Efficient GLP-1 gene delivery using two-step transcription amplification plasmid system with a secretion signal peptide and arginine-grafted bioreducible polymer

Journal of Controlled Release

Volumn 157, Issue 2, 2012, Pages 243-248

  Kim, Tae Il ^a,b   Lee, Minhyung ^c   Kim, Sung Wan ^c,d  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Hanyang University   (South Korea)

^d UNIVERSITY OF UTAH   (United States)

Author keywords

Arginine grafted bioreducible polymer; Gene delivery; Glucagon like peptide 1; Secretion signal peptide; Two step transcription amplification

Indexed keywords

BIOREDUCIBLE POLYMER; GENE CARRIER; GENE DELIVERY; GENE DELIVERY SYSTEMS; GENE TRANSCRIPTIONS; GLUCAGON-LIKE PEPTIDE-1; INSULINOMA CELLS; POLYPLEXES; SIGNAL PEPTIDE; TYPE-2 DIABETES;

ARGININE; DNA; GENE ENCODING; GENE THERAPY; GENE TRANSFER; GRAFTING (CHEMICAL); MOLECULAR BIOLOGY; PEPTIDES; PHYSIOLOGY; POLYMERS;

TRANSCRIPTION;

ARGININE; ARGININE GRAFTED BIOREDUCIBLE POLYMER; GLUCAGON LIKE PEPTIDE 1; INSULIN; MESSENGER RNA; PLASMID DNA; POLYMER; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ARTICLE; BIODEGRADATION; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOTOXICITY; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FIBROBLAST CULTURE; GENE AMPLIFICATION; GENE DELIVERY SYSTEM; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IN VITRO STUDY; INSULIN RELEASE; INSULINOMA; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL; ZETA POTENTIAL;

ANIMALS; ARGININE; CELL LINE, TUMOR; GENE THERAPY; GLUCAGON-LIKE PEPTIDE 1; INSULIN; MICE; NIH 3T3 CELLS; PLASMIDS; POLYAMINES; PROTEIN SORTING SIGNALS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 84855795348     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.09.072     Document Type: Article

References (32)

1. J.J. Holst Glucagonlike peptide 1: a newly discovered gastrointestinal hormone Gastroenterology 107 1994 1848 1855 (Pubitemid 24357644)
2. R.M. Elliott, L.M. Morgan, J.A. Tredger, S. Deacon, J. Wright, and V. Marks Glucagon-like peptide-1(7-36) amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns Endocrinology 138 1993 159 166 (Pubitemid 23266831)
3. J.J. Holst The physiology of glucagon-like peptide 1 Physiol. Rev. 87 2007 1409 1439 (Pubitemid 350041474)
4. D.J. Drucker The biology of incretin hormones Cell Metab. 3 2006 153 165
5. P.L. Brubaker Minireview: update on incretin biology: focus on glucagon-like peptide-1 Endocrinology 151 2010 1984 1989
6. D.M. Nathan, E. Schreiber, H. Fogel, S. Mojsov, and J.F. Habener Insulinotropic action of glucagon-like peptide-1(7-37) in diabetic and nondiabetic subjects Diabetes Care 15 1992 270 276
7. J. Buteau, R. Roduit, R. Susini, and M. Prentki Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells Diabetologia 42 1999 856 864 (Pubitemid 29325077)
8. D.J. Drucker Glucagon-like peptides: regulators of cell proliferation, differentiation and apoptosis Mol. Endocrinol. 17 2003 161 171 (Pubitemid 36183142)
9. L. Farilla, A. Bulotta, B. Hirshberg, S. Li Calzi, N. Khoury, H. Noushmehr, C. Bertolotto, U. Di Mario, D.M. Harlan, and R. Perfetti Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets Endocrinology 12 2003 5149 5158 (Pubitemid 37476040)
10. M.A. Nauck, M.M. Heimesaat, K. Behle, J.J. Holst, M.S. Nauck, R. Ritzel, M. Hüfner, and W.H. Schmiegel Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers J. Clin. Endocrinol. Metab. 87 2002 1239 1246 (Pubitemid 36121094)
11. W.O. Creutzfeldt, N. Kleine, B. Willms, C. Orskov, J.J. Holst, and M.A. Nauck Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide 1(7-36) amide in type 1 diabetic patients Diabetes Care 19 1996 580 586
12. M.C. Lawrence, H.S. Bhatt, and R.A. Easom NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1 Diabetes 51 2002 691 698 (Pubitemid 34760177)
13. T.J. Little, A.N. Pilichiewicz, A. Russo, L. Phillips, K.L. Jones, M.A. Nauck, J. Wishart, M. Horowitz, and C. Feinle-Bisset Effects of intravenous glucagon-like peptide-1 on gastric emptying and intragastric distribution in healthy subjects: relationships with postprandial glycemic and insulinemic responses J. Clin. Endocrinol. Metab. 91 2006 1916 1923
14. W.J. Malaisse, and P. Lebrun Mechanisms of sulfonylurea-induced insulin release Diabetes Care 13 1990 9 17 (Pubitemid 20323806)
15. P.E. MacDonald, W. El-Kholy, M.J. Riedel, A.M. Salapatek, P.E. Light, and M.B. Wheeler The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion Diabetes 51 2002 S434 S442
16. M.A. Nauck, N. Kleine, C. arskov, J.J. Holst, B. Willms, and W. Creutzfeldt Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients Diabetologia 36 1993 741 744 (Pubitemid 23218642)
17. M.A. Nauck, M.M. Heimesaat, C. Orskov, J.J. Holst, R. Ebert, and W. Creutzfeldt Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus J. Clin. Invest. 91 1993 301 307 (Pubitemid 23037285)
18. C.F. Deacon, A.H. Johnsen, and J.J. Holst Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo J. Clin. Endocrinol. Metab. 80 1995 952 957
19. J.J. Meier, M.A. Nauck, D. Kranz, J.J. Holst, C.F. Deacon, D. Gaeckler, W.E. Schmidt, and B. Gallwitz Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects Diabetes 53 2004 654 662 (Pubitemid 38270634)
20. H.C. Fehmann, R. Goke, and B. Goke Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide Endocr. Rev. 16 1995 390 410
21. S. Oh, L. Lee, K.S. Ko, S. Choi, and S.W. Kim GLP-1 gene delivery for the treatment of type 2 diabetes Mol. Ther. 7 2003 478 483 (Pubitemid 36553416)
22. S. Choi, S. Oh, M. Lee, and S.W. Kim Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes Mol. Ther. 12 2005 885 891 (Pubitemid 41614484)
23. J.H. Jeong, S.H. Kim, L.V. Christensen, J. Feijen, and S.W. Kim Reducible Poly(amido ethylenimine)-Based Gene Delivery System for Improved Nucleus Trafficking of Plasmid DNA Bioconjug. Chem. 21 2010 296 301
24. M. Lee, S. Oh, C.-H. Ahn, S.W. Kim, B.D. Rhee, and K.S. Ko An efficient GLP-1 expression system using two-step transcription amplification J. Control Release 115 2006 316 321 (Pubitemid 44634840)
25. G.B. Parsons, D.W. Souza, H. Wu, D. Yu, S.G. Wadsworth, R.J. Gregory, and D. Armentano Ectopic expression of glucagon-like peptide 1 for gene therapy of type II diabetes Gene Ther. 14 2007 38 48 (Pubitemid 44942864)
26. M. Jean, M. Alameh, M.D. Buschmann, and A. Merzouki Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes A Gene Ther. 18 2011 807 816
27. T.-i. Kim, M. Ou, M. Lee, and S.W. Kim Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems Biomaterials 30 2009 658 664
28. M. Zorko, and Ü. Langel Cell-penetrating peptides: mechanism and kinetics of cargo delivery Adv. Drug Deliv. Rev. 57 2005 529 545 (Pubitemid 40255559)
29. K. Hamaguchi, H.R. Gaskins, and E.H. Leiter NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse Diabetes 40 1991 842 849
30. W. Zauner, M. Ogris, and E. Wagner Polylysine-based transfection systems utilizing receptor-mediated delivery Adv. Drug Deliv. Rev. 30 1998 97 113 (Pubitemid 28201908)
31. I. Kopatz, J.-S. Remy, and J.P. Behr A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actin J. Gene Med. 6 2004 769 776 (Pubitemid 40228093)
32. T.-i. Kim, M. Lee, and S.W. Kim A guanidinylated bioreducible polymer with high nuclear localization ability for gene delivery systems Biomaterials 31 2010 1798 1804