메뉴 건너뛰기




Volumn 11, Issue 3, 2010, Pages 1185-1192

The impact of vehicles on the mucoadhesive properties of orally administrated nanoparticles: A case study with chitosan-4-thiobutylamidine conjugate

Author keywords

chitosan TBA; mucoadhesion; nanoparticles; thiomer; vehicles

Indexed keywords

CAPRYLIC TRIGLYCERIDE; CHITOSAN 4 THIOBUTYLAMIDINE; CREMOPHOR; FLUORESCEIN DIACETATE; MACROGOL; MACROGOL 300; MACROGOL 6000; MIGLYOL; NANOPARTICLE; POLYMER; UNCLASSIFIED DRUG;

EID: 78649905059     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-010-9479-8     Document Type: Article
Times cited : (55)

References (30)
  • 1
    • 26644454810 scopus 로고    scopus 로고
    • The basics and underlying mechanisms of mucoadhesion
    • DOI 10.1016/j.addr.2005.07.001, PII S0169409X05001390, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • J Smart 2005 The basics and underlying mechanisms of mucoadhesion Adv Drug Deliv Rev 57 11 1556 1568 1:CAS:528:DC%2BD2MXhtFSis7fP 10.1016/j.addr.2005. 07.001 16198441 (Pubitemid 41443469)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1556-1568
    • Smart, J.D.1
  • 2
    • 26644447977 scopus 로고    scopus 로고
    • Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems
    • DOI 10.1016/j.addr.2005.07.008, PII S0169409X05001419, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • H Takeuchi J Thongborisute Y Matsui H Sugihara H Yamamoto Y Kawashima 2005 Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems Adv Drug Deliv Rev 57 11 1583 1594 1:CAS:528:DC%2BD2MXhtFSis7fL 10.1016/j.addr.2005.07.008 16169120 (Pubitemid 41443471)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1583-1594
    • Takeuchi, H.1    Thongborisute, J.2    Matsui, Y.3    Sugihara, H.4    Yamamoto, H.5    Kawashima, Y.6
  • 3
    • 0031890348 scopus 로고    scopus 로고
    • Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites
    • 1:CAS:528:DyaK1cXit1eltb8%3D 9530983
    • Y Akiyama N Nagahara E Nara M Kitano S Iwasa I Yamamoto, et al. 1998 Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites J Pharm Pharmacol 50 2 159 166 1:CAS:528:DyaK1cXit1eltb8%3D 9530983
    • (1998) J Pharm Pharmacol , vol.50 , Issue.2 , pp. 159-166
    • Akiyama, Y.1    Nagahara, N.2    Nara, E.3    Kitano, M.4    Iwasa, S.5    Yamamoto, I.6
  • 4
    • 0025734920 scopus 로고
    • Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects
    • 1:CAS:528:DyaK3MXitFChtbg%3D 10.1023/A:1015849700421 2052525
    • A Coupe S Davis I Wilding 1991 Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects Pharm Res 8 3 360 364 1:CAS:528:DyaK3MXitFChtbg%3D 10.1023/A:1015849700421 2052525
    • (1991) Pharm Res , vol.8 , Issue.3 , pp. 360-364
    • Coupe, A.1    Davis, S.2    Wilding, I.3
  • 5
    • 33646802286 scopus 로고    scopus 로고
    • Preparation and characterization of mucoadhesive polymer-coated nanoparticles
    • DOI 10.1016/j.ijpharm.2006.02.031, PII S0378517306001748
    • F Cui F Qian C Yin 2006 Preparation and characterization of mucoadhesive polymer-coated nanoparticles Int J Pharm 316 1-2 154 161 1:CAS:528: DC%2BD28XkvVWrsbk%3D 10.1016/j.ijpharm.2006.02.031 16567070 (Pubitemid 43765702)
    • (2006) International Journal of Pharmaceutics , vol.316 , Issue.1-2 , pp. 154-161
    • Cui, F.1    Qian, F.2    Yin, C.3
  • 6
    • 33750811176 scopus 로고    scopus 로고
    • Ex-vivo evaluation of alginate microparticles for Polymyxin B oral administration
    • DOI 10.1080/10611860600864182, PII V1V00830HT288382
    • G Coppi N Sala M Bondi S Sergi V Iannuccelli 2006 Ex-vivo evaluation of alginate microparticles for polymyxin B oral administration J Drug Target 14 9 599 606 1:CAS:528:DC%2BD28XhtlSitL%2FN 10.1080/10611860600864182 17090395 (Pubitemid 44712355)
    • (2006) Journal of Drug Targeting , vol.14 , Issue.9 , pp. 599-606
    • Coppi, G.1    Sala, N.2    Bondi, M.3    Sergi, S.4    Iannuccelli, V.5
  • 7
    • 0025108791 scopus 로고
    • A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength
    • 1:CAS:528:DyaK3cXltVehtbk%3D 10.1023/A:1015812615635 1694990
    • E Hassan J Gallo 1990 A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength Pharm Res 7 5 491 495 1:CAS:528:DyaK3cXltVehtbk%3D 10.1023/A:1015812615635 1694990
    • (1990) Pharm Res , vol.7 , Issue.5 , pp. 491-495
    • Hassan, E.1    Gallo, J.2
  • 8
    • 26644434123 scopus 로고    scopus 로고
    • Comparison of the mucoadhesive properties of various polymers
    • DOI 10.1016/j.addr.2005.07.006, PII S0169409X05001468, Mucoadhesive Polymers: Strategies, Achievements and Future Challenges
    • V Grabovac D Guggi A Bernkop-Schnürch 2005 Comparison of the mucoadhesive properties of various polymers Adv Drug Deliv Rev 57 11 1713 1723 1:CAS:528:DC%2BD2MXhtFSisL7L 10.1016/j.addr.2005.07.006 16183163 (Pubitemid 41443475)
    • (2005) Advanced Drug Delivery Reviews , vol.57 , Issue.11 , pp. 1713-1723
    • Grabovac, V.1    Guggi, D.2    Bernkop-Schnurch, A.3
  • 9
    • 33745001611 scopus 로고    scopus 로고
    • Thiomers: Preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system
    • DOI 10.1016/j.ijpharm.2006.02.044, PII S0378517306001918
    • A Bernkop-Schnürch A Weithaler K Albrecht A Greimel 2006 Thiomers: preparation and in vitro evaluation of a mucoadhesive nanoparticulate drug delivery system Int J Pharm 317 1 76 81 10.1016/j.ijpharm.2006.02.044 16595166 (Pubitemid 43866341)
    • (2006) International Journal of Pharmaceutics , vol.317 , Issue.1 , pp. 76-81
    • Bernkop-Schnurch, A.1    Weithaler, A.2    Albrecht, K.3    Greimel, A.4
  • 10
    • 34547172248 scopus 로고    scopus 로고
    • Development and in vitro evaluation of surface modified poly(lactide-co-glycolide) nanoparticles with chitosan-4-thiobutylamidine
    • DOI 10.1080/03639040601050163, PII 780837506
    • V Grabovac A Bernkop-Schnürch 2007 Development and in vitro evaluation of surface modified poly(lactide-co-glycolide) nanoparticles with chitosan-4-thiobutylamidine Drug Dev Ind Pharm 33 7 767 774 1:CAS:528: DC%2BD2sXotVOgsL8%3D 10.1080/03639040601050163 17654025 (Pubitemid 47123803)
    • (2007) Drug Development and Industrial Pharmacy , vol.33 , Issue.7 , pp. 767-774
    • Grabovac, V.1    Bernkop-Schnurch, A.2
  • 11
    • 33750176860 scopus 로고    scopus 로고
    • Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system
    • DOI 10.1016/j.biomaterials.2006.08.017, PII S0142961206007186
    • T Schmitz I Bravo-Osuna C Vauthier G Ponchel B Loretz A Bernkop-Schnürch 2007 Development and in vitro evaluation of a thiomer-based nanoparticulate gene delivery system Biomaterials 28 3 524 531 1:CAS:528:DC%2BD28XhtFeiu7jO 10.1016/j.biomaterials.2006.08.017 16979757 (Pubitemid 44602224)
    • (2007) Biomaterials , vol.28 , Issue.3 , pp. 524-531
    • Schmitz, T.1    Bravo-Osuna, I.2    Vauthier, C.3    Ponchel, G.4    Loretz, B.5    Bernkop-Schnurch, A.6
  • 13
    • 33750891059 scopus 로고    scopus 로고
    • Preparation of thiomer microparticles and in vitro evaluation of parameters influencing their mucoadhesive properties
    • DOI 10.1080/03639040600712334, PII G47J89H01N575522
    • K Albrecht E Zirm T Palmberger W Schlocker A Bernkop-Schnürch 2006 Preparation of thiomer microparticles and in vitro evaluation of parameters influencing their mucoadhesive properties Drug Dev Ind Pharm 32 10 1149 1157 1:CAS:528:DC%2BD28Xht1GntL7P 10.1080/03639040600712334 17090437 (Pubitemid 44721729)
    • (2006) Drug Development and Industrial Pharmacy , vol.32 , Issue.10 , pp. 1149-1157
    • Albrecht, K.1    Zirm, E.J.2    Palmberger, T.F.3    Schlocker, W.4    Bernkop-Schnurch, A.5
  • 14
    • 0033020555 scopus 로고    scopus 로고
    • Polymers with thiol groups: A new generation of mucoadhesive polymers?
    • DOI 10.1023/A:1018830204170
    • A Bernkop-Schnürch V Schwarz S Steininger 1999 Polymers with thiol groups: a new generation of mucoadhesive polymers? Pharm Res 16 6 876 881 10.1023/A:1018830204170 10397608 (Pubitemid 29284199)
    • (1999) Pharmaceutical Research , vol.16 , Issue.6 , pp. 876-881
    • Bernkop-Schnurch, A.1    Schwarz, V.2    Steininger, S.3
  • 15
    • 33344454616 scopus 로고    scopus 로고
    • Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine
    • DOI 10.1016/j.jconrel.2005.11.011, PII S0168365905006541
    • M Werle M Hoffer 2006 Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine J Control Release 111 1-2 41 46 1:CAS:528:DC%2BD28XhslKjtL8%3D 10.1016/j.jconrel.2005.11.011 16377016 (Pubitemid 43289993)
    • (2006) Journal of Controlled Release , vol.111 , Issue.1-2 , pp. 41-46
    • Werle, M.1    Hoffer, M.2
  • 16
    • 34548324792 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of non-thiolated and thiolated chitosan nanoparticles for oral gene delivery
    • DOI 10.1080/17435390701554200, PII 781127263
    • B Loretz A Bernkop-Schnürch 2007 In vitro cytotoxicity testing of non-thiolated and thiolated chitosan nanoparticles for oral gene delivery Nanotoxicology 1 2 139 148 1:CAS:528:DC%2BD2sXhtV2ns77N 10.1080/ 17435390701554200 (Pubitemid 47344128)
    • (2007) Nanotoxicology , vol.1 , Issue.2 , pp. 139-148
    • Loretz, B.1    Bernkop-Schnurch, A.2
  • 17
    • 33748786235 scopus 로고    scopus 로고
    • Comparative in vivo mucoadhesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection
    • DOI 10.1016/j.jconrel.2006.06.023, PII S0168365906003178
    • K Albrecht M Greindl C Kremser C Wolf P Debbage A Bernkop-Schnürch 2006 Comparative in vivo mucoadhesion studies of thiomer formulations using magnetic resonance imaging and fluorescence detection J Control Release 115 1 78 84 1:CAS:528:DC%2BD28XpvVOhtL0%3D 10.1016/j.jconrel.2006.06.023 16901569 (Pubitemid 44415072)
    • (2006) Journal of Controlled Release , vol.115 , Issue.1 , pp. 78-84
    • Albrecht, K.1    Greindl, M.2    Kremser, C.3    Wolf, C.4    Debbage, P.5    Bernkop-Schnurch, A.6
  • 18
    • 3543051289 scopus 로고    scopus 로고
    • The depolymerization of chitosan: Effects on physicochemical and biological properties
    • DOI 10.1016/j.ijpharm.2004.05.019, PII S037851730400300X
    • S Mao X Shuai F Unger M Simon D Bi T Kissel 2004 The depolymerization of chitosan: effects on physicochemical and biological properties Int J Pharm 281 1-2 45 54 1:CAS:528:DC%2BD2cXmtFCmurc%3D 10.1016/j.ijpharm.2004.05.019 15288342 (Pubitemid 39024262)
    • (2004) International Journal of Pharmaceutics , vol.281 , Issue.1-2 , pp. 45-54
    • Mao, S.1    Shuai, X.2    Unger, F.3    Simon, M.4    Bi, D.5    Kissel, T.6
  • 19
    • 0347985635 scopus 로고    scopus 로고
    • Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: Synthesis and in vitro evaluation
    • DOI 10.1016/S0939-6411(03)00157-7
    • M Roldo M Hornof P Caliceti A Bernkop-Schnürch 2004 Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery: synthesis and in vitro evaluation Eur J Pharm Biopharm 57 1 115 121 1:CAS:528: DC%2BD2cXjsFakug%3D%3D 10.1016/S0939-6411(03)00157-7 14729087 (Pubitemid 38058810)
    • (2004) European Journal of Pharmaceutics and Biopharmaceutics , vol.57 , Issue.1 , pp. 115-121
    • Roldo, M.1    Hornof, M.2    Caliceti, P.3    Bernkop-Schnurch, A.4
  • 20
    • 2942608192 scopus 로고    scopus 로고
    • Comparative evaluation of cytotoxicity of a glucosamine-TBA conjugate and a chitosan-TBA conjugate
    • DOI 10.1016/j.ijpharm.2004.03.016, PII S0378517304002030
    • D Guggi N Langoth M Hoffer M Wirth A Bernkop-Schnürch 2004 Comparative evaluation of cytotoxicity of a glucosamine-TBA conjugate and a chitosan-TBA conjugate Int J Pharm 278 2 353 360 1:CAS:528:DC%2BD2cXkslKlsr0%3D 10.1016/j.ijpharm.2004.03.016 15196640 (Pubitemid 38759508)
    • (2004) International Journal of Pharmaceutics , vol.278 , Issue.2 , pp. 353-360
    • Guggi, D.1    Langoth, N.2    Hoffer, M.H.3    Wirth, M.4    Bernkop-Schnurch, A.5
  • 21
    • 33646814008 scopus 로고    scopus 로고
    • Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles
    • DOI 10.1016/j.ijpharm.2006.02.037, PII S0378517306001827
    • I Bravo-Osuna T Schmitz A Bernkop-Schnürch C Vauthier G Ponchel 2006 Elaboration and characterization of thiolated chitosan-coated acrylic nanoparticles Int J Pharm 316 1-2 170 175 1:CAS:528:DC%2BD28XkvVWrtrw%3D 10.1016/j.ijpharm.2006.02.037 16580797 (Pubitemid 43765693)
    • (2006) International Journal of Pharmaceutics , vol.316 , Issue.1-2 , pp. 170-175
    • Bravo-Osuna, I.1    Schmitz, T.2    Bernkop-Schnurch, A.3    Vauthier, C.4    Ponchel, G.5
  • 22
    • 32644440948 scopus 로고    scopus 로고
    • Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats
    • DOI 10.1002/jps.20566
    • T Goto M Morishita N Kavimandan K Takayama N Peppas 2006 Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats J Pharm Sci 95 2 462 469 1:CAS:528:DC%2BD28XhsFeksL8%3D 10.1002/jps.20566 16381013 (Pubitemid 43241986)
    • (2006) Journal of Pharmaceutical Sciences , vol.95 , Issue.2 , pp. 462-469
    • Goto, T.1    Morishita, M.2    Kavimandan, N.J.3    Takayama, K.4    Peppas, N.A.5
  • 23
    • 0042140521 scopus 로고    scopus 로고
    • Thiolated polymers: Evidence for the formation of disulphide bonds with mucus glycoproteins
    • DOI 10.1016/S0939-6411(03)00061-4
    • VM Leitner GF Walker A Bernkop-Schnurch 2003 Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins Eur J Pharm Biopharm 56 2 207 214 1:CAS:528:DC%2BD3sXmvFSjtrw%3D 10.1016/S0939-6411(03) 00061-4 12957634 (Pubitemid 37072104)
    • (2003) European Journal of Pharmaceutics and Biopharmaceutics , vol.56 , Issue.2 , pp. 207-214
    • Leitner, V.M.1    Walker, G.F.2    Bernkop-Schnurch, A.3
  • 24
    • 33846799473 scopus 로고    scopus 로고
    • Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles
    • DOI 10.1016/j.biomaterials.2007.01.005, PII S0142961207000117
    • I Bravo-Osuna C Vauthier A Farabollini G Palmieri G Ponchel 2007 Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutyl cyanoacrylate) core-shell nanoparticles Biomaterials 28 13 2233 2243 1:CAS:528:DC%2BD2sXhsFCkurc%3D 10.1016/j.biomaterials.2007.01.005 17261330 (Pubitemid 46216448)
    • (2007) Biomaterials , vol.28 , Issue.13 , pp. 2233-2243
    • Bravo-Osuna, I.1    Vauthier, C.2    Farabollini, A.3    Palmieri, G.F.4    Ponchel, G.5
  • 25
    • 0020523525 scopus 로고
    • Controlled entry of orally administered drugs: Physiological considerations
    • 10.3109/03639048309046314
    • AF Hofmann JH Pressman CF Code 1983 Controlled entry of orally administered drugs: physiological considerations Drug Dev Ind Pharm 9 7 1077 1109 10.3109/03639048309046314
    • (1983) Drug Dev Ind Pharm , vol.9 , Issue.7 , pp. 1077-1109
    • Hofmann, A.F.1    Pressman, J.H.2    Code, C.F.3
  • 26
    • 0023369683 scopus 로고
    • Gastrointestinal pH measurement in rats: Influence of the microbial flora, diet and fasting
    • 1:STN:280:DyaL2szhtlansw%3D%3D 10.1258/002367787781268693 3626468
    • F Ward M Coates 1987 Gastrointestinal pH measurement in rats: influence of the microbial flora, diet and fasting Lab Anim 21 3 216 222 1:STN:280:DyaL2szhtlansw%3D%3D 10.1258/002367787781268693 3626468
    • (1987) Lab Anim , vol.21 , Issue.3 , pp. 216-222
    • Ward, F.1    Coates, M.2
  • 27
    • 0034812650 scopus 로고    scopus 로고
    • The effect of polyethylene glycol 400 on gastrointestinal transit: Implications for the formulation of poorly-water soluble drugs
    • DOI 10.1023/A:1010927026837
    • A Basit J Newton M Short W Waddington P Ell L Lacey 2001 The effect of polyethylene glycol 400 on gastrointestinal transit: implications for the formulation of poorly-water soluble drugs Pharm Res 18 8 1146 1150 1:CAS:528:DC%2BD3MXnt1ekt7o%3D 10.1023/A:1010927026837 11587486 (Pubitemid 32900400)
    • (2001) Pharmaceutical Research , vol.18 , Issue.8 , pp. 1146-1150
    • Basit, A.W.1    Newton, J.M.2    Short, M.D.3    Waddington, W.A.4    Ell, P.J.5    Lacey, L.F.6
  • 28
    • 0037472115 scopus 로고    scopus 로고
    • Chitosan-based gastrointestinal delivery systems
    • DOI 10.1016/S0168-3659(03)00126-3
    • R Hejazi M Amiji 2003 Chitosan-based gastrointestinal delivery systems J Control Release 89 2 151 165 1:CAS:528:DC%2BD3sXjtVegtbg%3D 10.1016/S0168- 3659(03)00126-3 12711440 (Pubitemid 36507012)
    • (2003) Journal of Controlled Release , vol.89 , Issue.2 , pp. 151-165
    • Hejazi, R.1    Amiji, M.2
  • 29
    • 0022538998 scopus 로고
    • Transit of pharmaceutical dosage forms through the small intestine
    • 1:STN:280:DyaL283ns1WmtA%3D%3D 10.1136/gut.27.8.886 3732895
    • S Davis J Hardy J Fara 1986 Transit of pharmaceutical dosage forms through the small intestine Gut 27 8 886 892 1:STN:280:DyaL283ns1WmtA%3D%3D 10.1136/gut.27.8.886 3732895
    • (1986) Gut , vol.27 , Issue.8 , pp. 886-892
    • Davis, S.1    Hardy, J.2    Fara, J.3
  • 30
    • 0035078138 scopus 로고    scopus 로고
    • Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats
    • DOI 10.1016/S0278-6915(00)00136-8, PII S0278691500001368
    • J DeSesso C Jacobson 2001 Anatomical and physiological parameters affecting gastrointestinal absorption in humans and rats Food Chem Toxicol 39 3 209 228 1:CAS:528:DC%2BD3MXitF2nurw%3D 10.1016/S0278-6915(00)00136-8 11278053 (Pubitemid 32244129)
    • (2001) Food and Chemical Toxicology , vol.39 , Issue.3 , pp. 209-228
    • DeSesso, J.M.1    Jacobson, C.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.