Glia: The fulcrum of brain diseases

Cell Death and Differentiation

Volumn 14, Issue 7, 2007, Pages 1324-1335

  Giaume, C ^a   Kirchhoff, F ^b   Matute, C ^c   Reichenbach, A ^d   Verkhratsky, A ^e,f  

^a INSERM   (France)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d UNIVERSITY OF LEIPZIG   (Germany)

^e UNIVERSITY OF MANCHESTER   (United Kingdom)

^f INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; ANTIINFLAMMATORY AGENT; BASIC FIBROBLAST GROWTH FACTOR; CILIARY NEUROTROPHIC FACTOR; CONNEXIN 26; CONNEXIN 30; CONNEXIN 32; CONNEXIN 36; CONNEXIN 37; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; CONNEXIN 46; CONNEXIN 47; EPIDERMAL GROWTH FACTOR; GLUTAMATE AMMONIA LIGASE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; GLUTATHIONE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PURINE P2X7 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VASCULOTROPIN;

ASTROCYTE; BRAIN DISEASE; BRAIN ISCHEMIA; BRAIN METABOLISM; CELL COMMUNICATION; CELL FUNCTION; CELL SURVIVAL; CEREBRAL PALSY; DISEASE COURSE; DRUG EFFICACY; DRUG TARGETING; ENCEPHALITIS; GLIA CELL; HUMAN; MENTAL DISEASE; MICROGLIA; MUELLER CELL; MULTIPLE SCLEROSIS; NERVE CELL MEMBRANE; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINOPATHY; REVIEW; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE; STROKE;

ANIMALS; BRAIN; BRAIN DISEASES; CELL DIFFERENTIATION; GAP JUNCTIONS; GLIOSIS; HUMANS; NERVE REGENERATION; NEUROGLIA; NEURONAL PLASTICITY; RECEPTORS, GLUTAMATE;

EID: 34250755404     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4402144     Document Type: Review

References (80)

1. Exner S. Entwurf zur physiologischen Erkdärung der Psychischen Erscheinungen. Leipzig/ Vienna: Deiticke, 1894.
2. Ramon y, Cajal S. Histologie du systeme nerveux de l'homme et des vertebres. Paris: Masson, 1909.
3. DeFelipe J, Alonso-Nanclares L, Arellano JI. Microstructure of the neocortex: Comparative aspects. J Neurocytol 2002; 31: 299-316.
4. Oberheim NA, Wang X, Goldman S, Nedergaard M. Astrocytic complexity distinguishes the human brain. Trends Neurosci. 2006; 29: 547-553.
5. Sherwood CC, Stimpson CD, Raghanti MA, Wildman DE, Uddin M, Grossman LI et al. Evolution of increased glia-neuron ratios in the human frontal cortex. Proc Natl Acad Sci USA 2006; 103: 13606-13611.
6. Retzius G. Biologische Untersuchungen, Vols 5, 6. Stockholm: Verlag Von, Gustav, Fischer in Jena, 1894.
7. Colombo JA, Reisin HD. Interlaminar astroglia of the cerebral cortex: A marker of the primate brain. Brain Res 2004; 1006: 126-131.
8. Haydon PG, Carmignoto G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 2006; 86: 1009-1031.
9. Verkhratsky A. Calcium ions and integration in neural circuits. Acts Physiol (Oxl) 2006; 187: 357-369.
10. Volterra A, Meldolesi J. Astrocytes, from brain glue to communication elements: The revolution continues. Nat Rev Neurosci 2005; 6 626-640.
11. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T et al. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 2003; 6: 43-50.
12. Magistretti PJ. Neuron-glia metabolic coupling and plasticity. J Exp Biol 2006; 209: 2304-2311.
13. Danbolt NC. Glutamate uptake. Prog Neurobiol 2001; 65: 1-105.
14. Kofuji P, Newman EA. Potassium buffering in the central nervous system. Neuroscience 2004; 129: 1045-1056.
15. Simard M, Nedergaard M. The neurobiology of glia in the context of water and ion homeostasis. Neurosciencè 2004; 129: 877-898.
16. Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005; 50: 427-434.
17. Matute C, Domercq M, Sanchez-Gomez MV. Glutamate-mediated glial injury: mechanisms and clinical importance. Glia 2006; 53: 212-224.
18. Kettenmann H. Triggering the brain's pathology sensor. Nat Neurosci 2006; 9: 1463-1464.
19. Nedergaard M, Dimagl U. Role of glial cells in cerebral ischemia. Glia 2005; 50: 281-286.
20. Westbrook GL. Glutamate receptors and excitotoxicity. Res Publ Assoc Res Nerv Ment Dis 1993; 71: 35-50.
21. Verkhratsky A, Kirchhoff F. NMDA receptors in glia. Neuroscientist 2007; 13: 28-37.
22. Nicotera P, Bellomo G, Orrenius S. Calcium-mediated mechanisms in chemically induced cell death. Annu Rev Pharmacol Toxicol 1992; 32: 449-470.
23. Allen NJ, Karadottir R, Attwell D. Reversal or reduction of glutamate and GABA transport in CNS pathology and therapy. Pflugers Arch 2004; 449: 132-142.
24. Contreras JE, Sanchez HA, Veliz LP, Bukauskas FF, Bennett MV, Saez JC. Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev 2004; 47: 290-303.
25. Budd SL, Lipton SA. Calcium tsunamis: Do astrocytes transmit cell death messages via gap junctions during ischemia? Nat Neurosci 1998; 1: 431-432.
26. Giaume C, McCarthy KD. Control of gap-junctional communication in astrocytic networks. Trends Neurosci 1996; 19: 319-325
27. Spray DC, Ye ZC, Ransom BR. Functional connexin 'hemichannels': A critical appraisal. Glia 2006; 54: 758-773.
28. Bruzzone R, Giaume C. Connexins and information trander through glia. Adv. Exp. Med. Biol. 1999; 468: 321-337.
29. Tabernero A, Medina JM, Giaume C. Glucose metabolism and proliferation in glia: Role of astrocylic gap junctions. J Neurochem 2006; 99 1049-1061.
30. Blomstrand F, Giaume C. Kinetics of endothelin-induced inhibition and glucose permeability of astrocyte gap junctions. J Neurosci Res 2006; 83: 996-1003.
31. Blomstrand F, Venance L, Siren AL, Ezan P, Hanse E, Glowinski J et al. Endothelins regulate astrocyte gap junctions in rat hippocampal slices. Eur J Neurosci 2004; 19: 1005-1015.
32. D'Ambrosio R, Wenzel J, Schwartzkroin PA, McKhann II GM, Janigro D. Functional specialization and topographic segregation of hippocampal astrocytes. J Neurosci 1998; 18: 4425-4438.
33. Nagy JI, Dudek FE, Rash JE. Update on connexins and gap junctions in neurons and glia in the mammalian nervous system. Brain Res Brain Res Rev 2004; 47: 191-215.
34. Filippov MA, Hormuzdi SG, Fuchs EC, Monyer H. A reporter allelle for investigating connexin 26 gene expression in the mouse brain. Eur J Neurosci. 2003; 18: 3183-3192.
35. Nagy JI, Li X, Rempel J, Stelmack G, Patel D, Staines WA et al. Connexin 26 in adult rodent central nervous system: Demonstration at astrocytic gap junctions and colocalization with connexin30 and connexin43. J Comp Neurol 2001; 441: 302-323.
36. Rash JE, Duffy HS, Dudek FE, Bilhartz BL, Whalen LR, Yasumura T. Grid-mapped freeze-fracture analysis of gap junctions in gray and white matter of adult rat central nervous system, with evidence for a 'panglial syncytium' that is not coupled to neurons. J Comp Neurol 1997; 388: 265-292.
37. Theis M, Sohl G, Eiberger J, Willecke K. Emerging complexities in identity and function of glial connexins. Trends Neurosci 2005; 28: 188-195.
38. Venance L, Cordier J, Monge M, Zalc B, Glowinski J, Giaume C. Homotypic and heterotypic coupling mediated by gap junctions during glial cell differentiation in vitro. Eur J Neurosci 1995; 7: 451-461.
39. Altevogt BM, Paul DL. Four classes of intercellular channels between glial cells in the CNS. J Neurosci 2004; 24: 4313-4323.
40. Eugenin EA, Eckardt D, Theis M, Willecke K, Bennett MV, Saez JC. Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with inteferon-gamma and tumor necrosis factor-alpha. Proc Natl Acad Sci USA 2001; 98 4190-4195.
41. Rouach N, Avignone E, Meme W, Koulakoff A, Venance L, Blomstrand F et al. Gap junctions and connexin expression in the normal and pathological central nervous system. Biol Cell 2002; 94: 457-475.
42. John GR, Scemes E, Suadicani SO, Liu JS, Charles PC, Lee SC et al. IL-1beta differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels. Proc Natl Acad Sci USA 1999; 96: 11613-11618.
43. Hinkerohe D, Smikalla D, Haghikia A, Heupel K, Haase CG, Dermietzel R et al. Effects of cytokines on microglial phenotypes and astroglial coupling in an inflammatory coculture model. Glia 2005; 52: 85-97.
44. Perez Velazquez JL, Frantseva MV, Naus CC. Gap junctions and neuronal injury: Protectants or executioners? Neuroscientist 2003; 9: 5-9.
45. Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN et al. Muller cells in the healthy and diseased retina. Prog Retin Eye Res 2006; 25: 397-424.
46. Kofuji P, Biedermann B, Siddharthan V, Raap M, Iandiev I, Milankovic I et al. Kir potassium channel subunit expression in retinal glial cells: Implications for spatial potassium buffering. Glia 2002; 39: 292-303.
47. Newman EA. Regional specialization of retinal glial cell membrane. Nature 1984; 309: 155-157.
48. Bringmann A, Reichenbach A, Wiedemann P. Pathomechanisms of cystoid macular edema. Ophthalmic Res 2004; 36: 241-249.
49. Barnett NL, Pow DV, Robinson SR. Inhibition of Muller cell glutamine synthetase rapidly impairs the retinal response to light. Glia 2000; 30: 64-73.
50. Francke M, Faude F, Pannicke T, Bringmann A, Eckstein P, Reichelt W et al. Electrophysiology of rabbit Muller (glial) cells in experimental retinal detachment and PVR. Invest Ophthalmol Vis Sci 2001; 42: 1072-1079.
51. Pannicke T, Uckermann O, Iandiev I, Biedermann B, Wiedemann P, Perlman I et al. Altered membrane physiology in Muller glial cells after transient ischemia of the rat retina. Glia 2005; 50: 1-11.
52. Kobayashi M, Kuroiwa T, Shimokawa R, Okeda R, Tokoro T. Nitric oxide synthase expression in ischemic rat retinas. Jpn J Ophthalmol 2000; 44: 235-244.
53. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LE. Vascular endothelial growth factor/ vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA 1995; 92 905-909.
54. Shima DT, Adamis AP, Ferrara N, Yeo KT, Yeo TK, Allende R et al. Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen. Mol Med 1995; 1: 182-193.
55. Nakazawa T, Matsubara A, Noda K, Hisatomi T, She H, Skondra D et al. Characterization of cytokine responses to retinal detachment in rats. Mol Vis 2006; 12: 867-878.
56. Pastor JC. Proliferative vitreoretinopathy: An overview. Surv Ophthalmol 1998; 43: 3-18.
57. Kreutzberg GW. Microglia: A sensor for pathological events in the CNS. Trends Neurosci 1996; 19: 312-318.
58. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005; 308: 1314-1318.
59. i signaling in mouse microglia. J Neurosci 1997; 17: 615-624.
60. Schwartz M, Butovsky O, Bruck W, Hanisch UK. Microglial phenotype: Is the commitment reversible? Trends Neurosci 2006; 29: 68-74.
61. Farber K, Kettenmann H. Purinergic signaling and microglia. Pflugers Arch 2006; 452: 615-621.
62. Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, Jung S et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005; 8: 752-758.
63. 3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 2000; 20: 4106-4114.
64. 12 receptor regulates microglial activation by extracellular nucleotides. Nat Neurosci 2006; 9: 1512-1519.
65. Alberdi E, Sanchez-Gomez MV, Matute C. Calcium and glial cell death. Cell Calcium 2005; 38: 417-425.
66. Domercq M, Etxebarria E, Perez-Samartin A, Matute C. Excitotoxic oligodendrocyte death and axonal damage induced by glutamate transporter inhibition. Glia 2005; 52: 36-46.
67. Alberdi E, Sanchaz-Gomez MV, Torre I, Domercq M, Perez-Samartin A, Perez-Cerda F et al. Activation of kainate receptors sensitizes oligodendrocytes to complement attack. J Neurosci 2006; 26: 3220-3228.
68. Matute C. Oligodendrocyte NMDA receptors: A novel therapeutic target. Trends Mol Med 2006; 12: 289-292.
69. Petito CK, Olarte JP, Roberts B, Nowak Jr TS, Pulsinelli WA. Selective glial vulnerability following transient global ischemia in rat brain. J Neuropathol Exp Neurol 1998; 57: 231-238.
70. Mandai K, Matsumoto M, Kitagawa K, Matsushita K, Ohtsuki T, Mabuchi T et al. Ischemic damage and subsequent proliferation of oligodendrocytes in focal cerebral ischemia. Neuroscience 1997; 77: 849-861.
71. Gottlieb M, Domercq M, Matute C. Altered expression of the glutamate transporter EAAC1 in neurons and immature oligodendrocytes after transient forebrain ischemia. J Cereb Blood Flow Metab 2000; 20 678-687.
72. Back SA, Rivkees SA. Emerging concepts in periventricular white matter injury. Semin Perinatol 2004; 28: 405-414.
73. Li J, Lin JC, Wang H, Peterson JW, Furie BC, Furie B et al. Novel role of vitamin K in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci 2003; 23: 5816-5826.
74. Matute C, Alberdi E, Domercq M, Perez-Cerda F, Perez-Samartin A, Sanchez-Gomez MV. The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci 2001; 24: 224-230.
75. Kanwar JR, Kanwar RK, Krissansen GW. Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis. Brain 2004; 127: 1313-1331.
76. Srinivasen R, Sallasuta N, Hurd R, Nelson S, Pelletier D. Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3T. Brain 2005; 128: 1016-1025.
77. Werner P, Pitt D, Raine CS. Multiple sclerosis: Altered glutamate homeostasis in lesions correlates wilh oligodendrocyte and axonal damage. Ann Neurol 2001; 50: 169-180.
78. Vallejo-Illarramendi A, Domercq M, Perez-Cerda F, Ravid R, Matute C. Increased expression and function of glutamate transporters in multiple sclerosis. Neurobiol Dis 2006; 21: 154-164.
79. Romera C, Hurtado O, Botella SH, Lizasoain I, Cardenas A, Fernandez-Torne P et al. In vitro ischemic tolerance involves upregulation of glutamate transport party mediated by the TACE/ ADAM17-tumor necrosis factor-alpha pathway. J Neurosci 2004; 24 1350-1357.
80. Domercq M, Malute C. Neuroprotection by tetracyclines. Trends Pharmacol Sci 2004; 25: 609-612.