Semaphorins and their receptors in vertebrates and invertebrates

Current Opinion in Neurobiology

Volumn 10, Issue 1, 2000, Pages 88-94

  Raper, Jonathan A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPILIN; PLEXIN; RECEPTOR; SEMAPHORIN; UNCLASSIFIED DRUG;

IMMUNE SYSTEM; INVERTEBRATE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; VERTEBRATE;

EID: 0033956733     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(99)00057-4     Document Type: Review

References (44)

1. Unified nomenclature for the semaphorins/collapsins. Cell. 97:1998;551-552.
2. Klostermann A., Lohrum M., Adams R.H., Puschel A.W. The chemorepulsive activity of the axonal guidance signal semaphorin D requires dimerization. J Biol Chem. 273:1998;7326-7331.
3. Koppel A.M., Raper J.A. Collapsin-1 covalently dimerizes, and dimerization is necessary for collapsing activity. J Biol Chem. 273:1998;15708-15713.
4. Koppel A.M., Feiner L., Kobayashi H., Raper J.A. A 70 amino acid region within the semaphorin domain activates specific cellular response of semaphorin family members. Neuron. 19:1997;531-537.
5. He Z., Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell. 90:1997;739-751.
6. Kolodkin A.L., Levengood D.V., Rowe E.G., Tai Y.T., Giger R.J., Ginty D.D. Neuropilin is a semaphorin III receptor. Cell. 90:1997;753-762.
7. Takagi S., Hirata T., Agata K., Mochii M., Eguchi G., Fujisawa H. The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors. Neuron. 7:1991;295-307.
8. Nakamura F., Tanaka M., Takahashi T., Kalb R.G., Strittmatter S.M. Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Neuron. 21:1998;1093-1100.
9. Renzi M.J., Feiner L., Koppel A.M., Raper J.A. A dominant negative receptor for specific secreted semaphorins is generated by deleting an extracellular domain from neuropilin-1. J Neurosci. 19:1999;7870-7880.
10. Kitsukawa T., Shimizu M., Sanbo M., Hirata T., Taniguchi M., Bekku Y., Yagi T., Fujisawa H. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron. 19:1997;995-1005.
11. Feiner L., Koppel A.M., Kobayashi H., Raper J.A. Secreted chick semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ. Neuron. 19:1997;539-545.
12. Chen H., Chedotal A., He Z., Goodman C.S., Tessier-Lavigne M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron. 19:1997;547-559.
13. Chen H., He Z., Bagri A., Tessier-Lavigne M. Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins. Neuron. 21:1998;1283-1290. The authors use immunoprecipitation, binding, and antibody perturbation studies to make a strong case that selective responses to class III secreted semaphorins are at least partially determined by the expression of various combinations of neuropilins-1 and -2.
14. Takahashi T., Fournier A., Nakamura F., Wang L.H., Murakami Y., Kalb R.G., Fujisawa H., Strittmatter S.M. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell. 99:1999;59-69. Plexin 1 is shown to form a complex with neuropilin-1 to form an active SEMA-3A receptor. Of particular interest is the development of a COS cell-based assay in which the reconstitution of receptor complexes allows SEMA-3A to induce shape-changes reminiscent of growth cone collapse.
15. Comeau M.R., Johnson R., DuBose R.F., Petersen M., Gearing P., VandenBos T., Park L., Farrah T., Buller R.M., Cohen J.I.et al. A poxvirus-encoded semaphorin induces cytokine production from monocytes and binds to a novel cellular semaphorin receptor, VESPR. Immunity. 8:1998;473-482.
16. Tamagnone L., Artigiani S., Chen H., He Z., Ming G.I., Song H., Chedotal A., Winberg M.L., Goodman C.S., Poo M.et al. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Cell. 99:1999;71-80.
17. Ohta K., Takagi S., Asou H., Fujisawa H. Involvement of neuronal cell surface molecule B2 in the formation of retinal plexiform layers. Neuron. 9:1992;151-161.
18. Winberg M.L., Noordermeer J.N., Tamagnone L., Comoglio P.M., Spriggs M.K., Tessier-Lavigne M., Goodman C.S. Plexin A is a neuronal semaphorin receptor that controls axon guidance. Cell. 95:1998;903-916. This study was the first demonstration that a plexin can be a neuronal semaphorin receptor. The ability of plexin A to bind Sema 1a and 1b, the ability of plexin A mutants to phenocopy Sema 1a guidance defects, and the genetic interactions between plexin A, Sema 1a and 1b mutations all indicate that plexin A is a receptor for these two transmembrane semaphorins.
19. Kolodkin A.L., Matthes D.J., O'Connor T.P., Patel N.H., Admon A., Bentley D., Goodman C.S. Fasciclin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo. Neuron. 9:1992;831-845.
20. Wong J.T., Yu W.T., O'Connor T.P. Transmembrane grasshopper Semaphorin I promotes axon outgrowth in vivo. Development. 124:1997;3597-3607.
21. Isbister C.M., Tsai A., Wong S.T., Kolodkin A.L., O'Connor T.P. Discrete roles for secreted and transmembrane semaphorins in neuronal growth cone guidance in vivo. Development. 126:1999;2007-2019. The authors report the identification of secreted grasshopper semaphorin, Sema 2a, that is expressed in a gradient in the developing limb bud. Its concentration is highest at the distal tip and lowest at the proximal base of the limb. Antibodies to Sema 2a increase the probability of proximal-growing Ti pioneer axons to extend distally in organ culture. The simultaneous application of antibodies against Sema I and Sema 2a induce larger deviations in Ti axon trajectories than either antibody alone.
22. Yu H.H., Araj H.H., Ralls S.A., Kolodkin A.L. The transmembrane Semaphorin Sema I is required in Drosophila for embryonic motor and CNS axon guidance. Neuron. 20:1998;207-220. Sema 1a is shown through the analysis of null mutants, ectopic expression, and rescue experiments to be required for the guidance of specific motor axons through particular choice points in the drosophila embryo.
23. Luo Y., Raible D., Raper J.A. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell. 75:1993;217-227.
24. Adams R.H., Lohrum M., Klostermann A., Betz H., Puschel A.W. The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing. EMBO J. 16:1997;6077-6086.
25. Shepherd I., Luo Y., Raper J.A., Chang S. The distribution of collapsin-1 mRNA in the developing chick nervous system. Dev Biol. 173:1996;185-199.
26. Varela-Echavarria A., Tucker A., Puschel A.W., Guthrie S. Motor axon subpopulations respond differentially to the chemorepellents netrin-1 and semaphorin D. Neuron. 18:1997;193-207.
27. Kobayashi H., Koppel A.M., Luo Y., Raper J.A. A role for collapsin-1 in olfactory and cranial sensory axon guidance. J Neurosci. 17:1997;8339-8352.
28. Rabacchi S.A., Solowska J.M., Kruk B., Luo Y., Raper J.A., Baird D.H. Collapsin-1/semaphorin-III/D is regulated developmentally in Purkinje cells and collapses pontocerebellar mossy fiber neuronal growth cones. J Neurosci. 19:1999;4437-4448.
29. Bagnard D., Lohrum M., Uziel D., Puschel A.W., Bolz J. Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections. Development. 125:1998;5043-5053.
30. Chedoytal A., Del Rio J.A., Ruiz M., He Z., Borrell V., de Castro F., Ezan F., Goodman C.S., Tessier-Lavigne M., Sotelo C., Soriano E. Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development. 125:1998;4313-4323.
31. Steup A., Ninnemann O., Savaskan N.E., Nitsch R., Puschel A.W., Skutella T. Semaphorin D acts as a repulsive factor for entorhinal and hippocampal neurons. Eur J Neurosci. 1:1999;729-734.
32. de Castro F., Hu L., Drabkin H., Sotelo C., Chedotal A. Chemoattraction and chemorepulsion of olfactory bulb axons by different secreted semaphorins. J Neurosci. 19:1999;4428-4436.
33. Song H., Ming G., He Z., Lehmann M., McKerracher L., Tessier-Lavigne M., Poo M. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science. 281:1998;1515-1518. The authors show that by elevating cGMP levels in cultured Xenopus spinal neurons, SEMA-3A is converted from a repellent to an attractant. Neuropilin-1 is required for both the normal repellent and the abnormal attractant activities of SEMA-3A.
34. Tanelian D.L., Barry M.A., Johnston S.A., Le T., Smith G.M. Semaphorin III can repulse and inhibit adult sensory afferents in vivo. Nat Med. 3:1997;1398-1401.
35. Shoji W., Yee C.S., Kuwada J.Y. Zebrafish semaphorin Z1a collapsen specific growth cones and alters their pathway in vivo. Development. 125:1998;1275-1283.
36. Behar O., Golden J.A., Mashimo H., Schoen F.J., Fishman M.C. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature. 383:1996;525-528.
37. Messersmith E.K., Leonardo E.D., Shatz C.J., Tessier-Lavigne M., Goodman C.S., Kolodkin A.L. Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron. 14:1995;949-959.
38. Shepherd I.T., Luo Y., Lefcort F., Reichardt L.F., Raper J.A. A sensory axon repellent secreted from ventral spinal cord explants is neutralized by antibodies raised against collapsin-1. Development. 124:1997;1377-1385.
39. Taniguchi M., Yuasa S., Fujisawa H., Naruse I., Saga S., Mishina M., Yagi T. Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron. 19:1997;519-530.
40. Polleux F., Giger R.J., Ginty D.D., Kolodkin A.L., Ghosh A. Patterning of cortical efferent projections by semaphorin-neuropilin interactions. Science. 282:1998;1904-1906. This cultured-slice study suggests that SEMA-3A production in the superficial marginal zone of the cortex helps to orient extending cortical axons by repelling them towards the ventricular margin.
41. Catalano S.M., Messersmith E.K., Goodman C.S., Shatz C.J., Chedotal A. Many major CNS axon projections develop normally in the absence of semaphorin III. Mol Cell Neurosci. 11:1998;173-182. Surprisingly, nearly all axonal projections examined in SEMA-3A knockout mice appeared to be normal. These included cerebellar climbing and mossy fibers, thalamocortical projections, and the roots of cranial nerves.
42. Ulupinar E., Datwani A., Behar O., Fujisawa H., Erzurumlu R. Role of semaphorin III in the developing rodent trigeminal system. Mol Cell Neurosci. 13:1999;281-292.
43. Eickholt B.J., Mackenzie S.L., Graham A., Walsh F.S., Doherty P. Evidence for collapsin-1 functioning in the control of neural crest migration in both trunk and hindbrain regions. Development. 126:1999;2181-2189.
44. Soker S., Takashima S., Miao H.Q., Neufeld G., Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell. 92:1998;735-745.