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Volumn 65, Issue 6, 2013, Pages 865-879

Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules

Author keywords

Bioavailability; Mucoadhesion; Oral drug delivery; Paracellular pathway; Tight junction; Transcellular pathway

Indexed keywords

BIOAVAILABILITY; MUCOADHESION; ORAL DRUG DELIVERY; PARACELLULAR; TIGHT JUNCTIONS; TRANSCELLULAR PATHWAY;

EID: 84878862620     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.10.010     Document Type: Review
Times cited : (395)

References (173)
  • 1
    • 78650641554 scopus 로고    scopus 로고
    • Nanocarriers for pulmonary administration of peptides and therapeutic proteins
    • Andrade F., Videira M., Ferreira D., Sarmento B. Nanocarriers for pulmonary administration of peptides and therapeutic proteins. Nanomedicine 2011, 6:123-141.
    • (2011) Nanomedicine , vol.6 , pp. 123-141
    • Andrade, F.1    Videira, M.2    Ferreira, D.3    Sarmento, B.4
  • 2
    • 0035888373 scopus 로고    scopus 로고
    • Insulin therapies-past, present and future
    • Pillai O., Panchagnula R. Insulin therapies-past, present and future. Drug Discov. Today 2001, 6:1056-1061.
    • (2001) Drug Discov. Today , vol.6 , pp. 1056-1061
    • Pillai, O.1    Panchagnula, R.2
  • 3
    • 80054061227 scopus 로고    scopus 로고
    • A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery
    • Chen M.C., Sonaje K., Chen K.J., Sung H.W. A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery. Biomaterials 2011, 32:9826-9838.
    • (2011) Biomaterials , vol.32 , pp. 9826-9838
    • Chen, M.C.1    Sonaje, K.2    Chen, K.J.3    Sung, H.W.4
  • 5
    • 0030460690 scopus 로고    scopus 로고
    • Oral controlled release technology for peptides: status and future prospects
    • Fix J.A. Oral controlled release technology for peptides: status and future prospects. Pharm. Res. 1996, 13:1760-1764.
    • (1996) Pharm. Res. , vol.13 , pp. 1760-1764
    • Fix, J.A.1
  • 6
    • 0035813752 scopus 로고    scopus 로고
    • Oral drug absorption enhancement by chitosan and its derivatives
    • Thanou M., Verhoef J., Junginger H. Oral drug absorption enhancement by chitosan and its derivatives. Adv. Drug Deliv. Rev. 2001, 52:117-126.
    • (2001) Adv. Drug Deliv. Rev. , vol.52 , pp. 117-126
    • Thanou, M.1    Verhoef, J.2    Junginger, H.3
  • 7
    • 80052297372 scopus 로고    scopus 로고
    • Chitosan: its applications in drug-eluting devices
    • Chen M.C., Mi F.L., Liao Z.X., Sung H.W. Chitosan: its applications in drug-eluting devices. Adv. Polym. Sci. 2011, 243:185-230.
    • (2011) Adv. Polym. Sci. , vol.243 , pp. 185-230
    • Chen, M.C.1    Mi, F.L.2    Liao, Z.X.3    Sung, H.W.4
  • 8
    • 33747846583 scopus 로고    scopus 로고
    • Chitin and chitosan: properties and applications
    • Rinaudo M. Chitin and chitosan: properties and applications. Prog. Polym. Sci. 2006, 31:603-632.
    • (2006) Prog. Polym. Sci. , vol.31 , pp. 603-632
    • Rinaudo, M.1
  • 9
    • 85007774154 scopus 로고
    • Increasing effect of a chitosan and ascorbic acid mixture on fecal dietary fat excretion
    • Kanauchi O., Deuchi K., Imasato Y., Kobayashi E. Increasing effect of a chitosan and ascorbic acid mixture on fecal dietary fat excretion. Biosci. Biotechnol. Biochem. 1994, 58:1617-1620.
    • (1994) Biosci. Biotechnol. Biochem. , vol.58 , pp. 1617-1620
    • Kanauchi, O.1    Deuchi, K.2    Imasato, Y.3    Kobayashi, E.4
  • 12
    • 0032958073 scopus 로고    scopus 로고
    • Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
    • Roy K., Mao H.Q., Huang S.K., Leong K.W. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat. Med. 1999, 5:387-391.
    • (1999) Nat. Med. , vol.5 , pp. 387-391
    • Roy, K.1    Mao, H.Q.2    Huang, S.K.3    Leong, K.W.4
  • 13
    • 78649905059 scopus 로고    scopus 로고
    • The impact of vehicles on the mucoadhesive properties of orally administrated nanoparticles: a case study with chitosan-4-thiobutylamidine conjugate
    • Sakloetsakun D., Perera G., Hombach J., Millotti G., Bernkop-Schnürch A. The impact of vehicles on the mucoadhesive properties of orally administrated nanoparticles: a case study with chitosan-4-thiobutylamidine conjugate. AAPS PharmSciTech 2010, 11:1185-1192.
    • (2010) AAPS PharmSciTech , vol.11 , pp. 1185-1192
    • Sakloetsakun, D.1    Perera, G.2    Hombach, J.3    Millotti, G.4    Bernkop-Schnürch, A.5
  • 14
    • 80052278049 scopus 로고    scopus 로고
    • Chitosan and its derivatives for drug delivery perspective
    • Sonia T., Sharma C. Chitosan and its derivatives for drug delivery perspective. Adv. Polym. Sci. 2011, 243:23-54.
    • (2011) Adv. Polym. Sci. , vol.243 , pp. 23-54
    • Sonia, T.1    Sharma, C.2
  • 18
    • 70349784917 scopus 로고    scopus 로고
    • The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin
    • Chen M.C., Wong H.S., Lin K.J., Chen H.L., Wey S.P., Sonaje K., Lin Y.H., Chu C.Y., Sung H.W. The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials 2009, 30:6629-6637.
    • (2009) Biomaterials , vol.30 , pp. 6629-6637
    • Chen, M.C.1    Wong, H.S.2    Lin, K.J.3    Chen, H.L.4    Wey, S.P.5    Sonaje, K.6    Lin, Y.H.7    Chu, C.Y.8    Sung, H.W.9
  • 19
    • 35549012407 scopus 로고    scopus 로고
    • Oral bioavailability of insulin contained in polysaccharide nanoparticles
    • Sarmento B., Ribeiro A., Veiga F., Ferreira D., Neufeld R. Oral bioavailability of insulin contained in polysaccharide nanoparticles. Biomacromolecules 2007, 8:3054-3060.
    • (2007) Biomacromolecules , vol.8 , pp. 3054-3060
    • Sarmento, B.1    Ribeiro, A.2    Veiga, F.3    Ferreira, D.4    Neufeld, R.5
  • 20
    • 79251593382 scopus 로고    scopus 로고
    • The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo
    • Nguyen H.N., Wey S.P., Juang J.H., Sonaje K., Ho Y.C., Chuang E.Y., Hsu C.W., Yen T.C., Lin K.J., Sung H.W. The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo. Biomaterials 2011, 32:2673-2682.
    • (2011) Biomaterials , vol.32 , pp. 2673-2682
    • Nguyen, H.N.1    Wey, S.P.2    Juang, J.H.3    Sonaje, K.4    Ho, Y.C.5    Chuang, E.Y.6    Hsu, C.W.7    Yen, T.C.8    Lin, K.J.9    Sung, H.W.10
  • 21
    • 33644922361 scopus 로고    scopus 로고
    • Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery
    • Prego C., Fabre M., Torres D., Alonso M. Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery. Pharm. Res. 2006, 23:549-556.
    • (2006) Pharm. Res. , vol.23 , pp. 549-556
    • Prego, C.1    Fabre, M.2    Torres, D.3    Alonso, M.4
  • 22
    • 33846799473 scopus 로고    scopus 로고
    • Mucoadhesion mechanism of chitosan and thiolated chitosan-poly (isobutyl cyanoacrylate) core-shell nanoparticles
    • Bravo-Osuna I., Vauthier C., Farabollini A., Palmieri G.F., Ponchel G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly (isobutyl cyanoacrylate) core-shell nanoparticles. Biomaterials 2007, 28:2233-2243.
    • (2007) Biomaterials , vol.28 , pp. 2233-2243
    • Bravo-Osuna, I.1    Vauthier, C.2    Farabollini, A.3    Palmieri, G.F.4    Ponchel, G.5
  • 23
    • 0344359721 scopus 로고    scopus 로고
    • Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments
    • Kotze A.F., Luessen H.L., de Boer A.G., Verhoef J.C., Junginger H.E. Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments. Eur. J. Pharm. Sci. 1999, 7:145-151.
    • (1999) Eur. J. Pharm. Sci. , vol.7 , pp. 145-151
    • Kotze, A.F.1    Luessen, H.L.2    de Boer, A.G.3    Verhoef, J.C.4    Junginger, H.E.5
  • 24
  • 25
    • 77950916224 scopus 로고    scopus 로고
    • Insulin-loaded nanoparticles based on N-trimethyl chitosan: in vitro (Caco-2 model) and ex vivo (excised rat jejunum, duodenum, and ileum) evaluation of penetration enhancement properties
    • Sandri G., Bonferoni M.C., Rossi S., Ferrari F., Boselli C., Caramella C. Insulin-loaded nanoparticles based on N-trimethyl chitosan: in vitro (Caco-2 model) and ex vivo (excised rat jejunum, duodenum, and ileum) evaluation of penetration enhancement properties. AAPS PharmSciTech 2010, 11:362-371.
    • (2010) AAPS PharmSciTech , vol.11 , pp. 362-371
    • Sandri, G.1    Bonferoni, M.C.2    Rossi, S.3    Ferrari, F.4    Boselli, C.5    Caramella, C.6
  • 26
    • 0034879035 scopus 로고    scopus 로고
    • Chitosan: some pharmaceutical and biological aspects-an update
    • Singla A., Chawla M. Chitosan: some pharmaceutical and biological aspects-an update. J. Pharm. Pharmacol. 2001, 53:1047-1067.
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 1047-1067
    • Singla, A.1    Chawla, M.2
  • 27
    • 0037472115 scopus 로고    scopus 로고
    • Chitosan-based gastrointestinal delivery systems
    • Hejazi R., Amiji M. Chitosan-based gastrointestinal delivery systems. J. Control. Release 2003, 89:151-165.
    • (2003) J. Control. Release , vol.89 , pp. 151-165
    • Hejazi, R.1    Amiji, M.2
  • 28
    • 0033960143 scopus 로고    scopus 로고
    • Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers
    • Thanou M., Kotze A., Scharringhausen T., Lueßen H., De Boer A., Verhoef J., Junginger H. Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal Caco-2 cell monolayers. J. Control. Release 2000, 64:15-25.
    • (2000) J. Control. Release , vol.64 , pp. 15-25
    • Thanou, M.1    Kotze, A.2    Scharringhausen, T.3    Lueßen, H.4    De Boer, A.5    Verhoef, J.6    Junginger, H.7
  • 29
    • 0038460837 scopus 로고    scopus 로고
    • Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates
    • Bernkop-Schnürch A., Hornof M., Zoidl T. Thiolated polymers-thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates. Int. J. Pharm. 2003, 260:229-237.
    • (2003) Int. J. Pharm. , vol.260 , pp. 229-237
    • Bernkop-Schnürch, A.1    Hornof, M.2    Zoidl, T.3
  • 30
    • 0347985635 scopus 로고    scopus 로고
    • Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation
    • Roldo M., Hornof M., Caliceti P., Bernkop-Schnürch A. Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation. Eur. J. Pharm. Biopharm. 2004, 57:115-121.
    • (2004) Eur. J. Pharm. Biopharm. , vol.57 , pp. 115-121
    • Roldo, M.1    Hornof, M.2    Caliceti, P.3    Bernkop-Schnürch, A.4
  • 31
    • 0346735298 scopus 로고    scopus 로고
    • Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system
    • Bernkop-Schnürch A., Guggi D., Pinter Y. Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. J. Control. Release 2004, 94:177-186.
    • (2004) J. Control. Release , vol.94 , pp. 177-186
    • Bernkop-Schnürch, A.1    Guggi, D.2    Pinter, Y.3
  • 32
    • 33646492929 scopus 로고    scopus 로고
    • Tight junction modulation and its relationship to drug delivery
    • Salama N.N., Eddington N.D., Fasano A. Tight junction modulation and its relationship to drug delivery. Adv. Drug Deliv. Rev. 2006, 58:15-28.
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , pp. 15-28
    • Salama, N.N.1    Eddington, N.D.2    Fasano, A.3
  • 34
    • 0016358918 scopus 로고
    • Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine I. Columnar cell
    • Cheng H., Leblond C.P. Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine I. Columnar cell. Am. J. Anat. 1974, 141:461-479.
    • (1974) Am. J. Anat. , vol.141 , pp. 461-479
    • Cheng, H.1    Leblond, C.P.2
  • 35
    • 85013717278 scopus 로고    scopus 로고
    • 4th edition, in: E.M. Wright, D.D.F. Loo, B.A. Hirayama, and E. Turk (eds.), Chapter 64. Sugar Absorption, edited by Johnson et al. Elsevier Inc., San Diego
    • L.R. Johnson, K.E. Barret, F.K. Gishan, J.L. Merchant, H.M. Said, J.D. Wood, Physiology of the gastrointestinal tract. 4th edition, in: E.M. Wright, D.D.F. Loo, B.A. Hirayama, and E. Turk (eds.), Chapter 64. Sugar Absorption, edited by Johnson et al. Elsevier Inc., San Diego, 2006, pp. 1653-1665.
    • (2006) Physiology of the gastrointestinal tract , pp. 1653-1665
    • Johnson, L.R.1    Barret, K.E.2    Gishan, F.K.3    Merchant, J.L.4    Said, H.M.5    Wood, J.D.6
  • 36
    • 0017686274 scopus 로고
    • Glycoprotein synthesis, transport, and secretion by epithelial cells of human rectal mucosa: normal and cystic fibrosis
    • Neutra M., Grand R., Trier J. Glycoprotein synthesis, transport, and secretion by epithelial cells of human rectal mucosa: normal and cystic fibrosis. Lab. Invest. 1977, 36:535-546.
    • (1977) Lab. Invest. , vol.36 , pp. 535-546
    • Neutra, M.1    Grand, R.2    Trier, J.3
  • 37
    • 0013924545 scopus 로고
    • Synthesis of the carbohydrate of mucus in the Golgi complex as shown by electron microscope radioautography of goblet cells from rats injected with glucose-H3
    • Neutra M., Leblond C. Synthesis of the carbohydrate of mucus in the Golgi complex as shown by electron microscope radioautography of goblet cells from rats injected with glucose-H3. J. Cell Biol. 1966, 30:119-136.
    • (1966) J. Cell Biol. , vol.30 , pp. 119-136
    • Neutra, M.1    Leblond, C.2
  • 38
    • 4544258068 scopus 로고    scopus 로고
    • NALT- versus Peyer's-patch-mediated mucosal immunity
    • Kiyono H., Fukuyama S. NALT- versus Peyer's-patch-mediated mucosal immunity. Nat. Rev. Immunol. 2004, 4:699-710.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 699-710
    • Kiyono, H.1    Fukuyama, S.2
  • 39
    • 33745370633 scopus 로고    scopus 로고
    • Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells
    • Bourdet D.L., Pollack G.M., Thakker D.R. Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells. Pharm. Res. 2006, 23:1178-1187.
    • (2006) Pharm. Res. , vol.23 , pp. 1178-1187
    • Bourdet, D.L.1    Pollack, G.M.2    Thakker, D.R.3
  • 40
    • 33846410236 scopus 로고    scopus 로고
    • Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery
    • Lin Y.H., Mi F.L., Chen C.T., Chang W.C., Peng S.F., Liang H.F., Sung H.W. Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules 2007, 8:146-152.
    • (2007) Biomacromolecules , vol.8 , pp. 146-152
    • Lin, Y.H.1    Mi, F.L.2    Chen, C.T.3    Chang, W.C.4    Peng, S.F.5    Liang, H.F.6    Sung, H.W.7
  • 41
    • 0035722976 scopus 로고    scopus 로고
    • Effect of preparation conditions on properties and permeability of chitosansodium hexametaphosphate capsules
    • Angelova N., Hunkeler D. Effect of preparation conditions on properties and permeability of chitosansodium hexametaphosphate capsules. J. Biomater. Sci. Polym. Ed. 2001, 12:1317-1337.
    • (2001) J. Biomater. Sci. Polym. Ed. , vol.12 , pp. 1317-1337
    • Angelova, N.1    Hunkeler, D.2
  • 42
    • 0036692366 scopus 로고    scopus 로고
    • Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport
    • Behrens I., Pena A.I.V., Alonso M.J., Kissel T. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm. Res. 2002, 19:1185-1193.
    • (2002) Pharm. Res. , vol.19 , pp. 1185-1193
    • Behrens, I.1    Pena, A.I.V.2    Alonso, M.J.3    Kissel, T.4
  • 43
    • 73849149819 scopus 로고    scopus 로고
    • Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes
    • Kadiyala I., Loo Y., Roy K., Rice J., Leong K.W. Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes. Eur. J. Pharm. Sci. 2010, 39:103-109.
    • (2010) Eur. J. Pharm. Sci. , vol.39 , pp. 103-109
    • Kadiyala, I.1    Loo, Y.2    Roy, K.3    Rice, J.4    Leong, K.W.5
  • 44
    • 33751253462 scopus 로고    scopus 로고
    • Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach
    • Des Rieux A., Fievez V., Garinot M., Schneider Y.J., Préat V. Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach. J. Control. Release 2006, 116:1-27.
    • (2006) J. Control. Release , vol.116 , pp. 1-27
    • Des Rieux, A.1    Fievez, V.2    Garinot, M.3    Schneider, Y.J.4    Préat, V.5
  • 45
    • 21744458087 scopus 로고    scopus 로고
    • Nanoparticle uptake by the oral route: fulfilling its potential?
    • Florence A.T. Nanoparticle uptake by the oral route: fulfilling its potential?. Drug Discov. Today 2005, 2:75-81.
    • (2005) Drug Discov. Today , vol.2 , pp. 75-81
    • Florence, A.T.1
  • 46
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: effect of particle size
    • Desai M.P., Labhasetwar V., Amidon G.L., Levy R.J. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 1996, 13:1838-1845.
    • (1996) Pharm. Res. , vol.13 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.2    Amidon, G.L.3    Levy, R.J.4
  • 47
    • 0030993565 scopus 로고    scopus 로고
    • The oral absorption of micro-and nanoparticulates: neither exceptional nor unusual
    • Florence A.T. The oral absorption of micro-and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 1997, 14:259-266.
    • (1997) Pharm. Res. , vol.14 , pp. 259-266
    • Florence, A.T.1
  • 48
    • 57049145802 scopus 로고    scopus 로고
    • Bioavailability of nanoparticles in nutrient and nutraceutical delivery
    • Acosta E. Bioavailability of nanoparticles in nutrient and nutraceutical delivery. Colloid Interface Sci. 2009, 14:3-15.
    • (2009) Colloid Interface Sci. , vol.14 , pp. 3-15
    • Acosta, E.1
  • 49
    • 0035937594 scopus 로고    scopus 로고
    • Mucoadhesive nanoparticulate systems for peptide drug delivery
    • Takeuchi H., Yamamoto H., Kawashima Y. Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv. Drug Deliv. Rev. 2001, 47:39-54.
    • (2001) Adv. Drug Deliv. Rev. , vol.47 , pp. 39-54
    • Takeuchi, H.1    Yamamoto, H.2    Kawashima, Y.3
  • 50
    • 68549122512 scopus 로고    scopus 로고
    • Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery
    • Yin L., Ding J., He C., Cui L., Tang C., Yin C. Drug permeability and mucoadhesion properties of thiolated trimethyl chitosan nanoparticles in oral insulin delivery. Biomaterials 2009, 30:5691-5700.
    • (2009) Biomaterials , vol.30 , pp. 5691-5700
    • Yin, L.1    Ding, J.2    He, C.3    Cui, L.4    Tang, C.5    Yin, C.6
  • 51
    • 0032971987 scopus 로고    scopus 로고
    • Evaluation of the clearance characteristics of bioadhesive systems in humans
    • Soane R., Frier M., Perkins A., Jones N., Davis S., Illum L. Evaluation of the clearance characteristics of bioadhesive systems in humans. Int. J. Pharm. 1999, 178:55-65.
    • (1999) Int. J. Pharm. , vol.178 , pp. 55-65
    • Soane, R.1    Frier, M.2    Perkins, A.3    Jones, N.4    Davis, S.5    Illum, L.6
  • 53
    • 33748131292 scopus 로고    scopus 로고
    • Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination
    • Borges O., Cordeiro-da-Silva A., Romeijn S.G., Amidi M., De Sousa A., Borchard G., Junginger H.E. Uptake studies in rat Peyer's patches, cytotoxicity and release studies of alginate coated chitosan nanoparticles for mucosal vaccination. J. Control. Release 2006, 114:348-358.
    • (2006) J. Control. Release , vol.114 , pp. 348-358
    • Borges, O.1    Cordeiro-da-Silva, A.2    Romeijn, S.G.3    Amidi, M.4    De Sousa, A.5    Borchard, G.6    Junginger, H.E.7
  • 55
    • 19444373410 scopus 로고    scopus 로고
    • θ Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability
    • Banan A., Zhang L., Shaikh M., Fields J., Choudhary S., Forsyth C., Farhadi A., Keshavarzian A. θ Isoform of protein kinase C alters barrier function in intestinal epithelium through modulation of distinct claudin isotypes: a novel mechanism for regulation of permeability. J. Pharmacol. Exp. Ther. 2005, 313:962-982.
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 962-982
    • Banan, A.1    Zhang, L.2    Shaikh, M.3    Fields, J.4    Choudhary, S.5    Forsyth, C.6    Farhadi, A.7    Keshavarzian, A.8
  • 56
    • 0344465840 scopus 로고    scopus 로고
    • Potential role of MCP-1 in endothelial cell tight junction opening: signaling via Rho and Rho kinase
    • Stamatovic S.M., Keep R.F., Kunkel S.L., Andjelkovic A.V. Potential role of MCP-1 in endothelial cell tight junction opening: signaling via Rho and Rho kinase. J. Cell Sci. 2003, 116:4615-4628.
    • (2003) J. Cell Sci. , vol.116 , pp. 4615-4628
    • Stamatovic, S.M.1    Keep, R.F.2    Kunkel, S.L.3    Andjelkovic, A.V.4
  • 58
    • 67650306418 scopus 로고    scopus 로고
    • Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers
    • Sheth P., Samak G., Shull J., Seth A., Rao R. Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers. Biochem. J. 2009, 421:59-70.
    • (2009) Biochem. J. , vol.421 , pp. 59-70
    • Sheth, P.1    Samak, G.2    Shull, J.3    Seth, A.4    Rao, R.5
  • 59
    • 0034599992 scopus 로고    scopus 로고
    • Pores in the wall: claudins constitute tight junction strands containing aqueous pores
    • Tsukita S., Furuse M. Pores in the wall: claudins constitute tight junction strands containing aqueous pores. J. Cell Biol. 2000, 149:13-16.
    • (2000) J. Cell Biol. , vol.149 , pp. 13-16
    • Tsukita, S.1    Furuse, M.2
  • 60
    • 79959876473 scopus 로고    scopus 로고
    • Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening
    • Yeh T.H., Hsu L.W., Tseng M.T., Lee P.L., Sonjae K., Ho Y.C., Sung H.W. Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening. Biomaterials 2011, 32:6164-6173.
    • (2011) Biomaterials , vol.32 , pp. 6164-6173
    • Yeh, T.H.1    Hsu, L.W.2    Tseng, M.T.3    Lee, P.L.4    Sonjae, K.5    Ho, Y.C.6    Sung, H.W.7
  • 61
    • 84860726458 scopus 로고    scopus 로고
    • Opening of epithelial tight junctions and enhancement of paracellular permeation by chitosan: microscopic, ultra-structural and computed-tomographic observations
    • Sonaje K., Chuang E.Y., Lin K.J., Yen T.C., Su F.Y., Tseng M.T., Sung H.W. Opening of epithelial tight junctions and enhancement of paracellular permeation by chitosan: microscopic, ultra-structural and computed-tomographic observations. Mol. Pharm. 2012, 10.1021/mp200572t.
    • (2012) Mol. Pharm.
    • Sonaje, K.1    Chuang, E.Y.2    Lin, K.J.3    Yen, T.C.4    Su, F.Y.5    Tseng, M.T.6    Sung, H.W.7
  • 62
    • 33646085268 scopus 로고
    • PH and cd measurements on a fully deacetylated chitosan: application to CuII-polymer interactions
    • Domard A. pH and cd measurements on a fully deacetylated chitosan: application to CuII-polymer interactions. Int. J. Biol. Macromol. 1987, 9:98-104.
    • (1987) Int. J. Biol. Macromol. , vol.9 , pp. 98-104
    • Domard, A.1
  • 63
    • 0025954040 scopus 로고
    • (B) Mechanisms of peptide and protein absorption: (1) paracellular intestinal transport: modulation of absorption
    • Nellans H.N. (B) Mechanisms of peptide and protein absorption: (1) paracellular intestinal transport: modulation of absorption. Adv. Drug Deliv. Rev. 1991, 7:339-364.
    • (1991) Adv. Drug Deliv. Rev. , vol.7 , pp. 339-364
    • Nellans, H.N.1
  • 64
    • 0029102179 scopus 로고
    • Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers
    • Adson A., Burton P.S., Raub T.J., Barsuhn C.L., Audus K.L., Ho N.F. Passive diffusion of weak organic electrolytes across Caco-2 cell monolayers: uncoupling the contributions of hydrodynamic, transcellular, and paracellular barriers. J. Pharm. Sci. 1995, 84:1197-1204.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 1197-1204
    • Adson, A.1    Burton, P.S.2    Raub, T.J.3    Barsuhn, C.L.4    Audus, K.L.5    Ho, N.F.6
  • 65
    • 60849130683 scopus 로고    scopus 로고
    • In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
    • Sonaje K., Lin Y.H., Juang J.H., Wey S.P., Chen C.T., Sung H.W. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 2009, 30:2329-2339.
    • (2009) Biomaterials , vol.30 , pp. 2329-2339
    • Sonaje, K.1    Lin, Y.H.2    Juang, J.H.3    Wey, S.P.4    Chen, C.T.5    Sung, H.W.6
  • 66
  • 67
    • 75149149000 scopus 로고    scopus 로고
    • Chitosan-based hydrogels for controlled, localized drug delivery
    • Bhattarai N., Gunn J., Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Adv. Drug Deliv. Rev. 2010, 62:83-99.
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 83-99
    • Bhattarai, N.1    Gunn, J.2    Zhang, M.3
  • 68
    • 79955478547 scopus 로고    scopus 로고
    • Chitosan-A versatile semi-synthetic polymer in biomedical applications
    • Dash M., Chiellini F., Ottenbrite R., Chiellini E. Chitosan-A versatile semi-synthetic polymer in biomedical applications. Prog. Polym. Sci. 2011, 36:981-1014.
    • (2011) Prog. Polym. Sci. , vol.36 , pp. 981-1014
    • Dash, M.1    Chiellini, F.2    Ottenbrite, R.3    Chiellini, E.4
  • 69
    • 33746474818 scopus 로고    scopus 로고
    • Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan-a review
    • George M., Abraham T.E. Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan-a review. J. Control. Release 2006, 114:1-14.
    • (2006) J. Control. Release , vol.114 , pp. 1-14
    • George, M.1    Abraham, T.E.2
  • 70
    • 4444246205 scopus 로고    scopus 로고
    • Chemically modified chitin and chitosan as biomaterials
    • Sashiwa H., Aiba S. Chemically modified chitin and chitosan as biomaterials. Prog. Polym. Sci. 2004, 29:887-908.
    • (2004) Prog. Polym. Sci. , vol.29 , pp. 887-908
    • Sashiwa, H.1    Aiba, S.2
  • 71
    • 0033007333 scopus 로고    scopus 로고
    • Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2)
    • Kotzé A.F., Thanou M.M., Lueben H.L., De Boer A., Verhoef J., Junginger H.E. Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2). J. Pharm. Sci. 1999, 88:253-257.
    • (1999) J. Pharm. Sci. , vol.88 , pp. 253-257
    • Kotzé, A.F.1    Thanou, M.M.2    Lueben, H.L.3    De Boer, A.4    Verhoef, J.5    Junginger, H.E.6
  • 72
    • 42649142580 scopus 로고    scopus 로고
    • Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies
    • Bayat A., Dorkoosh F.A., Dehpour A.R., Moezi L., Larijani B., Junginger H.E., Rafiee-Tehrani M. Nanoparticles of quaternized chitosan derivatives as a carrier for colon delivery of insulin: ex vivo and in vivo studies. Int. J. Pharm. 2008, 356:259-266.
    • (2008) Int. J. Pharm. , vol.356 , pp. 259-266
    • Bayat, A.1    Dorkoosh, F.A.2    Dehpour, A.R.3    Moezi, L.4    Larijani, B.5    Junginger, H.E.6    Rafiee-Tehrani, M.7
  • 73
    • 33344467489 scopus 로고    scopus 로고
    • Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system
    • Amidi M., Romeijn S.G., Borchard G., Junginger H.E., Hennink W.E., Jiskoot W. Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J. Control. Release 2006, 111:107-116.
    • (2006) J. Control. Release , vol.111 , pp. 107-116
    • Amidi, M.1    Romeijn, S.G.2    Borchard, G.3    Junginger, H.E.4    Hennink, W.E.5    Jiskoot, W.6
  • 74
    • 45749109076 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs using nanoparticles self-assembled by poly(γ-glutamic acid) and a chitosan derivative functionalized by trimethylation
    • Mi F.L., Wu Y.Y., Lin Y.H., Sonaje K., Ho Y.C., Chen C.T., Juang J.H., Sung H.W. Oral delivery of peptide drugs using nanoparticles self-assembled by poly(γ-glutamic acid) and a chitosan derivative functionalized by trimethylation. Bioconjug. Chem. 2008, 19:1248-1255.
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1248-1255
    • Mi, F.L.1    Wu, Y.Y.2    Lin, Y.H.3    Sonaje, K.4    Ho, Y.C.5    Chen, C.T.6    Juang, J.H.7    Sung, H.W.8
  • 75
    • 83355173904 scopus 로고    scopus 로고
    • Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport
    • Jin Y., Song Y., Zhu X., Zhou D., Chen C., Zhang Z., Huang Y. Goblet cell-targeting nanoparticles for oral insulin delivery and the influence of mucus on insulin transport. Biomaterials 2012, 33:1573-1582.
    • (2012) Biomaterials , vol.33 , pp. 1573-1582
    • Jin, Y.1    Song, Y.2    Zhu, X.3    Zhou, D.4    Chen, C.5    Zhang, Z.6    Huang, Y.7
  • 76
    • 33750351790 scopus 로고    scopus 로고
    • Chitosan graft copolymer nanoparticles for oral protein drug delivery: preparation and characterization
    • Qian F., Cui F., Ding J., Tang C., Yin C. Chitosan graft copolymer nanoparticles for oral protein drug delivery: preparation and characterization. Biomacromolecules 2006, 7:2722-2727.
    • (2006) Biomacromolecules , vol.7 , pp. 2722-2727
    • Qian, F.1    Cui, F.2    Ding, J.3    Tang, C.4    Yin, C.5
  • 77
    • 44449154695 scopus 로고    scopus 로고
    • Preparation and characterization of insulin nanoparticles using chitosan and its quaternized derivatives
    • Bayat A., Larijani B., Ahmadian S., Junginger H.E., Rafiee-Tehrani M. Preparation and characterization of insulin nanoparticles using chitosan and its quaternized derivatives. Nanomed. Nanotechnol. 2008, 4:115-120.
    • (2008) Nanomed. Nanotechnol. , vol.4 , pp. 115-120
    • Bayat, A.1    Larijani, B.2    Ahmadian, S.3    Junginger, H.E.4    Rafiee-Tehrani, M.5
  • 78
    • 50249129610 scopus 로고    scopus 로고
    • Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells
    • Sadeghi A., Dorkoosh F., Avadi M., Weinhold M., Bayat A., Delie F., Gurny R., Larijani B., Rafiee-Tehrani M., Junginger H. Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells. Eur. J. Pharm. Biopharm. 2008, 70:270-278.
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , pp. 270-278
    • Sadeghi, A.1    Dorkoosh, F.2    Avadi, M.3    Weinhold, M.4    Bayat, A.5    Delie, F.6    Gurny, R.7    Larijani, B.8    Rafiee-Tehrani, M.9    Junginger, H.10
  • 81
    • 41349110165 scopus 로고    scopus 로고
    • Preparation, characterization and antibacterial activities of chitosan, N-trimethyl chitosan (TMC) and N-diethylmethyl chitosan (DEMC) nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods
    • Sadeghi A.M.M., Dorkoosh F., Avadi M., Saadat P., Rafiee-Tehrani M., Junginger H. Preparation, characterization and antibacterial activities of chitosan, N-trimethyl chitosan (TMC) and N-diethylmethyl chitosan (DEMC) nanoparticles loaded with insulin using both the ionotropic gelation and polyelectrolyte complexation methods. Int. J. Pharm. 2008, 355:299-306.
    • (2008) Int. J. Pharm. , vol.355 , pp. 299-306
    • Sadeghi, A.M.M.1    Dorkoosh, F.2    Avadi, M.3    Saadat, P.4    Rafiee-Tehrani, M.5    Junginger, H.6
  • 84
    • 84855435709 scopus 로고    scopus 로고
    • Enhanced oral absorption of hydrophobic and hydrophilic drugs using quaternary ammonium palmitoyl glycol chitosan nanoparticles
    • Siew A., Le H., Thiovolet M., Schätzlein A., Gellert P., Uchegbu I. Enhanced oral absorption of hydrophobic and hydrophilic drugs using quaternary ammonium palmitoyl glycol chitosan nanoparticles. Mol. Pharm. 2012, 9:14-28.
    • (2012) Mol. Pharm. , vol.9 , pp. 14-28
    • Siew, A.1    Le, H.2    Thiovolet, M.3    Schätzlein, A.4    Gellert, P.5    Uchegbu, I.6
  • 86
    • 26644452975 scopus 로고    scopus 로고
    • Thiomers: a new generation of mucoadhesive polymers
    • Bernkop-Schnürch A. Thiomers: a new generation of mucoadhesive polymers. Adv. Drug Deliv. Rev. 2005, 57:1569-1582.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 1569-1582
    • Bernkop-Schnürch, A.1
  • 87
    • 0034925740 scopus 로고    scopus 로고
    • Thiolated polymers-thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates
    • Kast C.E., Bernkop-Schnürch A. Thiolated polymers-thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates. Biomaterials 2001, 22:2345-2352.
    • (2001) Biomaterials , vol.22 , pp. 2345-2352
    • Kast, C.E.1    Bernkop-Schnürch, A.2
  • 89
    • 24044555891 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of a novel chitosan-glutathione conjugate
    • Kafedjiiski K., Föger F., Werle M., Bernkop-Schnürch A. Synthesis and in vitro evaluation of a novel chitosan-glutathione conjugate. Pharm. Res. 2005, 22:1480-1488.
    • (2005) Pharm. Res. , vol.22 , pp. 1480-1488
    • Kafedjiiski, K.1    Föger, F.2    Werle, M.3    Bernkop-Schnürch, A.4
  • 90
    • 33646159752 scopus 로고    scopus 로고
    • In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan
    • Föger F., Schmitz T., Bernkop-Schnürch A. In vivo evaluation of an oral delivery system for P-gp substrates based on thiolated chitosan. Biomaterials 2006, 27:4250-4255.
    • (2006) Biomaterials , vol.27 , pp. 4250-4255
    • Föger, F.1    Schmitz, T.2    Bernkop-Schnürch, A.3
  • 92
    • 24044501942 scopus 로고    scopus 로고
    • Improved synthesis and in vitro characterization of chitosan-thioethylamidine conjugate
    • Kafedjiiski K., Hoffer M., Werle M., Bernkop-Schnürch A. Improved synthesis and in vitro characterization of chitosan-thioethylamidine conjugate. Biomaterials 2006, 27:127-135.
    • (2006) Biomaterials , vol.27 , pp. 127-135
    • Kafedjiiski, K.1    Hoffer, M.2    Werle, M.3    Bernkop-Schnürch, A.4
  • 93
    • 0042140521 scopus 로고    scopus 로고
    • Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins
    • Leitner V.M., Walker G.F., Bernkop-Schnürch A. Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins. Eur. J. Pharm. Biopharm. 2003, 56:207-214.
    • (2003) Eur. J. Pharm. Biopharm. , vol.56 , pp. 207-214
    • Leitner, V.M.1    Walker, G.F.2    Bernkop-Schnürch, A.3
  • 94
    • 34447287587 scopus 로고    scopus 로고
    • Characterization of chitosan thiolation and application to thiol quantification onto nanoparticle surface
    • Bravo-Osuna I., Teutonico D., Arpicco S., Vauthier C., Ponchel G. Characterization of chitosan thiolation and application to thiol quantification onto nanoparticle surface. Int. J. Pharm. 2007, 340:173-181.
    • (2007) Int. J. Pharm. , vol.340 , pp. 173-181
    • Bravo-Osuna, I.1    Teutonico, D.2    Arpicco, S.3    Vauthier, C.4    Ponchel, G.5
  • 97
    • 77956631702 scopus 로고    scopus 로고
    • Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery
    • Sajeesh S., Vauthier C., Gueutin C., Ponchel G., Sharma C.P. Thiol functionalized polymethacrylic acid-based hydrogel microparticles for oral insulin delivery. Acta Biomater. 2010, 6:3072-3080.
    • (2010) Acta Biomater. , vol.6 , pp. 3072-3080
    • Sajeesh, S.1    Vauthier, C.2    Gueutin, C.3    Ponchel, G.4    Sharma, C.P.5
  • 99
    • 48549107174 scopus 로고    scopus 로고
    • Polymeric enhancers of mucosal epithelia permeability: synthesis, transepithelial penetration-enhancing properties, mechanism of action, safety issues
    • Di Colo G., Zambito Y., Zaino C. Polymeric enhancers of mucosal epithelia permeability: synthesis, transepithelial penetration-enhancing properties, mechanism of action, safety issues. J. Pharm. Sci. 2008, 97:1652-1680.
    • (2008) J. Pharm. Sci. , vol.97 , pp. 1652-1680
    • Di Colo, G.1    Zambito, Y.2    Zaino, C.3
  • 100
    • 77953808647 scopus 로고    scopus 로고
    • Thiolated trimethyl chitosan nanocomplexes as gene carriers with high in vitro and in vivo transfection efficiency
    • Zhao X., Yin L., Ding J., Tang C., Gu S., Yin C., Mao Y. Thiolated trimethyl chitosan nanocomplexes as gene carriers with high in vitro and in vivo transfection efficiency. J. Control. Release 2010, 144:46-54.
    • (2010) J. Control. Release , vol.144 , pp. 46-54
    • Zhao, X.1    Yin, L.2    Ding, J.3    Tang, C.4    Gu, S.5    Yin, C.6    Mao, Y.7
  • 101
    • 77954143772 scopus 로고    scopus 로고
    • Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications
    • Jayakumar R., Prabaharan M., Nair S., Tokura S., Tamura H., Selvamurugan N. Novel carboxymethyl derivatives of chitin and chitosan materials and their biomedical applications. Prog. Mater. Sci. 2010, 55:675-709.
    • (2010) Prog. Mater. Sci. , vol.55 , pp. 675-709
    • Jayakumar, R.1    Prabaharan, M.2    Nair, S.3    Tokura, S.4    Tamura, H.5    Selvamurugan, N.6
  • 103
    • 34948860159 scopus 로고    scopus 로고
    • Nanoparticles incorporated in bilaminated films: a smart drug delivery system for oral formulations
    • Cui F., He C., Yin L., Qian F., He M., Tang C., Yin C. Nanoparticles incorporated in bilaminated films: a smart drug delivery system for oral formulations. Biomacromolecules 2007, 8:2845-2850.
    • (2007) Biomacromolecules , vol.8 , pp. 2845-2850
    • Cui, F.1    He, C.2    Yin, L.3    Qian, F.4    He, M.5    Tang, C.6    Yin, C.7
  • 104
    • 66149083634 scopus 로고    scopus 로고
    • Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly (methyl methacrylate) nanoparticles
    • Cui F., Qian F., Zhao Z., Yin L., Tang C., Yin C. Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly (methyl methacrylate) nanoparticles. Biomacromolecules 2009, 10:1253-1258.
    • (2009) Biomacromolecules , vol.10 , pp. 1253-1258
    • Cui, F.1    Qian, F.2    Zhao, Z.3    Yin, L.4    Tang, C.5    Yin, C.6
  • 106
    • 46549086982 scopus 로고    scopus 로고
    • The aggregative behavior of hydrophobically modified chitosans with high substitution degree in aqueous solution
    • Ortona O., D'Errico G., Mangiapia G., Ciccarelli D. The aggregative behavior of hydrophobically modified chitosans with high substitution degree in aqueous solution. Carbohydr. Polym. 2008, 74:16-22.
    • (2008) Carbohydr. Polym. , vol.74 , pp. 16-22
    • Ortona, O.1    D'Errico, G.2    Mangiapia, G.3    Ciccarelli, D.4
  • 107
    • 65249164789 scopus 로고    scopus 로고
    • Biodegradable nanoparticles based on linoleic acid and poly(β-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs
    • Zhao Z., He M., Yin L., Bao J., Shi L., Wang B., Tang C., Yin C. Biodegradable nanoparticles based on linoleic acid and poly(β-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs. Biomacromolecules 2009, 10:565-572.
    • (2009) Biomacromolecules , vol.10 , pp. 565-572
    • Zhao, Z.1    He, M.2    Yin, L.3    Bao, J.4    Shi, L.5    Wang, B.6    Tang, C.7    Yin, C.8
  • 108
    • 77952692576 scopus 로고    scopus 로고
    • Cholesterol succinyl chitosan anchored liposomes: preparation, characterization, physical stability, and drug release behavior
    • Wang Y., Tu S., Li R., Yang X.Y., Liu L., Zhang Q. Cholesterol succinyl chitosan anchored liposomes: preparation, characterization, physical stability, and drug release behavior. Nanomed. Nanotechnol. 2010, 6:471-477.
    • (2010) Nanomed. Nanotechnol. , vol.6 , pp. 471-477
    • Wang, Y.1    Tu, S.2    Li, R.3    Yang, X.Y.4    Liu, L.5    Zhang, Q.6
  • 109
    • 41549087356 scopus 로고    scopus 로고
    • Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin
    • Hu F.Q., Wu X., Du Y.Z., You J., Yuan H. Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin. Eur. J. Pharm. Biopharm. 2008, 69:117-125.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 117-125
    • Hu, F.Q.1    Wu, X.2    Du, Y.Z.3    You, J.4    Yuan, H.5
  • 110
    • 75149147998 scopus 로고    scopus 로고
    • Targeted delivery of low molecular drugs using chitosan and its derivatives
    • Park J.H., Saravanakumar G., Kim K., Kwon I.C. Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv. Drug Deliv. Rev. 2010, 62:28-41.
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 28-41
    • Park, J.H.1    Saravanakumar, G.2    Kim, K.3    Kwon, I.C.4
  • 111
    • 33645968393 scopus 로고    scopus 로고
    • Trends in muco-adhesive analysis
    • Harding S.E. Trends in muco-adhesive analysis. Trends Food Sci. Technol. 2006, 17:255-262.
    • (2006) Trends Food Sci. Technol. , vol.17 , pp. 255-262
    • Harding, S.E.1
  • 112
    • 62849083225 scopus 로고    scopus 로고
    • Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption
    • Rekha M., Sharma C.P. Synthesis and evaluation of lauryl succinyl chitosan particles towards oral insulin delivery and absorption. J. Control. Release 2009, 135:144-151.
    • (2009) J. Control. Release , vol.135 , pp. 144-151
    • Rekha, M.1    Sharma, C.P.2
  • 113
  • 114
    • 0033991816 scopus 로고    scopus 로고
    • Chitosan and its derivatives: potential excipients for peroral peptide delivery systems
    • Bernkop-Schnürch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int. J. Pharm. 2000, 194:1-13.
    • (2000) Int. J. Pharm. , vol.194 , pp. 1-13
    • Bernkop-Schnürch, A.1
  • 115
    • 0032473473 scopus 로고    scopus 로고
    • The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins
    • Bernkop-Schnürch A. The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J. Control. Release 1998, 52:1-16.
    • (1998) J. Control. Release , vol.52 , pp. 1-16
    • Bernkop-Schnürch, A.1
  • 116
    • 0026505270 scopus 로고
    • Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells
    • Citi S. Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells. J. cell Biol. 1992, 117:169-178.
    • (1992) J. cell Biol. , vol.117 , pp. 169-178
    • Citi, S.1
  • 117
    • 0142020885 scopus 로고    scopus 로고
    • Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines
    • Guo X., Rao J.N., Liu L., Zou T.T., Turner D.J., Bass B.L., Wang J.Y. Regulation of adherens junctions and epithelial paracellular permeability: a novel function for polyamines. Am. J. Physiol. Cell Physiol. 2003, 285:C1174-C1187.
    • (2003) Am. J. Physiol. Cell Physiol. , vol.285
    • Guo, X.1    Rao, J.N.2    Liu, L.3    Zou, T.T.4    Turner, D.J.5    Bass, B.L.6    Wang, J.Y.7
  • 118
    • 43049175030 scopus 로고    scopus 로고
    • Chitosan-modifications and applications: opportunities galore
    • Mourya V., Inamdar N.N. Chitosan-modifications and applications: opportunities galore. React. Funct. Polym. 2008, 68:1013-1051.
    • (2008) React. Funct. Polym. , vol.68 , pp. 1013-1051
    • Mourya, V.1    Inamdar, N.N.2
  • 119
    • 0031915514 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins
    • Bernkop-Schnürch A., Scerbe-Saiko A. Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins. Pharm. Res. 1998, 15:263-269.
    • (1998) Pharm. Res. , vol.15 , pp. 263-269
    • Bernkop-Schnürch, A.1    Scerbe-Saiko, A.2
  • 120
    • 0032472305 scopus 로고    scopus 로고
    • Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates
    • Bernkop-Schnürch A., Krajicek M.E. Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates. J. Control. Release 1998, 50:215-223.
    • (1998) J. Control. Release , vol.50 , pp. 215-223
    • Bernkop-Schnürch, A.1    Krajicek, M.E.2
  • 121
    • 26944452043 scopus 로고    scopus 로고
    • PEGylation, successful approach to drug delivery
    • Veronese F.M., Pasut G. PEGylation, successful approach to drug delivery. Drug Discov. Today 2005, 10:1451-1458.
    • (2005) Drug Discov. Today , vol.10 , pp. 1451-1458
    • Veronese, F.M.1    Pasut, G.2
  • 122
    • 80052067468 scopus 로고    scopus 로고
    • A novel method for synthesizing PEGylated chitosan nanoparticles: strategy, preparation, and in vitro analysis
    • Malhotra M., Lane C., Tomaro-Duchesneau C., Saha S., Prakash S. A novel method for synthesizing PEGylated chitosan nanoparticles: strategy, preparation, and in vitro analysis. Int. J. Nanomedicine 2011, 6:485-494.
    • (2011) Int. J. Nanomedicine , vol.6 , pp. 485-494
    • Malhotra, M.1    Lane, C.2    Tomaro-Duchesneau, C.3    Saha, S.4    Prakash, S.5
  • 123
    • 84859602944 scopus 로고    scopus 로고
    • Formulation and in vitro characterization of PEGylated chitosan and polyethylene imine polymers with thrombospondin-I gene bearing pDNA
    • Mehmet Saka O., Bozkir A. Formulation and in vitro characterization of PEGylated chitosan and polyethylene imine polymers with thrombospondin-I gene bearing pDNA. J. Biomed. Mater. Res. B Appl. Biomater. 2012, 100:984-992.
    • (2012) J. Biomed. Mater. Res. B Appl. Biomater. , vol.100 , pp. 984-992
    • Mehmet Saka, O.1    Bozkir, A.2
  • 124
    • 79954420700 scopus 로고    scopus 로고
    • Recent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agents
    • Chaudhury A., Das S. Recent advancement of chitosan-based nanoparticles for oral controlled delivery of insulin and other therapeutic agents. AAPS PharmSciTech 2011, 12:10-20.
    • (2011) AAPS PharmSciTech , vol.12 , pp. 10-20
    • Chaudhury, A.1    Das, S.2
  • 125
    • 71649103464 scopus 로고    scopus 로고
    • The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake
    • Jintapattanakit A., Junyaprasert V.B., Kissel T. The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake. J. Pharm. Sci. 2009, 98:4818-4830.
    • (2009) J. Pharm. Sci. , vol.98 , pp. 4818-4830
    • Jintapattanakit, A.1    Junyaprasert, V.B.2    Kissel, T.3
  • 126
    • 80053937972 scopus 로고    scopus 로고
    • Effect of PEGylation on the diffusion and stability of chitosan-DNA polyplexes in collagen gels
    • Lelu S., Strand S.P., Steine J., Davies C.L. Effect of PEGylation on the diffusion and stability of chitosan-DNA polyplexes in collagen gels. Biomacromolecules 2011, 12:3656-3665.
    • (2011) Biomacromolecules , vol.12 , pp. 3656-3665
    • Lelu, S.1    Strand, S.P.2    Steine, J.3    Davies, C.L.4
  • 127
  • 128
    • 20444441841 scopus 로고    scopus 로고
    • Synthesis, characterization and cytotoxicity of poly(ethylene glycol)-graft-trimethyl chitosan block copolymers
    • Mao S., Shuai X., Unger F., Wittmar M., Xie X., Kissel T. Synthesis, characterization and cytotoxicity of poly(ethylene glycol)-graft-trimethyl chitosan block copolymers. Biomaterials 2005, 26:6343-6356.
    • (2005) Biomaterials , vol.26 , pp. 6343-6356
    • Mao, S.1    Shuai, X.2    Unger, F.3    Wittmar, M.4    Xie, X.5    Kissel, T.6
  • 129
    • 18244365849 scopus 로고    scopus 로고
    • Protein drug stability: a formulation challenge
    • Frokjaer S., Otzen D.E. Protein drug stability: a formulation challenge. Nat. Rev. Drug Discov. 2005, 4:298-306.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 298-306
    • Frokjaer, S.1    Otzen, D.E.2
  • 130
    • 0036105205 scopus 로고    scopus 로고
    • Development of oral insulin: progress and current status
    • Gordon Still J. Development of oral insulin: progress and current status. Diabetes Metab. Res. Rev. 2002, 18:S29-S37.
    • (2002) Diabetes Metab. Res. Rev. , vol.18
    • Gordon Still, J.1
  • 131
    • 47049095564 scopus 로고    scopus 로고
    • Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation
    • Woitiski C.B., Carvalho R.A., Ribeiro A.J., Neufeld R.J., Veiga F. Strategies toward the improved oral delivery of insulin nanoparticles via gastrointestinal uptake and translocation. BioDrugs 2008, 22:223-237.
    • (2008) BioDrugs , vol.22 , pp. 223-237
    • Woitiski, C.B.1    Carvalho, R.A.2    Ribeiro, A.J.3    Neufeld, R.J.4    Veiga, F.5
  • 132
    • 33846543799 scopus 로고    scopus 로고
    • Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats
    • Damgé C., Maincent P., Ubrich N. Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats. J. Control. Release 2007, 117:163-170.
    • (2007) J. Control. Release , vol.117 , pp. 163-170
    • Damgé, C.1    Maincent, P.2    Ubrich, N.3
  • 133
    • 4344640503 scopus 로고    scopus 로고
    • The physiological rationale for oral insulin administration
    • Arbit E. The physiological rationale for oral insulin administration. Diabetes Technol. Ther. 2004, 6:510-517.
    • (2004) Diabetes Technol. Ther. , vol.6 , pp. 510-517
    • Arbit, E.1
  • 135
    • 22244488749 scopus 로고    scopus 로고
    • Oral delivery of peptide drugs: barriers and developments
    • Hamman J.H., Enslin G.M., Kotze A.F. Oral delivery of peptide drugs: barriers and developments. BioDrugs 2005, 19:165-177.
    • (2005) BioDrugs , vol.19 , pp. 165-177
    • Hamman, J.H.1    Enslin, G.M.2    Kotze, A.F.3
  • 136
    • 76749103819 scopus 로고    scopus 로고
    • Enteric-coated capsules filled with freeze-dried chitosan/poly ([gamma]-glutamic acid) nanoparticles for oral insulin delivery
    • Sonaje K., Chen Y.J., Chen H.L., Wey S.P., Juang J.H., Nguyen H.N., Hsu C.W., Lin K.J., Sung H.W. Enteric-coated capsules filled with freeze-dried chitosan/poly ([gamma]-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials 2010, 31:3384-3394.
    • (2010) Biomaterials , vol.31 , pp. 3384-3394
    • Sonaje, K.1    Chen, Y.J.2    Chen, H.L.3    Wey, S.P.4    Juang, J.H.5    Nguyen, H.N.6    Hsu, C.W.7    Lin, K.J.8    Sung, H.W.9
  • 137
    • 77954385916 scopus 로고    scopus 로고
    • Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection
    • Sonaje K., Lin K.J., Wey S.P., Lin C.K., Yeh T.H., Nguyen H.N., Hsu C.W., Yen T.C., Juang J.H., Sung H.W. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection. Biomaterials 2010, 31:6849-6858.
    • (2010) Biomaterials , vol.31 , pp. 6849-6858
    • Sonaje, K.1    Lin, K.J.2    Wey, S.P.3    Lin, C.K.4    Yeh, T.H.5    Nguyen, H.N.6    Hsu, C.W.7    Yen, T.C.8    Juang, J.H.9    Sung, H.W.10
  • 140
    • 39449092067 scopus 로고    scopus 로고
    • Thiolated chitosans: useful excipients for oral drug delivery
    • Werle M., Bernkop-Schnürch A. Thiolated chitosans: useful excipients for oral drug delivery. J. Pharm. Pharmacol. 2008, 60:273-281.
    • (2008) J. Pharm. Pharmacol. , vol.60 , pp. 273-281
    • Werle, M.1    Bernkop-Schnürch, A.2
  • 141
    • 0348026751 scopus 로고    scopus 로고
    • In vivo evaluation of an oral salmon calcitonin-delivery system based on a thiolated chitosan carrier matrix
    • Guggi D., Kast C.E., Bernkop-Schnürch A. In vivo evaluation of an oral salmon calcitonin-delivery system based on a thiolated chitosan carrier matrix. Pharm. Res. 2003, 20:1989-1994.
    • (2003) Pharm. Res. , vol.20 , pp. 1989-1994
    • Guggi, D.1    Kast, C.E.2    Bernkop-Schnürch, A.3
  • 144
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding X., Saxena N.K., Lin S., Gupta N., Anania F.A. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 2006, 43:173-181.
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.4    Anania, F.A.5
  • 145
    • 69249195769 scopus 로고    scopus 로고
    • Exenatide efficacy and safety: a systematic review
    • Norris S., Lee N., Thakurta S., Chan B. Exenatide efficacy and safety: a systematic review. Diabet. Med. 2009, 26:837-846.
    • (2009) Diabet. Med. , vol.26 , pp. 837-846
    • Norris, S.1    Lee, N.2    Thakurta, S.3    Chan, B.4
  • 147
    • 0029450581 scopus 로고
    • 25years of salmon calcitonin: from synthesis to therapeutic use
    • Azria M., Copp D., Zanelli J. 25years of salmon calcitonin: from synthesis to therapeutic use. Calcif. Tissue Int. 1995, 57:405-408.
    • (1995) Calcif. Tissue Int. , vol.57 , pp. 405-408
    • Azria, M.1    Copp, D.2    Zanelli, J.3
  • 148
    • 0026034777 scopus 로고
    • Cyclosporin metabolism by the gastrointestinal mucosa
    • Tjia J., Webber I., Back D. Cyclosporin metabolism by the gastrointestinal mucosa. J. Clin. Pharmacol. 1991, 31:344-346.
    • (1991) J. Clin. Pharmacol. , vol.31 , pp. 344-346
    • Tjia, J.1    Webber, I.2    Back, D.3
  • 149
    • 0037027833 scopus 로고    scopus 로고
    • Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A
    • El-Shabouri M. Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Int. J. Pharm. 2002, 249:101-108.
    • (2002) Int. J. Pharm. , vol.249 , pp. 101-108
    • El-Shabouri, M.1
  • 151
    • 77957298626 scopus 로고    scopus 로고
    • Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly[gamma]-glutamic acid
    • Liao Z.X., Ho Y.C., Chen H.L., Peng S.F., Hsiao C.W., Sung H.W. Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly[gamma]-glutamic acid. Biomaterials 2010, 31:8780-8788.
    • (2010) Biomaterials , vol.31 , pp. 8780-8788
    • Liao, Z.X.1    Ho, Y.C.2    Chen, H.L.3    Peng, S.F.4    Hsiao, C.W.5    Sung, H.W.6
  • 152
    • 33846456199 scopus 로고    scopus 로고
    • Amino ester glycol urethane
    • Tseng S.J., Tang S.C. Synthesis and characterization of the novel transfection reagent poly. Biomacromolecules 2007, 8:50-58.
    • (2007) Biomacromolecules , vol.8 , pp. 50-58
    • Tseng, S.J.1    Tang, S.C.2
  • 154
    • 84856587267 scopus 로고    scopus 로고
    • Mechanistic study of transfection of chitosan/DNA complexes coated by anionic poly(γ-glutamic acid)
    • Liao Z.X., Peng S.F., Ho Y.C., Mi F.L., Maiti B., Sung H.W. Mechanistic study of transfection of chitosan/DNA complexes coated by anionic poly(γ-glutamic acid). Biomaterials 2012, 3306-3315.
    • (2012) Biomaterials , pp. 3306-3315
    • Liao, Z.X.1    Peng, S.F.2    Ho, Y.C.3    Mi, F.L.4    Maiti, B.5    Sung, H.W.6
  • 155
    • 84855795348 scopus 로고    scopus 로고
    • Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer
    • Kim T., Lee M., Kim S.W. Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer. J. Control. Release 2012, 157:243-248.
    • (2012) J. Control. Release , vol.157 , pp. 243-248
    • Kim, T.1    Lee, M.2    Kim, S.W.3
  • 156
    • 44549084568 scopus 로고    scopus 로고
    • Electrostatic immobilization of DNA polyplexes on small intestinal submucosa for tissue substrate-mediated transfection
    • Tseng S., Chuang C.J., Tang S.C. Electrostatic immobilization of DNA polyplexes on small intestinal submucosa for tissue substrate-mediated transfection. Acta Biomater. 2008, 4:799-807.
    • (2008) Acta Biomater. , vol.4 , pp. 799-807
    • Tseng, S.1    Chuang, C.J.2    Tang, S.C.3
  • 157
    • 80055005101 scopus 로고    scopus 로고
    • Self-organized nanoparticles prepared by guanidine-and disulfide-modified chitosan as a gene delivery carrier
    • Ho Y.C., Liao Z.X., Panda N., Tang D.W., Yu S.H., Mi F.L., Sung H.W. Self-organized nanoparticles prepared by guanidine-and disulfide-modified chitosan as a gene delivery carrier. J. Mater. Chem. 2011, 21:16918-16927.
    • (2011) J. Mater. Chem. , vol.21 , pp. 16918-16927
    • Ho, Y.C.1    Liao, Z.X.2    Panda, N.3    Tang, D.W.4    Yu, S.H.5    Mi, F.L.6    Sung, H.W.7
  • 158
    • 75149133614 scopus 로고    scopus 로고
    • Chitosan-based formulations for delivery of DNA and siRNA
    • Mao S., Sun W., Kissel T. Chitosan-based formulations for delivery of DNA and siRNA. Adv. Drug Deliv. Rev. 2010, 62:12-27.
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 12-27
    • Mao, S.1    Sun, W.2    Kissel, T.3
  • 160
    • 0028798530 scopus 로고
    • Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer's patch M cells
    • Ermak T.H., Dougherty E.P., Bhagat H.R., Kabok Z., Pappo J. Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer's patch M cells. Cell Tissue Res. 1995, 279:433-436.
    • (1995) Cell Tissue Res. , vol.279 , pp. 433-436
    • Ermak, T.H.1    Dougherty, E.P.2    Bhagat, H.R.3    Kabok, Z.4    Pappo, J.5
  • 161
    • 0035144059 scopus 로고    scopus 로고
    • Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches
    • Van der Lubben I., Verhoef J., Van Aelst A., Borchard G., Junginger H. Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches. Biomaterials 2001, 22:687-694.
    • (2001) Biomaterials , vol.22 , pp. 687-694
    • Van der Lubben, I.1    Verhoef, J.2    Van Aelst, A.3    Borchard, G.4    Junginger, H.5
  • 162
    • 0027869836 scopus 로고
    • Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells
    • Jepson M., Simmons N., O'hagan D., Hirst B. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J. Drug Target. 1993, 1:245-249.
    • (1993) J. Drug Target. , vol.1 , pp. 245-249
    • Jepson, M.1    Simmons, N.2    O'hagan, D.3    Hirst, B.4
  • 163
    • 0030465871 scopus 로고    scopus 로고
    • The intestinal uptake of particles and the implications for drug and antigen delivery
    • O'hagan D. The intestinal uptake of particles and the implications for drug and antigen delivery. J. Anat. 1996, 189:477-482.
    • (1996) J. Anat. , vol.189 , pp. 477-482
    • O'hagan, D.1
  • 164
    • 0035801903 scopus 로고    scopus 로고
    • Mechanism of cell transfection with plasmid/chitosan complexes
    • Ishii T., Okahata Y., Sato T. Mechanism of cell transfection with plasmid/chitosan complexes. Biochim. Biophys. Acta 2001, 1514:51-64.
    • (2001) Biochim. Biophys. Acta , vol.1514 , pp. 51-64
    • Ishii, T.1    Okahata, Y.2    Sato, T.3
  • 165
    • 0346685833 scopus 로고    scopus 로고
    • Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles
    • Chen J., Yang W.L., Li G., Qian J., Xue J.L., Fu S.K., Lu D.R. Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles. World J. Gastroenterol. 2004, 10:112-116.
    • (2004) World J. Gastroenterol. , vol.10 , pp. 112-116
    • Chen, J.1    Yang, W.L.2    Li, G.3    Qian, J.4    Xue, J.L.5    Fu, S.K.6    Lu, D.R.7
  • 167
    • 56949084718 scopus 로고    scopus 로고
    • Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles
    • Bowman K., Sarkar R., Raut S., Leong K.W. Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles. J. Control. Release 2008, 132:252-259.
    • (2008) J. Control. Release , vol.132 , pp. 252-259
    • Bowman, K.1    Sarkar, R.2    Raut, S.3    Leong, K.W.4
  • 169
    • 28444477001 scopus 로고    scopus 로고
    • Chitosan microparticles containing plasmid DNA as potential oral gene delivery system
    • Guliyeva U., Oner F., Ozsoy S., Haziroǧlu R. Chitosan microparticles containing plasmid DNA as potential oral gene delivery system. Eur. J. Pharm. Biopharm. 2006, 62:17-25.
    • (2006) Eur. J. Pharm. Biopharm. , vol.62 , pp. 17-25
    • Guliyeva, U.1    Oner, F.2    Ozsoy, S.3    Haziroǧlu, R.4
  • 170
    • 0038513487 scopus 로고    scopus 로고
    • Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice
    • Chew J.L., Wolfowicz C.B., Mao H.Q., Leong K.W., Chua K.Y. Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine 2003, 21:2720-2729.
    • (2003) Vaccine , vol.21 , pp. 2720-2729
    • Chew, J.L.1    Wolfowicz, C.B.2    Mao, H.Q.3    Leong, K.W.4    Chua, K.Y.5
  • 171
    • 0035805579 scopus 로고    scopus 로고
    • Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence
    • Chuang Y.J., Swanson R., Raja S.M., Olson S.T. Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. J. Biol. Chem. 2001, 276:14961-14971.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14961-14971
    • Chuang, Y.J.1    Swanson, R.2    Raja, S.M.3    Olson, S.T.4
  • 172
  • 173
    • 32044444307 scopus 로고    scopus 로고
    • Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation
    • Kim S.K., Vaishali B., Lee E., Lee S., Lee Y., Kumar T.S., Moon H.T., Byun Y. Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation. Thromb. Res. 2006, 117:419-427.
    • (2006) Thromb. Res. , vol.117 , pp. 419-427
    • Kim, S.K.1    Vaishali, B.2    Lee, E.3    Lee, S.4    Lee, Y.5    Kumar, T.S.6    Moon, H.T.7    Byun, Y.8


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