Discovery and characterization of cnidarian peptide toxins that affect neuronal potassium ion channels

Toxicon

Volumn 54, Issue 8, 2009, Pages 1119-1124

  Castañeda, Olga ^a   Harvey, Alan L ^b  

^a UNIVERSITY OF HAVANA   (Cuba)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Cnidarian; Peptide toxins; Potassium ion channel; Sea anemone

Indexed keywords

ACTINIA EQUINA TOXIN; ANEMONIA ERYTHRAEA TOXIN; ANEMONIA SULCATA TOXIN; ANEMONIA VIRIDIS TOXIN; ANTHEOPSIS MACULATA TOXIN; ANTHOPLEURA ELEGANTISSIMA TOXIN; BDS TOXIN; BUNODOSOMA CANGICUM TOXIN; BUNODOSOMA GRANULIFERA TOXIN; COELENTERATE VENOM; CYTOLYSIN; DENDROTOXIN; FASCICULIN; KALICLUDINE; KALISEPTINE; MARINE TOXIN; MUSCARINIC AGENT; NEUROTOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KV1.2; SEA ANEMONE TOXIN; SERINE PROTEINASE INHIBITOR; SHAKER POTASSIUM CHANNEL; SHAW POTASSIUM CHANNEL; STICHODACTYLA HADDONI TOXIN; STICHODACTYLA HELIANTHUS TOXIN; UNCLASSIFIED DRUG;

ACTINIA EQUINA; ANEMONIA ERYTHRAEA; ANEMONIA SULCATA; ANEMONIA VIRIDIS; ANTHEOPSIS MACULATA; ANTHOPLEURA ELEGANTISSIMA; ARTICLE; BUNODOSOMA CANGICUM; BUNODOSOMA GRANULIFERA; COELENTERATE; DISULFIDE BOND; HUMAN; ISOTOPE LABELING; MOLECULAR PROBE; NEUROTOXICITY; NONHUMAN; POTASSIUM CURRENT; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; SEA ANEMONE; STICHODACTYLA HADDONI; STICHODACTYLA HELIANTHUS; STRUCTURE ACTIVITY RELATION; SYNAPTIC MEMBRANE; TOXIN ANALYSIS; TOXIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; CNIDARIAN VENOMS; MOLECULAR SEQUENCE DATA; NEURONS; PEPTIDES; POTASSIUM CHANNELS; SEA ANEMONES;

ACTINIARIA; ANEMONIA SULCATA; BUNODOSOMA GRANULIFERA; STICHODACTYLA HELIANTHUS;

EID: 70350399657     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2009.02.032     Document Type: Article

References (57)

1. Abbott G.W., Butler M.H., Bendahhou S., Dalakas M.C., Ptacek L.J., and Goldstein S.A. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell 104 (2001) 217-231
2. Alvarez C., Tejuca M., Morera V., Besada V., Pazos F., Lanio M.E., and Padrón G. Novel primary structure of sticholysin and its interaction with membranes. Toxicon 34 (1996) 301
3. Anderson A.J., and Harvey A.L. Effects of the potassium channel blocking dendrotoxins on acetylcholine release and motor nerve terminal activity. Br. J. Pharmacol 93 (1988) 215-221
4. Aneiros A., García-Alonso I., Martínez J.R., Harvey A.L., Marshall D.L., Engstrom A., Hellman U., and Karlsson E. A potassium channel toxin from the sea anemone Bunodosoma granulífera. Isolation, amino acid sequence and biological activity. Biochim. Biophys. Acta 1157 (1993) 86-92
5. + current in crayfish neuromuscular system and chromaffin cells by sea anemone Bunodosoma cangicum venom. J. Neurosci. Res. 42 (1995) 539-546
6. Béress, L., Doppelfeld, I.S., Etschenberg, E., Graf, E., Henschen-Edman, A., Zwick, J., 1985. Polypeptide, verfahen zu ihrer herstelleng und ihre verwendung als blutdrucksendkrende wirkstoffe. DE3324689 A1, Deutsches Patentamt.
7. Bernheimer A.W., and Avigad L.S. Properties of a toxin from the sea anemone Stoichactis helianthus, including specific binding to sphingomyelin. Proc. Natl. Acad. Sci. USA 73 (1976) 467-471
8. Blumenthal K.M., and Kem W.R. Primary structure of Stoichactis helianthus cytolysin III. J. Biol. Chem. 258 (1983) 5574-5581
9. Castañeda O., Sotolongo V., Amor A.M., Stöcklin R., Anderson A.J., Harvey A.L., Engström A., Wernstedt C., and Karlsson E. Characterization of a potassium channel toxin from the Caribbean sea anemone Stichodactyla helianthus. Toxicon 33 (1995) 603-613
10. Chávez M., Gómez T., Barral A.M., Márquez M., and Más R. Aislamiento y purificación de un inhibidor de proteasas presente en la anémona Stoichactis helianthus. In: Contribuciones. Simposio de Ciencias del Mar y VII Jornada Científica del Instituto de Oceanología. Editorial Academia. La Habana. Cuba (1985) 289-293
11. Cotton J., Crest M., Bouet F., Alessandri N., Gola M., Forest E., Karlsson E., Castañeda O., Harvey A.L., Vita C., and Ménez A. A potassium-channel toxin from the sea anemone Bunodosoma granulífera, an inhibitor of Kv1 channels. Revision of the amino acid sequence, disulphide assignment, chemical synthesis and biological activity. Eur. J. Biochem 244 (1997) 192-202
12. Delfín J., Martínez I., Antuch W., Morera V., González Y., Rodríguez R., Márquez M., Saroyán A., Larionova N., Díaz J., Padrón G., and Chávez M. Purification, characterization and immobilization of proteinase inhibitors from Stichodactyla helianthus. Toxicon 34 (1996) 1367-1376
13. Devlin J.P. Isolation and partial purification of hemolytic toxin from sea anemone, Stoichactis helianthus. J. Pharm. Sci. 63 (1974) 1478-1480
14. Diochot S., Schweitz H., Béres L., and Lazdunski M. Sea anemone peptides with a specific blocking activity against the fast inactivating potassium channel Kv3.4. J. Biol. Chem. 273 (1998) 744-6749
15. Diochot S., Loret E., Bruhn T., Béres L., and Lazdunski M. APETx1, a new toxin from the sea anemone Anthopleura elegantisima, blocks voltage gated human ether-à-go-go-related gene potassium channel. Mol. Pharmacol 64 (2003) 59-69
16. + currents in snail neurons. Brain Res. 12 (2000) 312-314
17. Gendeh G.S., Young L.C., de Medeiros L.C., Jeyaseelan K., Harvey A.L., and Chung M.C.M. A new potassium channel toxin from the sea anemone Heteractis magnifica: isolation, cDNA cloning and functional expression. Biochemistry 36 (1997) 11461-11471
18. Gilquin B., Racapé J., Wrisch A., Visan V., Lecoq A., Grissmer S., Ménez A., and Gasparini S. Structure of the BgK-Kv1.1 complex based on distance restraints identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers. J. Biol. Chem. 277 (2002) 37406-37413
19. Harvey A.L. Twenty years of dendrotoxins. Toxicon 39 (2001) 15-26
20. Harvey A.L., and Anderson A.J. Dendrotoxins: Snake toxins that block potassium channels and facilitate neurotransmitter release. Pharmacol. Ther 31 (1985) 35-55
21. Harvey A.L., and Karlsson E. Dendrotoxin from the venom of the green mamba Dendroaspis angusticeps, a neurotoxin that enhances acetylcholine release at neuromuscular junctions. Naunyn-Schmiedberg's Arch. Pharmacol 312 (1980) 1-6
22. Harvey A.L., and Karlsson E. Protease inhibitor homologues from mamba venoms: facilitation of acetylcholine release and interactions with prejunctional blocking toxins. Br. J. Pharmacol 77 (1982) 153-161
23. Harvey A.L., Rowan E.G., Vatanpour H., Young L., Castañeda O., Mebs D., Cerveñansky C., and Karlsson E. Potassium channel neurotoxins from sea anemones. In: Lazaovici P., Spira M.E., and Zlotkin E. (Eds). Biochemical Aspects of Marine Pharmacology (1996), Fort Collins, Alaken, Inc 121-131 CO, Chapter 9
24. Hasegawa Y., Honma T., Nagai H., Ishida M., Nagashima Y., and Shiomi K. Isolation and cDNA cloning of a potassium channel peptide toxin from the sea anemone Anemonia erythraea. Toxicon 48 (2006) 536-542
25. Honma T., and Shiomi K. Peptide toxins in sea anemones: structural and functional aspects. Mar. Biotechnol. (NY) 8 (2006) 1-10
26. Honma T., Hasegawa Y., Ishida M., Nagai H., Nagashima Y., and Shiomi K. Isolation and molecular cloning of novel peptide toxins from the sea anemone Antheopsis maculata. Toxicon 45 (2005) 33-41
27. Honma T., Kawahata S., Ishida M., Nagai H., Nagashima Y., and Shiomi K. Novel peptide toxins from the sea anemone Stichodactyla haddoni. Peptides 29 (2008) 536-544
28. Karlsson E., Adem A., Aneiros A., Castañeda O., Harvey A.L., Hellman U., Jolkokonen M., and Sotolongo V. New Toxins from marine organisms. In: Dajas F., and Tipton K. (Eds). Neurotoxins in Neurobiology: Their Actions and Applications (1993), Ellis Horwood, Chichester 45-58
29. Kem W.R., and Dunn B.M. Separation and characterization of four different amino acid sequence variants of a sea anemone (Stichodactyla helianthus) protein cytolysin. Toxicon 26 (1988) 997-1008
30. Kem W.R., Parten B., Pennington M.W., Price D.A., and Dunn B.M. Isolation, characterization, and amino acid sequence of a polypeptide neurotoxin occurring in the sea anemone Stichodactyla helianthus. Biochemistry 28 (1989) 3483-3489
31. Kem W.R., Pennington M.W., and Dunn B.M. Sea anemone polypeptide toxins affecting sodium channels. Initial structure activity investigations. In: Hall S., and Strichartz G. (Eds). Marine Toxins. Origin Structure and Molecular Pharmacology (1990), ACS, Washington DC 279-289
32. Kem W.R., Sanyals G., Williams R.W., and Pennington M.W. Secondary structure of ShK toxin, a potassium channel blocking peptide. Lett. Peptide Sci. 3 (1996) 69-72
33. Lagos P., Duran R., Cerveñansky C., Freitas J.C., and Silveira R. Identification of hemolytic and neuroactive fractions in the venom of the sea anemone Bunodosoma cangicum. Braz. J. Med. Biol. Res. 34 (2001) 895-902
34. Loret E.P., del Valle R.M., Mansuelle P., Sampieri F., and Rochat H. Positively charged amino acid residues located similarly in sea anemone and scorpion toxins. J. Biol. Chem. 269 (1994) 16785-16788
35. Mebs D., and Gebauer E. Isolation of proteinase inhibitory, toxic and hemolytic polypeptides from a sea anemone. Stoichactis sp. Toxicon 18 (1980) 97-106
36. Michaels D.W. Membrane damage by a toxin from the sea anemone Stoichactis helianthus. I. Formation of transmembrane channels in lipid bilayers. Biochim. Biophys. Acta 555 (1979) 67-78
37. Minagawa S., Ishida M., Nagashima Y., and Shiomi K. Primary structure of a potassium channel toxin from the sea anemone Actinia equina. FEBS Lett. 427 (1998) 149-151
38. Molgó J., and Mallart A. Effects of Anemonia sulcata toxin II on presynaptic currents and evoked transmitter release at neuromuscular junctions of the mouse. Pflugers Arch. 405 (1985) 349-353
39. Norton R.S. Structure and structure-function relationships of sea anemone proteins that interact with sodium channel. Toxicon 29 (1991) 1051-1084
40. Pannaccione A., Boscia F., Scorziello A., Adornetto A., Castaldo P., Sirabella R., Taglialatela M., Di Renzo G.F., and Annunziato L. Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death. Mol. Pharmacol 272 (2007) 665-673
41. + channel inhibitor from a sea anemone. Int. J. Peptide Protein Res. 46 (1995) 354-358
42. Pennington M.W., Kem W.R., Mahnir V.M., Byrnes M.E., Zaydenberg I., Khaytin I., Krafte D.S., and Hill R. Identification of essential residues in the potassium channel inhibitor ShK toxin: analysis of monosubstituted analogs. In: Kaumaya P.T.P., and Hodges R.S. (Eds). Peptides: Chemistry, Structure and Biology (1995), Escom, Leiden, Netherlands 14-16
43. Pennington M.W., Mahnir V.M., Krafte D.S., Zaydenberg I., Byrnes M.E., Khaytin I., Crowley K., and Kem W.R. Identification of three separate binding sites on ShK toxin, a potent inhibitor of voltage dependent potassium channels in human T-lymphocytes and rat brain. Biochem. Biophys. Res. Commun 219 (1996) 696-701
44. Pohl J., Hubalek F., Byrnes M.E., Nielsen K.R., Woods A., and Pennington M.W. Assignment of the three disulphide bonds in ShK toxin: a potent potassium channel inhibitor from the sea anemone Stichodactyla helianthus. Lett. Peptide Sci. 1 (1995) 291-297
45. Rauer H., Pennington M., Cahalan M., and Candí K.G. Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin. J. Biol. Chem. 274 (1999) 21885-21892
46. Salgado V.L., and Kem W.R. Actions of three structurally distinct sea anemone toxins on crustacean and insect sodium channels. Toxicon 30 (1992) 1365-1381
47. + channels. J. Biol. Chem. 270 (1995) 25121-25126
48. Shiomi K., Qian W.H., Lin X.Y., Shimakura K., Nagashima Y., and Ishida M. Novel polypeptide toxins with crab lethality from the sea anemone Anemonia erythraea. Biochim. Biophys. Acta 1335 (1997) 191-198
49. Stevens S.M., Kem W.R., and Prokai L. Investigation of cytolysin variants by peptide mapping: Enhanced protein characterization using complementary ionization and mass spectrometric techniques. Rapid Commun. Mass Spectrom 16 (2002) 2094-2101
50. Suarez-Kurtz G., Vianna-Jorge R., Pereira B.F., Garcia M.L., and Kaczorowski G.J. Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release. J. Pharmacol. Exp. Ther 289 (1999) 1517-1522
51. Tudor J.E., Pallaghy P.K., Pennington M.W., and Norton R.S. Solution structure of ShK toxin, a novel inhibitor from a sea anemone. Nat. Struct. Biol. 3 (1996) 317-320
52. Varanda W., and Finkelstein A. Ion and nonelectrolyte permeability properties of channels formed in planar lipid bilayer membranes by the cytolytic toxin from the sea anemone, Stoichactis helianthus. J. Membr. Biol. 55 (1980) 203-211
53. Wanke E., and Restano-Cassulini R. Toxins interacting with ether-à-go-go-related gene voltage-dependent potassium channels. Toxicon 49 (2007) 239-248
54. Yan L., Herrington J., Goldberg E., Dulsky P.M., Bugianesi R.M., Slaughter R.S., Banerjee P., Brochu R.M., Priest B.T., Kaczorowski G.R., and García M.L. Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3.2 channels. Mol. Pharmacol 67 (2005) 1513-1521
55. Yeung S.Y., Thompson D., Wang Z., Fedida D., and Robertson B. Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies. J. Neurosci 25 (2005) 8735-8745
56. Zaharenko A.J., Ferreira Jr. W.A., Oliveira J.S., Richardson M., Pimenta D.C., Konno K., Portaro F.C.V., and de Freitas J.C. Proteomics of the neurotoxic fraction from the sea anemone Bunodosoma cangicum venom: Novel peptides belonging to new classes of toxins. Comp. Biochem. Physiol. D: Genomics Proteomics 3 (2008) 219-225
57. Zhang M., Liu X.S., Diochot S., Lazdunski M., and Tseng G.N. APETx1 from sea anemone Anthopleura elegantissima is a gating modifier peptide toxin of the human ether-à-go-go-related potassium channel. Mol. Pharmacol 72 (2007) 259-268