Nitric oxide prevents tumor necrosis factor α-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8

Hepatology

Volumn 32, Issue 4 I, 2000, Pages 770-778

  Kim, Young Myeong ^a,b   Kim, Tae Hyoung ^c   Chung, Hun Taeg ^d   Talanian, Robert V ^e   Yin, Xiao Ming ^c   Billiar, Timothy R ^b  

^a Kangwon National University   (South Korea)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d Wonkwang University   (South Korea)

^e BASF Bioresearch Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; CYTOCHROME C OXIDASE; DACTINOMYCIN; GAMMA INTERFERON; INTERLEUKIN 1BETA; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MODIFICATION; LIVER CELL; LIVER MITOCHONDRION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033797774     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2000.18291     Document Type: Article

References (52)

1. Mechanisms and genes of cellular suicide
2. Apoptosis in the pathogenesis and treatment of disease
3. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
4. A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
5. Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling
6. Caspase-14 is a novel developmentally regulated protease
7. Caspases: Enemies within
8. Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases
9. Death receptors: Signaling and modulation
10. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
11. Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis
12. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
13. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
14. Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release
15. Blocking cytochrome c activity within intact neurons inhibits apoptosis
16. Caspases induce cytochrome c release from mitochondria by activating cytosolic factors
17. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
18. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
19. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-Rl/Fas death
20. Nitric oxide as a secretory product of mammalian cells
21. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity
22. Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes
23. Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration
24. Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms
25. Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis
26. Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes
27. Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation
28. BID: A novel BH3 domain-only death agonist
29. Nonheme iron-nitrosyl complex formation in rat hepatocytes: Detection by electron paramagnetic resonance spectroscopy
30. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
31. Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
32. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver
33. Apaf-1 is required for mitochondrial pathways of apoptosis and brain development
34. Bax membrane insertion during Fas(CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2
35. Nitric oxide (NO): An effector of apoptosis
36. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide
37. Nitrogen oxide-induced autoprotection in isolated rat hepatocytes
38. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation
39. Splenic B lymphocyte programmed cell death is prevented by nitric oxide release through mechanisms involving sustained Bcl-2 levels
40. Disruption of fas receptor signaling by nitric oxide in eosinophils
41. Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production
42. Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release
43. Nitric oxide inhibits Fas-induced apoptosis
44. Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression
45. Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor
46. Fas-induced caspase denitrosylation
47. Mass spectrometric analysis of nitric oxide-modified caspase-3
48. LPS challenge in D-galactosamine-sensitized mice accounts for caspase-dependent fulminant hepatitis, not for septic shock
49. Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death
50. Inhibition of caspase activity prevents CD95-mediated hepatic microvascular perfusion failure and restores Kupffer cell clearance capacity
51. Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia
52. Impaired liver regeneration in inducible nitric oxide synthase deficient mice