Enhanced oral absorption of hydrophobic and hydrophilic drugs using quaternary ammonium palmitoyl glycol chitosan nanoparticles

Molecular Pharmaceutics

Volumn 9, Issue 1, 2012, Pages 14-28

  Siew, Adeline ^a   Le, Hang ^a   Thiovolet, Marion ^a   Gellert, Paul ^b   Schatzlein, Andreas ^a   Uchegbu, Ijeoma ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

chitosan amphiphiles; cyclosporin A; griseofulvin; hydrophilic drugs; hydrophobic drugs; idarubicin; mucoadhesion; oral absorption; ranitidine; transcellular transport

Indexed keywords

AMPHOPHILE; CHITOSAN DERIVATIVE; CYCLOSPORIN A; GRISEOFULVIN; NANOPARTICLE; QUATERNARY AMMONIUM DERIVATIVE; QUATERNARY AMMONIUM PALMITOYLGLYCOL CHITOSAN; RANITIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL TRANSPORT; DOSE CALCULATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG SOLUBILITY; EPITHELIUM CELL; GASTROINTESTINAL MUCOSA; HYDROPHILICITY; HYDROPHOBICITY; MALE; MAXIMUM PLASMA CONCENTRATION; NANOMEDICINE; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADHESIVENESS; ANIMALS; ANTI-ULCER AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIFUNGAL AGENTS; CACO-2 CELLS; CHITOSAN; CYCLOSPORINE; DRUG CARRIERS; GRISEOFULVIN; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IDARUBICIN; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINE, SMALL; MALE; NANOPARTICLES; QUATERNARY AMMONIUM COMPOUNDS; RANITIDINE; RATS; RATS, WISTAR;

EID: 84855435709     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200469a     Document Type: Article

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