Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin

Journal of Biological Chemistry

Volumn 276, Issue 18, 2001, Pages 14961-14971

  Chuang, Yung Jen ^b   Swanson, Richard ^b   Raja, Srikumar M ^b   Olson, Steven T ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; MUTAGENESIS; POLYSACCHARIDES; PROTEINS;

ANTITHROMBIN;

BIOCHEMISTRY;

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; HEPARIN; THROMBIN; PRIMER DNA; SERINE PROTEINASE INHIBITOR;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CATALYSIS; CELL STRAIN BHK; ENZYME ACTIVATION; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STOICHIOMETRY; CHEMISTRY; GENETICS; HUMAN; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

ALLOSTERIC REGULATION; ANTITHROMBINS; BASE SEQUENCE; DNA PRIMERS; FACTOR XA; HEPARIN; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SERPINS; SUBSTRATE SPECIFICITY; THROMBIN;

EID: 0035805579     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011550200     Document Type: Article

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