Acidotoxicity and acid-sensing ion channels contribute to motoneuron degeneration

Cell Death and Differentiation

Volumn 20, Issue 4, 2013, Pages 589-598

  Behan, A T ^a   Breen, B ^a   Hogg, M ^a   Woods, I ^a   Coughlan, K ^a   Mitchem, M ^a   Prehn, J H M ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

5 (N,N dimethyl) amiloride hydrochloride; Acidotoxicity; Motoneuron; Neurodegeneration; SOD1 mouse

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE HYDROCHLORIDE; ACID SENSING ION CHANNEL; AMILORIDE DERIVATIVE; COPPER ZINC SUPEROXIDE DISMUTASE; RILUZOLE; UNCLASSIFIED DRUG;

ACIDOTOXICITY; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CROSS BREEDING; DISEASE COURSE; FEMALE; IN VITRO STUDY; LIFESPAN; MALE; MOTONEURON; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; MOUSE; NERVE CELL CULTURE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXICITY;

ACID SENSING ION CHANNELS; ACIDS; AMILORIDE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMANS; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; SUPEROXIDE DISMUTASE;

MUS;

EID: 84874950486     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2012.158     Document Type: Article

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