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Volumn 101, Issue 1, 2011, Pages 13-17

DNA double-strand break - Induced pro-survival signaling

Author keywords

AKT; ATM; DNA repair; EGFR; ERK; MAP kinase; Phosphatase; ROS

Indexed keywords

ATM PROTEIN; DOUBLE STRANDED DNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

EID: 80655149127     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.05.074     Document Type: Review
Times cited : (40)

References (41)
  • 1
    • 0141757494 scopus 로고    scopus 로고
    • Regulation and mechanisms of mammalian double-strand break repair
    • DOI 10.1038/sj.onc.1206679
    • K. Valerie, and L.F. Povirk Regulation and mechanisms of mammalian double-strand break repair Oncogene 22 2003 5792 5812 (Pubitemid 37176701)
    • (2003) Oncogene , vol.22 , Issue.REV. ISS. 3 , pp. 5792-5812
    • Valerie, K.1    Povirk, L.F.2
  • 3
    • 0024195429 scopus 로고
    • DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability
    • J.F. Ward DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability Prog Nucleic Acid Res Mol Biol 35 1988 95 125
    • (1988) Prog Nucleic Acid Res Mol Biol , vol.35 , pp. 95-125
    • Ward, J.F.1
  • 6
    • 47349107760 scopus 로고    scopus 로고
    • ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin
    • DOI 10.1016/j.molcel.2008.05.017, PII S109727650800395X
    • A.A. Goodarzi, A.T. Noon, and D. Deckbar ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin Mol Cell 31 2008 167 177 (Pubitemid 352001394)
    • (2008) Molecular Cell , vol.31 , Issue.2 , pp. 167-177
    • Goodarzi, A.A.1    Noon, A.T.2    Deckbar, D.3    Ziv, Y.4    Shiloh, Y.5    Lobrich, M.6    Jeggo, P.A.7
  • 7
    • 3242875642 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase: The director at the end
    • DOI 10.1111/j.0105-2896.2004.00162.x
    • K. Meek, S. Gupta, D.A. Ramsden, and S.P. Lees-Miller The DNA-dependent protein kinase: the director at the end Immunol Rev 200 2004 132 141 (Pubitemid 38998198)
    • (2004) Immunological Reviews , vol.200 , pp. 132-141
    • Meek, K.1    Gupta, S.2    Ramsden, D.A.3    Lees-Miller, S.P.4
  • 9
    • 33747888634 scopus 로고    scopus 로고
    • Modeling oncogenic translocations: Distinct roles for double-strand break repair pathways in translocation formation in mammalian cells
    • DOI 10.1016/j.dnarep.2006.05.028, PII S1568786406001686, Mechanisms of Chromosomal Translocations
    • D.M. Weinstock, C.A. Richardson, B. Elliott, and M. Jasin Modeling oncogenic translocations: distinct roles for double-strand break repair pathways in translocation formation in mammalian cells DNA Repair (Amst) 5 2006 1065 1074 (Pubitemid 44291619)
    • (2006) DNA Repair , vol.5 , Issue.9-10 , pp. 1065-1074
    • Weinstock, D.M.1    Richardson, C.A.2    Elliott, B.3    Jasin, M.4
  • 10
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • S. Burma, B.P. Chen, M. Murphy, A. Kurimasa, and D.J. Chen ATM phosphorylates histone H2AX in response to DNA double-strand breaks J Biol Chem 276 2001 42462 42467
    • (2001) J Biol Chem , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 11
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
    • DOI 10.1158/0008-5472.CAN-03-3207
    • T. Stiff, M. O'Driscoll, N. Rief, K. Iwabuchi, M. Lobrich, and P.A. Jeggo ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation Cancer Res 64 2004 2390 2396 (Pubitemid 38523891)
    • (2004) Cancer Research , vol.64 , Issue.7 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 12
    • 70350238489 scopus 로고    scopus 로고
    • Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
    • S.E. Golding, E. Rosenberg, and N. Valerie Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion Mol Cancer Ther 8 2009 2894 2902
    • (2009) Mol Cancer Ther , vol.8 , pp. 2894-2902
    • Golding, S.E.1    Rosenberg, E.2    Valerie, N.3
  • 13
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • DOI 10.1128/MCB.23.16.5706-5715.2003
    • K. Rothkamm, I. Kruger, L.H. Thompson, and M. Lobrich Pathways of DNA double-strand break repair during the mammalian cell cycle Mol Cell Biol 23 2003 5706 5715 (Pubitemid 36951334)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.16 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 14
    • 77956327999 scopus 로고    scopus 로고
    • Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants
    • B.R. Adams, S.E. Golding, R.R. Rao, and K. Valerie Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants PLoS One 5 2010 e10001
    • (2010) PLoS One , vol.5 , pp. 10001
    • Adams, B.R.1    Golding, S.E.2    Rao, R.R.3    Valerie, K.4
  • 16
    • 66149094649 scopus 로고    scopus 로고
    • Prosurvival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells
    • S.E. Golding, R.N. Morgan, B.R. Adams, A.J. Hawkins, L.F. Povirk, and K. Valerie Prosurvival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells Cancer Biol Ther 8 2009 730 738
    • (2009) Cancer Biol Ther , vol.8 , pp. 730-738
    • Golding, S.E.1    Morgan, R.N.2    Adams, B.R.3    Hawkins, A.J.4    Povirk, L.F.5    Valerie, K.6
  • 17
    • 33847066413 scopus 로고    scopus 로고
    • Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response
    • S.E. Golding, E. Rosenberg, S. Neill, P. Dent, L.F. Povirk, and K. Valerie Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response Cancer Res 67 2007 1046 1053
    • (2007) Cancer Res , vol.67 , pp. 1046-1053
    • Golding, S.E.1    Rosenberg, E.2    Neill, S.3    Dent, P.4    Povirk, L.F.5    Valerie, K.6
  • 20
    • 78149358861 scopus 로고    scopus 로고
    • ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway
    • M. Toulany, M. Minjgee, R. Kehlbach, J. Chen, M. Baumann, and H.P. Rodemann ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway Radiother Oncol: J Eur Soc Ther Radiol Oncol 97 2010 338 345
    • (2010) Radiother Oncol: J Eur Soc Ther Radiol Oncol , vol.97 , pp. 338-345
    • Toulany, M.1    Minjgee, M.2    Kehlbach, R.3    Chen, J.4    Baumann, M.5    Rodemann, H.P.6
  • 21
    • 36849032852 scopus 로고    scopus 로고
    • Radiation-induced EGFR-signaling and control of DNA-damage repair
    • DOI 10.1080/09553000701769970, PII 787783391
    • H.P. Rodemann, K. Dittmann, and M. Toulany Radiation-induced EGFR-signaling and control of DNA-damage repair Int J Radiat Biol 83 2007 781 791 (Pubitemid 350219102)
    • (2007) International Journal of Radiation Biology , vol.83 , Issue.11-12 , pp. 781-791
    • Rodemann, H.P.1    Dittmann, K.2    Toulany, M.3
  • 22
    • 51049105757 scopus 로고    scopus 로고
    • Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA doublestrand break repair
    • M. Toulany, R. Kehlbach, and U. Florczak Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA doublestrand break repair Mol Cancer Ther 7 2008 1772 1781
    • (2008) Mol Cancer Ther , vol.7 , pp. 1772-1781
    • Toulany, M.1    Kehlbach, R.2    Florczak, U.3
  • 23
    • 66249149058 scopus 로고    scopus 로고
    • EGFRvIII and DNA double-strand break repair: A molecular mechanism for radioresistance in glioblastoma
    • B. Mukherjee, B. McEllin, and C.V. Camacho EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma Cancer Res 69 2009 4252 4259
    • (2009) Cancer Res , vol.69 , pp. 4252-4259
    • Mukherjee, B.1    McEllin, B.2    Camacho, C.V.3
  • 24
    • 77955655466 scopus 로고    scopus 로고
    • Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation
    • F. Wei, Y. Xie, L. Tao, and D. Tang Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation Cell Signal 22 2010 1783 1789
    • (2010) Cell Signal , vol.22 , pp. 1783-1789
    • Wei, F.1    Xie, Y.2    Tao, L.3    Tang, D.4
  • 25
    • 77749233738 scopus 로고    scopus 로고
    • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
    • A. Alexander, S.L. Cai, and J. Kim ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS Proc Natl Acad Sci USA 107 2010 4153 4158
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4153-4158
    • Alexander, A.1    Cai, S.L.2    Kim, J.3
  • 29
    • 0035937841 scopus 로고    scopus 로고
    • Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia
    • N. Gueven, K.E. Keating, and P. Chen Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia J Biol Chem 276 2001 8884 8891
    • (2001) J Biol Chem , vol.276 , pp. 8884-8891
    • Gueven, N.1    Keating, K.E.2    Chen, P.3
  • 31
    • 0035811559 scopus 로고    scopus 로고
    • Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
    • DOI 10.1038/sj.onc.1204565
    • V.M. Macaulay, A.J. Salisbury, E.A. Bohula, M.P. Playford, N.I. Smorodinsky, and Y. Shiloh Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase Oncogene 20 2001 4029 4040 (Pubitemid 32681608)
    • (2001) Oncogene , vol.20 , Issue.30 , pp. 4029-4040
    • Macaulay, V.M.1    Salisbury, A.J.2    Bohula, E.A.3    Playford, M.P.4    Smorodinsky, N.I.5    Shiloh, Y.6
  • 32
    • 79851506488 scopus 로고    scopus 로고
    • ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks
    • A. Khalil, R.N. Morgan, and B.R. Adams ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks Cell Cycle 10 2011 481 491
    • (2011) Cell Cycle , vol.10 , pp. 481-491
    • Khalil, A.1    Morgan, R.N.2    Adams, B.R.3
  • 33
    • 21444434296 scopus 로고    scopus 로고
    • UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal
    • DOI 10.1074/jbc.M412867200
    • A. Charruyer, S. Grazide, C. Bezombes, S. Muller, G. Laurent, and J.P. Jaffrezou UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal J Biol Chem 280 2005 19196 19204 (Pubitemid 41379626)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.19 , pp. 19196-19204
    • Charruyer, A.1    Grazide, S.2    Bezombes, C.3    Muller, S.4    Laurent, G.5    Jaffrezou, J.-P.6
  • 34
    • 0034806972 scopus 로고    scopus 로고
    • Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress
    • DOI 10.1128/MCB.21.20.6913-6926.2001
    • M. Benhar, I. Dalyot, D. Engelberg, and A. Levitzki Enhanced ROS production in oncogenically transformed cells potentiates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and sensitization to genotoxic stress Mol Cell Biol 21 2001 6913 6926 (Pubitemid 32911252)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.20 , pp. 6913-6926
    • Benhar, M.1    Dalyot, I.2    Engelberg, D.3    Levitzki, A.4
  • 35
    • 0036184190 scopus 로고    scopus 로고
    • Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo
    • DOI 10.1016/S1097-2765(02)00445-8
    • T.C. Meng, T. Fukada, and N.K. Tonks Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo Mol Cell 9 2002 387 399 (Pubitemid 34195563)
    • (2002) Molecular Cell , vol.9 , Issue.2 , pp. 387-399
    • Meng, T.-C.1    Fukada, T.2    Tonks, N.K.3
  • 36
    • 33748743056 scopus 로고    scopus 로고
    • Oxidative inhibition of receptor-type protein-tyrosine phosphatase κ by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes
    • DOI 10.1074/jbc.M602355200
    • Y. Xu, Y. Shao, J.J. Voorhees, and G.J. Fisher Oxidative inhibition of receptor-type proteintyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes J Biol Chem 281 2006 27389 27397 (Pubitemid 44401766)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.37 , pp. 27389-27397
    • Xu, Y.1    Shao, Y.2    Voorhees, J.J.3    Fisher, G.J.4
  • 37
    • 78149464883 scopus 로고    scopus 로고
    • Serine/threonine phosphatases in the DNA damage response and cancer
    • A. Peng, and J.L. Maller Serine/threonine phosphatases in the DNA damage response and cancer Oncogene 29 2010 5977 5988
    • (2010) Oncogene , vol.29 , pp. 5977-5988
    • Peng, A.1    Maller, J.L.2
  • 38
    • 0141509963 scopus 로고    scopus 로고
    • Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence
    • DOI 10.1074/jbc.M211739200
    • H.S. Kim, M.C. Song, I.H. Kwak, T.J. Park, and I.K. Lim Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence J Biol Chem 278 2003 37497 37510 (Pubitemid 37175271)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.39 , pp. 37497-37510
    • Kim, H.S.1    Song, M.-C.2    Kwak, I.H.3    Park, T.J.4    Lim, I.K.5
  • 39
    • 0016430783 scopus 로고
    • Cell cycle redistribution as a factor in multifraction irradiation
    • H.R. Withers Cell cycle redistribution as a factor in multifraction irradiation Radiology 114 1975 199 202
    • (1975) Radiology , vol.114 , pp. 199-202
    • Withers, H.R.1


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