Chitosan: Some pharmaceutical and biological aspects - An update

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 8, 2001, Pages 1047-1067

  Singla, A K ^a   Chawla, M ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALGINIC ACID; AMINO ACID; ANION; ANTIINFLAMMATORY AGENT; ARGIPRESSIN[DEGLYCINAMIDE]; BACITRACIN; BOWMAN BIRK INHIBITOR; CARBOXYPEPTIDASE A; CHITIN; CHITOSAN; CHLORPROMAZINE; CHYMOSTATIN; DILTIAZEM; EDETIC ACID; ELASTATINAL; EXCIPIENT; GLUCOSAMINE; INDOMETACIN; LEUCINE ENKEPHALIN; MANNITOL; MICROSOMAL AMINOPEPTIDASE; N ACETYLGLUCOSAMINE; PEPTIDE; POLYACRYLIC ACID; POLYMER; POLYSACCHARIDE; SULFAMETHOXAZOLE; THEOPHYLLINE; TRYPSIN; UNINDEXED DRUG;

ANTIMICROBIAL ACTIVITY; CONTROLLED DRUG RELEASE; CRUSTACEA; DEACETYLATION; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG COATING; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG SCREENING; DRUG SYNTHESIS; EXCIPIENT COMPATIBILITY; FUNGUS; HYPOCHOLESTEROLEMIA; INSECT; MOLECULAR WEIGHT; NONHUMAN; PHYSICAL CHEMISTRY; REVIEW; VISCOSITY; WOUND HEALING;

ANIMALS; CHITIN; CHITOSAN; DIGESTIVE SYSTEM; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HEMOSTATICS; HUMANS;

EID: 0034879035     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011776441     Document Type: Review

References (144)

1. Chitosan microspheres of diclofenac sodium. II. In vitro and in vivo evaluation
2. Effect of the physicochemical properties of a drug on its release from chitosan malate matrix tablets
3. Effect of formulation variables on cis-platin loaded chitosan microsphere properties
4. Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone
5. Toxicity of chitosan
6. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
7. Chitosan: Effects on wound healing in urogenital tissue: Preliminary report
8. Preparation of casein-chitosan microspheres containing diltiazem hydrochloride by an aqueous coacervation technique
9. Chitosan and its derivatives: Potential excipients for peroral peptide delivery systems
10. Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: Synthesis and evaluation of different chitosan-EDTA conjugates
11. Intestinal peptide and protein delivery: Novel bioadhesive drug carrier matrix shielding from enzymatic attack
12. Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins
13. Novel bio-adhesive chitosan-EDTA conjugate protects leucine enkephalin from degradation by aminopeptidase
14. Basic studies on bioadhesive delivery systems for peptide and protein drugs
15. Preparation and characterisation of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model anti-inflammatory drug
16. Potentiometric method for determination of the degree of acetylation of chitosan
17. Controlled insulin release from chitosan microparticles
18. Evaluation of the biological properties of soluble chitosan and chitosan microspheres
19. Chitosan-poly (acrylic acid): Mechanism of complex formation and potential industrial applications
20. Antibacterial effects of N-sulphonated and N-sulphobenzoyl chitosan and application to oyster preservation
21. Phytotherapeutic aspects of diseases of the circulatory system. 4. Chitin and chitosan
22. Effect of the viscosity or deacetylation degree of chitosan on faecal fat excreted from rats fed on a high-fat diet
23. Effect of chitosan on epithelial permeability and structure
24. Physical characteristics and release behaviour of salbutamol sulphate beads prepared with different ionic polysaccharides
25. Chitosan-based vector/DNA complexes for gene delivery: Biophysical characteristics and transfection ability
26. Hydrodynamic characterisation of chitosans varying in molecular weight and degree of acetylation
27. Nomenclature for synthetic gene delivery systems
28. Chitosan: A unique polysaccharide for drug delivery
29. Enhancement of nasal absorption of insulin using chitosan nanoparticles
30. Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration. S. T. P.
31. 13C CP/MAS NMR and dispersive IR)
32. Optimisation of the measuring of chitin/chitosan degree of acetylation by FT-IR spectroscopy
33. Polyelectrolyte complexes of chitosan with sodium carboxymethyldrextran
34. Chitosan and chondroitin microspheres for oral-administration controlled release of metoclopromide
35. Different molecular weight chitosan microspheres: Influence on drug loading and drug release
36. Reduction in fat storage during chitin-chitosan treatment in mice fed a high fat diet
37. Polynucleotide-chitosan complex, and insoluble but reactive form of polynucleotide
38. In vitro evaluation of the mucoadhesive properties of chitosan microspheres
39. Sustained release chitosan microspheres prepared by novel spray drying methods
40. Chitosan microspheres prepared by spray drying
41. Bioadhesion of hydrated chitosans: An in vitro and in vivo study
42. Percutaneous microcrystalline chitosan application for sealing arterial puncture sites
43. Preparation of a chitosan hybrid of an antimetastatic laminin-related peptide
44. Microencapsulation of chlorpheniramine maleate-resin particles with crosslinked chitosan for sustained release
45. Studies on tables of sulfamethoxazole using chitosan
46. Chitosan as a new pharmaceutical excipient
47. Dissolution studies on tablets of ibuprofen using chitosan
48. Chitosan and its use as a pharmaceutical excipient
49. Interaction of indomethacin with low molecular weight chitosan and improvements of some pharmaceutical properties of indomethacin by low molecular weight chitosans
50. A comparison of the lipid-lowering and intestinal morphological effects of cholestyramine, chitosan, and oat gum in rats
51. Effect of chitosan on renal functions in patients with chronic renal failure
52. Mechanism for the inhibition of fat digestion by chitosan and for the synergistic effect of ascorbate
53. Chitosan: Properties, preparation and application to microparticulate systems
54. The effects of thickness and hardness of the coating film on the drug release rate of theophylline granules coated with chitosan tripolyphosphate complex
55. Chitosan: Evaluation of a new haemostatic agent
56. The effect of chitosan (poly-N-acetyl glucosamine) on lingual haemostasis in heparinised rabbits
57. Preclinical study of antimycotic chitosan hydrogel efficacy
58. Requirements of chitosan for pharmaceutical and biomedical applications
59. Preparation and drug retention of biodegradable chitosan gel beads
60. The effect of chitosan on the paracellular transport pathway
61. N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces: In vitro evaluation in intestinal epithelial cells (Caco-2)
62. Chitosan for enhanced intestinal permeability: Prospects for derivatives soluble in neutral and basic environments
63. Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
64. Heparin-chitosan complexes stimulate wound healing in human skin
65. Hydrocolloids and gels of chitosan as drug carriers
66. Chitosan matrix tablets: The influence of excipients on drug release
67. Some effects of chitosan on liver function in the rat
68. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
69. DNA-polycation nanospheres as non-viral gene delivery vehicles
70. Preparation of chitosan microspheres containing fluorouracil using the "dry-in-oil" method and its release characteristics
71. Effect of magnesium stearate on chitosan microspheres prepared by an emulsification-coacervation technique
72. Controlled release of interleukin-2 for tumour immunotherapy using alginate/chitosan porous microspheres
73. Bioadhesive polymers for the peroral delivery of peptide drugs
74. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo
75. Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro
76. The potential use of mixed films of pectin, chitosan and HPMC for bimodal drug release
77. Chitosan: A new haemostatic
78. Rheological properties and fractal structure of concentrated polyion complexes of chitosan and alginate
79. Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behaviour of chlorpromazine HCl
80. A new approach to encapsulating nonsteroidal anti-inflammatory drugs. IV. Effect of cellulose derivatives with different functional groups on the bioavailability and gastric ulcerogenic activity of acidic as well as basic nonsteroidal anti-inflammatory drugs
81. Sustained-release of oxytetracycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods
82. Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice
83. Sustained-release and intragastric-floating granules of indomethacin using chitosan in rabbits
84. Use of chitosan as a pharmaceutical material: Effectiveness as an additional additive of sodium alginate
85. Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery
86. Drug release from oral mucosal adhesive tablets of chitosan and sodium alginate
87. Influence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cell monolayers
88. Additive effect of chondroitin sulphate and chitosan on drug release from calcium-induced alginate gel beads
89. In vitro assessment of bioadhesion for periodontal and buccal drug delivery
90. Investigation of prolonged drug release from matrix formulations of chitosan
91. Release characteristics of cis-platin chitosan microspheres and effect of containing chitin
92. Antigenotoxic activities of chitin and chitosan as assayed by sister chromatid exchange
93. Evaluation of chitin and chitosan in open wound healing in dogs
94. Photocrosslinkable chitosan as a biological adhesive
95. Dietary chitosan inhibits hypercholesterolemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis
96. An in vitro mucosal model predictive of bioadhesive agents in the oral cavity
97. Chitosan, a drug carrier for the 21st century: A review
98. Randomised, double-blind trial of chitosan for body weight reduction
99. Effect of chitosan and chitosan glutamate enhancing the dissolution properties of the poorly water soluble drug nifedipine
100. DNA protection from extracapsular nucleases, within chitosan - or poly-L-lysine coated alginate beads
101. Use of chitosan as a biomaterial: Studies on its safety and haemostatic potential
102. Chitinosans as tableting excipients for modified release delivery systems
103. Design and evaluation of chitosan/ethylcellulose muco-adhesive bilayered devices for buccal drug delivery
104. Potential of low molecular mass chitosan as a DNA delivery system. Biocompatibility, body distribution and ability to complex and protect DNA
105. Modelling mucoadhesion by use of surface energy terms obtained from the Lewis acid-Lewis base approach. II. Studies on anionic, cationic, and unionisable polymers
106. Modelling mucoadhesion by use of surface energy terms obtained from the Lewis acid-Lewis base approach
107. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
108. Use of chitosan in compressed tablets of diclofenac sodium: Inhibition of drug release in an acidic environment
109. The effect of chitosan on corneal wound healing
110. Chitosan and alginate: New forms of commercial interest
111. Use of chitosan for sustained-release preparations of water-soluble drugs
112. Enhancement of dissolution properties of griseofulvin from ground mixtures with chitin or chitosan
113. Chitosan as absorption enhancers for poorly absorbable drugs. 1: Influence of molecular weight and degree of acetylation on drug transport across human epithelial (Caco-2) cells
114. Chitosans as absorption enhancers for poorly absorbable drugs. 2: Mechanism of absorption enhancement
115. Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement
116. Chitosan films and hydrogels of chlorhexidine gluconate for oral mucosal delivery
117. Release characteristics of chitosan treated alginate beads. I. Sustained release of a macromolecular drug from chitosan treated alginate beads
118. Evaluation of the factors influencing stomach-specific delivery of antibacterial agents for Helicobacter pylori infection
119. Enhancement of dissolution rates of several drugs by low-molecular weight chitosan and alginate
120. Chitosan - New biopolymer for cosmetics and drugs
121. Evaluation of the clearance characteristics of bioadhesive systems in humans
122. Studies on antibacterial and antifungal activity of chitosan
123. Healing at skin graft donor sites dressed with chitosan
124. Hypocholesterolemic action of chitosans with different viscosity in rats
125. Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate
126. Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate
127. Enteral absorption of insulin in rats from mucoadhesive chitosan-coated liposomes
128. Inhibition of Streptococcus mutans adsorption to hydroxyapatite by low-molecular-weight chitosans
129. Pharmacokinetics of an injectable sustained-release formulation of morphine for use in dogs
130. Development of an injectable sustained-release formulation of morphine: Antinociceptive properties in rats
131. Chitosan capsules for colon specific drug delivery: Improvement of insulin absorption from the rat colon
132. Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicyclic acid on 2,4,6-trinitrobenzene sulphonic acid-induced ulcerative colitis in rats
133. Colon specific delivery of R 68070, a new thromboxane synthase inhibitor using chitosan capsules: Therapeutic effects against 2,4,6-trinitrobenzene sulphonic acid-induced ulcerative colitis in rats
134. Antibacterial activity of shrimp chitosan against Escherichia coli
135. Chitosan as a tablet binder
136. 2
137. Chitosan-EDTA conjugate: A novel polymer for topical gels
138. Chitosan-membrane interactions and their probable role in chitosan-mediated transfection
139. Accelerating effect of chitosan intake on urinary calcium excretion by rats
140. Pathohistological observation and biochemical analysis of burn wound healing with CHIMEHERB artificial skin
141. Decrease in serum LDL cholesterol with microcrystalline chitosan
142. Some chemical and analytical aspects of polysaccharide modifications: Formation of branched-chain, soluble chitosan derivatives
143. Tableting of coated particles. I. Small particle size chitosan as an agent protecting coating membrane from mechanical damage of compression force
144. Sustained-release effect of the direct compressed tablet based on chitosan and Na alginate