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Volumn 375, Issue 9725, 2010, Pages 1569-1577

Ziconotide for treatment of severe chronic pain

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL N TYPE; MORPHINE; OMEGA CONOTOXIN MVIIA; PLACEBO;

EID: 77951652246     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(10)60354-6     Document Type: Review
Times cited : (303)

References (65)
  • 2
    • 33645231857 scopus 로고    scopus 로고
    • Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment
    • Breivik H., Collett B., Ventafridda V., Cohen R., and Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain 10 (2006) 287-333
    • (2006) Eur J Pain , vol.10 , pp. 287-333
    • Breivik, H.1    Collett, B.2    Ventafridda, V.3    Cohen, R.4    Gallacher, D.5
  • 3
    • 0036829011 scopus 로고    scopus 로고
    • Can we conquer pain?
    • Scholz J., and Woolf C.J. Can we conquer pain?. Nat Neurosci 5 suppl (2002) 1062-1067
    • (2002) Nat Neurosci , vol.5 , Issue.SUPPL , pp. 1062-1067
    • Scholz, J.1    Woolf, C.J.2
  • 4
    • 70349481938 scopus 로고    scopus 로고
    • Treatment of neuropathic pain: an overview of recent guidelines
    • O'Connor A.B., and Dworkin R.H. Treatment of neuropathic pain: an overview of recent guidelines. Am J Med 122 suppl (2009) 22-32
    • (2009) Am J Med , vol.122 , Issue.SUPPL , pp. 22-32
    • O'Connor, A.B.1    Dworkin, R.H.2
  • 5
    • 67349126560 scopus 로고    scopus 로고
    • Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews
    • Kroenke K., Krebs E.E., and Bair M.J. Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews. Gen Hosp Psychiatry 31 (2009) 206-219
    • (2009) Gen Hosp Psychiatry , vol.31 , pp. 206-219
    • Kroenke, K.1    Krebs, E.E.2    Bair, M.J.3
  • 6
    • 9144230737 scopus 로고    scopus 로고
    • Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial
    • Staats P.S., Yearwood T., Charapata S.G., et al. Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA 291 (2004) 63-70
    • (2004) JAMA , vol.291 , pp. 63-70
    • Staats, P.S.1    Yearwood, T.2    Charapata, S.G.3
  • 7
    • 41749102879 scopus 로고    scopus 로고
    • Future directions for intrathecal pain management: a review and update from the interdisciplinary Polyanalgesic Consensus Conference 2007
    • Deer T., Krames E.T., Hassenbusch S., et al. Future directions for intrathecal pain management: a review and update from the interdisciplinary Polyanalgesic Consensus Conference 2007. Neuromodulation 11 (2008) 92-97
    • (2008) Neuromodulation , vol.11 , pp. 92-97
    • Deer, T.1    Krames, E.T.2    Hassenbusch, S.3
  • 8
    • 34748814292 scopus 로고    scopus 로고
    • Polyanalgesic Consensus Conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel
    • Deer T., Krames E., Hassenbusch S., et al. Polyanalgesic Consensus Conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation 10 (2007) 300-328
    • (2007) Neuromodulation , vol.10 , pp. 300-328
    • Deer, T.1    Krames, E.2    Hassenbusch, S.3
  • 9
    • 0036628335 scopus 로고    scopus 로고
    • Conus peptides and neuroprotection
    • Heading C.E. Conus peptides and neuroprotection. Curr Opin Investig Drugs 3 (2002) 915-920
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 915-920
    • Heading, C.E.1
  • 10
    • 33845992556 scopus 로고    scopus 로고
    • Conus peptides: biodiversity-based discovery and exogenomics
    • Olivera B.M. Conus peptides: biodiversity-based discovery and exogenomics. J Biol Chem 281 (2006) 31173-31177
    • (2006) J Biol Chem , vol.281 , pp. 31173-31177
    • Olivera, B.M.1
  • 11
    • 0022373275 scopus 로고
    • Peptide neurotoxins from fish-hunting cone snails
    • Olivera B.M., Gray W.R., Zeikus R., et al. Peptide neurotoxins from fish-hunting cone snails. Science 230 (1985) 1338-1343
    • (1985) Science , vol.230 , pp. 1338-1343
    • Olivera, B.M.1    Gray, W.R.2    Zeikus, R.3
  • 12
    • 17044409643 scopus 로고    scopus 로고
    • A toxin against pain
    • Stix G. A toxin against pain. Sci Am 292 (2005) 70-75
    • (2005) Sci Am , vol.292 , pp. 70-75
    • Stix, G.1
  • 13
    • 35349014163 scopus 로고    scopus 로고
    • Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery
    • Olivera B.M., and Teichert R.W. Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery. Mol Interv 7 (2007) 251-260
    • (2007) Mol Interv , vol.7 , pp. 251-260
    • Olivera, B.M.1    Teichert, R.W.2
  • 14
    • 33750611879 scopus 로고    scopus 로고
    • Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain
    • Wallace M.S. Ziconotide: a new nonopioid intrathecal analgesic for the treatment of chronic pain. Expert Rev Neurother 6 (2006) 1423-1428
    • (2006) Expert Rev Neurother , vol.6 , pp. 1423-1428
    • Wallace, M.S.1
  • 15
    • 9144272640 scopus 로고    scopus 로고
    • Ziconotide: neuronal calcium channel blocker for treating severe chronic pain
    • Miljanich G.P. Ziconotide: neuronal calcium channel blocker for treating severe chronic pain. Curr Med Chem 11 (2004) 3029-3040
    • (2004) Curr Med Chem , vol.11 , pp. 3029-3040
    • Miljanich, G.P.1
  • 16
    • 0023187486 scopus 로고
    • Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom
    • Olivera B.M., Cruz L.J., de Santos V., et al. Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom. Biochemistry 26 (1987) 2086-2090
    • (1987) Biochemistry , vol.26 , pp. 2086-2090
    • Olivera, B.M.1    Cruz, L.J.2    de Santos, V.3
  • 17
    • 0028987884 scopus 로고
    • Antagonists of neuronal calcium channels: structure, function, and therapeutic implications
    • Miljanich G.P., and Ramachandran J. Antagonists of neuronal calcium channels: structure, function, and therapeutic implications. Annu Rev Pharmacol Toxicol 35 (1995) 707-734
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 707-734
    • Miljanich, G.P.1    Ramachandran, J.2
  • 18
    • 33645329856 scopus 로고    scopus 로고
    • Targeting N-type and T-type calcium channels for the treatment of pain
    • McGivern J.G. Targeting N-type and T-type calcium channels for the treatment of pain. Drug Discov Today 11 (2006) 245-253
    • (2006) Drug Discov Today , vol.11 , pp. 245-253
    • McGivern, J.G.1
  • 19
    • 55949121591 scopus 로고    scopus 로고
    • Localization and targeting of voltage-dependent ion channels in mammalian central neurons
    • Vacher H., Mohapatra D.P., and Trimmer J.S. Localization and targeting of voltage-dependent ion channels in mammalian central neurons. Physiol Rev 88 (2008) 1407-1447
    • (2008) Physiol Rev , vol.88 , pp. 1407-1447
    • Vacher, H.1    Mohapatra, D.P.2    Trimmer, J.S.3
  • 20
    • 0028105906 scopus 로고
    • Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium-channel antagonist, SNX-230 (omega-conopeptide MVIIC)
    • Gohil K., Bell J.R., Ramachandran J., and Miljanich G.P. Neuroanatomical distribution of receptors for a novel voltage-sensitive calcium-channel antagonist, SNX-230 (omega-conopeptide MVIIC). Brain Res 653 (1994) 258-266
    • (1994) Brain Res , vol.653 , pp. 258-266
    • Gohil, K.1    Bell, J.R.2    Ramachandran, J.3    Miljanich, G.P.4
  • 21
    • 66249111509 scopus 로고    scopus 로고
    • No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing
    • Schmidtko A., Tegeder I., and Geisslinger G. No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends Neurosci 32 (2009) 339-346
    • (2009) Trends Neurosci , vol.32 , pp. 339-346
    • Schmidtko, A.1    Tegeder, I.2    Geisslinger, G.3
  • 22
    • 50849107634 scopus 로고    scopus 로고
    • ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn
    • Motin L., and Adams D.J. ω-Conotoxin inhibition of excitatory synaptic transmission evoked by dorsal root stimulation in rat superficial dorsal horn. Neuropharmacology 55 (2008) 860-864
    • (2008) Neuropharmacology , vol.55 , pp. 860-864
    • Motin, L.1    Adams, D.J.2
  • 23
    • 0242475309 scopus 로고    scopus 로고
    • Central sensitization and LTP: do pain and memory share similar mechanisms?
    • Ji R.R., Kohno T., Moore K.A., and Woolf C.J. Central sensitization and LTP: do pain and memory share similar mechanisms?. Trends Neurosci 26 (2003) 696-705
    • (2003) Trends Neurosci , vol.26 , pp. 696-705
    • Ji, R.R.1    Kohno, T.2    Moore, K.A.3    Woolf, C.J.4
  • 24
    • 0036450543 scopus 로고    scopus 로고
    • 2+ channels in the rat spinal cord following chronic constrictive nerve injury
    • 2+ channels in the rat spinal cord following chronic constrictive nerve injury. Exp Brain Res 147 (2002) 456-463
    • (2002) Exp Brain Res , vol.147 , pp. 456-463
    • Cizkova, D.1    Marsala, J.2    Lukacova, N.3
  • 25
    • 0344851852 scopus 로고    scopus 로고
    • Plastic change of N-type Ca channel expression after preconditioning is responsible for prostaglandin E2-induced long-lasting allodynia
    • Yokoyama K., Kurihara T., Makita K., and Tanabe T. Plastic change of N-type Ca channel expression after preconditioning is responsible for prostaglandin E2-induced long-lasting allodynia. Anesthesiology 99 (2003) 1364-1370
    • (2003) Anesthesiology , vol.99 , pp. 1364-1370
    • Yokoyama, K.1    Kurihara, T.2    Makita, K.3    Tanabe, T.4
  • 27
    • 33751232667 scopus 로고    scopus 로고
    • Identification of the α2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin
    • Field M.J., Cox P.J., Stott E., et al. Identification of the α2-δ-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. Proc Natl Acad Sci U S A 103 (2006) 17537-17542
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17537-17542
    • Field, M.J.1    Cox, P.J.2    Stott, E.3
  • 28
    • 0035869568 scopus 로고    scopus 로고
    • Upregulation of dorsal root ganglion α2δ calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats
    • Luo Z.D., Chaplan S.R., Higuera E.S., et al. Upregulation of dorsal root ganglion α2δ calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci 21 (2001) 1868-1875
    • (2001) J Neurosci , vol.21 , pp. 1868-1875
    • Luo, Z.D.1    Chaplan, S.R.2    Higuera, E.S.3
  • 29
    • 60049094857 scopus 로고    scopus 로고
    • Mechanisms of analgesia by gabapentin and pregabalin-calcium channel α2-δ[Cavα2-δ] ligands
    • Taylor C.P. Mechanisms of analgesia by gabapentin and pregabalin-calcium channel α2-δ[Cavα2-δ] ligands. Pain 142 (2009) 13-16
    • (2009) Pain , vol.142 , pp. 13-16
    • Taylor, C.P.1
  • 30
    • 0031796866 scopus 로고    scopus 로고
    • Pharmacotherapeutic potential of omega-conotoxin MVIIA (SNX-111), an N-type neuronal calcium channel blocker found in the venom of Conus magus
    • Bowersox S.S., and Luther R. Pharmacotherapeutic potential of omega-conotoxin MVIIA (SNX-111), an N-type neuronal calcium channel blocker found in the venom of Conus magus. Toxicon 36 (1998) 1651-1658
    • (1998) Toxicon , vol.36 , pp. 1651-1658
    • Bowersox, S.S.1    Luther, R.2
  • 31
    • 25844456918 scopus 로고    scopus 로고
    • Targeting chronic and neuropathic pain: the N-type calcium channel comes of age
    • Snutch T.P. Targeting chronic and neuropathic pain: the N-type calcium channel comes of age. NeuroRx 2 (2005) 662-670
    • (2005) NeuroRx , vol.2 , pp. 662-670
    • Snutch, T.P.1
  • 32
    • 33645794750 scopus 로고    scopus 로고
    • Intrathecal ziconotide in the treatment of chronic nonmalignant pain: a randomized, double-blind, placebo-controlled clinical trial
    • for the Ziconotide Nonmalignant Pain Study 96-002 Group
    • Wallace M.S., Charapata S.G., Fisher R., et al., for the Ziconotide Nonmalignant Pain Study 96-002 Group. Intrathecal ziconotide in the treatment of chronic nonmalignant pain: a randomized, double-blind, placebo-controlled clinical trial. Neuromodulation 9 (2006) 75-86
    • (2006) Neuromodulation , vol.9 , pp. 75-86
    • Wallace, M.S.1    Charapata, S.G.2    Fisher, R.3
  • 33
    • 33746516663 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain
    • the Ziconotide 301 Study Group
    • Rauck R.L., Wallace M.S., Leong M.S., et al., the Ziconotide 301 Study Group. A randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain. J Pain Symptom Manage 31 (2006) 393-406
    • (2006) J Pain Symptom Manage , vol.31 , pp. 393-406
    • Rauck, R.L.1    Wallace, M.S.2    Leong, M.S.3
  • 35
    • 77951652880 scopus 로고    scopus 로고
    • EMEA (accessed March 25, 2009).
    • EMEA. Scientific discussion of ziconotide (2005). http://www.emea.europa.eu/humandocs/PDFs/EPAR/Prialt/14122704en6.pdf (accessed March 25, 2009).
    • (2005) Scientific discussion of ziconotide
  • 36
    • 61349140138 scopus 로고    scopus 로고
    • Long-term intrathecal ziconotide for chronic pain: an open-label study
    • Webster L.R., Fisher R., Charapata S., and Wallace M.S. Long-term intrathecal ziconotide for chronic pain: an open-label study. J Pain Symptom Manage 37 (2009) 363-372
    • (2009) J Pain Symptom Manage , vol.37 , pp. 363-372
    • Webster, L.R.1    Fisher, R.2    Charapata, S.3    Wallace, M.S.4
  • 37
    • 38549174565 scopus 로고    scopus 로고
    • Intrathecal ziconotide for severe chronic pain: safety and tolerability results of an open-label, long-term trial
    • for the Ziconotide 98-022 Study Group
    • Wallace M.S., Rauck R., Fisher R., Charapata S.G., Ellis D., Dissanayake S., and for the Ziconotide 98-022 Study Group. Intrathecal ziconotide for severe chronic pain: safety and tolerability results of an open-label, long-term trial. Anesth Analg 106 (2008) 628-637
    • (2008) Anesth Analg , vol.106 , pp. 628-637
    • Wallace, M.S.1    Rauck, R.2    Fisher, R.3    Charapata, S.G.4    Ellis, D.5    Dissanayake, S.6
  • 38
    • 41549099649 scopus 로고    scopus 로고
    • Open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain
    • Webster L.R., Fakata K.L., Charapata S., Fisher R., and MineHart M. Open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain. Pain Med 9 (2008) 282-290
    • (2008) Pain Med , vol.9 , pp. 282-290
    • Webster, L.R.1    Fakata, K.L.2    Charapata, S.3    Fisher, R.4    MineHart, M.5
  • 39
    • 77951652748 scopus 로고    scopus 로고
    • Ziconotide: a viewpoint by Tony L Yaksh
    • Yaksh T.L. Ziconotide: a viewpoint by Tony L Yaksh. CNS Drugs 20 (2006) 340-341
    • (2006) CNS Drugs , vol.20 , pp. 340-341
    • Yaksh, T.L.1
  • 40
    • 0034013024 scopus 로고    scopus 로고
    • Bioavailability of Ziconotide in brain: influx from blood, stability, and diffusion
    • Newcomb R., Abbruscato T.J., Singh T., Nadasdi L., Davis T.P., and Miljanich G. Bioavailability of Ziconotide in brain: influx from blood, stability, and diffusion. Peptides 21 (2000) 491-501
    • (2000) Peptides , vol.21 , pp. 491-501
    • Newcomb, R.1    Abbruscato, T.J.2    Singh, T.3    Nadasdi, L.4    Davis, T.P.5    Miljanich, G.6
  • 41
    • 23244431760 scopus 로고    scopus 로고
    • Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic pain
    • Wermeling D.P. Ziconotide, an intrathecally administered N-type calcium channel antagonist for the treatment of chronic pain. Pharmacotherapy 25 (2005) 1084-1094
    • (2005) Pharmacotherapy , vol.25 , pp. 1084-1094
    • Wermeling, D.P.1
  • 42
    • 33646582948 scopus 로고    scopus 로고
    • Treatment challenges and complications with ziconotide monotherapy in established pump patients
    • Thompson J.C., Dunbar E., and Laye R.R. Treatment challenges and complications with ziconotide monotherapy in established pump patients. Pain Physician 9 (2006) 147-152
    • (2006) Pain Physician , vol.9 , pp. 147-152
    • Thompson, J.C.1    Dunbar, E.2    Laye, R.R.3
  • 43
    • 33749645832 scopus 로고    scopus 로고
    • Ziconotide-a novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain-a short review
    • Klotz U. Ziconotide-a novel neuron-specific calcium channel blocker for the intrathecal treatment of severe chronic pain-a short review. Int J Clin Pharmacol Ther 44 (2006) 478-483
    • (2006) Int J Clin Pharmacol Ther , vol.44 , pp. 478-483
    • Klotz, U.1
  • 45
    • 41549159805 scopus 로고    scopus 로고
    • Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain
    • Wallace M.S., Kosek P.S., Staats P., Fisher R., Schultz D.M., and Leong M. Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain. Pain Med 9 (2008) 271-281
    • (2008) Pain Med , vol.9 , pp. 271-281
    • Wallace, M.S.1    Kosek, P.S.2    Staats, P.3    Fisher, R.4    Schultz, D.M.5    Leong, M.6
  • 46
    • 0033972437 scopus 로고    scopus 로고
    • Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats
    • Wang Y.X., Gao D., Pettus M., Phillips C., and Bowersox S.S. Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. Pain 84 (2000) 271-281
    • (2000) Pain , vol.84 , pp. 271-281
    • Wang, Y.X.1    Gao, D.2    Pettus, M.3    Phillips, C.4    Bowersox, S.S.5
  • 47
    • 0037566977 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intrathecal ziconotide in chronic pain patients
    • Wermeling D., Drass M., Ellis D., et al. Pharmacokinetics and pharmacodynamics of intrathecal ziconotide in chronic pain patients. J Clin Pharmacol 43 (2003) 624-636
    • (2003) J Clin Pharmacol , vol.43 , pp. 624-636
    • Wermeling, D.1    Drass, M.2    Ellis, D.3
  • 48
    • 33746985015 scopus 로고    scopus 로고
    • Intrathecal ziconotide for refractory chronic pain
    • Lynch S.S., Cheng C.M., and Yee J.L. Intrathecal ziconotide for refractory chronic pain. Ann Pharmacother 40 (2006) 1293-1300
    • (2006) Ann Pharmacother , vol.40 , pp. 1293-1300
    • Lynch, S.S.1    Cheng, C.M.2    Yee, J.L.3
  • 50
    • 67650649427 scopus 로고    scopus 로고
    • Intrathecal ziconotide for complex regional pain syndrome: seven case reports
    • Kapural L., Lokey K., Leong M.S., et al. Intrathecal ziconotide for complex regional pain syndrome: seven case reports. Pain Pract 9 (2009) 296-303
    • (2009) Pain Pract , vol.9 , pp. 296-303
    • Kapural, L.1    Lokey, K.2    Leong, M.S.3
  • 51
    • 33845224664 scopus 로고    scopus 로고
    • An effective treatment of severe complex regional pain syndrome type 1 in a child using high doses of intrathecal ziconotide
    • Stanton-Hicks M., and Kapural L. An effective treatment of severe complex regional pain syndrome type 1 in a child using high doses of intrathecal ziconotide. J Pain Symptom Manage 32 (2006) 509-511
    • (2006) J Pain Symptom Manage , vol.32 , pp. 509-511
    • Stanton-Hicks, M.1    Kapural, L.2
  • 52
    • 77949433165 scopus 로고    scopus 로고
    • Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain
    • Smith H.S., and Deer T.R. Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain. Ther Clin Risk Manag 5 (2009) 521-534
    • (2009) Ther Clin Risk Manag , vol.5 , pp. 521-534
    • Smith, H.S.1    Deer, T.R.2
  • 53
    • 0031441105 scopus 로고    scopus 로고
    • Sympatholysis after neuron-specific, N-type, voltage-sensitive calcium channel blockade: first demonstration of N-channel function in humans
    • McGuire D., Bowersox S., Fellmann J.D., and Luther R.R. Sympatholysis after neuron-specific, N-type, voltage-sensitive calcium channel blockade: first demonstration of N-channel function in humans. J Cardiovasc Pharmacol 30 (1997) 400-403
    • (1997) J Cardiovasc Pharmacol , vol.30 , pp. 400-403
    • McGuire, D.1    Bowersox, S.2    Fellmann, J.D.3    Luther, R.R.4
  • 54
    • 4344661569 scopus 로고    scopus 로고
    • 2+ channels to treat pain: T-type versus N-type
    • 2+ channels to treat pain: T-type versus N-type. Trends Pharmacol Sci 25 (2004) 465-470
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 465-470
    • Altier, C.1    Zamponi, G.W.2
  • 55
    • 0347224274 scopus 로고    scopus 로고
    • Cell-specific alternative splicing increases calcium channel current density in the pain pathway
    • Bell T.J., Thaler C., Castiglioni A.J., Helton T.D., and Lipscombe D. Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron 41 (2004) 127-138
    • (2004) Neuron , vol.41 , pp. 127-138
    • Bell, T.J.1    Thaler, C.2    Castiglioni, A.J.3    Helton, T.D.4    Lipscombe, D.5
  • 56
    • 0037490146 scopus 로고    scopus 로고
    • Determinants of inhibition of transiently expressed voltage-gated calcium channels by omega-conotoxins GVIA and MVIIA
    • Feng Z.P., Doering C.J., Winkfein R.J., Beedle A.M., Spafford J.D., and Zamponi G.W. Determinants of inhibition of transiently expressed voltage-gated calcium channels by omega-conotoxins GVIA and MVIIA. J Biol Chem 278 (2003) 20171-20178
    • (2003) J Biol Chem , vol.278 , pp. 20171-20178
    • Feng, Z.P.1    Doering, C.J.2    Winkfein, R.J.3    Beedle, A.M.4    Spafford, J.D.5    Zamponi, G.W.6
  • 57
    • 66449104102 scopus 로고    scopus 로고
    • Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke
    • Yamamoto T., and Takahara A. Recent updates of N-type calcium channel blockers with therapeutic potential for neuropathic pain and stroke. Curr Top Med Chem 9 (2009) 377-395
    • (2009) Curr Top Med Chem , vol.9 , pp. 377-395
    • Yamamoto, T.1    Takahara, A.2
  • 58
    • 0033533868 scopus 로고    scopus 로고
    • Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties
    • Hu L.Y., Ryder T.R., Rafferty M.F., et al. Synthesis of a series of 4-benzyloxyaniline analogues as neuronal N-type calcium channel blockers with improved anticonvulsant and analgesic properties. J Med Chem 42 (1999) 4239-4249
    • (1999) J Med Chem , vol.42 , pp. 4239-4249
    • Hu, L.Y.1    Ryder, T.R.2    Rafferty, M.F.3
  • 59
    • 17944377489 scopus 로고    scopus 로고
    • Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers
    • Seko T., Kato M., Kohno H., et al. Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers. Bioorg Med Chem Lett 11 (2001) 2067-2070
    • (2001) Bioorg Med Chem Lett , vol.11 , pp. 2067-2070
    • Seko, T.1    Kato, M.2    Kohno, H.3
  • 60
    • 18544381669 scopus 로고    scopus 로고
    • L-Cysteine based N-type calcium channel blockers: structure-activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models
    • Seko T., Kato M., Kohno H., et al. L-Cysteine based N-type calcium channel blockers: structure-activity relationships of the C-terminal lipophilic moiety, and oral analgesic efficacy in rat pain models. Bioorg Med Chem Lett 12 (2002) 2267-2269
    • (2002) Bioorg Med Chem Lett , vol.12 , pp. 2267-2269
    • Seko, T.1    Kato, M.2    Kohno, H.3
  • 61
    • 33745138593 scopus 로고    scopus 로고
    • Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity
    • Yamamoto T., Niwa S., Iwayama S., et al. Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity. Bioorg Med Chem 14 (2006) 5333-5339
    • (2006) Bioorg Med Chem , vol.14 , pp. 5333-5339
    • Yamamoto, T.1    Niwa, S.2    Iwayama, S.3
  • 62
    • 30344488749 scopus 로고    scopus 로고
    • Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels
    • Yamamoto T., Niwa S., Ohno S., et al. Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels. Bioorg Med Chem Lett 16 (2006) 798-802
    • (2006) Bioorg Med Chem Lett , vol.16 , pp. 798-802
    • Yamamoto, T.1    Niwa, S.2    Ohno, S.3
  • 63
    • 43549116793 scopus 로고    scopus 로고
    • Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence
    • Meng G., Wu N., Zhang C., et al. Analgesic activity of ZC88, a novel N-type voltage-dependent calcium channel blocker, and its modulation of morphine analgesia, tolerance and dependence. Eur J Pharmacol 586 (2008) 130-138
    • (2008) Eur J Pharmacol , vol.586 , pp. 130-138
    • Meng, G.1    Wu, N.2    Zhang, C.3
  • 64
    • 70349975877 scopus 로고    scopus 로고
    • Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker
    • Koganei H., Shoji M., and Iwata S. Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker. Biol Pharm Bull 32 (2009) 1695-1700
    • (2009) Biol Pharm Bull , vol.32 , pp. 1695-1700
    • Koganei, H.1    Shoji, M.2    Iwata, S.3
  • 65
    • 71049127913 scopus 로고    scopus 로고
    • Scaffold-based design and synthesis of potent N-type calcium channel blockers
    • Zamponi G.W., Feng Z.P., Zhang L., et al. Scaffold-based design and synthesis of potent N-type calcium channel blockers. Bioorg Med Chem Lett 19 (2009) 6467-6472
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 6467-6472
    • Zamponi, G.W.1    Feng, Z.P.2    Zhang, L.3


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