Chitosan-based formulations for delivery of DNA and siRNA

Advanced Drug Delivery Reviews

Volumn 62, Issue 1, 2010, Pages 12-27

  Mao, Shirui ^a   Sun, Wei ^a   Kissel, Thomas ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Chitosan; DNA; Formulation; Gene delivery; siRNA

Indexed keywords

BIOLOGICAL FLUIDS; CATIONIC CHARGES; CELL DELIVERY; CHARGE RATIO; CHITOSAN DERIVATIVES; CHITOSAN SALTS; CLINICAL APPLICATION; DEGREE OF DEACETYLATION; DELIVERY SYSTEMS; FORMULATION; FORMULATION OPTIMIZATION; GENE DELIVERY; IN-VITRO; NONVIRAL VECTORS; POLYPLEXES; PREPARATION TECHNIQUE; SIRNA DELIVERY; STRUCTURE MODIFICATION; TRANSFECTION EFFICIENCY;

ACETYLATION; ADDITIVES; BIOCOMPATIBILITY; BIODEGRADATION; BODY FLUIDS; CHITOSAN; DNA; DRUG THERAPY; DYES; GENE TRANSFER; GENES; LEAKAGE (FLUID); NUCLEIC ACIDS; RNA; STRUCTURAL OPTIMIZATION;

CHITIN;

CHITIN; CHITOSAN; CHITOSAN DERIVATIVE; CHONDROITIN SULFATE; DEXTRAN; DNA VACCINE; DRUG ADDITIVE; FOLIC ACID; GREEN FLUORESCENT PROTEIN; HEPARIN; HYALURONIC ACID; LUCIFERASE; NANOPARTICLE; NITROGEN; NONSTRUCTURAL PROTEIN 1; PHOSPHATE; PLASMID DNA; POLYANION; POLYETHYLENEIMINE; POLYGLACTIN; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA; STEARIC ACID; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UROCANIC ACID;

BREAST CANCER; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CULTURE MEDIUM; DEACETYLATION; DNA BINDING; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; HEAT SENSITIVITY; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; LIGAND BINDING; LYSOSOME; MATERIAL COATING; MOLECULAR STABILITY; MOLECULAR WEIGHT; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVIEW; RNA INTERFERENCE; STOICHIOMETRY; TARGET CELL;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; DNA; GENE TRANSFER TECHNIQUES; HUMANS; RNA, SMALL INTERFERING;

EID: 75149133614     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2009.08.004     Document Type: Review

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