Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content. Vascular endothelial growth factor decreases occludin in retinal endothelial cells

Diabetes

Volumn 47, Issue 12, 1998, Pages 1953-1959

  Antonetti, David A ^a   Barber, Alistair J ^a   Khin, Sonny ^a   Lieth, Erich ^a   Tarbell, John M ^b   Gardner, Thomas W ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b The Pennsylvania State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; GLUCOSE TRANSPORTER; OCCLUDIN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD RETINA BARRIER; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM; FLUORESCENCE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA; STREPTOZOCIN DIABETES;

EID: 0031737671     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.12.1953     Document Type: Article

References (44)

1. Cunha-Vaz JG, Faria de Abreu JR, Campos AJ, Figo GM: Early breakdown of the blood-retinal barrier in diabetes. Br J Ophthalmol 59:649-656, 1975
2. Enea NA, Hollis TM, Kern JA, Gardner TW: Histamine H1 receptors mediate increased blood-retinal barrier permeability in experimental diabetes. Arch Ophthalmol 107:270-274, 1989
3. Klein R, Klein BEK, Moss SE, Cruscishanks KJ: The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XV. The long-term incidence of macular edema. Ophthalmology 102:7-16, 1995
4. Ishibashi T, Tanaka K, Taniguchi Y: Disruption of the blood-retinal barrier in experimental diabetic rats: an electron microscopic study, Exp Eye Res 30:401-410, 1980
5. Wallow IHL, Enerman RL: Permeability and patency of retinal blood vessels in experimental diabetes. Invest Ophthalmol Vis Sci 16:447-461, 1977
6. Vinores SA, McGehee R, Lee A, Gadegbeku C, Campochiaro PA: Ultrastructural localization of blood-retinal barrier breakdown in diabetic and galactosemic rats. J Histochem Cytochem 38:1341-1352, 1990
7. Grimes PA, Laties AM: Early morphological alteration of the pigment epithelium in streptozotocin-induced diabetes: increased surface area of the basal cell membrane. Exp Eye Res 30:631-639, 1980
8. Wallow IHL: Posterior and anterior permeability defects? Morphologic observations on streptozotocin-treated rats. Invest Ophthalmol Vis Sci 24:1259-1268, 1983
9. Blair NP, Tso MOM, Dodge JT: Pathologic studies of the blood-retinal barrier in the spontaneously diabetic BB rat. Invest Ophthalmol Vis Sci 25:302-311, 1984
10. Sagaties MJ, Raviola G, Schaeffer S, Miller C: The structural basis of the inner blood-retinal barrier in the eye of Macaca mulatta. Invest Ophthalmol Vis Sci 28:2000-2014, 1987
11. Engler CB, Sander B, Larsen M, Koefoed P, Parving HH, Lund-Andersen H: Probenecid inhibition of the outward transport of fluorescein across the human blood-retinal barrier. Acta Ophthalmologica 72:663-667, 1994
12. Anderson JM, Van Itallie CM: Tight junctions and the molecular basis for regulation of paracellular permeability. Am J Physiol 269:G467-G476, 1995
13. Furuse M, Hirase T, Ith M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S: Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 123:1777-1788, 1993
14. Watson PM, Anderson JM, Van Itallie CM, Doctrow SR: The tight-junction-specific protein ZO-1 is a component of the human and rat blood-brain barriers. Neurosci Lett 129:6-10, 1991
15. Hirase T, Staddon JM, Saitou M, Anod-Akatsuka Y, Itoh M, Furuse M, Fujimoto K, Tsukita S, Rubin LL: Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci 110:1603-1613, 1997
16. Gardner TW, Lieth W, Khin SA, Barber AJ, Bonsall DJ, Lesher T, Rice K, Brennan WA: Astrocytes increase barrier function and Zo-1 protein expression in cultured retinal capillary endothelial cells. Invest Ophthalmol Vis Sci 38:2423-2427, 1997
17. Gardner TW, Lesher T, Khin S, Vu C, Barber AJ, Brennan WA: Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells. Biochem J 320:717-721, 1996
18. Murata T, Nakagawa K, Khalil A, Ishibashi T, Inomata H, Sueishi K: The relation between expression of vascular endothelial growth factor and breakdown of the blood-retinal barrier in diabetic rat retinas. Lab Invest 74:819-825, 1996
19. Lutty GA, McLeod DS, Merges C, Diggs A, Plouèt J: Localization of vascular endothelial growth factor in human retina and choroid. Arch Ophthalmol 114:971-977, 1996
20. Amin RH, Frank RN, Kennedy A, Eliott D, Puklin JE, Abrams GW: Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 38:36-47, 1997
21. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, Nguyen HV, Aiello LM, Ferrara N, King GL: Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 331:1480-1487, 1994
22. Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LEH, King GL: Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective β-isoform-selective inhibitor. Diabetes 46:1473-1480, 1997
23. Carroll W, Hollis T, Gardner T: Retinal histamine synthesis is increased in experimental diabetes. Invest Ophthalmol Vis Sci 29:1201-1204, 1988
24. Khin S, Gardner TW, Barber A, Lieth E, McRill C, Antonetti DA: Histidine decarboxylase mRNA is increased in diabetic rat retina (Abstract). Diabetes 46 (Suppl. 1):128A, 1997
25. Barber AJ, Lieth E: Agrin accumulates in the brain microvascular basal lamina during development of the blood-brain barrier. Dev Dynamics 208:62-74, 1997
26. Poulsom R, Prockop DJ, Boot-Handfor RP: Effects of long-term diabetes and galactosaemia upon lens and retinal mRNA levels in the rat. Exp Eye Res 51:27-32, 1990
27. Engler C, Krosgaa B, Lund-Anderson H: Blood-retinal barrier permeability and its relation to the progression of diabetic retinopathy in type 1 diabetics: an 8-year follow-up study. Graefe's Arch Clin Exp Ophthalmol 229:442-446, 1991
28. Rotrosen D, Gallin JI: Histamine type I receptor occupancy increases endothelial cytosolic calcium, reduces F-actin, and promotes albumin diffusion across cultured endothelial monolayers. J Cell Biol 103:2379-2387, 1986
29. Bottaro D, Shepro D, Peterson S, Hechtman HB: Serotonin, epinephrine, and histamine mediate endothelial barrier function in vitro. J Cell Physiol 128:189-194, 1987
30. Williamson JR, Chang K, Tilton RG, Prater C, Jeffrey JR, Weigel C, Sherman WR, Eades DM, Kilo C: Increased vascular permeability in spontaneously diabetic BB/W rats and in rats with mild versus severe streptozocin-induced diabetes prevention by aldose reductase inhibitors and castration. Diabetes 36:813-821, 1987
31. Balda MS, Whitney JA, Flores S, Gonzalez M, Cereijido M, Matter K: Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol 134:1031-1049, 1996
32. McCarthy KM, Skare I, Stankewich MC, Furuse M, Tsukita S, Rogers RA, Lynch RD, Schneeberger E: Occludin is a functional component of the tight junction. J Cell Sci 109:2287-2298, 1996
33. Van Itallie CM, Anderson JM: Occludin confers adhesiveness when expressed fibroblasts. J Cell Sci 110:1113-1121, 1997
34. Chen Y, Merzdorf C, Paul DL, Goodenough DA: COOH terminus of occludin is required for tight junction barrier function in early Xenopus embryos. J Cell Biol 138:891-899, 1997
35. Wong V, Gunibiner BM: A synthetic peptide corresponding to the extracellular domain of occluding perturbs the tight junction permeability barrier. J Cell Biol 136:399-409, 1997
36. Furuse M: Occludin: toward a structure-function analysis of tight junctions. Endothelium, Keystone Meeting, Incline Village, Nevada, 1998
37. Gardner TW: Histamine, ZO-1, and blood-retinal barrier permeability in diabetic retinopathy. Trans Am Ophthalmol Soc 93:583-621, 1995
38. Mullin JM, Marano CW, Laughlin KV, Nuciglio M, Stevenson BR, Peralta Soler A: Different size limitations for increased transepithelial paracellular solute flux across phorbol ester and tumor necrosis factor-treated epithelial cell sheets. J Cell Physiol 171:226-233, 1997
39. Stauber W, Ong S, McCuskey R: Selective extravascular escape of albumin into the cerebral cortex of the diabetic rat. Diabetes 30:500-503, 1981
40. Mogensen DE, Christensen CK, Viitinghus E: The stages in diabetic renal disease with emphasis on the stage of incipient diabetic nephropathy. Diabetes 32:64-78, 1983
41. Weinbaum S, Tzeghai G, Ganatos P, Pfeffer R, Chien S: Effect of cell turnover and leaky junctions on arterial macromolecular transport. Am J Physiol 248:H945-H960, 1985
42. Yaccino J, Chang Y, Hollis T, Gardner T, Tarbell J: Physiologic transport properties of cultured retinal microvascular endothelial cell monolayers. Curr Eye Res 16:761-768, 1997
43. Luna JD, Chart CC, Derevjanik NL, Mahlow J, Chiu C, Peng B, Tobe T, Campchiaro PA, Vinores SA: Blood retinal barrier (BRB) breakdown in experimental autoimmune uveoretinitis: comparison with VEGF-, TNF-, and IL1B-mediated breakdown. J Neurosci Res 49:268-280, 1997
44. Satoh H, Zhong Y, Isomura H, Saitoh M, Enomoto K, Sawada N, Mori M: Localization of 7H6 tight junction-associated antigen along the cell border of vascular endothelial cells correlates with paracellular barrier function against ions, large molecules, and cancer cells. Exp Cell Res 222:269-274, 1996