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Volumn 194, Issue 1, 2000, Pages 1-13

Chitosan and its derivatives: Potential excipients for peroral peptide delivery systems

Author keywords

Chitosan; Chitosan derivatives; Drug delivery systems; Peroral peptide application

Indexed keywords

BUSERELIN; CALCITONIN; CHITOSAN; CHITOSAN DERIVATIVE; EDETIC ACID; EXCIPIENT; INSULIN;

EID: 0033991816     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00365-8     Document Type: Review
Times cited : (235)

References (52)
  • 1
    • 0030799947 scopus 로고    scopus 로고
    • Chitosan microcapsules as controlled release systems for insulin
    • Aiedeh K., Gianasi E., Orienti I., Zecchi V. Chitosan microcapsules as controlled release systems for insulin. J. Microencapsul. 14:1997;567-576.
    • (1997) J. Microencapsul. , vol.14 , pp. 567-576
    • Aiedeh, K.1    Gianasi, E.2    Orienti, I.3    Zecchi, V.4
  • 3
    • 0028071051 scopus 로고
    • Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
    • Artursson P., Lindmark T., Davis S.S., Illum L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm. Res. 11:1994;1358-1361.
    • (1994) Pharm. Res. , vol.11 , pp. 1358-1361
    • Artursson, P.1    Lindmark, T.2    Davis, S.S.3    Illum, L.4
  • 5
    • 0030765867 scopus 로고    scopus 로고
    • Strategien zur peroralen Applikation von Peptid- Und Proteinwirkstoffen
    • Bernkop-Schnürch A. Strategien zur peroralen Applikation von Peptid- und Proteinwirkstoffen. Sci. Pharm. 65:1997;61-82.
    • (1997) Sci. Pharm. , vol.65 , pp. 61-82
    • Bernkop-Schnürch, A.1
  • 6
    • 0030813427 scopus 로고    scopus 로고
    • Development and in vitro evaluation of a drug delivery system protecting from trypsinic degradation
    • Bernkop-Schnürch A., Bratengeyer I., Valenta C. Development and in vitro evaluation of a drug delivery system protecting from trypsinic degradation. Int. J. Pharm. 157:1997;17-25.
    • (1997) Int. J. Pharm. , vol.157 , pp. 17-25
    • Bernkop-Schnürch, A.1    Bratengeyer, I.2    Valenta, C.3
  • 7
    • 0030740816 scopus 로고    scopus 로고
    • Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N.
    • Bernkop-Schnürch A., Paikl C., Valenta C. Novel bioadhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase N. Pharm. Res. 14:1997;917-922.
    • (1997) Pharm. Res. , vol.14 , pp. 917-922
    • Bernkop-Schnürch, A.1    Paikl, C.2    Valenta, C.3
  • 8
    • 0032473473 scopus 로고    scopus 로고
    • The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins
    • Bernkop-Schnürch A. The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. J. Control Release. 52:1998;1-16.
    • (1998) J. Control Release , vol.52 , pp. 1-16
    • Bernkop-Schnürch, A.1
  • 9
    • 0032472305 scopus 로고    scopus 로고
    • Mucoadhesive polymers for peroral peptide delivery: Synthesis and evaluation of chitosan-EDTA conjugates
    • Bernkop-Schnürch A., Krajicek M.E. Mucoadhesive polymers for peroral peptide delivery: synthesis and evaluation of chitosan-EDTA conjugates. J. Control Release. 50:1998;215-223.
    • (1998) J. Control Release , vol.50 , pp. 215-223
    • Bernkop-Schnürch, A.1    Krajicek, M.E.2
  • 10
    • 0031901490 scopus 로고    scopus 로고
    • Intestinal peptide and protein delivery: Novel bioadhesive drug carrier matrix shielding from enzymatic attack
    • Bernkop-Schnürch A., Pasta M. Intestinal peptide and protein delivery: novel bioadhesive drug carrier matrix shielding from enzymatic attack. J. Pharm. Sci. 87:1998;430-434.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 430-434
    • Bernkop-Schnürch, A.1    Pasta, M.2
  • 12
    • 0031915514 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins
    • Bernkop-Schnürch A., Scerbe-Saiko A. Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins. Pharm. Res. 15:1998;263-269.
    • (1998) Pharm. Res. , vol.15 , pp. 263-269
    • Bernkop-Schnürch, A.1    Scerbe-Saiko, A.2
  • 13
    • 0032516229 scopus 로고    scopus 로고
    • Basic studies on bioadhesive delivery systems for peptide and protein drugs
    • Bernkop-Schnürch A., Humenberger C., Valenta C. Basic studies on bioadhesive delivery systems for peptide and protein drugs. Int. J. Pharm. 165:1998;217-225.
    • (1998) Int. J. Pharm. , vol.165 , pp. 217-225
    • Bernkop-Schnürch, A.1    Humenberger, C.2    Valenta, C.3
  • 14
    • 0032411591 scopus 로고    scopus 로고
    • Development and in vitro evaluation of a drug delivery system based on chitosan-EDTA BBI conjugate
    • Bernkop-Schnürch A., Krauland A., Valenta C. Development and in vitro evaluation of a drug delivery system based on chitosan-EDTA BBI conjugate. J. Drug Targ. 6:1998;207-214.
    • (1998) J. Drug Targ. , vol.6 , pp. 207-214
    • Bernkop-Schnürch, A.1    Krauland, A.2    Valenta, C.3
  • 15
    • 0032883740 scopus 로고    scopus 로고
    • Polymer-inhibitor conjugates: A promising strategy to overcome the enzymatic barrier to perorally administered (poly)peptide drugs
    • Bernkop-Schnürch A. Polymer-inhibitor conjugates: a promising strategy to overcome the enzymatic barrier to perorally administered (poly)peptide drugs. STP Pharma Sciences. 9:1999;78-87.
    • (1999) STP Pharma Sciences , vol.9 , pp. 78-87
    • Bernkop-Schnürch, A.1
  • 16
    • 0032956002 scopus 로고    scopus 로고
    • Comparative in vitro study of different chitosan-complexing agent conjugates
    • Bernkop-Schnürch A., Freudl J. Comparative in vitro study of different chitosan-complexing agent conjugates. Pharmazie. 54:1999;369-371.
    • (1999) Pharmazie , vol.54 , pp. 369-371
    • Bernkop-Schnürch, A.1    Freudl, J.2
  • 17
    • 0033619906 scopus 로고    scopus 로고
    • Synthesis and in vitro Evaluation of chitosan-cysteine conjugates
    • in press
    • Bernkop-Schnürch, A., Brandt, U.-M., Clausen, A., 1999. Synthesis and in vitro Evaluation of chitosan-cysteine conjugates. Sci. Pharm., in press.
    • (1999) Sci. Pharm.
    • Bernkop-Schnürch, A.1    Brandt, U.-M.2    Clausen, A.3
  • 18
  • 19
    • 0343150936 scopus 로고    scopus 로고
    • The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
    • Borchard G., Lueßen H.L., Verhoef J.C., Lehr C.-M., de Boer A.G., Junginger H.E. The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption III: effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro. J. Control Release. 39:1996;131-138.
    • (1996) J. Control Release , vol.39 , pp. 131-138
    • Borchard, G.1    Lueßen, H.L.2    Verhoef, J.C.3    Lehr, C.-M.4    De Boer, A.G.5    Junginger, H.E.6
  • 20
    • 0032917517 scopus 로고    scopus 로고
    • Effect of chitosan on epithelial permeability and structure
    • Dodane V., Khan A., Merwin J.R. Effect of chitosan on epithelial permeability and structure. Int. J. Pharm. 182:1999;21-32.
    • (1999) Int. J. Pharm. , vol.182 , pp. 21-32
    • Dodane, V.1    Khan, A.2    Merwin, J.R.3
  • 21
    • 0031714427 scopus 로고    scopus 로고
    • Chitosan: A unique polysaccharide for drug delivery
    • Felt O., Buri P., Gurny R. Chitosan: a unique polysaccharide for drug delivery. Drug Dev. Ind. Pharm. 24:1998;979-993.
    • (1998) Drug Dev. Ind. Pharm. , vol.24 , pp. 979-993
    • Felt, O.1    Buri, P.2    Gurny, R.3
  • 22
    • 0021871421 scopus 로고
    • Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs
    • Fujii S., Yokoyama T., Ikegaya K., Sato F., Yokoo N. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J. Pharm. Pharmacol. 37:1985;545-549.
    • (1985) J. Pharm. Pharmacol. , vol.37 , pp. 545-549
    • Fujii, S.1    Yokoyama, T.2    Ikegaya, K.3    Sato, F.4    Yokoo, N.5
  • 23
    • 0027327379 scopus 로고
    • The effect of trypsin inhibitor on the pancreas and small intestine of mice
    • Ge Y.C., Morgan R.G.H. The effect of trypsin inhibitor on the pancreas and small intestine of mice. Br. J. Nutr. 70:1993;333-345.
    • (1993) Br. J. Nutr. , vol.70 , pp. 333-345
    • Ge, Y.C.1    Morgan, R.G.H.2
  • 24
    • 0025108791 scopus 로고
    • A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength
    • Hassan E.E., Gallo J.M. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm. Res. 7:1990;491-495.
    • (1990) Pharm. Res. , vol.7 , pp. 491-495
    • Hassan, E.E.1    Gallo, J.M.2
  • 25
    • 0027233875 scopus 로고
    • Degradation of proteins by guinea pig intestinal enzymes
    • Ikesue K., Kopeckova P., Kopecek J. Degradation of proteins by guinea pig intestinal enzymes. Int. J. Pharm. 95:1993;171-179.
    • (1993) Int. J. Pharm. , vol.95 , pp. 171-179
    • Ikesue, K.1    Kopeckova, P.2    Kopecek, J.3
  • 26
    • 0028124642 scopus 로고
    • Chitosan as a novel nasal delivery system for peptide drugs
    • Illum L., Farraj N.F., Davis S.S. Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res. 11:1994;1186-1189.
    • (1994) Pharm. Res. , vol.11 , pp. 1186-1189
    • Illum, L.1    Farraj, N.F.2    Davis, S.S.3
  • 27
    • 0031783879 scopus 로고    scopus 로고
    • Chitosan and its use as a pharmaceutical excipient
    • Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm. Res. 15:1998;1326-1331.
    • (1998) Pharm. Res. , vol.15 , pp. 1326-1331
    • Illum, L.1
  • 28
    • 0006627390 scopus 로고    scopus 로고
    • Adsorption behaviors of some complexane types of chemically modified chitosan for metal ions
    • A. Domard, C. Jeuniaux, R. Muzzarelli, & G. Roberts. Lyon: Jacques André
    • Inoue K., Yamaguchi T., Shinbaru R., Hirakawa H., Yoshizuka K., Ohto K. Adsorption behaviors of some complexane types of chemically modified chitosan for metal ions. Domard A., Jeuniaux C., Muzzarelli R., Roberts G. Advances in Chitin Science. 1996;271-278 Jacques André Lyon.
    • (1996) Advances in Chitin Science , pp. 271-278
    • Inoue, K.1    Yamaguchi, T.2    Shinbaru, R.3    Hirakawa, H.4    Yoshizuka, K.5    Ohto, K.6
  • 29
    • 0006539520 scopus 로고    scopus 로고
    • Complexane types of chemically modified chitosan: Novel chelating absorbents for separating nickel and cobalt
    • Inoue K. Complexane types of chemically modified chitosan: Novel chelating absorbents for separating nickel and cobalt. Proc. Nickel-Cobalt 97 Int. Symp. 1:1997;211-219.
    • (1997) Proc. Nickel-Cobalt 97 Int. Symp. , vol.1 , pp. 211-219
    • Inoue, K.1
  • 30
    • 0023119830 scopus 로고
    • The effect of polycarbophil on the gastric emptying of pellets
    • Khosla R., Davis S.S. The effect of polycarbophil on the gastric emptying of pellets. J. Pharm. Pharmacol. 39:1987;47-49.
    • (1987) J. Pharm. Pharmacol. , vol.39 , pp. 47-49
    • Khosla, R.1    Davis, S.S.2
  • 31
    • 0031574261 scopus 로고    scopus 로고
    • Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: In vitro evaluation in Caco-2 cell monolayers
    • Kotzé A.F., de Leeuw B.J., Lueßen H.L., de Boer A.G., Verhoef J.C., Junginger H.E. Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers. Int. J. Pharm. 159:1997;243-253.
    • (1997) Int. J. Pharm. , vol.159 , pp. 243-253
    • Kotzé, A.F.1    De Leeuw, B.J.2    Lueßen, H.L.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 32
    • 0344359721 scopus 로고    scopus 로고
    • Chitosan for enhanced intestinal permeability: Prospects for derivatives soluble in neutral and basic environments
    • Kotzé A.F., Lueßen H.L., de Boer A.G., Verhoef J.C., Junginger H.E. Chitosan for enhanced intestinal permeability: prospects for derivatives soluble in neutral and basic environments. Eur. J. Pharm. Sci. 7:1998;145-151.
    • (1998) Eur. J. Pharm. Sci. , vol.7 , pp. 145-151
    • Kotzé, A.F.1    Lueßen, H.L.2    De Boer, A.G.3    Verhoef, J.C.4    Junginger, H.E.5
  • 33
    • 0033007333 scopus 로고    scopus 로고
    • Enhancement of paracellular drug transport with highly quarternized N-trimethyl chitosan chloride in natural environments: In vitro evaluation in intestinal epithelial cells (Caco-2)
    • Kotzé A.F., Thanou M.M., Lueßen H.L., de Boer A.G., Verhoef J.C., Junginger H.E. Enhancement of paracellular drug transport with highly quarternized N-trimethyl chitosan chloride in natural environments: in vitro evaluation in intestinal epithelial cells (Caco-2). J. Pharm. Sci. 88:1999;253-257.
    • (1999) J. Pharm. Sci. , vol.88 , pp. 253-257
    • Kotzé, A.F.1    Thanou, M.M.2    Lueßen, H.L.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 34
    • 0028215218 scopus 로고
    • Oral absorption of peptides: The effect of absorption site and enzyme inhibition on the systemic availability of metkephamid
    • Langguth P., Merkle H.P., Amidon G.L. Oral absorption of peptides: the effect of absorption site and enzyme inhibition on the systemic availability of metkephamid. Pharm. Res. 11:1994;528-535.
    • (1994) Pharm. Res. , vol.11 , pp. 528-535
    • Langguth, P.1    Merkle, H.P.2    Amidon, G.L.3
  • 35
    • 0000888475 scopus 로고
    • Oral route of peptide and protein drug delivery
    • M.L.G. Gardner, & K.-J. Steffens. Berlin: Springer Verlag
    • Lee V.H.L. Oral route of peptide and protein drug delivery. Gardner M.L.G., Steffens K.-J. Absorption of Orally Administered Enzymes. 1995;39-46 Springer Verlag, Berlin.
    • (1995) Absorption of Orally Administered Enzymes , pp. 39-46
    • Lee, V.H.L.1
  • 36
    • 0028609750 scopus 로고
    • Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract
    • Lehr C.-M. Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract. Crit. Rev. Ther. Drug. 11:1994;119-160.
    • (1994) Crit. Rev. Ther. Drug , vol.11 , pp. 119-160
    • Lehr, C.-M.1
  • 37
    • 0026800237 scopus 로고
    • In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
    • Lehr C.-M., Bouwstra J.A., Schacht E.H., Junginger H.E. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 78:1992;43-48.
    • (1992) Int. J. Pharm. , vol.78 , pp. 43-48
    • Lehr, C.-M.1    Bouwstra, J.A.2    Schacht, E.H.3    Junginger, H.E.4
  • 38
    • 0030927353 scopus 로고    scopus 로고
    • Characterization of fluids from the stomach and proximal jejunum in men and women
    • Lindahl A., Ungell A.-L., Knutson L., Lennernäs H. Characterization of fluids from the stomach and proximal jejunum in men and women. Pharm. Res. 14:1997;497-502.
    • (1997) Pharm. Res. , vol.14 , pp. 497-502
    • Lindahl, A.1    Ungell, A.-L.2    Knutson, L.3    Lennernäs, H.4
  • 39
    • 0031018133 scopus 로고    scopus 로고
    • Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro
    • Lueßen H.L., Rentel C.-O., Kotzé A.F., Lehr C.-M., de Boer A.G., Verhoef J.C. et al. Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J. Control Release. 45:1997;15-23.
    • (1997) J. Control Release , vol.45 , pp. 15-23
    • Lueßen, H.L.1    Rentel, C.-O.2    Kotzé, A.F.3    Lehr, C.-M.4    De Boer, A.G.5    Verhoef, J.C.6
  • 40
    • 0030453145 scopus 로고    scopus 로고
    • Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo
    • Lueßen H.L., de Leeuw B.J., Langemeyer M.W., de Boer A.G., Verhoef J.C., Junginger H.E. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm. Res. 13:1996;1668-1672.
    • (1996) Pharm. Res. , vol.13 , pp. 1668-1672
    • Lueßen, H.L.1    De Leeuw, B.J.2    Langemeyer, M.W.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 41
    • 0017289856 scopus 로고
    • Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soy bean trypsin inhibitor
    • Melmed R.N., El-Aaser A.A., Holt S.J. Hypertrophy and hyperplasia of the neonatal rat exocrine pancreas induced by orally administered soy bean trypsin inhibitor. Biochim. Biophys. Acta. 421:1976;280-288.
    • (1976) Biochim. Biophys. Acta , vol.421 , pp. 280-288
    • Melmed, R.N.1    El-Aaser, A.A.2    Holt, S.J.3
  • 42
    • 0026789983 scopus 로고
    • Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats
    • Morishita I., Morishita M., Takayama K., Machida Y., Nagai T. Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats. Int. J. Pharm. 78:1992;9-16.
    • (1992) Int. J. Pharm. , vol.78 , pp. 9-16
    • Morishita, I.1    Morishita, M.2    Takayama, K.3    Machida, Y.4    Nagai, T.5
  • 43
    • 0030455292 scopus 로고    scopus 로고
    • Chitosans as absorption enhancers for poorly absorbable drugs. 1: Influence of molecular weight and degree of acetlyation on drug transport across human intestinal epithelial (Caco-2) cells
    • Schipper N.G.M., Varum K.M., Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs. 1: influence of molecular weight and degree of acetlyation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm. Res. 13:1996;1686-1691.
    • (1996) Pharm. Res. , vol.13 , pp. 1686-1691
    • Schipper, N.G.M.1    Varum, K.M.2    Artursson, P.3
  • 44
  • 45
  • 46
    • 0029895328 scopus 로고    scopus 로고
    • Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes
    • Takeuchi H., Yamamoto H., Toshiyuki N., Tomoaki H., Kawashima Y. Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes. Pharm. Res. 13:1996;896-901.
    • (1996) Pharm. Res. , vol.13 , pp. 896-901
    • Takeuchi, H.1    Yamamoto, H.2    Toshiyuki, N.3    Tomoaki, H.4    Kawashima, Y.5
  • 48
    • 0030603044 scopus 로고    scopus 로고
    • Metal-chelating chitin derivatives via reaction of chitosan with nitrilotriacetic acid
    • Tikhonov V.E., Radigina L.A., Yamskov Y.A. Metal-chelating chitin derivatives via reaction of chitosan with nitrilotriacetic acid. Carbohydr. Res. 290:1996;33-41.
    • (1996) Carbohydr. Res. , vol.290 , pp. 33-41
    • Tikhonov, V.E.1    Radigina, L.A.2    Yamskov, Y.A.3
  • 49
    • 0031745232 scopus 로고    scopus 로고
    • Chitosan-EDTA conjugate: A novel polymer for topical used gels
    • Valenta, C., Christen, B., Bernkop-Schnürch, A., 1998. Chitosan-EDTA conjugate: a novel polymer for topical used gels. J. Pharm. Pharmacol. 50, 445-452.
    • (1998) J. Pharm. Pharmacol. , vol.50 , pp. 445-452
    • Valenta, C.1    Christen, B.2    Bernkop-Schnürch, A.3
  • 50
    • 0028657017 scopus 로고
    • Enzymatic barriers for GI peptide and protein delivery
    • Woodley J.F. Enzymatic barriers for GI peptide and protein delivery. Crit. Rev. Ther. Drug. 11:1994;61-95.
    • (1994) Crit. Rev. Ther. Drug , vol.11 , pp. 61-95
    • Woodley, J.F.1
  • 51
    • 0027988721 scopus 로고
    • Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats
    • Yamamoto A., Taniguchi T., Rikyuu K., Tsuji T., Fujita T., Murakami M. et al. Effects of various protease inhibitors on the intestinal absorption and degradation of insulin in rats. Pharm. Res. 11:1994;1496-1500.
    • (1994) Pharm. Res. , vol.11 , pp. 1496-1500
    • Yamamoto, A.1    Taniguchi, T.2    Rikyuu, K.3    Tsuji, T.4    Fujita, T.5    Murakami, M.6
  • 52
    • 0028239031 scopus 로고
    • Overcoming enzymatic and absorption barriers to nonparenterally administered protein and peptide drugs
    • Zhou X.H. Overcoming enzymatic and absorption barriers to nonparenterally administered protein and peptide drugs. J. Control Release. 29:1994;239-252.
    • (1994) J. Control Release , vol.29 , pp. 239-252
    • Zhou, X.H.1


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