Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins

Pharmaceutical Research

Volumn 15, Issue 2, 1998, Pages 263-269

  Bernkop Schnürch, Andreas ^a   Scerbe Saiko, Andreas ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Chitosan EDTA inhibitor conjugates; Enzymatic barrier; Inhibition of intestinal proteases; Peroral peptide delivery

Indexed keywords

ANTIPAIN; CARBOXYPEPTIDASE A; CARBOXYPEPTIDASE B; CHITOSAN; CHYMOSTATIN; CHYMOTRYPSIN; EDETIC ACID; ELASTASE; ELASTATINAL; ENZYME INHIBITOR; INTESTINE ENZYME; MICROSOMAL AMINOPEPTIDASE; POLYPEPTIDE; TRYPSIN;

ARTICLE; BINDING SITE; CONJUGATE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ORAL DRUG ADMINISTRATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEINASE INHIBITION;

ADHESIVES; ADMINISTRATION, ORAL; CHITIN; CHITOSAN; DRUG CARRIERS; DRUG EVALUATION; EDETIC ACID; PEPTIDES; PROTEASE INHIBITORS; PROTEINS; TENSILE STRENGTH;

EID: 0031915514     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011970703087     Document Type: Article

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