Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1

Nature Cell Biology

Volumn 4, Issue 6, 2002, Pages 432-438

  Ryoo, Hyung Don ^a   Bergmann, Andreas ^b   Gonen, Hedva ^c   Ciechanover, Aaron ^c   Steller, Hermann ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CYTOKINE; HEAD INVOLUTION DEFECTIVE PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; PROTEIN RPR; PROTEIN UBCD1; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; GENE MUTATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; REGULATORY MECHANISM;

AGE FACTORS; ANIMALS; APOPTOSIS; CASPASES; CELL COUNT; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INHIBITOR OF APOPTOSIS PROTEINS; LIGASES; MUTAGENESIS; NEURONS, AFFERENT; NEUROPEPTIDES; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RNA PROCESSING, POST-TRANSCRIPTIONAL; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES;

ANIMALIA; ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; INTRACISTERNAL A-PARTICLES; MELANOGASTER;

EID: 0036300083     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb795     Document Type: Article

References (53)

1. Programmed cell death in animal development
2. The biochemistry of apoptosis
3. Cell death inhibition: Keeping caspases in check
4. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
5. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID
6. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function
7. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila
8. Structural analysis of a functional DIAP1 fragment bound to grim and hid peptides
9. Genetic control of programmed cell death in Drosophila
10. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP proteins
11. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
12. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts IAP-caspase interaction
13. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a Reaper-like motif
14. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
15. HtrA2 promotes cell death through its serine protease activity and its ability to antagonise inhibitor of apoptosis proteins
16. RING finger proteins: Mediators of ubiquitin ligase activity
17. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin protein ligase and promotes in vitro monoubiquitination of caspase 3 and 7
18. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
19. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
20. Mechanisms of compartment formation: Evidence that non-proliferating cells do not play a critical role in defining the D/V lineage restriction in the developing wing of Drosophila
21. Prevention of apoptosis by a baculovirus gene during infection of insect cells
22. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
23. The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye
24. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
25. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signalling
26. Ras promotes cell survival in Drosophila by downregulating hid expression
27. The RING finger of DIAP1 is essential for regulating apoptosis
28. Identification of an essential gene, l(3)73Ai, with a dominant temperature-sensitive lethal allele, encoding a Drosophila proteasome subunit
29. The fat facets gene is required for Drosophila eye and embryo development
30. Drosophila UbcD1 encodes a highly conserved ubiquitin conjugating enzyme involved in selective protein degradation
31. UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behaviour
32. A genetic screen to identify components of the sina signaling pathway in Drosophila eye development
33. Identification of a novel family of ubiquitin-conjugating enzymes with distinct amino-terminal extensions
34. The Drosophila caspase DRONC is regulated by DIAP1
35. An essential role for the caspase dronc in developmentally programmed cell death in Drosophila
36. Analysis of genetic mosaics in developing and adult Drosophila tissues
37. Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
38. Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway
39. Bcl-2 and bax mammalian regulators of apoptosis are functional in Drosophila
40. Steroid regulation of programmed cell death during Drosophila development
41. E93 directs steroid-triggered programmed cell death in Drosophila
42. A steroid-triggered transcriptional hierarachy controls salivary gland cell death during Drosophila metamorphosis
43. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
44. Cell killing by the Drosophila gene reaper
45. The head involution defective gene of Drosophila melanogaster functions in programmed cell death
46. Cooperative functions of the reaper and head involution defective genes in programmed cell death of Drosophila CNS midline cells
47. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
48. Visualization of gene expression in living adult Drosophila
49. Allocation of the thoracic imaginal primordia in the Drosophila embryo
50. Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition
51. Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1
52. Drosophila Morgue is a novel F box/ubiquitin conjugase domain protein important for grim-reaper-mediated apoptosis
53. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms