Response of postmitotic neurons to x-irradiation: Implications for the role of DNA damage in neuronal apoptosis

Journal of Neuroscience

Volumn 18, Issue 1, 1998, Pages 147-155

  Gobbel, Glenn T ^a   Bellinzona, Mattia ^a   Vogt, Axel R ^b   Gupta, Nalin ^b   Fike, John R ^b   Chan, Pak H ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

ADP ribosylation; Apoptosis; Astrocyte; Benzamide; DNA damage; Neuron; Rat; X irradiation

Indexed keywords

BENZAMIDE; CYCLOHEXIMIDE; DNA;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; APOPTOSIS; ARTICLE; ASTROCYTE; CELL CYCLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FETUS; NERVE CELL NECROSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RAT; X RAY;

EID: 0031975026     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-01-00147.1998     Document Type: Article

References (7)

1. Banasik M, Komura H, Shimoyama M, Ueda K (1992) Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl) transferase. J Biol Chem 267:1569-1575.
2. Bellinzona M, Gobbel GT, Shinohara C, Fike JR (1996) Apoptosis is induced in the subependyma of young adult rats by ionizing radiation. Neurosci Lett 208:163-166.
3. Bowling AC, Schulz JB, Brown Jr RH, Beal MF (1993) Superoxide dismutase activity, oxidative damage, and mitochondrial energy metabolism in familial and sporadic amyotrophic lateral sclerosis. J Neurochem 61:2322-2325.
4. Buettner GR (1993) The pecking order of free radicals and antioxidants: lipid peroxidation, alpha-tocopherol, and ascorbate. Arch Biochem Biophys 300:535-543.
5. Bump E, Brown J (1990) Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacol Ther 47:117-136.
6. Carrano AV (1979) Chromosome aberrations and radiation-induced cell death. II. Predicted and observed cell survival. Mutat Res 17:355-366.
7. Chan PH (1996) Role of oxidants in ischemic brain damage. Stroke 27:1124-1129.