Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2

British Journal of Pharmacology

Volumn 161, Issue 4, 2010, Pages 950-960

  Karczewski, Jerzy ^a   Spencer, Robert H ^a   Garsky, Victor M ^a   Liang, Annie ^a   Leitl, Michael D ^a   Cato, Matthew J ^a   Cook, Sean P ^a   Kane, Stefanie ^a   Urban, Mark O ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

acid sensitive ion channels; amiloride; APETx2; inflammatory pain

Indexed keywords

ACID; ACID SENSITIVE ION CHANNEL 3; APETX2 PEPTIDE; FREUND ADJUVANT; ION CHANNEL; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; GASTROCNEMIUS MUSCLE; GENE EXPRESSION; IC 50; IN VIVO STUDY; INFLAMMATION; MALE; MECHANICAL STIMULATION; MYALGIA; NONHUMAN; PATCH CLAMP; PAW EDEMA; PRIORITY JOURNAL; RAT;

ANALGESICS; ANIMALS; CHO CELLS; CNIDARIAN VENOMS; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; FREUND'S ADJUVANT; HYDROGEN-ION CONCENTRATION; INFLAMMATION; MALE; MUSCLE, SKELETAL; NERVE TISSUE PROTEINS; PAIN; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; SODIUM CHLORIDE;

EID: 77957231525     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00918.x     Document Type: Article

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