Kim, T.H.8    Kim, J.Y.9
  • 47
    • 0032514685 scopus 로고    scopus 로고
    • Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes
    • Ivanov SV, Kuzmin I, Wei MH, Pack S, Geil L, Johnson BE, Stanbridge EJ, Lerman MI. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes. Proc Natl Acad Sci USA 1998;95:12596-601.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12596-12601
    • Ivanov, S.V.1    Kuzmin, I.2    Wei, M.H.3    Pack, S.4    Geil, L.5    Johnson, B.E.6    Stanbridge, E.J.7    Lerman, M.I.8
  • 48
    • 2542601328 scopus 로고    scopus 로고
    • Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target
    • Potter C, Harris AL. Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target. Cell Cycle 2004;3:164-7.
    • (2004) Cell Cycle , vol.3 , pp. 164-167
    • Potter, C.1    Harris, A.L.2
  • 49
    • 33748526494 scopus 로고    scopus 로고
    • Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: Impact of patient characteristics and Von Hippel-Lindau gene status
    • Rini BI, Jaeger E, Weinberg V, Sein N, Chew K, Fong K, Simko J, Small EJ, Waldman FM. Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: impact of patient characteristics and Von Hippel-Lindau gene status. BJU Int 2006;98:756-62.
    • (2006) BJU Int , vol.98 , pp. 756-762
    • Rini, B.I.1    Jaeger, E.2    Weinberg, V.3    Sein, N.4    Chew, K.5    Fong, K.6    Simko, J.7    Small, E.J.8    Waldman, F.M.9


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