Inhibition of acid-sensing ion channels in articular chondrocytes by amiloride attenuates articular cartilage destruction in rats with adjuvant arthritis

Inflammation Research

Volumn 59, Issue 11, 2010, Pages 939-947

  Feng Lai, Yuan ^a,b   Fei Hu, Chen ^a   Wei Guo, Lu ^b   Xia, Li ^b   Jian Ping, Li ^b   Cheng Wan, Li ^b   Rui Sheng, Xu ^b   Fan Rong, Wu ^a   Wei, Hu ^a   Teng Yue, Zhang ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b NANTONG UNIVERSITY   (China)

Author keywords

Acid sensing ion channel; Adjuvant arthritis; Amiloride; Articular chondrocytes; Cartilage breakdown

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1; AGGRECAN; AMILORIDE; COLLAGEN TYPE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LACTATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG ACTIVITY; ELECTRON MICROSCOPY; ENZYME ASSAY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; MALE; MORPHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGGRECANS; AMILORIDE; ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; COLLAGEN TYPE II; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 78651275140     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-010-0206-4     Document Type: Article

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