Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles

World Journal of Gastroenterology

Volumn 10, Issue 1, 2004, Pages 112-116

  Chen, Jing ^a   Yang, Wu Li ^a   Li, Ge ^a   Qian, Ji ^a   Xue, Jing Lun ^a   Fu, Shou Kuan ^a   Lu, Da Ru ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CHITOSAN; COMPLEMENTARY DNA; DEOXYRIBONUCLEASE; DNA; ERYTHROPOIETIN; NANOPARTICLE; NUCLEASE; PLASMID DNA; TETRACYCLINE; VIRUS VECTOR;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; DRUG EFFECT; DRUG EFFICACY; DRUG EXPOSURE; DRUG TRANSPORT; ENCAPSULATION; ENZYME DEGRADATION; FEEDING; GENE; GENE DELIVERY SYSTEM; GENE TRANSFER; GENETIC TRANSFECTION; HEMATOCRIT; IN VIVO STUDY; INTESTINE CELL; INTESTINE EPITHELIUM; INVERTED TERMINAL REPEAT; MOUSE; MOUSE STRAIN; NONHUMAN; PHYSIOLOGY; PLASMID; SMALL INTESTINE; STAINING; STOMACH; TRANSMISSION ELECTRON MICROSCOPY;

EID: 0346685833     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v10.i1.112     Document Type: Article

References (39)

1. Page DT, Cudmore S. Innovations in oral gene delivery: Challenges and potentials. Drug Discov Today 2001; 6: 92-101
2. Jung T, Kamm W, Breitenbach A, Kaiserling E, Xiao JX, Kissel T. Biodegradable nanoparticles for oral delivery of peptides: Is there a role for polymers to affect mucosal uptake? Eur J Pharm Biopharm 2000; 50: 147-160
3. Ren JM, Zou QM, Wang FK, He Q, Chen W, Zen WK. PELA microspheres loaded H pylori lysates and their mucosal immune response. World J Gastroenterol 2002; 8: 1098-1102
4. Ko JA, Park HJ, Hwang SJ, Park JB, Lee JS. Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int J Pharm 2002; 249: 165-174
5. Shimono N, Takatori T, Ueda M, Mori M, Higashi Y, Nakamura Y. Chitosan dispersed system for colon-specific drug delivery. Int J Pharm 2002; 245: 45-54
6. Tozaki H, Odoriba T, Okada N, Fujita T, Terabe A, Suzuki T, Okabe S, Muranishi S, Yamamoto A. Chitosan capsules for colon-specific drug delivery: Enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. J Control Release 2002; 82: 51-61
7. Lee JY, Nam SH, Im SY, Park YJ, Lee YM, Seol YJ, Chung CP, Lee SJ. Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials. J Control Release 2002; 78: 187-197
8. Vila A, Sanchez A, Tobio M, Calvo P, Alonso MJ. Design of biodegradable particles for protein delivery. J Control Release 2002; 78: 15-24
9. Tozaki H, Komoike J, Tada C, Maruyama T, Terabe A, Suzuki T, Yamamoto A, Muranishi S. Chitosan capsules for colon-specific drug delivery: Improvement of insulin absorption from the rat colon. J Pharm Sci 1997; 86: 1016-1021
10. Leong KW, Mao HQ, Truong-Le VL, Roy K, Walsh SM, August JT. DNA-polycation nanospheres as non-viral gene delivery vehicles. J Control Release 1998; 53: 183-193
11. Kumar M, Behera AK, Lockey RF, Zhang J, Bhullar G, De La Cruz CP, Chen LC, Leong KW, Huang SK, Mohapatra SS. Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection. Hum Gene Ther 2002; 13: 1415-1425
12. Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 1999; 5: 387-391
13. Artursson P, Lindmark T, Davis SS, Illum L. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res 1994; 11: 1358-1361
14. Ranaldi G, Marigliano I, Vespignani I, Perozzi G, Sambuy Y. The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line(1). J Nutr Biochem 2002; 13: 157-167
15. Dodane V, Amin Khan M, Merwin JR. Effect of chitosan on epithelial permeability and structure. Int J Pharm 1999; 182: 21-32
16. Gossen M, Freundlieb S, Bender G, Muller G, Hillen W, Bujard H. Transcriptional activation by tetracyclines in mammalian cells. Science 1995; 268: 1766-1769
17. Wang Y, O'Malley BW Jr, Tasai SY, O'Malley BW. A regulatory system for use in gene transfer. Proc Natl Acad Sci U S A 1994; 91: 8180-8184
18. No D, Yao TP, Evans RM. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A 1996; 93: 3346-3351
19. Rivera VM, Clarkson T, Natesan S, Pollock R, Amara JF, Keenan T, Magari SR, Phillips T, Courage NL, Cerasoli F Jr, Holt DA, Gilman M. A humanized system for pharmacologic control of gene expression. Nat Med 1996; 2: 1028-1032
20. Bohl D, Naffakh N, Heard JM. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nat Med 1997; 3: 299-305
21. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 1992; 89: 5547-5551
22. Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci U S A 1993; 90: 3539-3543
23. Bohl D, Salvetti A, Moullier P, Heard IM. Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector. Blood 1998; 92: 1512-1517
24. Ghazizadeh S, Taichman LB. Virus-mediated gene transfer for cutaneous gene therapy. Hum Gene Ther 2000; 11: 2247-2251
25. May C, Rivella S, Callegari J, Heller G, Gaensler KM, Luzzatto L, Sadelain M. Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin. Nature 2000; 406: 82-86
26. Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature 2000; 408: 483-488
27. Cao YJ, Shibata T, Rainov NG. Liposome-mediated transfer of the bcl-2 gene results in neuroprotection after in vivo transient focal cerebral ischemia in an animal model. Gene Ther 2002; 9: 415-419
28. Bragonzi A, Boletta A, Biffi A, Muggia A, Sersale G, Cheng SH, Bordignon C, Assael BM, Conese M. Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs. Gene Ther 1999; 6: 1995-2004
29. Lu QL, Bou-Gharios G, Partridge TA. Non-viral gene delivery in skeletal muscle: A protein factory. Gene Ther 2003; 10: 131-142
30. Taniyama Y, Tachibana K, Hiraoka K, Aoki M, Yamamoto S, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Morishita R. Development of safe and efficient novel nonviral gene transfer using ultrasound: Enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle. Gene Ther 2002; 9: 372-380
31. Niidome T, Huang L. Gene therapy progress and prospects: Nonviral vectors. Gene Ther 2002; 9: 1647-1652
32. Gallaher CM, Munion J, Hesslink R Jr, Wise J, Gallaher DD. Cholesterol reduction by glucomannan and chitosan is mediated by changes in cholesterol absorption and bile acid and fat excretion in rats. J Nutr 2000; 130: 2753-2759
33. MacLaughlin FC, Mumper RJ, Wang J, Tagliaferri JM, Gill I, Hinchcliffe M, Rolland AP. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release 1998; 56: 259-272
34. Koping-Hoggard M, Tubulekas I, Guan H, Edwards K, Nilsson M, Varum KM, Artursson P. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Gene Ther 2001; 8: 1108-1121
35. Bokura H, Kobayashi S. Chitosan decreases total cholesterol in women: A randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 2003; 57: 721-725
36. Borchard G. Chitosans for gene delivery. Adv Drug Deliv Rev 2001; 52: 145-150
37. Takeuchi H, Yamamoto H, Niwa T, Hino T, Kawashima Y. Mucoadhesion of polymer-coated liposomes to rat intestine in vitro. Chem Pharm Bull 1994; 42: 1954-1956
38. Bernkop-Schnurch A, Krajicek ME. Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: Synthesis and evaluation of different chitosan-EDTA conjugates. J Control Release 1998; 50: 215-223
39. Ferrari F, Rossi S, Bonferoni MC, Caramella C, Karlsen J. Characterization of rheological and mucoadhesive properties of three grades of chitosan hydrochloride. Farmaco 1997; 52: 493-497