Caspases 3 and 7: Key mediators of mitochondrial events of apoptosis

Science

Volumn 311, Issue 5762, 2006, Pages 847-851

  Lakhani, Saquib A ^a   Masud, Ali ^a   Kuida, Keisuke ^b   Porter Jr , George A ^a   Booth, Carmen J ^a   Mehal, Wajahat Z ^a   Inayat, Irteza ^a   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BIOTECHNOLOGY; CARDIOLOGY; CELLS; DEFECTS;

APOPTOSIS; APOPTOSIS-INDUCING FACTORS (AIF); NUCLEAR TRANSLOCATIONS;

ENZYME KINETICS;

APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 7; CYTOCHROME C; DEATH RECEPTOR; PROTEIN BAX;

BIOLOGY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MEMBRANE POTENTIAL; CONGENITAL HEART MALFORMATION; EMBRYO; ENZYME ACTIVATION; ENZYME DEFICIENCY; FIBROBLAST; HEART DEVELOPMENT; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; APOPTOSIS INDUCING FACTOR; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 7; CASPASES; CELL NUCLEUS; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; DNA FRAGMENTATION; FEMALE; FIBROBLASTS; HEART; HEART DEFECTS, CONGENITAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PERMEABILITY; T-LYMPHOCYTES;

ANIMALIA;

EID: 32444434664     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1115035     Document Type: Article

References (22)

1. G. van Loo et al., Cell Death Differ. 9, 1031 (2002).
2. A. P. Halestrap, G. P. McStay, S. J. Clarke, Biochimie 84, 1S3 (2002).
3. D. R. Green, G. Kroemer, Science 305, 626 (2004).
4. M. C. Wei et al., Science 292, 727 (2001).
5. Y. Quo, S. M. Srinivasula, A. Druilhe, T. Fernandes-Alnemri, E. S. Alnemri, J. Biol. Chem. 277, 13430 (2002).
6. H. Li, H. Zhu, C. J. Xu, J. Yuan, Cell 94, 491 (1998).
7. J. A. Lippke, Y. Gu, C. Sarnecki, P. R. Caron, M. S. Su, J. Biol. Chem. 271, 1825 (1996).
8. T. S. Zheng et al., Nat. Med. 6, 1241 (2000).
9. K. Kuida et al., Nature 384, 368 (1996).
10. J. R. Leonard, B. J. Klocke, C. D'Sa, R. A. Flavell, K. A. Roth, J. Neuropathol. Exp. Neurol. 61, 673 (2002).
11. E. E. Varfolomeev et al., Immunity 9, 267 (1998).
12. W. C. Yeh et al., Science 279, 1954 (1998).
13. W. C. Yeh et al., Immunity 12, 633 (2000).
14. M. Woo et al., Genes Dev. 12, 806 (1998).
15. E. Bossy-Wetzel, D. D. Newmeyer, D. R. Green, EMBO J. 17, 37 (1998).
16. J. E. Ricci, R. A. Gottlieb, D. R. Green, J. Cell Biol. 160, 65 (2003).
17. J. E. Ricci et al. Cell 117, 773 (2004).
18. G. Hausmann et al., J. Cell Biol. 149, 623 (2000).
19. V. S. Marsden et al., Nature 419, 634 (2002).
20. S. A. Susin et al., Nature 397, 441 (1999).
21. C. Cande, N. Vahsen, C. Garrido, G. Kroemer, Cell Death Differ. 11, 591 (2004).
22. The authors wish to thank Y. Lazebnik (Cold Spring Harbor) for caspase 7 antibody and Biogen Idee for their contribution of interleukin-2; Yale Liver Center Core Facilities for hepatocyte preparation; A. Ferrandino and A. Mohapatra for technical assistance; and F. Manzo for assistance with manuscript preparation. This work was supported in part by NIH grants K12 HD00850, 5 K12 HD01401, 1 K08 HD044580 (S.A.L.); Liver Center Grant NIDDK P30-34989 (R.A.F.); R.A.F. is an investigator of the Howard Hughes Medical Institute.