Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly(γ-glutamic acid)

Biomaterials

Volumn 31, Issue 33, 2010, Pages 8780-8788

  Liao, Zi Xian ^a   Ho, Yi Cheng ^b   Chen, Hsin Lung ^a   Peng, Shu Fen ^a   Hsiao, Chun Wen ^a   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b VANUNG UNIVERSITY   (Taiwan)

Author keywords

Chitosan; Gene silencing; Poly( glutamic acid); Small interfering RNA; Transfection

Indexed keywords

CELLULAR UPTAKE; COMPACT STRUCTURES; COMPLEX FORMATIONS; CYTOSOLS; ELECTROSTATIC INTERACTIONS; GENE KNOCK DOWN; GENE SILENCING; GLUTAMIC ACID; INHIBITION EFFICIENCY; MOLECULAR DYNAMIC SIMULATIONS; SMALL INTERFERING RNA; TRANSFECTION;

CHITIN; CHITOSAN; COMPLEXATION; COMPUTER SIMULATION; ENZYME ACTIVITY; GENETIC ENGINEERING; MOLECULAR DYNAMICS; NUCLEIC ACIDS;

RNA;

CHITOSAN; POLYGLUTAMIC ACID; SMALL INTERFERING RNA;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; DRUG RELEASE; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTERNALIZATION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; SIMULATION;

CELL LINE, TUMOR; CHITOSAN; CYTOSOL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE SILENCING; GREEN FLUORESCENT PROTEINS; HUMANS; INTRACELLULAR SPACE; LUCIFERASES; MICROSCOPY, CONFOCAL; MOLECULAR DYNAMICS SIMULATION; POLYGLUTAMIC ACID; RNA, SMALL INTERFERING;

EID: 77957298626     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.07.086     Document Type: Article

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