The aging brain: Accumulation of DNA damage or neuron loss?

Neurobiology of Aging

Volumn 28, Issue 1, 2007, Pages 91-98

  Rutten, Bart P F ^a,b   Schmitz, Christoph ^a,b   Gerlach, Oliver H H ^a   Oyen, Hans M ^a   de Mesquita, Emmily Bueno ^a   Steinbusch, Harry W M ^a,b   Korr, Hubert ^a,b,c  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b European Graduate School of Neuroscience Maastricht   (Netherlands)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Aging; Cell loss; Cell type specificity; Cerebellum; Hippocampus; In situ nick translation; Nuclear DNA damage; Selective neurovulnerability; Stereology

Indexed keywords

DNA; SINGLE STRANDED DNA;

AGED; ANIMAL CELL; ARTICLE; CELL AGING; CELL COUNT; CELL LOSS; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; GRANULE CELL; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; PYRAMIDAL NERVE CELL;

AGING; ANIMALS; BRAIN; CELL NUCLEUS; DNA DAMAGE; MALE; MICE; NEURONS;

EID: 33751214500     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2005.10.019     Document Type: Article

References (47)

1. Abrous D.N., Koehl M., and Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiol Rev 85 (2005) 523-569
2. Armon C. Acquired nucleic acid changes may trigger sporadic amyotrophic lateral sclerosis. Muscle Nerve 32 (2005) 373-377
3. Bohr V.A. Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radic Biol Med 32 (2002) 804-812
4. Brazel C.Y., and Rao M.S. Aging and neuronal replacement. Ageing Res Rev 3 (2004) 465-483
5. Caldecott K.W. Mammalian DNA single-strand break repair: an X-ra(y)ted affair. Bioessays 23 (2001) 447-455
6. Caldecott K.W. XRCC1 and DNA strand break repair. DNA Repair 2 (2003) 955-969
7. Caldecott K.W. DNA single-strand breaks and neurodegeneration. DNA Repair 3 (2004) 875-882
8. Cavalieri B. Geometria indivisibilibus continuorum. Typis Clementis Ferronij, Bononiae, 1635 (reprinted 1966 as Geometria Degli Indivisibili. Unione Tipografico-Editrice Torinese, Torino).
9. Cervos-Navarro J., and Diemer N.H. Selective vulnerability in brain hypoxia. Crit Rev Neurobiol 6 (1991) 149-182
10. Cho E.A., Prindle M.J., and Dressler G.R. BRCT domain-containing protein PTIP is essential for progression through mitosis. Mol Cell Biol 23 (2003) 1666-1673
11. Cotman C.W., and Su J.H. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol 6 (1996) 493-506
12. Dam M., Bolwig T., Hertz M., Bajorec J., Lomax P., and Dam A.M. Does seizure activity produce Purkinje cell loss?. Epilepsia 25 (1984) 747-751
13. Dlugos C.A., and Pentney R.J. Morphometric analyses of Purkinje and granule cells in aging F344 rats. Neurobiol Aging 15 (1994) 435-440
14. Duffy P.H., and Feuers R.J. Biomarkers of aging: changes in circadian rhythms related to the modulation of metabolic output. Biomed Environ Sci 4 (1991) 182-191
15. El-Khamisy S.F., Saifi G.M., Weinfeld M., Johansson F., Helleday T., Lupski J.R., et al. Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1. Nature 434 (2005) 108-113
16. Gouras G.K., Almeida C.G., Takahashi R.H., and Intraneuronal. A beta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging 26 (2005) 1235-1244
17. Gower A.J., and Lamberty Y. The aged mouse as a model of cognitive decline with special emphasis on studies in NMRI mice. Behav Brain Res 57 (1993) 163-173
18. Itzhaki R.F. Possible factors in the etiology of Alzheimer's disease. Mol Neurobiol 9 (1994) 1-13
19. Keuker J.I., de Biurrun G., Luiten P.G., and Fuchs E. Preservation of hippocampal neuron numbers and hippocampal subfield volumes in behaviorally characterized aged tree shrews. J Comp Neurol 468 (2004) 509-517
20. Kirkwood T.B., and Austas S.N. Why do we age?. Nature 408 (2000) 223-238
21. Korr H., Rohde H.T., Benders J., Dafotakis M., Grolms N., and Schmitz C. Neuron loss during early adulthood following prenatal low-dose X-irradiation in the mouse brain. Int J Radiat Biol 77 (2001) 567-580
22. Kretschmann H.J., Tafesse U., and Herrmann A. Different volume changes of cerebral cortex and white matter during histological preparation. Microsc Acta 86 (1982) 13-24
23. Landles C., and Bates G.P. Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series. EMBO Rep 5 (2004) 958-963
24. Lieber M.R., and Karanjawala Z.E. Ageing, repetitive genomes and DNA damage. Nat Rev Mol Cell Biol 5 (2004) 69-75
25. Lu T., Pan Y., Kao S.Y., Li C., Kohane I., Chan J., et al. Gene regulation and DNA damage in the ageing human brain. Nature 429 (2004) 883-891
26. Maehara Y., Anai H., Kusumoto T., Sakaguchi Y., and Sugimachi K. Nick translation detection in situ of cellular DNA strand break induced by radiation. Am J Pathol 134 (1989) 7-10
27. Mandavilli B.S., and Rao K.S. Neurons in the cerebral cortex are most susceptible to DNA-damage in aging rat brain. Biochem Mol Biol Int 40 (1996) 507-514
28. Moore D.J., West A.B., Dawson V.L., and Dawson T.M. Molecular pathophysiology of Parkinson's disease. Annu Rev Neurosci 28 (2005) 57-87
29. Morrison J.H., and Hof P.R. Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease. Prog Brain Res 136 (2002) 467-486
30. Mos J., and Hollander C.F. Analysis of survival data on aging rat cohorts: pitfalls and some practical considerations. Mech Ageing Dev 38 (1987) 89-105
31. Rademakers R., Cruts M., Sleegers K., Dermaut B., Theuns J., Aulchenko Y., et al. Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a dutch population-based sample. Am J Hum Genet 77 (2005) 643-652
32. Rapp P.R., and Gallagher M. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad Sci USA 93 (1996) 9926-9930
33. Rapp P.R., Stack E.C., and Gallagher M. Morphometric studies of the aged hippocampus. I. Volumetric analysis in behaviorally characterized rats. J Comp Neurol 403 (1999) 459-470
34. Robbins J.H. Parkinson's disease, twins, and the DNA-damage hypothesis. Ann Neurol 21 (1987) 412
35. Robison S.H., and Bradley W.G. DNA damage and chronic neuronal degenerations. J Neurol Sci 64 (1984) 11-20
36. Rutten B.P., Korr H., Steinbusch H.W., and Schmitz C. The aging brain: less neurons could be better. Mech Ageing Dev 124 (2003) 349-355
37. Rutten B.P., Wirths O., Van de Berg W.D., Lichtenthaler S.F., Vehoff J., Steinbusch H.W., et al. No alterations of hippocampal neuronal number and synaptic bouton number in a transgenic mouse model expressing the beta-cleaved C-terminal APP fragment. Neurobiol Dis 12 (2003) 110-120
38. Schmitz C. Variation of fractionator estimates and its prediction. Anat Embryol 198 (1998) 371-397
39. Schmitz C., and Hof P.R. Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach. J Chem Neuroanat 20 (2000) 93-114
40. Schmitz C., and Hof P.R. Design-based stereology in neuroscience. Neuroscience 130 (2005) 813-831
41. Schmitz C., Axmacher B., Zunker U., and Korr H. Age-related changes of DNA repair and mitochondrial DNA synthesis in the mouse brain. Acta Neuropathol 97 (1999) 71-81
42. Schmitz C., Materne S., and Korr H. Cell-type-specific differences in age-related changes of dna repair in the mouse brain-molecular basis for a new approach to understand the selective neuronal vulnerability in Alzheimer's disease. J Alzheimers Dis 1 (1999) 387-407
43. Sturrock R.R. Changes in neuron number in the cerebellar cortex of the ageing mouse. J Hirnforsch 30 (1989) 499-503
44. Turlejski K., and Djavadian R. Life-long stability of neurons: a century of research on neurogenesis, neuronal death and neuron quantification in adult CNS. Prog Brain Res 136 (2002) 39-65
45. Welsh J.P., Yuen G., Placantonakis D.G., Vu T.Q., Haiss F., O'Hearn E., et al. Why do Purkinje cells die so easily after global brain ischemia? Aldolase C, EAAT4, and the cerebellar contribution to posthypoxic myoclonus. Adv Neurol 89 (2002) 331-359
46. West M.J. New stereological methods for counting neurons. Neurobiol Aging 14 (1993) 275-285
47. Zanjani H., Lemaigre-Dubreuil Y., Tillakaratne N.J., Blokhin A., McMahon R.P., Tobin A.J., et al. Cerebellar Purkinje cell loss in aging Hu-Bcl-2 transgenic mice. J Comp Neurol 475 (2004) 481-492