-
1
-
-
0036187036
-
Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
-
Acehan D., Jiang X, Morgan DG, Heuser JE, Wang X, Akey CW. 2002. Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation. Mol Cell 9: 423-432.
-
(2002)
Mol Cell
, vol.9
, pp. 423-432
-
-
Acehan, D.1
Jiang, X.2
Morgan, D.G.3
Heuser, J.E.4
Wang, X.5
Akey, C.W.6
-
2
-
-
34247232176
-
Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis
-
Allan L.A., Clarke PR. 2007. Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis. Mol Cell 26: 301-310.
-
(2007)
Mol Cell
, vol.26
, pp. 301-310
-
-
Allan, L.A.1
Clarke, P.R.2
-
3
-
-
70349956567
-
Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation
-
Allan L.A., Clarke PR. 2009. Apoptosis and autophagy: Regulation of caspase-9 by phosphorylation. FEBS J 276: 6063-6073.
-
(2009)
FEBS J
, vol.276
, pp. 6063-6073
-
-
Allan, L.A.1
Clarke, P.R.2
-
4
-
-
0038726089
-
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
-
Allan L.A., Morrice N, Brady S, Magee G, Pathak S, Clarke PR. 2003. Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 5: 647-654.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 647-654
-
-
Allan, L.A.1
Morrice, N.2
Brady, S.3
Magee, G.4
Pathak, S.5
Clarke, P.R.6
-
5
-
-
0033778360
-
Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis
-
Allsopp T.E., McLuckie J, Kerr LE, Macleod M, Sharkey J, Kelly JS. 2000. Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis. Cell Death Differ 7: 984-993.
-
(2000)
Cell Death Differ
, vol.7
, pp. 984-993
-
-
Allsopp, T.E.1
McLuckie, J.2
Kerr, L.E.3
McLeod, M.4
Sharkey, J.5
Kelly, J.S.6
-
6
-
-
0009530192
-
Human ICE/CED-3 protease nomenclature
-
Alnemri E.S., Livingston DJ, Nicholson DW, Salvesen G, Thornberry N.A., Wong WW, Yuan J. 1996. Human ICE/CED-3 protease nomenclature. Cell 87: 171.
-
(1996)
Cell
, vol.87
, pp. 171
-
-
Alnemri, E.S.1
Livingston, D.J.2
Nicholson, D.W.3
Salvesen, G.4
Thornberry, N.A.5
Wong, W.W.6
Yuan, J.7
-
7
-
-
14044268205
-
Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPKand its substrate caspase 3
-
Alvarado-Kristensson M, Andersson T. 2005. Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPKand its substrate caspase 3. J Biol Chem 280: 6238-6244.
-
(2005)
J Biol Chem
, vol.280
, pp. 6238-6244
-
-
Alvarado-Kristensson, M.1
Andersson, T.2
-
8
-
-
1242276248
-
p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils
-
Alvarado-Kristensson M, Melander F, Leandersson K, Ronnstrand L, Wernstedt C, Andersson T. 2004. p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils. J Exp Med 199: 449-458.
-
(2004)
J Exp Med
, vol.199
, pp. 449-458
-
-
Alvarado-Kristensson, M.1
Melander, F.2
Leandersson, K.3
Ronnstrand, L.4
Wernstedt, C.5
Andersson, T.6
-
9
-
-
70350347735
-
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2
-
Andersen J.L., Johnson CE, Freel CD, Parrish AB, Day JL, Buchakjian M.R., Nutt LK, Thompson JW, Moseley MA, Kornbluth S. 2009. Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J 28: 3216-3227.
-
(2009)
EMBO J
, vol.28
, pp. 3216-3227
-
-
Andersen, J.L.1
Johnson, C.E.2
Freel, C.D.3
Parrish, A.B.4
Day, J.L.5
Buchakjian, M.R.6
Nutt, L.K.7
Thompson, J.W.8
Moseley, M.A.9
Kornbluth, S.10
-
10
-
-
40249115224
-
Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and-10 in vitro
-
Bae S., Ha TS, Yoon Y, Lee J, Cha HJ, Yoo H, Choe TB, Li S, Sohn I., Kim JY, et al. 2008. Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and-10 in vitro. Int J Mol Med 21: 381-386.
-
(2008)
Int J Mol Med
, vol.21
, pp. 381-386
-
-
Bae, S.1
Ha, T.S.2
Yoon, Y.3
Lee, J.4
Cha, H.J.5
Yoo, H.6
Choe, T.B.7
Li, S.8
Sohn, I.9
Kim, J.Y.10
-
11
-
-
8844224859
-
The biochemical mechanism of caspase-2 activation
-
Baliga B.C., Read SH, Kumar S. 2004. The biochemical mechanism of caspase-2 activation. Cell Death Differ 11: 1234-1241.
-
(2004)
Cell Death Differ
, vol.11
, pp. 1234-1241
-
-
Baliga, B.C.1
Read, S.H.2
Kumar, S.3
-
12
-
-
33846236461
-
Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1
-
Bao Q., Lu W, Rabinowitz JD, Shi Y. 2007. Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1. Mol Cell 25: 181-192.
-
(2007)
Mol Cell
, vol.25
, pp. 181-192
-
-
Bao, Q.1
Lu, W.2
Rabinowitz, J.D.3
Shi, Y.4
-
13
-
-
44149110803
-
Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner
-
Baptiste-Okoh N, Barsotti AM, Prives C. 2008. Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner. Cell Cycle 7: 1133-1138.
-
(2008)
Cell Cycle
, vol.7
, pp. 1133-1138
-
-
Baptiste-Okoh, N.1
Barsotti, A.M.2
Prives, C.3
-
14
-
-
69249206534
-
Evaluation of recombinant caspase specificity by competitive substrates
-
Benkova B., Lozanov V, Ivanov IP, Mitev V. 2009. Evaluation of recombinant caspase specificity by competitive substrates. Anal Biochem 394: 68-74.
-
(2009)
Anal Biochem
, vol.394
, pp. 68-74
-
-
Benkova, B.1
Lozanov, V.2
Ivanov, I.P.3
Mitev, V.4
-
15
-
-
0032080197
-
Defects in regulation of apoptosis in caspase-2-deficient mice
-
Bergeron L., Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JC, et al. 1998. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev 12: 1304-1314.
-
(1998)
Genes Dev
, vol.12
, pp. 1304-1314
-
-
Bergeron, L.1
Perez, G.I.2
McDonald, G.3
Shi, L.4
Sun, Y.5
Jurisicova, A.6
Varmuza, S.7
Latham, K.E.8
Flaws, J.A.9
Salter, J.C.10
-
16
-
-
26444433872
-
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD
-
Berube C., Boucher LM, Ma W, Wakeham A, Salmena L, Hakem R., Yeh WC, Mak TW, Benchimol S. 2005. Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci 102: 14314-14320.
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 14314-14320
-
-
Berube, C.1
Boucher, L.M.2
Ma, W.3
Wakeham, A.4
Salmena, L.5
Hakem, R.6
Yeh, W.C.7
Mak, T.W.8
Benchimol, S.9
-
17
-
-
0037291871
-
A unified model for apical caspase activation
-
Boatright K.M., Renatus M, Scott FL, Sperandio S, Shin H, Pedersen I.M., Ricci JE, EdrisWA, Sutherlin DP, Green DR, et al. 2003. A unified model for apical caspase activation. Mol Cell 11: 529-541.
-
(2003)
Mol Cell
, vol.11
, pp. 529-541
-
-
Boatright, K.M.1
Renatus, M.2
Scott, F.L.3
Sperandio, S.4
Shin, H.5
Pedersen, I.M.6
Ricci, J.E.7
Edris, W.A.8
Sutherlin, D.P.9
Green, D.R.10
-
18
-
-
4544288868
-
Activation of caspases-8 and-10 by FLIPL
-
Boatright K.M., Deis C, Denault JB, Sutherlin DP, Salvesen GS. 2004. Activation of caspases-8 and-10 by FLIPL. Biochem J 382: 651-657.
-
(2004)
Biochem J
, vol.382
, pp. 651-657
-
-
Boatright, K.M.1
Deis, C.2
Denault, J.B.3
Sutherlin, D.P.4
Salvesen, G.S.5
-
19
-
-
33745739717
-
Caspase-2-induced apoptosis requires bid cleavage: A physiological role for bid in heat shockinduced death
-
Bonzon C., Bouchier-Hayes L, Pagliari LJ, Green DR, Newmeyer DD. 2006. Caspase-2-induced apoptosis requires bid cleavage: A physiological role for bid in heat shockinduced death. Mol Biol Cell 17: 2150-2157.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 2150-2157
-
-
Bonzon, C.1
Bouchier-Hayes, L.2
Pagliari, L.J.3
Green, D.R.4
Newmeyer, D.D.5
-
20
-
-
27944469109
-
Regulation of caspase 9 through phosphorylation by protein kinase C z in response to hyperosmotic stress
-
Brady S.C., Allan LA, Clarke PR. 2005. Regulation of caspase 9 through phosphorylation by protein kinase C z in response to hyperosmotic stress. Mol Cell Biol 25: 10543-10555.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10543-10555
-
-
Brady, S.C.1
Allan, L.A.2
Clarke, P.R.3
-
21
-
-
0035283038
-
Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes
-
Bratton S.B., Walker G, Srinivasula SM, Sun XM, Butterworth M, Alnemri ES, Cohen GM. 2001. Recruitment, activation and retention of caspases-9 and-3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J 20: 998-1009.
-
(2001)
EMBO J
, vol.20
, pp. 998-1009
-
-
Bratton, S.B.1
Walker, G.2
Srinivasula, S.M.3
Sun, X.M.4
Butterworth, M.5
Alnemri, E.S.6
Cohen, G.M.7
-
22
-
-
0036718393
-
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95-and Bax-induced apoptosis
-
Bratton S.B., Lewis J, Butterworth M, Duckett CS, CohenGM. 2002. XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95-and Bax-induced apoptosis. Cell Death Differ 9: 881-892.
-
(2002)
Cell Death Differ
, vol.9
, pp. 881-892
-
-
Bratton, S.B.1
Lewis, J.2
Butterworth, M.3
Duckett, C.S.4
Cohen, G.M.5
-
23
-
-
77956932246
-
cIAP1 cooperatively inhibits procaspase-3 activation by the caspase-9 apoptosome
-
Burke S.P., Smith L, Smith JB. 2010. cIAP1 cooperatively inhibits procaspase-3 activation by the caspase-9 apoptosome. J Biol Chem 285: 30061-30068.
-
(2010)
J Biol Chem
, vol.285
, pp. 30061-30068
-
-
Burke, S.P.1
Smith, L.2
Smith, J.B.3
-
25
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone M.H., Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E., Frisch S, Reed JC. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
Frisch, S.7
Reed, J.C.8
-
26
-
-
0032544449
-
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
-
Cecconi F., Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P. 1998. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94: 727-737.
-
(1998)
Cell
, vol.94
, pp. 727-737
-
-
Cecconi, F.1
Alvarez-Bolado, G.2
Meyer, B.I.3
Roth, K.A.4
Gruss, P.5
-
27
-
-
0026517239
-
Molecular cloning of the interleukin-1 β converting enzyme
-
Cerretti D.P., Kozlosky CJ, Mosley B, Nelson N, Van Ness K, Greenstreet T.A., March CJ, Kronheim SR, Druck T, Cannizzaro L.A., et al. 1992. Molecular cloning of the interleukin-1 β converting enzyme. Science 256: 97-100.
-
(1992)
Science
, vol.256
, pp. 97-100
-
-
Cerretti, D.P.1
Kozlosky, C.J.2
Mosley, B.3
Nelson, N.4
van Ness, K.5
Greenstreet, T.A.6
March, C.J.7
Kronheim, S.R.8
Druck, T.9
Cannizzaro, L.A.10
-
28
-
-
0034710649
-
Structural and biochemical basis of apoptotic activation by Smac/ DIABLO
-
Chai J., Du C, Wu JW, Kyin S, Wang X, Shi Y. 2000. Structural and biochemical basis of apoptotic activation by Smac/ DIABLO. Nature 406: 855-862.
-
(2000)
Nature
, vol.406
, pp. 855-862
-
-
Chai, J.1
du, C.2
Wu, J.W.3
Kyin, S.4
Wang, X.5
Shi, Y.6
-
29
-
-
0035831021
-
Structural basis of caspase-7 inhibition by XIAP
-
Chai J., Shiozaki E, Srinivasula SM, Wu Q, Datta P, Alnemri ES, Shi Y. 2001. Structural basis of caspase-7 inhibition by XIAP. Cell 104: 769-780.
-
(2001)
Cell
, vol.104
, pp. 769-780
-
-
Chai, J.1
Shiozaki, E.2
Srinivasula, S.M.3
Wu, Q.4
Datta, P.5
Alnemri, E.S.6
Shi, Y.7
-
30
-
-
0032080004
-
Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver
-
Chandler J.M., Cohen GM, MacFarlane M. 1998. Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver. J Biol Chem 273: 10815-10818.
-
(1998)
J Biol Chem
, vol.273
, pp. 10815-10818
-
-
Chandler, J.M.1
Cohen, G.M.2
McFarlane, M.3
-
31
-
-
33745246534
-
Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome c and inhibiting apoptosome
-
Chandra D., Bratton SB, Person MD, Tian Y, Martin AG, Ayres M., Fearnhead HO, Gandhi V, Tang DG. 2006. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome c and inhibiting apoptosome. Cell 125: 1333-1346.
-
(2006)
Cell
, vol.125
, pp. 1333-1346
-
-
Chandra, D.1
Bratton, S.B.2
Person, M.D.3
Tian, Y.4
Martin, A.G.5
Ayres, M.6
Fearnhead, H.O.7
Gandhi, V.8
Tang, D.G.9
-
32
-
-
0037099678
-
c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis
-
Chang D.W., Xing Z, Pan Y, Algeciras-Schimnich A, Barnhart BC, Yaish-Ohad S, Peter ME, Yang X. 2002. c-FLIPL is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. EMBO J 21: 3704-3714.
-
(2002)
EMBO J
, vol.21
, pp. 3704-3714
-
-
Chang, D.W.1
Xing, Z.2
Pan, Y.3
Algeciras-Schimnich, A.4
Barnhart, B.C.5
Yaish-Ohad, S.6
Peter, M.E.7
Yang, X.8
-
33
-
-
0041842553
-
Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: Any single lysine or lysine pair of the small subunit is sufficient for ubiquitination
-
Chen L., Smith L, Wang Z, Smith JB. 2003. Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: Any single lysine or lysine pair of the small subunit is sufficient for ubiquitination. Mol Pharmacol 64: 334-345.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 334-345
-
-
Chen, L.1
Smith, L.2
Wang, Z.3
Smith, J.B.4
-
34
-
-
67650084825
-
Caspase-10-mediated heat shock protein 90 β cleavage promotes UVB irradiation-induced cell apoptosis
-
Chen H., Xia Y, Fang D, Hawke D, Lu Z. 2009. Caspase-10-mediated heat shock protein 90 β cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol 29: 3657-3664.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3657-3664
-
-
Chen, H.1
Xia, Y.2
Fang, D.3
Hawke, D.4
Lu, Z.5
-
35
-
-
75149114612
-
Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKTand activation of caspase-3
-
Choi W.Y., Jin CY, Han MH, Kim GY, Kim ND, Lee WH, Kim S.K., Choi YH. 2009. Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKTand activation of caspase-3. Anticancer Res 29: 4457-4465.
-
(2009)
Anticancer Res
, vol.29
, pp. 4457-4465
-
-
Choi, W.Y.1
Jin, C.Y.2
Han, M.H.3
Kim, G.Y.4
Kim, N.D.5
Lee, W.H.6
Kim, S.K.7
Choi, Y.H.8
-
36
-
-
0026344133
-
Prevention of apoptosis by a baculovirus gene during infection of insect cells
-
Clem R.J., Fechheimer M, Miller LK. 1991. Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 254: 1388-1390.
-
(1991)
Science
, vol.254
, pp. 1388-1390
-
-
Clem, R.J.1
Fechheimer, M.2
Miller, L.K.3
-
37
-
-
0032524885
-
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
-
Conradt B., Horvitz HR. 1998. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93: 519-529.
-
(1998)
Cell
, vol.93
, pp. 519-529
-
-
Conradt, B.1
Horvitz, H.R.2
-
38
-
-
0027537461
-
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif
-
Crook N.E., Clem RJ, Miller LK. 1993. An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. JVirol 67: 2168-2174.
-
(1993)
JVirol
, vol.67
, pp. 2168-2174
-
-
Crook, N.E.1
Clem, R.J.2
Miller, L.K.3
-
39
-
-
33646542701
-
Src kinase phosphorylates Caspase-8 on Tyr380: A novel mechanism of apoptosis suppression
-
Cursi S., Rufini A, Stagni V, Condo I, Matafora V, Bachi A, Bonifazi A.P., Coppola L, Superti-Furga G, Testi R, et al. 2006. Src kinase phosphorylates Caspase-8 on Tyr380: A novel mechanism of apoptosis suppression. EMBO J 25: 1895-1905.
-
(2006)
EMBO J
, vol.25
, pp. 1895-1905
-
-
Cursi, S.1
Rufini, A.2
Stagni, V.3
Condo, I.4
Matafora, V.5
Bachi, A.6
Bonifazi, A.P.7
Coppola, L.8
Superti-Furga, G.9
Testi, R.10
-
40
-
-
0141853168
-
Live and let die: Regulatory mechanisms in Fas-mediated apoptosis
-
Curtin J.F., Cotter TG. 2003. Live and let die: Regulatory mechanisms in Fas-mediated apoptosis. Cell Signal 15: 983-992.
-
(2003)
Cell Signal
, vol.15
, pp. 983-992
-
-
Curtin, J.F.1
Cotter, T.G.2
-
41
-
-
0842281645
-
Cell death: Critical control points
-
Danial N.N., Korsmeyer SJ. 2004. Cell death: Critical control points. Cell 116: 205-219.
-
(2004)
Cell
, vol.116
, pp. 205-219
-
-
Danial, N.N.1
Korsmeyer, S.J.2
-
42
-
-
0141817959
-
Human caspase-7 activity and regulation by its N-terminal peptide
-
Denault J.B., Salvesen GS. 2003. Human caspase-7 activity and regulation by its N-terminal peptide. J Biol Chem 278: 34042-34050.
-
(2003)
J Biol Chem
, vol.278
, pp. 34042-34050
-
-
Denault, J.B.1
Salvesen, G.S.2
-
43
-
-
33746892660
-
Identification of PP1α as a caspase-9 regulator in IL-2 deprivation-induced apoptosis
-
Dessauge F., Cayla X, Albar JP, Fleischer A, Ghadiri A, Duhamel M., Rebollo A. 2006. Identification of PP1α as a caspase-9 regulator in IL-2 deprivation-induced apoptosis. J Immunol 177: 2441-2451.
-
(2006)
J Immunol
, vol.177
, pp. 2441-2451
-
-
Dessauge, F.1
Cayla, X.2
Albar, J.P.3
Fleischer, A.4
Ghadiri, A.5
Duhamel, M.6
Rebollo, A.7
-
45
-
-
0037110732
-
Nuclear import of PKCd is required for apoptosis: Identification of a novel nuclear import sequence
-
DeVries TA, Neville MC, Reyland ME. 2002. Nuclear import of PKCd is required for apoptosis: Identification of a novel nuclear import sequence. EMBO J 21: 6050-6060.
-
(2002)
EMBO J
, vol.21
, pp. 6050-6060
-
-
DeVries, T.A.1
Neville, M.C.2
Reyland, M.E.3
-
46
-
-
0031037180
-
Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases
-
Dimmeler S., Haendeler J, Nehls M, Zeiher AM. 1997. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J Exp Med 185: 601-607.
-
(1997)
J Exp Med
, vol.185
, pp. 601-607
-
-
Dimmeler, S.1
Haendeler, J.2
Nehls, M.3
Zeiher, A.M.4
-
47
-
-
55949118522
-
Inactivation of effector caspases through nondegradative polyubiquitylation
-
Ditzel M., Broemer M, Tenev T, Bolduc C, Lee TV, Rigbolt KT, Elliott R, Zvelebil M, Blagoev B, Bergmann A, et al. 2008. Inactivation of effector caspases through nondegradative polyubiquitylation. Mol Cell 32: 540-553.
-
(2008)
Mol Cell
, vol.32
, pp. 540-553
-
-
Ditzel, M.1
Broemer, M.2
Tenev, T.3
Bolduc, C.4
Lee, T.V.5
Rigbolt, K.T.6
Elliott, R.7
Zvelebil, M.8
Blagoev, B.9
Bergmann, A.10
-
48
-
-
49549113643
-
Global mapping of the topography and magnitude of proteolytic events in apoptosis
-
Dix M.M., Simon GM, Cravatt BF. 2008. Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell 134: 679-691.
-
(2008)
Cell
, vol.134
, pp. 679-691
-
-
Dix, M.M.1
Simon, G.M.2
Cravatt, B.F.3
-
49
-
-
84864237480
-
Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome
-
Dix M.M., Simon GM, Wang C, Okerberg E, Patricelli MP, Cravatt BF. 2012. Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome. Cell 150: 426-440.
-
(2012)
Cell
, vol.150
, pp. 426-440
-
-
Dix, M.M.1
Simon, G.M.2
Wang, C.3
Okerberg, E.4
Patricelli, M.P.5
Cravatt, B.F.6
-
50
-
-
0034682825
-
Apoptosis induced by the nuclear death domain protein p84N5 is associated with caspase-6 and NF-κB activation
-
Doostzadeh-Cizeron J, Yin S, Goodrich DW. 2000. Apoptosis induced by the nuclear death domain protein p84N5 is associated with caspase-6 and NF-κB activation. J Biol Chem 275: 25336-25341.
-
(2000)
J Biol Chem
, vol.275
, pp. 25336-25341
-
-
Doostzadeh-Cizeron, J.1
Yin, S.2
Goodrich, D.W.3
-
51
-
-
0034616945
-
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
-
Du C., Fang M, Li Y, Li L, Wang X. 2000. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102: 33-42.
-
(2000)
Cell
, vol.102
, pp. 33-42
-
-
du, C.1
Fang, M.2
Li, Y.3
Li, L.4
Wang, X.5
-
52
-
-
0031021356
-
RAIDD is a new "death" adaptor molecule
-
Duan H., Dixit VM. 1997. RAIDD is a new "death" adaptor molecule. Nature 385: 86-89.
-
(1997)
Nature
, vol.385
, pp. 86-89
-
-
Duan, H.1
Dixit, V.M.2
-
53
-
-
0032885388
-
Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
-
EarnshawWC, Martins LM, Kaufmann SH. 1999. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68: 383-424.
-
(1999)
Annu Rev Biochem
, vol.68
, pp. 383-424
-
-
Earnshaw, W.C.1
Martins, L.M.2
Kaufmann, S.H.3
-
54
-
-
13344259987
-
Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells
-
Emoto Y., Manome Y, Meinhardt G, Kisaki H, Kharbanda S, Robertson M, Ghayur T, Wong WW, Kamen R, Weichselbaum R., et al. 1995. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J 14: 6148-6156.
-
(1995)
EMBO J
, vol.14
, pp. 6148-6156
-
-
Emoto, Y.1
Manome, Y.2
Meinhardt, G.3
Kisaki, H.4
Kharbanda, S.5
Robertson, M.6
Ghayur, T.7
Wong, W.W.8
Kamen, R.9
Weichselbaum, R.10
-
55
-
-
39449127365
-
Big wheel keeps on turning: Apoptosome regulation and its role in chemoresistance
-
Fadeel B., Ottosson A, Pervaiz S. 2008. Big wheel keeps on turning: Apoptosome regulation and its role in chemoresistance. Cell Death Differ 15: 443-452.
-
(2008)
Cell Death Differ
, vol.15
, pp. 443-452
-
-
Fadeel, B.1
Ottosson, A.2
Pervaiz, S.3
-
56
-
-
68149114498
-
Can't live without them, can live with them: Roles of caspases during vital cellular processes
-
Feinstein-Rotkopf Y, Arama E. 2009. Can't live without them, can live with them: Roles of caspases during vital cellular processes. Apoptosis 14: 980-995.
-
(2009)
Apoptosis
, vol.14
, pp. 980-995
-
-
Feinstein-Rotkopf, Y.1
Arama, E.2
-
57
-
-
30044435192
-
Unique and overlapping substrate specificities of caspase-8 and caspase-10
-
Fischer U., Stroh C, Schulze-Osthoff K. 2006. Unique and overlapping substrate specificities of caspase-8 and caspase-10. Oncogene 25: 152-159.
-
(2006)
Oncogene
, vol.25
, pp. 152-159
-
-
Fischer, U.1
Stroh, C.2
Schulze-Osthoff, K.3
-
58
-
-
0035889087
-
APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
-
Fortin A., Cregan SP, MacLaurin JG, Kushwaha N, Hickman ES, Thompson CS, Hakim A, Albert PR, Cecconi F, Helin K., et al. 2001. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol 155: 207-216.
-
(2001)
J Cell Biol
, vol.155
, pp. 207-216
-
-
Fortin, A.1
Cregan, S.P.2
McLaurin, J.G.3
Kushwaha, N.4
Hickman, E.S.5
Thompson, C.S.6
Hakim, A.7
Albert, P.R.8
Cecconi, F.9
Helin, K.10
-
59
-
-
18644381327
-
Apaf-1 is a mediator of E2F-1-induced apoptosis
-
Furukawa Y., Nishimura N, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M. 2002. Apaf-1 is a mediator of E2F-1-induced apoptosis. J Biol Chem 277: 39760-39768.
-
(2002)
J Biol Chem
, vol.277
, pp. 39760-39768
-
-
Furukawa, Y.1
Nishimura, N.2
Satoh, M.3
Endo, H.4
Iwase, S.5
Yamada, H.6
Matsuda, M.7
Kano, Y.8
Nakamura, M.9
-
60
-
-
33644663668
-
Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis
-
Gao Z., Shao Y, Jiang X. 2005. Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis. J Biol Chem 280: 38271-38275.
-
(2005)
J Biol Chem
, vol.280
, pp. 38271-38275
-
-
Gao, Z.1
Shao, Y.2
Jiang, X.3
-
61
-
-
12644268232
-
Proteolytic activation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis
-
Ghayur T., Hugunin M, Talanian RV, Ratnofsky S, Quinlan C, Emoto Y, Pandey P, Datta R, Huang Y, Kharbanda S, et al. 1996. Proteolytic activation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis. J Exp Med 184: 2399-2404.
-
(1996)
J Exp Med
, vol.184
, pp. 2399-2404
-
-
Ghayur, T.1
Hugunin, M.2
Talanian, R.V.3
Ratnofsky, S.4
Quinlan, C.5
Emoto, Y.6
Pandey, P.7
Datta, R.8
Huang, Y.9
Kharbanda, S.10
-
62
-
-
18244394529
-
HIV-1 Tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: A potential molecular mechanism to escape TRAIL cytotoxicity
-
Gibellini D., Re MC, Ponti C, Vitone F, Bon I, Fabbri G, Grazia Di Iasio M, Zauli G. 2005. HIV-1 Tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: A potential molecular mechanism to escape TRAIL cytotoxicity. J Cell Physiol 203: 547-556.
-
(2005)
J Cell Physiol
, vol.203
, pp. 547-556
-
-
Gibellini, D.1
Re, M.C.2
Ponti, C.3
Vitone, F.4
Bon, I.5
Fabbri, G.6
di Grazia Iasio, M.7
Zauli, G.8
-
63
-
-
0030877440
-
CASH, a novel caspase homologue with death effector domains
-
Goltsev Y.V., Kovalenko AV, Arnold E, Varfolomeev EE, Brodianskii VM, Wallach D. 1997. CASH, a novel caspase homologue with death effector domains. J Biol Chem 272: 19641-19644.
-
(1997)
J Biol Chem
, vol.272
, pp. 19641-19644
-
-
Goltsev, Y.V.1
Kovalenko, A.V.2
Arnold, E.3
Varfolomeev, E.E.4
Brodianskii, V.M.5
Wallach, D.6
-
64
-
-
0032493870
-
Differential requirement for caspase 9 in apoptotic pathways in vivo
-
Hakem R., Hakem A, Duncan GS, Henderson JT, Woo M, Soengas M.S., Elia A, de la Pompa JL, Kagi D, Khoo W, et al. 1998. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352.
-
(1998)
Cell
, vol.94
, pp. 339-352
-
-
Hakem, R.1
Hakem, A.2
Duncan, G.S.3
Henderson, J.T.4
Woo, M.5
Soengas, M.S.6
Elia, A.7
de la Pompa, J.L.8
Kagi, D.9
Khoo, W.10
-
65
-
-
0030758315
-
MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death
-
Han D.K., Chaudhary PM, Wright ME, Friedman C, Trask BJ, Riedel RT, Baskin DG, Schwartz SM, Hood L. 1997. MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. Proc Natl Acad Sci 94: 11333-11338.
-
(1997)
Proc Natl Acad Sci
, vol.94
, pp. 11333-11338
-
-
Han, D.K.1
Chaudhary, P.M.2
Wright, M.E.3
Friedman, C.4
Trask, B.J.5
Riedel, R.T.6
Baskin, D.G.7
Schwartz, S.M.8
Hood, L.9
-
66
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., Weinberg RA. 2000. The hallmarks of cancer. Cell 100: 57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
67
-
-
0037108859
-
Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines
-
Harada K., Toyooka S, Shivapurkar N, Maitra A, Reddy JL, Matta H., Miyajima K, Timmons CF, Tomlinson GE, Mastrangelo D., et al. 2002. Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines. Cancer Res 62: 5897-5901.
-
(2002)
Cancer Res
, vol.62
, pp. 5897-5901
-
-
Harada, K.1
Toyooka, S.2
Shivapurkar, N.3
Maitra, A.4
Reddy, J.L.5
Matta, H.6
Miyajima, K.7
Timmons, C.F.8
Tomlinson, G.E.9
Mastrangelo, D.10
-
68
-
-
0035037802
-
Characterization of XIAP-deficient mice
-
Harlin H., Reffey SB, Duckett CS, Lindsten T, Thompson CB. 2001. Characterization of XIAP-deficient mice. Mol Cell Biol 21: 3604-3608.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3604-3608
-
-
Harlin, H.1
Reffey, S.B.2
Duckett, C.S.3
Lindsten, T.4
Thompson, C.B.5
-
69
-
-
0028288277
-
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
-
Hengartner M.O., Horvitz HR. 1994. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 76: 665-676.
-
(1994)
Cell
, vol.76
, pp. 665-676
-
-
Hengartner, M.O.1
Horvitz, H.R.2
-
70
-
-
0036624845
-
Characterization of caspase-8 L: A novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade
-
Himeji D., Horiuchi T, Tsukamoto H, Hayashi K, Watanabe T, Harada M. 2002. Characterization of caspase-8 L: A novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade. Blood 99: 4070-4078.
-
(2002)
Blood
, vol.99
, pp. 4070-4078
-
-
Himeji, D.1
Horiuchi, T.2
Tsukamoto, H.3
Hayashi, K.4
Watanabe, T.5
Harada, M.6
-
71
-
-
79551632028
-
Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis
-
Hornle M., Peters N, Thayaparasingham B, Vorsmann H, Kashkar H., Kulms D. 2011. Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis. Oncogene 30: 575-587.
-
(2011)
Oncogene
, vol.30
, pp. 575-587
-
-
Hornle, M.1
Peters, N.2
Thayaparasingham, B.3
Vorsmann, H.4
Kashkar, H.5
Kulms, D.6
-
72
-
-
0034282432
-
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
-
Huang H., Joazeiro CA, Bonfoco E, Kamada S, Leverson JD, Hunter T. 2000. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7. J Biol Chem 275: 26661-26664.
-
(2000)
J Biol Chem
, vol.275
, pp. 26661-26664
-
-
Huang, H.1
Joazeiro, C.A.2
Bonfoco, E.3
Kamada, S.4
Leverson, J.D.5
Hunter, T.6
-
73
-
-
67549118622
-
Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway
-
Inoue S., Browne G, Melino G, Cohen GM. 2009. Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Differ 16: 1053-1061.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1053-1061
-
-
Inoue, S.1
Browne, G.2
Melino, G.3
Cohen, G.M.4
-
74
-
-
0030800070
-
Inhibition of death receptor signals by cellular FLIP
-
Irmler M., Thome M, Hahne M, Schneider P, Hofmann K, Steiner V., Bodmer JL, Schroter M, Burns K, Mattmann C, et al. 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388: 190-195.
-
(1997)
Nature
, vol.388
, pp. 190-195
-
-
Irmler, M.1
Thome, M.2
Hahne, M.3
Schneider, P.4
Hofmann, K.5
Steiner, V.6
Bodmer, J.L.7
Schroter, M.8
Burns, K.9
Mattmann, C.10
-
75
-
-
0027281373
-
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
-
Itoh N., Nagata S. 1993. A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen. J Biol Chem 268: 10932-10937.
-
(1993)
J Biol Chem
, vol.268
, pp. 10932-10937
-
-
Itoh, N.1
Nagata, S.2
-
76
-
-
41949117115
-
Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8
-
Jia S.H., Parodo J, Kapus A, Rotstein OD, Marshall JC. 2008. Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8. J Biol Chem 283: 5402-5413.
-
(2008)
J Biol Chem
, vol.283
, pp. 5402-5413
-
-
Jia, S.H.1
Parodo, J.2
Kapus, A.3
Rotstein, O.D.4
Marshall, J.C.5
-
77
-
-
62449249816
-
S-nitrosylation of caspase-3 is the mechanism by which adhesion fibroblasts manifest lower apoptosis
-
Jiang Z.L., Fletcher NM, Diamond MP, Abu-Soud HM, Saed GM. 2009. S-nitrosylation of caspase-3 is the mechanism by which adhesion fibroblasts manifest lower apoptosis. Wound Repair Regen 17: 224-229.
-
(2009)
Wound Repair Regen
, vol.17
, pp. 224-229
-
-
Jiang, Z.L.1
Fletcher, N.M.2
Diamond, M.P.3
Abu-Soud, H.M.4
Saed, G.M.5
-
78
-
-
65549085701
-
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
-
Jin Z., Li Y, Pitti R, Lawrence D, Pham VC, Lill JR, Ashkenazi A. 2009. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 137: 721-735.
-
(2009)
Cell
, vol.137
, pp. 721-735
-
-
Jin, Z.1
Li, Y.2
Pitti, R.3
Lawrence, D.4
Pham, V.C.5
Lill, J.R.6
Ashkenazi, A.7
-
79
-
-
0034266806
-
RING finger proteins: Mediators of ubiquitin ligase activity
-
Joazeiro C.A., Weissman AM. 2000. RING finger proteins: Mediators of ubiquitin ligase activity. Cell 102: 549-552.
-
(2000)
Cell
, vol.102
, pp. 549-552
-
-
Joazeiro, C.A.1
Weissman, A.M.2
-
80
-
-
38049136542
-
Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues
-
Johnson C.E., Huang YY, Parrish AB, Smith MI, Vaughn AE, Zhang Q., Wright KM, Van Dyke T, Wechsler-Reya RJ, Kornbluth S., et al. 2007. Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues. Proc Natl Acad Sci 104: 20820-20825.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 20820-20825
-
-
Johnson, C.E.1
Huang, Y.Y.2
Parrish, A.B.3
Smith, M.I.4
Vaughn, A.E.5
Zhang, Q.6
Wright, K.M.7
van Dyke, T.8
Wechsler-Reya, R.J.9
Kornbluth, S.10
-
81
-
-
77954927345
-
Gradients of a ubiquitin E3 ligase inhibitor and a caspase inhibitor determine differentiation or death in spermatids
-
Kaplan Y., Gibbs-Bar L, Kalifa Y, Feinstein-Rotkopf Y, Arama E. 2010. Gradients of a ubiquitin E3 ligase inhibitor and a caspase inhibitor determine differentiation or death in spermatids. Dev Cell 19: 160-173.
-
(2010)
Dev Cell
, vol.19
, pp. 160-173
-
-
Kaplan, Y.1
Gibbs-Bar, L.2
Kalifa, Y.3
Feinstein-Rotkopf, Y.4
Arama, E.5
-
82
-
-
36248979229
-
+ inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release
-
+ inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release. Cell Death Differ 14: 2068-2075.
-
(2007)
Cell Death Differ
, vol.14
, pp. 2068-2075
-
-
Karki, P.1
Seong, C.2
Kim, J.E.3
Hur, K.4
Shin, S.Y.5
Lee, J.S.6
Cho, B.7
Park, I.S.8
-
83
-
-
0015383455
-
Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
-
Kerr J.F., Wyllie AH, Currie AR. 1972. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257.
-
(1972)
Br J Cancer
, vol.26
, pp. 239-257
-
-
Kerr, J.F.1
Wyllie, A.H.2
Currie, A.R.3
-
84
-
-
0033797774
-
Nitric oxide prevents tumor necrosis factor α-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through Snitrosylation of caspase-8
-
Kim Y.M., Kim TH, Chung HT, Talanian RV, Yin XM, Billiar TR. 2000. Nitric oxide prevents tumor necrosis factor α-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through Snitrosylation of caspase-8. Hepatology 32: 770-778.
-
(2000)
Hepatology
, vol.32
, pp. 770-778
-
-
Kim, Y.M.1
Kim, T.H.2
Chung, H.T.3
Talanian, R.V.4
Yin, X.M.5
Billiar, T.R.6
-
85
-
-
43049147998
-
PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1
-
Kim H.E., Jiang X, Du F, Wang X. 2008. PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Mol Cell 30: 239-247.
-
(2008)
Mol Cell
, vol.30
, pp. 239-247
-
-
Kim, H.E.1
Jiang, X.2
du, F.3
Wang, X.4
-
86
-
-
0028883850
-
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
-
Kischkel F.C., Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME. 1995. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J 14: 5579-5588.
-
(1995)
EMBO J
, vol.14
, pp. 5579-5588
-
-
Kischkel, F.C.1
Hellbardt, S.2
Behrmann, I.3
Germer, M.4
Pawlita, M.5
Krammer, P.H.6
Peter, M.E.7
-
87
-
-
0035824635
-
Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8
-
Kischkel F.C., Lawrence DA, Tinel A, LeBlanc H, Virmani A, Schow P., Gazdar A, Blenis J, ArnottD, Ashkenazi A. 2001. Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8. J Biol Chem 276: 46639-46646.
-
(2001)
J Biol Chem
, vol.276
, pp. 46639-46646
-
-
Kischkel, F.C.1
Lawrence, D.A.2
Tinel, A.3
LeBlanc, H.4
Virmani, A.5
Schow, P.6
Gazdar, A.7
Blenis, J.8
Arnott, D.9
Ashkenazi, A.10
-
88
-
-
60649093275
-
Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells
-
Klaiman G., Champagne N, LeBlanc AC. 2009. Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells. Biochim Biophys Acta 1793: 592-601.
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 592-601
-
-
Klaiman, G.1
Champagne, N.2
LeBlanc, A.C.3
-
89
-
-
19444386896
-
Apoptosis in Drosophila: Neither fish nor fowl (nor man, nor worm)
-
Kornbluth S., White K. 2005. Apoptosis in Drosophila: Neither fish nor fowl (nor man, nor worm). J Cell Sci 118: 1779-1787.
-
(2005)
J Cell Sci
, vol.118
, pp. 1779-1787
-
-
Kornbluth, S.1
White, K.2
-
90
-
-
0035827569
-
Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex
-
Krueger A., Schmitz I, Baumann S, Krammer PH, Kirchhoff S. 2001. Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem 276: 20633-20640.
-
(2001)
J Biol Chem
, vol.276
, pp. 20633-20640
-
-
Krueger, A.1
Schmitz, I.2
Baumann, S.3
Krammer, P.H.4
Kirchhoff, S.5
-
91
-
-
58249101029
-
The enigma of caspase-2: The laymen's view
-
Krumschnabel G., Sohm B, Bock F, Manzl C, Villunger A. 2009. The enigma of caspase-2: The laymen's view. Cell Death Differ 16: 195-207.
-
(2009)
Cell Death Differ
, vol.16
, pp. 195-207
-
-
Krumschnabel, G.1
Sohm, B.2
Bock, F.3
Manzl, C.4
Villunger, A.5
-
92
-
-
0032493910
-
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
-
Kuida K., Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su M.S., Rakic P, Flavell RA. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337.
-
(1998)
Cell
, vol.94
, pp. 325-337
-
-
Kuida, K.1
Haydar, T.F.2
Kuan, C.Y.3
Gu, Y.4
Taya, C.5
Karasuyama, H.6
Su, M.S.7
Rakic, P.8
Flavell, R.A.9
-
93
-
-
33847367323
-
Nonapoptotic functions of caspases: Caspases as regulatory molecules for immunity and cell-fate determination
-
Kuranaga E., Miura M. 2007. Nonapoptotic functions of caspases: Caspases as regulatory molecules for immunity and cell-fate determination. Trends Cell Biol 17: 135-144.
-
(2007)
Trends Cell Biol
, vol.17
, pp. 135-144
-
-
Kuranaga, E.1
Miura, M.2
-
94
-
-
57049159874
-
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development
-
Laguna A., Aranda S, Barallobre MJ, Barhoum R, Fernandez E, Fotaki V, Delabar JM, de la Luna S, de la Villa P., Arbones ML. 2008. The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development. Dev Cell 15: 841-853.
-
(2008)
Dev Cell
, vol.15
, pp. 841-853
-
-
Laguna, A.1
Aranda, S.2
Barallobre, M.J.3
Barhoum, R.4
Fernandez, E.5
Fotaki, V.6
Delabar, J.M.7
de la Luna, S.8
de la Villa, P.9
Arbones, M.L.10
-
95
-
-
32444434664
-
Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis
-
Lakhani S.A., Masud A, Kuida K, Porter GA Jr, Booth CJ, Mehal W.Z., Inayat I, Flavell RA. 2006. Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis. Science 311: 847-851.
-
(2006)
Science
, vol.311
, pp. 847-851
-
-
Lakhani, S.A.1
Masud, A.2
Kuida, K.3
Porter Jr., G.A.4
Booth, C.J.5
Mehal, W.Z.6
Inayat, I.7
Flavell, R.A.8
-
96
-
-
0033551738
-
Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease
-
LeBlanc A, Liu H, Goodyer C, Bergeron C, Hammond J. 1999. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease. J Biol Chem 274: 23426-23436.
-
(1999)
J Biol Chem
, vol.274
, pp. 23426-23436
-
-
LeBlanc, A.1
Liu, H.2
Goodyer, C.3
Bergeron, C.4
Hammond, J.5
-
97
-
-
54249096028
-
Caspases in apoptosis and beyond
-
Li J., Yuan J. 2008. Caspases in apoptosis and beyond. Oncogene 27: 6194-6206.
-
(2008)
Oncogene
, vol.27
, pp. 6194-6206
-
-
Li, J.1
Yuan, J.2
-
98
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H., Zhu H, Xu CJ, Yuan J. 1998. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501.
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
99
-
-
77953271477
-
Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
-
Li Z., Jo J, Jia JM, Lo SC, Whitcomb DJ, Jiao S, Cho K, Sheng M. 2010. Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Cell 141: 859-871.
-
(2010)
Cell
, vol.141
, pp. 859-871
-
-
Li, Z.1
Jo, J.2
Jia, J.M.3
Lo, S.C.4
Whitcomb, D.J.5
Jiao, S.6
Cho, K.7
Sheng, M.8
-
100
-
-
79959367758
-
Phosphorylation of caspase-7 by P21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drugs-induced apoptosis of breast cancer cell lines
-
Li X., Wen W, Liu K, Zhu F, Malakhova M, Peng C, Li T, Kim H.G., MaW, Cho YY, et al. 2011. Phosphorylation of caspase-7 by P21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drugs-induced apoptosis of breast cancer cell lines. J Biol Chem 286: 22291-22299.
-
(2011)
J Biol Chem
, vol.286
, pp. 22291-22299
-
-
Li, X.1
Wen, W.2
Liu, K.3
Zhu, F.4
Malakhova, M.5
Peng, C.6
Li, T.7
Kim, H.G.8
Ma, W.9
Cho, Y.Y.10
-
101
-
-
0030581151
-
Induction of apoptotic program in cell-free extracts: Requirement for dATPand cytochrome c
-
Liu X., Kim CN, Yang J, Jemmerson R, Wang X. 1996. Induction of apoptotic program in cell-free extracts: Requirement for dATPand cytochrome c. Cell 86: 147-157.
-
(1996)
Cell
, vol.86
, pp. 147-157
-
-
Liu, X.1
Kim, C.N.2
Yang, J.3
Jemmerson, R.4
Wang, X.5
-
102
-
-
0032555716
-
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
-
Luo X., Budihardjo I, Zou H, Slaughter C, Wang X. 1998. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94: 481-490.
-
(1998)
Cell
, vol.94
, pp. 481-490
-
-
Luo, X.1
Budihardjo, I.2
Zou, H.3
Slaughter, C.4
Wang, X.5
-
103
-
-
33947426526
-
The CASBAH: A searchable database of caspase substrates
-
Luthi A.U., Martin SJ. 2007. The CASBAH: A searchable database of caspase substrates. Cell Death Differ 14: 641-650.
-
(2007)
Cell Death Differ
, vol.14
, pp. 641-650
-
-
Luthi, A.U.1
Martin, S.J.2
-
104
-
-
11144344931
-
Nitric oxide inhibits myocardial apoptosis by preventing caspase-3 activity via S-nitrosylation
-
Maejima Y., Adachi S, Morikawa K, Ito H, Isobe M. 2005. Nitric oxide inhibits myocardial apoptosis by preventing caspase-3 activity via S-nitrosylation. J Mol Cell Cardiol 38: 163-174.
-
(2005)
J Mol Cell Cardiol
, vol.38
, pp. 163-174
-
-
Maejima, Y.1
Adachi, S.2
Morikawa, K.3
Ito, H.4
Isobe, M.5
-
105
-
-
52649141086
-
Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini
-
Mahrus S., Trinidad JC, Barkan DT, Sali A, Burlingame AL, Wells JA. 2008. Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini. Cell 134: 866-876.
-
(2008)
Cell
, vol.134
, pp. 866-876
-
-
Mahrus, S.1
Trinidad, J.C.2
Barkan, D.T.3
Sali, A.4
Burlingame, A.L.5
Wells, J.A.6
-
106
-
-
67650455882
-
The Apaf-1* procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer
-
Malladi S., Challa-Malladi M, Fearnhead HO, Bratton SB. 2009. The Apaf-1* procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J 28: 1916-1925.
-
(2009)
EMBO J
, vol.28
, pp. 1916-1925
-
-
Malladi, S.1
Challa-Malladi, M.2
Fearnhead, H.O.3
Bratton, S.B.4
-
107
-
-
0033597449
-
Fas-induced caspase denitrosylation
-
Mannick J.B., Hausladen A, Liu L, Hess DT, Zeng M, Miao Q.X., Kane LS, Gow AJ, Stamler JS. 1999. Fas-induced caspase denitrosylation. Science 284: 651-654.
-
(1999)
Science
, vol.284
, pp. 651-654
-
-
Mannick, J.B.1
Hausladen, A.2
Liu, L.3
Hess, D.T.4
Zeng, M.5
Miao, Q.X.6
Kane, L.S.7
Gow, A.J.8
Stamler, J.S.9
-
108
-
-
0035904232
-
S-Nitrosylation of mitochondrial caspases
-
Mannick J.B., Schonhoff C, Papeta N, Ghafourifar P, Szibor M, Fang K, Gaston B. 2001. S-Nitrosylation of mitochondrial caspases. J Cell Biol 154: 1111-1116.
-
(2001)
J Cell Biol
, vol.154
, pp. 1111-1116
-
-
Mannick, J.B.1
Schonhoff, C.2
Papeta, N.3
Ghafourifar, P.4
Szibor, M.5
Fang, K.6
Gaston, B.7
-
109
-
-
65349178993
-
Caspase-2 activation in the absence of PIDDosome formation
-
Manzl C., Krumschnabel G, Bock F, Sohm B, Labi V, Baumgartner F, Logette E, Tschopp J, Villunger A. 2009. Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 185: 291-303.
-
(2009)
J Cell Biol
, vol.185
, pp. 291-303
-
-
Manzl, C.1
Krumschnabel, G.2
Bock, F.3
Sohm, B.4
Labi, V.5
Baumgartner, F.6
Logette, E.7
Tschopp, J.8
Villunger, A.9
-
110
-
-
17644387220
-
Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c
-
Martin M.C., Allan LA, Lickrish M, Sampson C, Morrice N, Clarke PR. 2005. Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c. J Biol Chem 280: 15449-15455.
-
(2005)
J Biol Chem
, vol.280
, pp. 15449-15455
-
-
Martin, M.C.1
Allan, L.A.2
Lickrish, M.3
Sampson, C.4
Morrice, N.5
Clarke, P.R.6
-
111
-
-
79960297569
-
Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity
-
Matthess Y., Raab M, Sanhaji M, Lavrik IN, Strebhardt K. 2010. Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity. Mol Cell Biol 30: 5726-5740.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 5726-5740
-
-
Matthess, Y.1
Raab, M.2
Sanhaji, M.3
Lavrik, I.N.4
Strebhardt, K.5
-
112
-
-
50649123015
-
Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8
-
McDonnell MA, Abedin MJ, Melendez M, Platikanova TN, Ecklund J.R., Ahmed K, Kelekar A. 2008. Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8. J Biol Chem 283: 20149-20158.
-
(2008)
J Biol Chem
, vol.283
, pp. 20149-20158
-
-
McDonnell, M.A.1
Abedin, M.J.2
Melendez, M.3
Platikanova, T.N.4
Ecklund, J.R.5
Ahmed, K.6
Kelekar, A.7
-
114
-
-
0037160117
-
The long form of FLIP is an activator of caspase-8 at the Fas deathinducing signaling complex
-
Micheau O., Thome M, Schneider P, Holler N, Tschopp J, Nicholson D.W., Briand C, Grutter MG. 2002. The long form of FLIP is an activator of caspase-8 at the Fas deathinducing signaling complex. J Biol Chem 277: 45162-45171.
-
(2002)
J Biol Chem
, vol.277
, pp. 45162-45171
-
-
Micheau, O.1
Thome, M.2
Schneider, P.3
Holler, N.4
Tschopp, J.5
Nicholson, D.W.6
Briand, C.7
Grutter, M.G.8
-
115
-
-
17044368875
-
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO
-
Morizane Y., Honda R, Fukami K, Yasuda H. 2005. X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO. J Biochem 137: 125-132.
-
(2005)
J Biochem
, vol.137
, pp. 125-132
-
-
Morizane, Y.1
Honda, R.2
Fukami, K.3
Yasuda, H.4
-
116
-
-
0034977277
-
Apaf-1 is a transcriptional target for E2F and p53
-
Moroni M.C., Hickman ES, Lazzerini Denchi E, Caprara G, Colli E., Cecconi F, Muller H, Helin K. 2001. Apaf-1 is a transcriptional target for E2F and p53. Nat Cell Biol 3: 552-558.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 552-558
-
-
Moroni, M.C.1
Hickman, E.S.2
Lazzerini Denchi, E.3
Caprara, G.4
Colli, E.5
Cecconi, F.6
Muller, H.7
Helin, K.8
-
117
-
-
0346668315
-
The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC
-
Muro I., Hay BA, Clem RJ. 2002. The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC. J Biol Chem 277: 49644-49650.
-
(2002)
J Biol Chem
, vol.277
, pp. 49644-49650
-
-
Muro, I.1
Hay, B.A.2
Clem, R.J.3
-
118
-
-
0029068871
-
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
-
Nicholson D.W., Ali A, Thornberry NA, Vaillancourt JP, Ding C.K., Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik Y.A., et al. 1995. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376: 37-43.
-
(1995)
Nature
, vol.376
, pp. 37-43
-
-
Nicholson, D.W.1
Ali, A.2
Thornberry, N.A.3
Vaillancourt, J.P.4
Ding, C.K.5
Gallant, M.6
Gareau, Y.7
Griffin, P.R.8
Labelle, M.9
Lazebnik, Y.A.10
-
119
-
-
26244453715
-
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2
-
Nutt L.K., Margolis SS, Jensen M, Herman CE, DunphyWG, Rathmell J.C., Kornbluth S. 2005. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell 123: 89-103.
-
(2005)
Cell
, vol.123
, pp. 89-103
-
-
Nutt, L.K.1
Margolis, S.S.2
Jensen, M.3
Herman, C.E.4
Dunphy, W.G.5
Rathmell, J.C.6
Kornbluth, S.7
-
120
-
-
66949181198
-
Metabolic control of oocyte apoptosis mediated by 14-3-3z-regulated dephosphorylation of caspase-2
-
Nutt L.K., Buchakjian MR, Gan E, Darbandi R, Yoon SY, Wu J.Q., Miyamoto YJ, Gibbons JA, Andersen JL, Freel CD, et al. 2009. Metabolic control of oocyte apoptosis mediated by 14-3-3z-regulated dephosphorylation of caspase-2. Dev Cell 16: 856-866.
-
(2009)
Dev Cell
, vol.16
, pp. 856-866
-
-
Nutt, L.K.1
Buchakjian, M.R.2
Gan, E.3
Darbandi, R.4
Yoon, S.Y.5
Wu, J.Q.6
Miyamoto, Y.J.7
Gibbons, J.A.8
Andersen, J.L.9
Freel, C.D.10
-
121
-
-
79952810024
-
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis
-
Oberst A., Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. 2011. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471: 363-367.
-
(2011)
Nature
, vol.471
, pp. 363-367
-
-
Oberst, A.1
Dillon, C.P.2
Weinlich, R.3
McCormick, L.L.4
Fitzgerald, P.5
Pop, C.6
Hakem, R.7
Salvesen, G.S.8
Green, D.R.9
-
122
-
-
77955793357
-
Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
-
Ohsawa S., Hamada S, Kuida K, Yoshida H, Igaki T, Miura M. 2010. Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity. Proc Natl Acad Sci 107: 13366-13371.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 13366-13371
-
-
Ohsawa, S.1
Hamada, S.2
Kuida, K.3
Yoshida, H.4
Igaki, T.5
Miura, M.6
-
123
-
-
33846702221
-
Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex
-
Park H.H., Logette E, Raunser S, Cuenin S, Walz T, Tschopp J, Wu H. 2007. Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell 128: 533-546.
-
(2007)
Cell
, vol.128
, pp. 533-546
-
-
Park, H.H.1
Logette, E.2
Raunser, S.3
Cuenin, S.4
Walz, T.5
Tschopp, J.6
Wu, H.7
-
125
-
-
79953214075
-
Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability
-
Peng C., Cho YY, Zhu F, Zhang J, WenW, Xu Y, Yao K, MaWY, Bode A.M., Dong Z. 2011. Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability. J Biol Chem 286: 6946-6954.
-
(2011)
J Biol Chem
, vol.286
, pp. 6946-6954
-
-
Peng, C.1
Cho, Y.Y.2
Zhu, F.3
Zhang, J.4
Wen, W.5
Xu, Y.6
Yao, K.7
Ma, W.Y.8
Bode, A.M.9
Dong, Z.10
-
126
-
-
33646024628
-
The apoptosome activates caspase-9 by dimerization
-
Pop C., Timmer J, Sperandio S, Salvesen GS. 2006. The apoptosome activates caspase-9 by dimerization. MolCell 22: 269-275.
-
(2006)
MolCell
, vol.22
, pp. 269-275
-
-
Pop, C.1
Timmer, J.2
Sperandio, S.3
Salvesen, G.S.4
-
128
-
-
77951881456
-
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4
-
Qi S., Pang Y, Hu Q, Liu Q, Li H, Zhou Y, He T, Liang Q, Liu Y, Yuan X, et al. 2010. Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell 141: 446-457.
-
(2010)
Cell
, vol.141
, pp. 446-457
-
-
Qi, S.1
Pang, Y.2
Hu, Q.3
Liu, Q.4
Li, H.5
Zhou, Y.6
He, T.7
Liang, Q.8
Liu, Y.9
Yuan, X.10
-
129
-
-
15744398903
-
c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage
-
Raina D., Pandey P, Ahmad R, Bharti A, Ren J, Kharbanda S, Weichselbaum R., Kufe D. 2005. c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J Biol Chem 280: 11147-11151.
-
(2005)
J Biol Chem
, vol.280
, pp. 11147-11151
-
-
Raina, D.1
Pandey, P.2
Ahmad, R.3
Bharti, A.4
Ren, J.5
Kharbanda, S.6
Weichselbaum, R.7
Kufe, D.8
-
130
-
-
0026728952
-
Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 β converting enzyme
-
Ray C.A., Black RA, Kronheim SR, Greenstreet TA, Sleath PR, Salvesen GS, Pickup DJ. 1992. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 β converting enzyme. Cell 69: 597-604.
-
(1992)
Cell
, vol.69
, pp. 597-604
-
-
Ray, C.A.1
Black, R.A.2
Kronheim, S.R.3
Greenstreet, T.A.4
Sleath, P.R.5
Salvesen, G.S.6
Pickup, D.J.7
-
131
-
-
0037049549
-
A novel Apaf-1-independent putative caspase-2 activation complex
-
Read S.H., Baliga BC, Ekert PG, Vaux DL, Kumar S. 2002. A novel Apaf-1-independent putative caspase-2 activation complex. J Cell Biol 159: 739-745.
-
(2002)
J Cell Biol
, vol.159
, pp. 739-745
-
-
Read, S.H.1
Baliga, B.C.2
Ekert, P.G.3
Vaux, D.L.4
Kumar, S.5
-
132
-
-
0035807966
-
Dimer formation drives the activation of the cell death protease caspase 9
-
Renatus M., Stennicke HR, Scott FL, Liddington RC, Salvesen GS. 2001. Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci 98: 14250-14255.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 14250-14255
-
-
Renatus, M.1
Stennicke, H.R.2
Scott, F.L.3
Liddington, R.C.4
Salvesen, G.S.5
-
133
-
-
64049086956
-
The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila
-
Ribaya J.P., Ranmuthu M, Copeland J, Boyarskiy S, Blair AP, Hay B., Laski FA. 2009. The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila. Dev Biol 329: 25-35.
-
(2009)
Dev Biol
, vol.329
, pp. 25-35
-
-
Ribaya, J.P.1
Ranmuthu, M.2
Copeland, J.3
Boyarskiy, S.4
Blair, A.P.5
Hay, B.6
Laski, F.A.7
-
134
-
-
38049016966
-
DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells
-
Ribeiro P.S., Kuranaga E, Tenev T, Leulier F, Miura M, Meier P. 2007. DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells. J Cell Biol 179: 1467-1480.
-
(2007)
J Cell Biol
, vol.179
, pp. 1467-1480
-
-
Ribeiro, P.S.1
Kuranaga, E.2
Tenev, T.3
Leulier, F.4
Miura, M.5
Meier, P.6
-
135
-
-
34247345833
-
The apoptosome: Signalling platform of cell death
-
Riedl S.J., Salvesen GS. 2007. The apoptosome: Signalling platform of cell death. Nat Rev Mol Cell Biol 8: 405-413.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 405-413
-
-
Riedl, S.J.1
Salvesen, G.S.2
-
136
-
-
0035831019
-
Structural basis for the inhibition of caspase-3 by XIAP
-
Riedl S.J., Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik S.W., Liddington RC, Salvesen GS. 2001. Structural basis for the inhibition of caspase-3 by XIAP. Cell 104: 791-800.
-
(2001)
Cell
, vol.104
, pp. 791-800
-
-
Riedl, S.J.1
Renatus, M.2
Schwarzenbacher, R.3
Zhou, Q.4
Sun, C.5
Fesik, S.W.6
Liddington, R.C.7
Salvesen, G.S.8
-
137
-
-
4444344019
-
Caspase 10 levels are increased following DNA damage in a p53-dependent manner
-
Rikhof B., Corn PG, El-DeiryWS. 2003. Caspase 10 levels are increased following DNA damage in a p53-dependent manner. Cancer Biol Ther 2: 707-712.
-
(2003)
Cancer Biol Ther
, vol.2
, pp. 707-712
-
-
Rikhof, B.1
Corn, P.G.2
El-Deiry, W.S.3
-
138
-
-
0037119491
-
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposideinduced apoptosis
-
Robertson J.D., Enoksson M, Suomela M, Zhivotovsky B, Orrenius S. 2002. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposideinduced apoptosis. J Biol Chem 277: 29803-29809.
-
(2002)
J Biol Chem
, vol.277
, pp. 29803-29809
-
-
Robertson, J.D.1
Enoksson, M.2
Suomela, M.3
Zhivotovsky, B.4
Orrenius, S.5
-
139
-
-
0345291185
-
Nitric oxide inhibits caspase-3 by S-nitrosation in vivo
-
Rossig L., Fichtlscherer B, Breitschopf K, Haendeler J, Zeiher AM, Mulsch A, Dimmeler S. 1999. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem 274: 6823-6826.
-
(1999)
J Biol Chem
, vol.274
, pp. 6823-6826
-
-
Rossig, L.1
Fichtlscherer, B.2
Breitschopf, K.3
Haendeler, J.4
Zeiher, A.M.5
Mulsch, A.6
Dimmeler, S.7
-
140
-
-
68849085068
-
Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells
-
Rudolf K., Cervinka M, Rudolf E. 2009. Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells. Cancer Invest 27: 704-717.
-
(2009)
Cancer Invest
, vol.27
, pp. 704-717
-
-
Rudolf, K.1
Cervinka, M.2
Rudolf, E.3
-
141
-
-
0036300083
-
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
-
RyooHD, Bergmann A, Gonen H, Ciechanover A, Steller H. 2002. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol 4: 432-438.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 432-438
-
-
Ryoo, H.D.1
Bergmann, A.2
Gonen, H.3
Ciechanover, A.4
Steller, H.5
-
142
-
-
0032536771
-
Two CD95 (APO-1/Fas) signaling pathways
-
Scaffidi C., Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME. 1998. Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17: 1675-1687.
-
(1998)
EMBO J
, vol.17
, pp. 1675-1687
-
-
Scaffidi, C.1
Fulda, S.2
Srinivasan, A.3
Friesen, C.4
Li, F.5
Tomaselli, K.J.6
Debatin, K.M.7
Krammer, P.H.8
Peter, M.E.9
-
144
-
-
33646087420
-
The apoptosome: Physiological, developmental, and pathological modes of regulation
-
Schafer Z.T., Kornbluth S. 2006. The apoptosome: Physiological, developmental, and pathological modes of regulation. Dev Cell 10: 549-561.
-
(2006)
Dev Cell
, vol.10
, pp. 549-561
-
-
Schafer, Z.T.1
Kornbluth, S.2
-
145
-
-
50049110244
-
Regulation of apoptosis by XIAP ubiquitin-ligase activity
-
Schile A.J., Garcia-Fernandez M, Steller H. 2008. Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev 22: 2256-2266.
-
(2008)
Genes Dev
, vol.22
, pp. 2256-2266
-
-
Schile, A.J.1
Garcia-Fernandez, M.2
Steller, H.3
-
146
-
-
69249222504
-
p38α-and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress
-
Seifert A., Clarke PR. 2009. p38α-and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress. Cell Signal 21: 1626-1633.
-
(2009)
Cell Signal
, vol.21
, pp. 1626-1633
-
-
Seifert, A.1
Clarke, P.R.2
-
147
-
-
56849127175
-
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine
-
Seifert A., Allan LA, Clarke PR. 2008. DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. FEBS J 275: 6268-6280.
-
(2008)
FEBS J
, vol.275
, pp. 6268-6280
-
-
Seifert, A.1
Allan, L.A.2
Clarke, P.R.3
-
148
-
-
37549062115
-
Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility
-
Senft J., Helfer B, Frisch SM. 2007. Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility. Cancer Res 67: 11505-11509.
-
(2007)
Cancer Res
, vol.67
, pp. 11505-11509
-
-
Senft, J.1
Helfer, B.2
Frisch, S.M.3
-
149
-
-
0033593201
-
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
-
Seol D.W., Billiar TR. 1999. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis. J Biol Chem 274: 2072-2076.
-
(1999)
J Biol Chem
, vol.274
, pp. 2072-2076
-
-
Seol, D.W.1
Billiar, T.R.2
-
150
-
-
57049143644
-
Regulation of the Drosophila apoptosome through feedback inhibition
-
Shapiro P.J., Hsu HH, Jung H, Robbins ES, Ryoo HD. 2008. Regulation of the Drosophila apoptosome through feedback inhibition. Nat Cell Biol 10: 1440-1446.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1440-1446
-
-
Shapiro, P.J.1
Hsu, H.H.2
Jung, H.3
Robbins, E.S.4
Ryoo, H.D.5
-
151
-
-
27144512715
-
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8
-
Shin S., Lee Y, KimW, Ko H, Choi H, Kim K. 2005. Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8. EMBO J 24: 3532-3542.
-
(2005)
EMBO J
, vol.24
, pp. 3532-3542
-
-
Shin, S.1
Lee, Y.2
Kim, W.3
Ko, H.4
Choi, H.5
Kim, K.6
-
152
-
-
0037291737
-
Mechanism of XIAP-mediated inhibition of caspase-9
-
Shiozaki E.N., Chai J, Rigotti DJ, Riedl SJ, Li P, Srinivasula SM, Alnemri ES, Fairman R, Shi Y. 2003. Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell 11: 519-527.
-
(2003)
Mol Cell
, vol.11
, pp. 519-527
-
-
Shiozaki, E.N.1
Chai, J.2
Rigotti, D.J.3
Riedl, S.J.4
Li, P.5
Srinivasula, S.M.6
Alnemri, E.S.7
Fairman, R.8
Shi, Y.9
-
153
-
-
78549234102
-
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a
-
Shultz J.C., Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, Minna JD, Chalfant CE. 2010. Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res 70: 9185-9196.
-
(2010)
Cancer Res
, vol.70
, pp. 9185-9196
-
-
Shultz, J.C.1
Goehe, R.W.2
Wijesinghe, D.S.3
Murudkar, C.4
Hawkins, A.J.5
Shay, J.W.6
Minna, J.D.7
Chalfant, C.E.8
-
154
-
-
44149090307
-
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3
-
Sidi S., Sanda T, Kennedy RD, Hagen AT, Jette CA, Hoffmans R, Pascual J, Imamura S, Kishi S, Amatruda JF, et al. 2008. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133: 864-877.
-
(2008)
Cell
, vol.133
, pp. 864-877
-
-
Sidi, S.1
Sanda, T.2
Kennedy, R.D.3
Hagen, A.T.4
Jette, C.A.5
Hoffmans, R.6
Pascual, J.7
Imamura, S.8
Kishi, S.9
Amatruda, J.F.10
-
155
-
-
84875138006
-
Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation
-
Silke J., Meier P. 2013. Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation. Cold Spring Harb Perspect Biol 5: a008730.
-
(2013)
Cold Spring Harb Perspect Biol
, vol.5
-
-
Silke, J.1
Meier, P.2
-
156
-
-
0032785181
-
Serial killers: Ordering caspase activation events in apoptosis
-
Slee E.A., Adrain C, Martin SJ. 1999. Serial killers: Ordering caspase activation events in apoptosis. Cell Death Differ 6: 1067-1074.
-
(1999)
Cell Death Differ
, vol.6
, pp. 1067-1074
-
-
Slee, E.A.1
Adrain, C.2
Martin, S.J.3
-
157
-
-
0037009370
-
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
-
Sprick M.R., Rieser E, Stahl H, Grosse-Wilde A, Weigand MA, Walczak H. 2002. Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. EMBO J 21: 4520-4530.
-
(2002)
EMBO J
, vol.21
, pp. 4520-4530
-
-
Sprick, M.R.1
Rieser, E.2
Stahl, H.3
Grosse-Wilde, A.4
Weigand, M.A.5
Walczak, H.6
-
158
-
-
0033104331
-
Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis
-
Srinivasula S.M., Ahmad M, Guo Y, Zhan Y, Lazebnik Y, Fernandes-Alnemri T., Alnemri ES. 1999. Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis. Cancer Res 59: 999-1002.
-
(1999)
Cancer Res
, vol.59
, pp. 999-1002
-
-
Srinivasula, S.M.1
Ahmad, M.2
Guo, Y.3
Zhan, Y.4
Lazebnik, Y.5
Fernandes-Alnemri, T.6
Alnemri, E.S.7
-
159
-
-
0035282570
-
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
-
Srinivasula S.M., Hegde R, Saleh A, Datta P, Shiozaki E, Chai J., Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y., et al. 2001. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 410: 112-116.
-
(2001)
Nature
, vol.410
, pp. 112-116
-
-
Srinivasula, S.M.1
Hegde, R.2
Saleh, A.3
Datta, P.4
Shiozaki, E.5
Chai, J.6
Lee, R.A.7
Robbins, P.D.8
Fernandes-Alnemri, T.9
Shi, Y.10
-
160
-
-
0034283578
-
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
-
Stennicke H.R., Renatus M, Meldal M, Salvesen GS. 2000. Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8. Biochem J 350 (Pt 2): 563-568.
-
(2000)
Biochem J
, vol.350
, Issue.PART 2
, pp. 563-568
-
-
Stennicke, H.R.1
Renatus, M.2
Meldal, M.3
Salvesen, G.S.4
-
161
-
-
0035902601
-
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
-
Suzuki Y., Nakabayashi Y, Takahashi R. 2001. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci 98: 8662-8667.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 8662-8667
-
-
Suzuki, Y.1
Nakabayashi, Y.2
Takahashi, R.3
-
162
-
-
4844222278
-
Regulation of caspase-6 and FLIP by the AMPK family member ARK5
-
Suzuki A., Kusakai G, Kishimoto A, Shimojo Y, Miyamoto S, Ogura T., Ochiai A, Esumi H. 2004. Regulation of caspase-6 and FLIP by the AMPK family member ARK5. Oncogene 23: 7067-7075.
-
(2004)
Oncogene
, vol.23
, pp. 7067-7075
-
-
Suzuki, A.1
Kusakai, G.2
Kishimoto, A.3
Shimojo, Y.4
Miyamoto, S.5
Ogura, T.6
Ochiai, A.7
Esumi, H.8
-
163
-
-
0030970013
-
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
-
Thome M., Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, Mattmann C, Burns K, Bodmer JL, Schroter M., et al. 1997. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386: 517-521.
-
(1997)
Nature
, vol.386
, pp. 517-521
-
-
Thome, M.1
Schneider, P.2
Hofmann, K.3
Fickenscher, H.4
Meinl, E.5
Neipel, F.6
Mattmann, C.7
Burns, K.8
Bodmer, J.L.9
Schroter, M.10
-
164
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson CB. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462.
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
165
-
-
0032575750
-
Caspases: Enemies within
-
Thornberry N.A., Lazebnik Y. 1998. Caspases: Enemies within. Science 281: 1312-1316.
-
(1998)
Science
, vol.281
, pp. 1312-1316
-
-
Thornberry, N.A.1
Lazebnik, Y.2
-
166
-
-
0030849093
-
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
-
Thornberry N.A., Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S., Vaillancourt JP, et al. 1997. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 272: 17907-17911.
-
(1997)
J Biol Chem
, vol.272
, pp. 17907-17911
-
-
Thornberry, N.A.1
Rano, T.A.2
Peterson, E.P.3
Rasper, D.M.4
Timkey, T.5
Garcia-Calvo, M.6
Houtzager, V.M.7
Nordstrom, P.A.8
Roy, S.9
Vaillancourt, J.P.10
-
167
-
-
2442453730
-
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
-
Tinel A., Tschopp J. 2004. The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science 304: 843-846.
-
(2004)
Science
, vol.304
, pp. 843-846
-
-
Tinel, A.1
Tschopp, J.2
-
168
-
-
0037085929
-
Nitric oxide inhibits apoptosis downstream of cytochrome c release by nitrosylating caspase 9
-
Torok N.J., Higuchi H, Bronk S, Gores GJ. 2002. Nitric oxide inhibits apoptosis downstream of cytochrome c release by nitrosylating caspase 9. Cancer Res 62: 1648-1653.
-
(2002)
Cancer Res
, vol.62
, pp. 1648-1653
-
-
Torok, N.J.1
Higuchi, H.2
Bronk, S.3
Gores, G.J.4
-
169
-
-
0024347970
-
Monoclonal antibodymediated tumor regression by induction of apoptosis
-
Trauth B.C., Klas C, Peters AM, Matzku S, Moller P, Falk W, Debatin K.M., Krammer PH. 1989. Monoclonal antibodymediated tumor regression by induction of apoptosis. Science 245: 301-305.
-
(1989)
Science
, vol.245
, pp. 301-305
-
-
Trauth, B.C.1
Klas, C.2
Peters, A.M.3
Matzku, S.4
Moller, P.5
Falk, W.6
Debatin, K.M.7
Krammer, P.H.8
-
170
-
-
30344459150
-
In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis
-
Tu S., McStay GP, Boucher LM, Mak T, Beere HM, Green DR. 2006. In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis. Nat Cell Biol 8: 72-77.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 72-77
-
-
Tu, S.1
McStay, G.P.2
Boucher, L.M.3
Mak, T.4
Beere, H.M.5
Green, D.R.6
-
171
-
-
33748685227
-
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage
-
Vakifahmetoglu H., Olsson M, Orrenius S, Zhivotovsky B. 2006. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene 25: 5683-5692.
-
(2006)
Oncogene
, vol.25
, pp. 5683-5692
-
-
Vakifahmetoglu, H.1
Olsson, M.2
Orrenius, S.3
Zhivotovsky, B.4
-
172
-
-
27144473929
-
Caspase-specific and nonspecific in vivo protein processing during Fasinduced apoptosis
-
Van Damme P, Martens L, Van Damme J, Hugelier K, Staes A, Vandekerckhove J, Gevaert K. 2005. Caspase-specific and nonspecific in vivo protein processing during Fasinduced apoptosis. Nat Methods 2: 771-777.
-
(2005)
Nat Methods
, vol.2
, pp. 771-777
-
-
van Damme, P.1
Martens, L.2
van Damme, J.3
Hugelier, K.4
Staes, A.5
Vandekerckhove, J.6
Gevaert, K.7
-
173
-
-
82755198022
-
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: The caspase-8 dimer controls cell fate
-
van Raam BJ, Salvesen GS. 2012. Proliferative versus apoptotic functions of caspase-8 Hetero or homo: The caspase-8 dimer controls cell fate. Biochim Biophys Acta 1824: 113-122.
-
(2012)
Biochim Biophys Acta
, vol.1824
, pp. 113-122
-
-
van Raam, B.J.1
Salvesen, G.S.2
-
174
-
-
20444440707
-
Regulation of monocyte apoptosis by the protein kinase Cd-dependent phosphorylation of caspase-3
-
Voss O.H., Kim S, WewersMD, Doseff AI. 2005. Regulation of monocyte apoptosis by the protein kinase Cd-dependent phosphorylation of caspase-3. J Biol Chem 280: 17371-17379.
-
(2005)
J Biol Chem
, vol.280
, pp. 17371-17379
-
-
Voss, O.H.1
Kim, S.2
Wewers, M.D.3
Doseff, A.I.4
-
175
-
-
77957098633
-
Activation and specificity of human caspase-10
-
Wachmann K., Pop C, van Raam BJ, Drag M, Mace PD, Snipas S.J., Zmasek C, Schwarzenbacher R, Salvesen GS, Riedl SJ. 2010. Activation and specificity of human caspase-10. Biochemistry 49: 8307-8315.
-
(2010)
Biochemistry
, vol.49
, pp. 8307-8315
-
-
Wachmann, K.1
Pop, C.2
van Raam, B.J.3
Drag, M.4
Mace, P.D.5
Snipas, S.J.6
Zmasek, C.7
Schwarzenbacher, R.8
Salvesen, G.S.9
Riedl, S.J.10
-
176
-
-
51349139607
-
Executioner caspase-3 and caspase-7 are functionally distinct proteases
-
Walsh J.G., Cullen SP, Sheridan C, Luthi AU, Gerner C, Martin SJ. 2008. Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci 105: 12815-12819.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 12815-12819
-
-
Walsh, J.G.1
Cullen, S.P.2
Sheridan, C.3
Luthi, A.U.4
Gerner, C.5
Martin, S.J.6
-
177
-
-
0035923653
-
Caspase-10 is an initiator caspase in death receptor signaling
-
Wang J., Chun HJ, WongW, Spencer DM, Lenardo MJ. 2001. Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci 98: 13884-13888.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 13884-13888
-
-
Wang, J.1
Chun, H.J.2
Wong, W.3
Spencer, D.M.4
Lenardo, M.J.5
-
178
-
-
78049347657
-
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation
-
Wang X.J., Cao Q, Liu X, Wang KT, Mi W, Zhang Y, Li LF, LeBlanc AC, Su XD. 2010. Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. EMBO Rep 11: 841-847.
-
(2010)
EMBO Rep
, vol.11
, pp. 841-847
-
-
Wang, X.J.1
Cao, Q.2
Liu, X.3
Wang, K.T.4
Mi, W.5
Zhang, Y.6
Li, L.F.7
LeBlanc, A.C.8
Su, X.D.9
-
179
-
-
0036300214
-
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
-
Wilson R., Goyal L, Ditzel M, Zachariou A, Baker DA, Agapite J., Steller H, Meier P. 2002. The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat Cell Biol 4: 445-450.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 445-450
-
-
Wilson, R.1
Goyal, L.2
Ditzel, M.3
Zachariou, A.4
Baker, D.A.5
Agapite, J.6
Steller, H.7
Meier, P.8
-
180
-
-
0036300215
-
Drosophila Morgue is an F box/ ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
-
Wing J.P., Schreader BA, Yokokura T, Wang Y, Andrews PS, Huseinovic N., Dong CK, Ogdahl JL, Schwartz LM, White K., et al. 2002. Drosophila Morgue is an F box/ ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat Cell Biol 4: 451-456.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 451-456
-
-
Wing, J.P.1
Schreader, B.A.2
Yokokura, T.3
Wang, Y.4
Andrews, P.S.5
Huseinovic, N.6
Dong, C.K.7
Ogdahl, J.L.8
Schwartz, L.M.9
White, K.10
-
181
-
-
28444491105
-
Mechanisms of apoptosis through structural biology
-
Yan N., Shi Y. 2005. Mechanisms of apoptosis through structural biology. Annu Rev Cell Dev Biol 21: 35-56.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 35-56
-
-
Yan, N.1
Shi, Y.2
-
182
-
-
0032575723
-
Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
-
Yang X., Chang HY, Baltimore D. 1998. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281: 1355-1357.
-
(1998)
Science
, vol.281
, pp. 1355-1357
-
-
Yang, X.1
Chang, H.Y.2
Baltimore, D.3
-
183
-
-
77956880563
-
Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc
-
Yang C.S., Thomenius MJ, Gan EC, Tang W, Freel CD, Merritt T.J., Nutt LK, Kornbluth S. 2010. Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc. EMBO J 29: 3196-3207.
-
(2010)
EMBO J
, vol.29
, pp. 3196-3207
-
-
Yang, C.S.1
Thomenius, M.J.2
Gan, E.C.3
Tang, W.4
Freel, C.D.5
Merritt, T.J.6
Nutt, L.K.7
Kornbluth, S.8
-
184
-
-
58149464289
-
The Jekyll and Hyde functions of caspases
-
Yi C.H., Yuan J. 2009. The Jekyll and Hyde functions of caspases. Dev Cell 16: 21-34.
-
(2009)
Dev Cell
, vol.16
, pp. 21-34
-
-
Yi, C.H.1
Yuan, J.2
-
185
-
-
0034641936
-
Apoptosis in the nervous system
-
Yuan J., Yankner BA. 2000. Apoptosis in the nervous system. Nature 407: 802-809.
-
(2000)
Nature
, vol.407
, pp. 802-809
-
-
Yuan, J.1
Yankner, B.A.2
-
186
-
-
0027525104
-
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme
-
Yuan J., Shaham S, Ledoux S, Ellis HM, Horvitz HR. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme. Cell 75: 641-652.
-
(1993)
Cell
, vol.75
, pp. 641-652
-
-
Yuan, J.1
Shaham, S.2
Ledoux, S.3
Ellis, H.M.4
Horvitz, H.R.5
-
187
-
-
77952652352
-
Structure of an apoptosome-procaspase-9 CARD complex
-
Yuan S., Yu X, Topf M, Ludtke SJ, Wang X, Akey CW. 2010. Structure of an apoptosome-procaspase-9 CARD complex. Structure 18: 571-583.
-
(2010)
Structure
, vol.18
, pp. 571-583
-
-
Yuan, S.1
Yu, X.2
Topf, M.3
Ludtke, S.J.4
Wang, X.5
Akey, C.W.6
-
188
-
-
0030745646
-
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
-
Zou H., Henzel WJ, Liu X, Lutschg A, Wang X. 1997. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413.
-
(1997)
Cell
, vol.90
, pp. 405-413
-
-
Zou, H.1
Henzel, W.J.2
Liu, X.3
Lutschg, A.4
Wang, X.5
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