Ziconotide: Neuronal calcium channel blocker for treating severe chronic pain

Current Medicinal Chemistry

Volumn 11, Issue 23, 2004, Pages 3029-3040

  Miljanich, George P ^a  

^a ELAN PHARMACEUTICALS   (United States)

Author keywords

Analgesia; Conopeptide; Conotoxin; N Type calcium channels; Pain; PRIALT; SNX 111; Ziconotide

Indexed keywords

ACETYLCHOLINE; AM 336; BENZOTHIAZEPINE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; CATECHOLAMINE; CLONIDINE; DIHYDROPYRIDINE DERIVATIVE; DOPAMINE; GLUTAMATE RECEPTOR; HISTAMINE; MORPHINE; NEUROPEPTIDE; NORADRENALIN; OMEGA AGATOXIN IVA; OMEGA CONOTOXIN CNVIIA; OMEGA CONOTOXIN CVID; OMEGA CONOTOXIN GVIA; OMEGA CONOTOXIN MVIIA; OMEGA CONOTOXIN MVIIC; OPIATE DERIVATIVE; OPIATE RECEPTOR; OXYTOCIN; PHENYLALKYLAMINE; PLACEBO; SEROTONIN; UNCLASSIFIED DRUG; VERAPAMIL; VOLTAGE GATED CALCIUM CHANNEL;

ANALGESIC ACTIVITY; ANTINOCICEPTION; BEHAVIOR DISORDER; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CEREBROVASCULAR DISEASE; CHRONIC PAIN; CLINICAL TRIAL; CONFUSION; CORRELATION ANALYSIS; DISEASE SEVERITY; DIZZINESS; DRUG APPROVAL; DRUG BLOOD LEVEL; DRUG CLASSIFICATION; DRUG CLEARANCE; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; ECG ABNORMALITY; EEG ABNORMALITY; ENZYME INHIBITION; FEVER; GAIT DISORDER; HEADACHE; HUMAN; NAUSEA; NEUROMUSCULAR SYNAPSE; NEUROPATHIC PAIN; NEUROSECRETORY CELL; NOCICEPTIVE RECEPTOR; NONHUMAN; NYSTAGMUS; ORTHOSTATIC HYPOTENSION; POSTOPERATIVE PAIN; REVIEW; SINUS BRADYCARDIA; SNAIL; SOMNOLENCE; TISSUE DISTRIBUTION; URINE RETENTION; VISCERAL PAIN; VISUAL IMPAIRMENT; VOMITING;

EID: 9144272640     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867043363884     Document Type: Review

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