Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins

Biomaterials

Volumn 32, Issue 33, 2011, Pages 8712-8721

  Sonaje, Kiran ^a   Lin, Kun Ju ^b,c   Tseng, Michael T ^d   Wey, Shiaw Pyng ^b   Su, Fang Yi ^a   Chuang, Er Yuan ^a   Hsu, Chia Wei ^a   Chen, Chiung Tong ^e   Sung, Hsing Wen ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^d University of Louisville School of Medicine   (United States)

^e NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Chitosan; Endotoxin; Insulin; Paracellular transport; Tight junction

Indexed keywords

BIODISTRIBUTIONS; CHARGE REPULSION; ENDOTOXIN; EPITHELIAL CELLS; GASTROINTESTINAL TRACT; HYPOGLYCEMIC EFFECT; IN-VIVO; INTESTINAL EPITHELIUM; LIPOPOLYSACCHARIDES; MUCUS LAYER; ORAL ABSORPTION; ORAL DELIVERY; PARACELLULAR TRANSPORT; PH-RESPONSIVE; PHYSIOLOGICAL CONDITION; PROTEIN DRUGS; SMALL INTESTINE; SYSTEMIC CIRCULATION; TIGHT JUNCTIONS; URINARY BLADDER;

BODY FLUIDS; CHITOSAN; INSULIN; IODINE; NANOPARTICLES; PH EFFECTS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TRANSMISSION ELECTRON MICROSCOPY;

MULTIPHOTON PROCESSES;

CHITOSAN; DRUG CARRIER; ENDOTOXIN; INSULIN; INSULIN I 131; LIPOPOLYSACCHARIDE; NANOPARTICLE; PERTECHNETIC ACID TC 99M;

ANIMAL EXPERIMENT; ARTICLE; BLADDER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EPITHELIUM CELL; GASTROINTESTINAL TRACT; IN VIVO STUDY; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; ISOTOPE LABELING; MALE; MICELLE; MOLECULAR WEIGHT; MUCUS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RADIOACTIVITY; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYSTEMIC CIRCULATION; TIGHT JUNCTION; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ANIMALS; CHITOSAN; ENDOTOXINS; MALE; MICELLES; NANOPARTICLES; RATS; RATS, WISTAR; TIGHT JUNCTIONS; TISSUE DISTRIBUTION;

EID: 80052966755     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.07.086     Document Type: Article

References (36)

1. Khafagy el S., Morishita M., Onuki Y., Takayama K. Current challenges in non-invasive insulin delivery systems: a comparative review. Adv Drug Deliv Rev 2007, 59:1521-1546.
2. Carino G.P., Mathiowitz E. Oral insulin delivery. Adv Drug Deliv Rev 1999, 35:249-257.
3. Sonaje K., Lin K.J., Wang J.J., Mi F.L., Chen C.T., Juang J.H., et al. Self-assembled ph-sensitive nanoparticles: a platform for oral delivery of protein drugs. Adv Funct Mater 2010, 20:3695-3700.
4. Sonaje K., Lin Y.H., Juang J.H., Wey S.P., Chen C.T., Sung H.W. In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials 2009, 30:2329-2339.
5. Smith J., Wood E., Dornish M. Effect of chitosan on epithelial cell tight junctions. Pharm Res 2004, 21:43-49.
6. Sonaje K., Chen Y.J., Chen H.L., Wey S.P., Juang J.H., Nguyen H.N., et al. Enteric-coated capsules filled with freeze-dried chitosan/poly(γ-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials 2010, 31:3384-3394.
7. Junginger H.E., Verhoef J.C. Macromolecules as safe penetration enhancers for hydrophilic drugs - a fiction?. Pharm Sci Technolo Today 2000, 3:346-358.
8. Lu F.C., Kacew S. Basic toxicology: fundamentals, target organs, and risk assessment. Chapter 2: Absorption, distribution, and excretion of toxicants 2009, Taylor & Francis, PA, USA, p. 15-28. 5th ed.
9. Walker R.L., Owen R.L. Intestinal barriers to bacteria and their toxins. Annu Rev Med 1990, 41:393-400.
10. Macpherson A.J., Geuking M.B., McCoy K.D. Immune responses that adapt the intestinal mucosa to commensal intestinal bacteria. Immunology 2005, 115:153-162.
11. Gutsmann T., Schromm A.B., Brandenburg K. The physicochemistry of endotoxins in relation to bioactivity. Int J Med Microbiol 2007, 297:341-352.
12. Piazza M., Colombo M., Zanoni I., Granucci F., Tortora P., Weiss J., et al. Uniform lipopolysaccharide (LPS)-loaded magnetic nanoparticles for the investigation of LPS-TLR4 signaling. Angew Chem Int Ed Engl 2011, 50:622-626.
13. Li G., Liu Y., Tzeng N.S., Cui G., Block M.L., Wilson B., et al. Protective effect of dextromethorphan against endotoxic shock in mice. Biochem Pharmacol 2005, 69:233-240.
14. Lin Y.H., Sonaje K., Lin K.M., Juang J.H., Mi F.L., Yang H.W., et al. Multi-ion-crosslinked nanoparticles with pH-responsive characteristics for oral delivery of protein drugs. J Control Release 2008, 132:141-149.
15. Sonaje K., Lin K.J., Wey S.P., Lin C.K., Yeh T.H., Nguyen H.N., et al. Biodistribution, pharmacodynamics and pharmacokinetics of insulin analogues in a rat model: oral delivery using pH-Responsive nanoparticles vs. subcutaneous injection. Biomaterials 2010, 31:6849-6858.
16. Yu L., Tan M., Ho B., Ding J.L., Wohland T. Determination of critical micelle concentrations and aggregation numbers by fluorescence correlation spectroscopy: aggregation of a lipopolysaccharide. Anal Chim Acta 2006, 556:216-225.
17. Rosenbaum J.T., Hendricks P.A., Shively J.E., McDougall I.R. Distribution of radiolabeled endotoxin with particular reference to the eye: concise communication. J Nucl Med 1983, 24:29-33.
18. Chen M.C., Wong H.S., Lin K.J., Chen H.L., Wey S.P., Sonaje K., et al. The characteristics, biodistribution and bioavailability of a chitosan-based nanoparticulate system for the oral delivery of heparin. Biomaterials 2009, 30:6629-6637.
19. Sodoyez J.C., Sodoyez-Goffaux F., Guillaume M., Merchie G. [123I]Insulin metabolism in normal rats and humans: external detection by a scintillation camera. Science 1983, 219:865-867.
20. Lin K.J., Liao C.H., Hsiao I.T., Yen T.C., Chen T.C., Jan Y.Y., et al. Improved hepatocyte function of future liver remnant of cirrhotic rats after portal vein ligation: a bonus other than volume shifting. Surgery 2009, 145:202-211.
21. Bagalkot V., Zhang L., Levy-Nissenbaum E., Jon S., Kantoff P.W., Langer R., et al. Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bi-fluorescence resonance energy transfer. Nano Lett 2007, 7:3065-3070.
22. Liang R.Q., Li W., Li Y., Tan C.Y., Li J.X., Jin Y.X., et al. An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe. Nucleic Acids Res 2005, 33. e17.
23. Friend D.S., Gilula N.B. Variations in tight and gap junctions in mammalian tissues. J Cell Biol 1972, 53:758-776.
24. Flynn A.N., Itani O.A., Moninger T.O., Welsh M.J. Acute regulation of tight junction ion selectivity in human airway epithelia. Proc Natl Acad Sci USA 2009, 106:3591-3596.
25. Salama N.N., Eddington N.D., Fasano A. Tight junction modulation and its relationship to drug delivery. Adv Drug Deliv Rev 2006, 58:15-28.
26. Smith J.M., Dornish M., Wood E.J. Involvement of protein kinase C in chitosan glutamate-mediated tight junction disruption. Biomaterials 2005, 26:3269-3276.
27. Beatty W.L., Meresse S., Gounon P., Davoust J., Mounier J., Sansonetti P.J., et al. Trafficking of Shigella lipopolysaccharide in polarized intestinal epithelial cells. J Cell Biol 1999, 145:689-698.
28. Ravin H.A., Rowley D., Jenkins C., Fine J. On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal. J Exp Med 1960, 112:783-792.
29. Cone R.A. Barrier properties of mucus. Adv Drug Deliv Rev 2009, 61:75-85.
30. Johansson M.E.V., Phillipson M., Petersson J., Velcich A., Holm L., Hansson G.C. The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA 2008, 105:15064-15069.
31. Atuma C., Strugala V., Allen A., Holm L. The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol Gastrointest Liver Physiol 2001, 280:G922-G929.
32. Vreugdenhil A.C., Snoek A.M., Greve J.W., Buurman W.A. Lipopolysaccharide-binding protein is vectorially secreted and transported by cultured intestinal epithelial cells and is present in the intestinal mucus of mice. J Immunol 2000, 165:4561-4566.
33. Ward P.D., Tippin T.K., Thakker D.R. Enhancing paracellular permeability by modulating epithelial tight junctions. Pharm Sci Technolo Today 2000, 3:346-358.
34. Mortensen L.J., Oberdorster G., Pentland A.P., Delouise L.A. In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR. Nano Lett 2008, 8:2779-2787.
35. Illyes G., Kovacs K., Kocsis B., Baintner K. Failure of oral E. coli O83 lipopolysaccharide to influence intestinal morphology and cell proliferation in rats: short communication. Acta Vet Hung 2008, 56:1-3.
36. Bertok L. Effect of bile acids on endotoxin in vitro and in vivo (physico-chemical defense). Bile deficiency and endotoxin translocation. Ann N Y Acad Sci 1998, 851:408-410.