Preparation, characterization, and oral delivery of insulin loaded carboxylated chitosan grafted poly(methyl methacrylate) nanoparticles

Biomacromolecules

Volumn 10, Issue 5, 2009, Pages 1253-1258

  Cui, Fuying ^a   Qian, Feng ^a   Zhao, Ziming ^a   Yin, Lichen ^a   Tang, Cui ^a   Yin, Chunhua ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD COMPATIBILITY; CORE SHELL STRUCTURE; DIABETIC RATS; ELECTROSTATIC INTERACTIONS; GASTRIC FLUIDS; HOMOGENEOUS MORPHOLOGY; HYDROGEN BONDINGS; HYPOGLYCEMIC EFFECT; INSULIN RELEASE; INTESTINAL FLUID; ORAL ADMINISTRATION; ORAL DELIVERY; ORAL ROUTE; PH SENSITIVE; PROTEIN DRUGS; RELEASE RATE; SLOW RELEASE; SPHERICAL SHAPE;

BIOCHEMISTRY; CHITIN; CHITOSAN; ESTERS; GRAFTING (CHEMICAL); HYDROGEN; HYDROGEN BONDS; NANOPARTICLES; POTENTIOMETRIC SENSORS; SUGAR (SUCROSE); TRANSMISSION ELECTRON MICROSCOPY; VAN DER WAALS FORCES; ZETA POTENTIAL;

INSULIN;

ALLOXAN; CARBOXYLATED CHITOSAN GRAFTED POLY(METHYLMETHACRYLATE) NANOPARTICLE; CHITOSAN DERIVATIVE; GLUCOSE; INSULIN; NANOPARTICLE; POLY(METHYL METHACRYLATE); UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; GLUCOSE BLOOD LEVEL; HEMOLYSIS; HYPOGLYCEMIA; MALE; NANOENCAPSULATION; NONHUMAN; PH; POLYMERIZATION; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOCOMPATIBLE MATERIALS; BLOOD GLUCOSE; CHITOSAN; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROPHOBICITY; INSULIN; MATERIALS TESTING; NANOPARTICLES; PARTICLE SIZE; POLYMETHYL METHACRYLATE; RATS; SURFACE PROPERTIES; TIME FACTORS;

RATTUS;

EID: 66149083634     PISSN: 15257797     EISSN: None     Source Type: Journal    
DOI: 10.1021/bm900035u     Document Type: Article

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