Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8

EMBO Journal

Volumn 21, Issue 17, 2002, Pages 4520-4530

  Sprick, Martin R ^a   Rieser, Eva ^a   Stahl, Heiko ^a   Grosse Wilde, Anne ^a   Weigand, Markus A ^a,b   Walczak, Henning ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Caspase; CD95 (APO 1 Fas); Death receptor; Death inducing signalling complex; TRAIL

Indexed keywords

ADAPTOR PROTEIN; CASPASE 10; CASPASE 8; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ANTIGENS, CD95; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; B-LYMPHOCYTES; CARRIER PROTEINS; CASPASE 10; CASPASE 8; CASPASE 9; CASPASES; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME INDUCTION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037009370     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf441     Document Type: Article

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