메뉴 건너뛰기




Volumn 66, Issue , 2012, Pages 415-430

Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer's disease;Wybrane mysie modele oparte na mutacji genów APP, MAPT oraz presenilin wykorzystywane w badaniach nad patogeneza̧ choroby alzheimera

Author keywords

Alzheimer's disease; Animal models; Behavioral tests; Transgenic mice

Indexed keywords


EID: 84867925904     PISSN: 00325449     EISSN: 17322693     Source Type: Journal    
DOI: 10.5604/17322693.1001098     Document Type: Review
Times cited : (5)

References (155)
  • 1
    • 18244384051 scopus 로고    scopus 로고
    • Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
    • Adlard P. A., Perreau V. M., Pop V., Cotman C. W.: Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J. Neurosci., 2005;25:4217-4221
    • (2005) J. Neurosci. , vol.25 , pp. 4217-4221
    • Adlard, P.A.1    Perreau, V.M.2    Pop, V.3    Cotman, C.W.4
  • 2
    • 84855798135 scopus 로고    scopus 로고
    • Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction
    • Alldred M. J., Duff K. E., Ginsberg S. D.: Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction. Neurobiol. Dis., 2012;45:751-762
    • (2012) Neurobiol. Dis. , vol.45 , pp. 751-762
    • Alldred, M.J.1    Duff, K.E.2    Ginsberg, S.D.3
  • 4
    • 84877929502 scopus 로고    scopus 로고
    • 19.04.2012
    • Alzheimer Research Forum. http://www.alzforum.org/res/com/tra/default.asp (19.04.2012)
  • 5
    • 33646535462 scopus 로고    scopus 로고
    • Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice
    • Ambrée O., Touma C., Görtz N., Keyvani K., Paulus W., Palme R., Sachser N.: Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice. Neurobiol. Aging, 2006;27:955-964
    • (2006) Neurobiol. Aging , vol.27 , pp. 955-964
    • Ambrée, O.1    Touma, C.2    Görtz, N.3    Keyvani, K.4    Paulus, W.5    Palme, R.6    Sachser, N.7
  • 6
    • 20044367108 scopus 로고    scopus 로고
    • Cellcycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    • Andorfer C., Acker C. M., Kress Y., Hof P. R., Duff K., Davies P.: Cellcycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J. Neurosci., 2005;25:5446-5454
    • (2005) J. Neurosci. , vol.25 , pp. 5446-5454
    • Andorfer, C.1    Acker, C.M.2    Kress, Y.3    Hof, P.R.4    Duff, K.5    Davies, P.6
  • 8
    • 0037088959 scopus 로고    scopus 로고
    • Intra-and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls
    • Arendash G. W., King D. L.: Intra-and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls. Physiol. Behav., 2002;75:643-652
    • (2002) Physiol. Behav. , vol.75 , pp. 643-652
    • Arendash, G.W.1    King, D.L.2
  • 9
    • 0035830686 scopus 로고    scopus 로고
    • Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    • Arendash G. W., King D. L., Gordon M. N., Morgan D., Hatcher J. M., Hope C. E., Diamond D. M.: Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res., 2001;891:42-53
    • (2001) Brain Res. , vol.891 , pp. 42-53
    • Arendash, G.W.1    King, D.L.2    Gordon, M.N.3    Morgan, D.4    Hatcher, J.M.5    Hope, C.E.6    Diamond, D.M.7
  • 10
    • 34547214510 scopus 로고    scopus 로고
    • Aβ ion channels. Prospects for treating Alzheimer's disease with Aβ channel blockers
    • Arispe N., Diaz J. C., Simakova O.: Aβ ion channels. Prospects for treating Alzheimer's disease with Aβ channel blockers. Biochim. Biophys. Acta, 2007;1768:1952-1965
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 1952-1965
    • Arispe, N.1    Diaz, J.C.2    Simakova, O.3
  • 11
    • 0025717816 scopus 로고
    • The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease
    • Arnold S. E., Hyman B. T., Flory J., Damasio A. R., Van Hoesen G. W.: The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease. Cereb. Cortex, 1991;1:103-116
    • (1991) Cereb. Cortex , vol.1 , pp. 103-116
    • Arnold, S.E.1    Hyman, B.T.2    Flory, J.3    Damasio, A.R.4    Van Hoesen, G.W.5
  • 12
    • 0035674312 scopus 로고    scopus 로고
    • Learning and memory in transgenic mice modeling Alzheimer's disease
    • Ashe K. H.: Learning and memory in transgenic mice modeling Alzheimer's disease. Learn. Mem., 2001;8:301-308
    • (2001) Learn. Mem. , vol.8 , pp. 301-308
    • Ashe, K.H.1
  • 13
    • 1642289188 scopus 로고    scopus 로고
    • Role of tau protein in both physiological and pathological conditions
    • Avila J., Lucas J. J., Perez M., Hernandez F.: Role of tau protein in both physiological and pathological conditions. Physiol. Rev., 2004;84:361-384
    • (2004) Physiol. Rev. , vol.84 , pp. 361-384
    • Avila, J.1    Lucas, J.J.2    Perez, M.3    Hernandez, F.4
  • 15
    • 81455131781 scopus 로고    scopus 로고
    • Molecular mechanisms of Alzheimer's disease
    • Bartoszewska M.: Molecular mechanisms of Alzheimer's disease. Postȩpy Biol. Kom., 2008;35:333-350
    • (2008) Postȩpy Biol. Kom. , vol.35 , pp. 333-350
    • Bartoszewska, M.1
  • 16
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings L. M., Oddo S., Green K. N., McGaugh J. L., La Ferla F. M.: Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron, 2005;45:675-688
    • (2005) Neuron , vol.45 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    La Ferla, F.M.5
  • 17
    • 78650840010 scopus 로고    scopus 로고
    • In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease
    • Bitner R. S., Markosyan S., Nikkel A. L., Brioni J. D.: In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer's disease. Neuropharmacology, 2011;60:460-466
    • (2011) Neuropharmacology , vol.60 , pp. 460-466
    • Bitner, R.S.1    Markosyan, S.2    Nikkel, A.L.3    Brioni, J.D.4
  • 19
    • 0001815909 scopus 로고
    • Pathology of Alzheimer's disease
    • W:, D. B. Calne red.
    • Braak H., Braak E.: Pathology of Alzheimer's disease. W: Neurodegenerative Diseases, D. B. Calne (red.), 1994;35:585-613
    • (1994) Neurodegenerative Diseases , vol.35 , pp. 585-613
    • Braak, H.1    Braak, E.2
  • 20
    • 0018120068 scopus 로고
    • Prestimulus effects on human startle reflex in normals and schizophrenics
    • Braff D., Stone C., Callaway E., Geyer M., Glick I., Bali L.: Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology, 1978;15:339-343
    • (1978) Psychophysiology , vol.15 , pp. 339-343
    • Braff, D.1    Stone, C.2    Callaway, E.3    Geyer, M.4    Glick, I.5    Bali, L.6
  • 21
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • Brody D. L., Holtzman D. M.: Active and passive immunotherapy for neurodegenerative disorders. Annu. Rev. Neurosci., 2008;31:175-193
    • (2008) Annu. Rev. Neurosci. , vol.31 , pp. 175-193
    • Brody, D.L.1    Holtzman, D.M.2
  • 22
    • 30444454374 scopus 로고    scopus 로고
    • Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury
    • Brody D. L., Holtzman D. M.: Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury. Exp. Neurol., 2006;197:330-340
    • (2006) Exp. Neurol. , vol.197 , pp. 330-340
    • Brody, D.L.1    Holtzman, D.M.2
  • 28
    • 9644305699 scopus 로고    scopus 로고
    • Effect of age on the duration and extent of amyloid plaque reduction and microglial activation after injection of anti-Aβ antibody into the third ventricle of TgCRND8 mice
    • Chauhan N. B., Siegel G. J., Lichtor T.: Effect of age on the duration and extent of amyloid plaque reduction and microglial activation after injection of anti-Aβ antibody into the third ventricle of TgCRND8 mice. J. Neurosci. Res., 2004;78:732-741
    • (2004) J. Neurosci. Res. , vol.78 , pp. 732-741
    • Chauhan, N.B.1    Siegel, G.J.2    Lichtor, T.3
  • 30
    • 9144272296 scopus 로고    scopus 로고
    • Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation
    • Cheng I. H., Palop J. J., Esposito L. A., Bien-Ly N., Yan F., Mucke L.: Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat. Med., 2004;10:1190-1192
    • (2004) Nat. Med. , vol.10 , pp. 1190-1192
    • Cheng, I.H.1    Palop, J.J.2    Esposito, L.A.3    Bien-Ly, N.4    Yan, F.5    Mucke, L.6
  • 34
    • 0036743625 scopus 로고    scopus 로고
    • Overexpression of hAP-Pswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
    • Corcoran K. A., Lu Y., Turner R. S., Maren S.: Overexpression of hAP-Pswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learn. Mem., 2002;9:243-252
    • (2002) Learn. Mem. , vol.9 , pp. 243-252
    • Corcoran, K.A.1    Lu, Y.2    Turner, R.S.3    Maren, S.4
  • 35
    • 4344564473 scopus 로고    scopus 로고
    • Increased seizure threshold and severity in young transgenic CRND8 mice
    • Del Vecchio R. A., Gold L. H., Novick S. J., Wong G., Hyde L. A.: Increased seizure threshold and severity in young transgenic CRND8 mice. Neurosci. Lett., 2004;367:164-167
    • (2004) Neurosci. Lett. , vol.367 , pp. 164-167
    • Del Vecchio, R.A.1    Gold, L.H.2    Novick, S.J.3    Wong, G.4    Hyde, L.A.5
  • 36
    • 0037155581 scopus 로고    scopus 로고
    • Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
    • De Mattos R. B., Bales K. R., Cummins D. J., Paul S. M., Holtzman D. M.: Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science, 2002;295:2264-2267
    • (2002) Science , vol.295 , pp. 2264-2267
    • De Mattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Paul, S.M.4    Holtzman, D.M.5
  • 37
    • 0037151046 scopus 로고    scopus 로고
    • Accelerated plaque accumulation, associative learning deficits, and up-regulation of α 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    • Dineley K. T., Xia X., Bui D., Sweatt J. D., Zheng H.: Accelerated plaque accumulation, associative learning deficits, and up-regulation of α 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J. Biol. Chem., 2002;277:22768-22780
    • (2002) J. Biol. Chem. , vol.277 , pp. 22768-22780
    • Dineley, K.T.1    Xia, X.2    Bui, D.3    Sweatt, J.D.4    Zheng, H.5
  • 39
    • 0034107615 scopus 로고    scopus 로고
    • Neuroanatomical abnormalities in behaviorally characterized APP (V717F) transgenic mice
    • Dodart J. C., Mathis C., Saura J., Bales K. R., Paul S. M., Ungerer A.: Neuroanatomical abnormalities in behaviorally characterized APP (V717F) transgenic mice. Neurobiol. Dis., 2000;7:71-85
    • (2000) Neurobiol. Dis. , vol.7 , pp. 71-85
    • Dodart, J.C.1    Mathis, C.2    Saura, J.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 40
    • 0033501744 scopus 로고    scopus 로고
    • Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein
    • Dodart J. C., Meziane H., Mathis C., Bales K. R., Paul S. M., Ungerer A.: Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein. Behav. Neurosci., 1999;113:982-990
    • (1999) Behav. Neurosci. , vol.113 , pp. 982-990
    • Dodart, J.C.1    Meziane, H.2    Mathis, C.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 41
    • 0037499139 scopus 로고    scopus 로고
    • Memory and learning impairment precede amyloid deposition in the V717F PDAPP transgenic mouse
    • Dodart J. C., Meziane H., Mathis C., Bales K. R., Paul S. M., Ungerer A.: Memory and learning impairment precede amyloid deposition in the V717F PDAPP transgenic mouse. Neurosci. Abstr., 1997;23:1637
    • (1997) Neurosci. Abstr. , vol.23 , pp. 1637
    • Dodart, J.C.1    Meziane, H.2    Mathis, C.3    Bales, K.R.4    Paul, S.M.5    Ungerer, A.6
  • 44
    • 33846466652 scopus 로고    scopus 로고
    • Plaques, tangles, and memory loss in mouse models of neurodegeneration
    • Eriksen J. L., Janus C. G.: Plaques, tangles, and memory loss in mouse models of neurodegeneration. Behav. Genet., 2007;37:79-100
    • (2007) Behav. Genet. , vol.37 , pp. 79-100
    • Eriksen, J.L.1    Janus, C.G.2
  • 50
    • 84880187096 scopus 로고    scopus 로고
    • Mice as models: Transgenic approaches and Alzheimer's disease
    • Games D., Buttini M., Kobayashi D., Schenk D., Seubert P.: Mice as models: transgenic approaches and Alzheimer's disease. J. Alzheimers Dis., 2006;9(Suppl. 3):133-149
    • (2006) J. Alzheimers Dis. , vol.9 , Issue.SUPPL. 3 , pp. 133-149
    • Games, D.1    Buttini, M.2    Kobayashi, D.3    Schenk, D.4    Seubert, P.5
  • 51
    • 80053931329 scopus 로고    scopus 로고
    • Presenilin1/γ-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid- enriched microdomains/Csk binding protein
    • Georgakopoulos A., Xu J., Xu C., Mauger G., Barthet G., Robakis N. K.: Presenilin1/γ-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein. FASEB J., 2011;25:3594-3604
    • (2011) FASEB J. , vol.25 , pp. 3594-3604
    • Georgakopoulos, A.1    Xu, J.2    Xu, C.3    Mauger, G.4    Barthet, G.5    Robakis, N.K.6
  • 52
    • 0037112079 scopus 로고    scopus 로고
    • Behavioral impairment of APP (V717F) mice in fear conditioning: Is it only cognition?
    • Gerlai R., Fitch T., Bales K. R., Gitter B. D.: Behavioral impairment of APP (V717F) mice in fear conditioning: is it only cognition? Behav. Brain Res., 2002;136:503-509
    • (2002) Behav. Brain Res. , vol.136 , pp. 503-509
    • Gerlai, R.1    Fitch, T.2    Bales, K.R.3    Gitter, B.D.4
  • 53
    • 0002037940 scopus 로고
    • Cholinergic systems and related neuropathological predilection patterns in Alzheimer disease
    • W: Terry R. D., Katzman R., Bick K. L. red., New York: Raven Press
    • Geula C., Mesulam M. M.: Cholinergic systems and related neuropathological predilection patterns in Alzheimer disease. W: Terry R. D., Katzman R., Bick K. L. (red.) Alzheimer's Disease. New York: Raven Press, 1994;263-294
    • (1994) Alzheimer's Disease , pp. 263-294
    • Geula, C.1    Mesulam, M.M.2
  • 54
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner G. G., Wong C. W.: Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun., 1984;122:1131-1135
    • (1984) Biochem. Biophys. Res. Commun. , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 57
    • 0035808361 scopus 로고    scopus 로고
    • Tau filament formation in transgenic mice expressing P301L tau
    • Götz J., Chen F., Barmettler R., Nitsch R. M.: Tau filament formation in transgenic mice expressing P301L tau. J. Biol. Chem., 2001;276:529-534
    • (2001) J. Biol. Chem. , vol.276 , pp. 529-534
    • Götz, J.1    Chen, F.2    Barmettler, R.3    Nitsch, R.M.4
  • 58
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Aβ 42 fibrils
    • Götz J., Chen F., van Dorpe J., Nitsch R. M.: Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Aβ 42 fibrils. Science, 2001;293:1491-1495
    • (2001) Science , vol.293 , pp. 1491-1495
    • Götz, J.1    Chen, F.2    Van Dorpe, J.3    Nitsch, R.M.4
  • 59
    • 0028965635 scopus 로고
    • Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
    • Götz J., Probst A., Spillantini M. G., Schäfer T., Jakes R., Bürki K., Goedert M.: Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J., 1995;14:1304-1313
    • (1995) EMBO J. , vol.14 , pp. 1304-1313
    • Götz, J.1    Probst, A.2    Spillantini, M.G.3    Schäfer, T.4    Jakes, R.5    Bürki, K.6    Goedert, M.7
  • 60
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer's disease
    • Hardy J.: Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci., 1997;20:154-159
    • (1997) Trends Neurosci. , vol.20 , pp. 154-159
    • Hardy, J.1
  • 61
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy J., Selkoe D. J.: The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science, 2002;297:353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 64
    • 0032756213 scopus 로고    scopus 로고
    • Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits
    • Holcomb L. A., Gordon M. N., Jantzen P., Hsiao K., Duff K., Morgan D.: Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav. Genet., 1999;29:177-185
    • (1999) Behav. Genet. , vol.29 , pp. 177-185
    • Holcomb, L.A.1    Gordon, M.N.2    Jantzen, P.3    Hsiao, K.4    Duff, K.5    Morgan, D.6
  • 67
    • 0141448940 scopus 로고    scopus 로고
    • Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235
    • Huang X. G., Yee B. K., Nag S., Chan S. T., Tang F.: Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235. Exp. Neurol., 2003;183:673-681
    • (2003) Exp. Neurol. , vol.183 , pp. 673-681
    • Huang, X.G.1    Yee, B.K.2    Nag, S.3    Chan, S.T.4    Tang, F.5
  • 71
    • 0030611097 scopus 로고    scopus 로고
    • Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
    • Irizarry M. C., Soriano F., McNamara M., Page K. J., Schenk D., Games D., Hyman B. T.: Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci., 1997;17:7053-7059
    • (1997) J. Neurosci. , vol.17 , pp. 7053-7059
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3    Page, K.J.4    Schenk, D.5    Games, D.6    Hyman, B.T.7
  • 72
    • 0042425738 scopus 로고    scopus 로고
    • Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice
    • Ishizawa T., Sahara N., Ishiguro K., Kersh J., McGowan E., Lewis J., Hutton M., Dickson D. W., Yen S. H.: Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice. Am. J. Pathol., 2003;163:1057-1067
    • (2003) Am. J. Pathol. , vol.163 , pp. 1057-1067
    • Ishizawa, T.1    Sahara, N.2    Ishiguro, K.3    Kersh, J.4    McGowan, E.5    Lewis, J.6    Hutton, M.7    Dickson, D.W.8    Yen, S.H.9
  • 73
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • Jackson G. R., Wiedau-Pazos M., Sang T. K., Wagle N., Brown C. A., Massachi S., Geschwind D. H.: Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron, 2002;34:509-519
    • (2002) Neuron , vol.34 , pp. 509-519
    • Jackson, G.R.1    Wiedau-Pazos, M.2    Sang, T.K.3    Wagle, N.4    Brown, C.A.5    Massachi, S.6    Geschwind, D.H.7
  • 75
    • 2542622162 scopus 로고    scopus 로고
    • Search strategies used by APP transgenic mice during navigation in the Morris water maze
    • Janus C.: Search strategies used by APP transgenic mice during navigation in the Morris water maze. Learn. Mem., 2004;11:337-346
    • (2004) Learn. Mem. , vol.11 , pp. 337-346
    • Janus, C.1
  • 78
    • 0001607842 scopus 로고    scopus 로고
    • Behavioral characterization of PDAPP transgenic Alzheimer mice
    • Justice A., Motter R.: Behavioral characterization of PDAPP transgenic Alzheimer mice. Soc. Neurosci. Abstr., 1997;23:1637
    • (1997) Soc. Neurosci. Abstr. , vol.23 , pp. 1637
    • Justice, A.1    Motter, R.2
  • 79
    • 0035863055 scopus 로고    scopus 로고
    • Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
    • Kawarabayashi T., Younkin L. H., Saido T. C., Shoji M., Ashe K. H., Younkin S. G.: Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J. Neurosci., 2001;21:372-381
    • (2001) J. Neurosci. , vol.21 , pp. 372-381
    • Kawarabayashi, T.1    Younkin, L.H.2    Saido, T.C.3    Shoji, M.4    Ashe, K.H.5    Younkin, S.G.6
  • 82
    • 81255157685 scopus 로고    scopus 로고
    • Characterization of nectin processing mediated by presenilin-dependent γ-secretase
    • Kim J., Chang A., Dudak A., Federoff H. J., Lim S. T.: Characterization of nectin processing mediated by presenilin-dependent γ-secretase. J. Neurochem., 2011;119:945-956
    • (2011) J. Neurochem. , vol.119 , pp. 945-956
    • Kim, J.1    Chang, A.2    Dudak, A.3    Federoff, H.J.4    Lim, S.T.5
  • 83
    • 17644370721 scopus 로고    scopus 로고
    • Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease
    • Kobayashi D. T., Chen K. S.: Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease. Genes Brain Behav., 2005;4:173-196
    • (2005) Genes Brain Behav. , vol.4 , pp. 173-196
    • Kobayashi, D.T.1    Chen, K.S.2
  • 86
    • 0037159635 scopus 로고    scopus 로고
    • Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation
    • Lalonde R., Dumont M., Staufenbiel M., Sturchler-Pierrat C., Strazielle C.: Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation. Brain Res., 2002;956:36-44
    • (2002) Brain Res. , vol.956 , pp. 36-44
    • Lalonde, R.1    Dumont, M.2    Staufenbiel, M.3    Sturchler-Pierrat, C.4    Strazielle, C.5
  • 87
    • 0038022595 scopus 로고    scopus 로고
    • Transgenic mice expressing the βAPP695SWE mutation: Effects on exploratory activity, anxiety, and motor coordination
    • Lalonde R., Lewis T. L., Strazielle C., Kim H., Fukuchi K.: Transgenic mice expressing the βAPP695SWE mutation: effects on exploratory activity, anxiety, and motor coordination. Brain Res., 2003;977:38-45
    • (2003) Brain Res. , vol.977 , pp. 38-45
    • Lalonde, R.1    Lewis, T.L.2    Strazielle, C.3    Kim, H.4    Fukuchi, K.5
  • 88
    • 84655162704 scopus 로고    scopus 로고
    • Soluble Aβ oligomer production and toxicity
    • Larson M. E., Lesné S. E.: Soluble Aβ oligomer production and toxicity. J. Neurochem., 2012;120(Suppl. 1):125-139
    • (2012) J. Neurochem. , vol.120 , Issue.SUPPL. 1 , pp. 125-139
    • Larson, M.E.1    Lesné, S.E.2
  • 89
    • 3242737470 scopus 로고    scopus 로고
    • Challenging the amyloid cascade hypothesis: Senile plaques and amyloid-β as protective adaptations to Alzheimer disease
    • Lee H. G., Casadesus G., Zhu X., Takeda A., Perry G., Smith M. A.: Challenging the amyloid cascade hypothesis: senile plaques and amyloid-β as protective adaptations to Alzheimer disease. Ann. N. Y. Acad. Sci., 2004;1019:1-4
    • (2004) Ann. N. Y. Acad. Sci. , vol.1019 , pp. 1-4
    • Lee, H.G.1    Casadesus, G.2    Zhu, X.3    Takeda, A.4    Perry, G.5    Smith, M.A.6
  • 92
    • 38949208262 scopus 로고    scopus 로고
    • Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function
    • Lesné S., Kotilinek L., Ashe K. H.: Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function. Neuroscience, 2008;151:745-749
    • (2008) Neuroscience , vol.151 , pp. 745-749
    • Lesné, S.1    Kotilinek, L.2    Ashe, K.H.3
  • 96
    • 17644382712 scopus 로고    scopus 로고
    • Invertebrate models of Alzheimer's disease
    • Link C. D.: Invertebrate models of Alzheimer's disease. Genes Brain Behav., 2005;4:147-156
    • (2005) Genes Brain Behav. , vol.4 , pp. 147-156
    • Link, C.D.1
  • 97
    • 0037454478 scopus 로고    scopus 로고
    • Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice
    • Liu L., Tapiola T., Herukka S. K., Heikkilá M., Tanila H.: Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice. Neuroreport, 2003;14:163-166
    • (2003) Neuroreport , vol.14 , pp. 163-166
    • Liu, L.1    Tapiola, T.2    Herukka, S.K.3    Heikkilá, M.4    Tanila, H.5
  • 98
    • 17644412057 scopus 로고    scopus 로고
    • Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease
    • Lovasic L., Bauschke H., Janus C.: Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease. Genes Brain Behav., 2005;4:197-208
    • (2005) Genes Brain Behav. , vol.4 , pp. 197-208
    • Lovasic, L.1    Bauschke, H.2    Janus, C.3
  • 99
    • 0035057591 scopus 로고    scopus 로고
    • Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
    • Masliah E., Sisk A., Mallory M., Games D.: Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. J. Neuropathol. Exp. Neurol., 2001;60:357-368
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 357-368
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Games, D.4
  • 100
    • 0344875100 scopus 로고    scopus 로고
    • Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein
    • McCool M. F., Varty G. B., Del Vecchio R. A., Kazdoba T. M., Parker E. M., Hunter J. C., Hyde L. A.: Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein. Brain Res., 2003;994:99-106
    • (2003) Brain Res. , vol.994 , pp. 99-106
    • McCool, M.F.1    Varty, G.B.2    Del Vecchio, R.A.3    Kazdoba, T.M.4    Parker, E.M.5    Hunter, J.C.6    Hyde, L.A.7
  • 101
    • 84880189986 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • Morgan D.: Immunotherapy for Alzheimer's disease. J. Alzheimers Dis., 2006;9(Suppl.3):425-432
    • (2006) J. Alzheimers Dis. , vol.9 , Issue.SUPPL. 3 , pp. 425-432
    • Morgan, D.1
  • 102
    • 0038632272 scopus 로고    scopus 로고
    • Learning and memory deficits in APP transgenic mouse models of amyloid deposition
    • Morgan D.: Learning and memory deficits in APP transgenic mouse models of amyloid deposition. Neurochem. Res., 2003;28:1029-1034
    • (2003) Neurochem. Res. , vol.28 , pp. 1029-1034
    • Morgan, D.1
  • 104
    • 84857497814 scopus 로고    scopus 로고
    • Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice
    • Mori T., Rezai-Zadeh K., Koyama N., Arendash G. W., Yamaguchi H., Kakuda N., Horikoshi-Sakuraba Y., Tan J., Town T.: Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J. Biol. Chem., 2012;287:6912-6927
    • (2012) J. Biol. Chem. , vol.287 , pp. 6912-6927
    • Mori, T.1    Rezai-Zadeh, K.2    Koyama, N.3    Arendash, G.W.4    Yamaguchi, H.5    Kakuda, N.6    Horikoshi-Sakuraba, Y.7    Tan, J.8    Town, T.9
  • 105
    • 0030698871 scopus 로고    scopus 로고
    • Life and death of neurons in the aging brain
    • Morrison J. H., Hof P. R.: Life and death of neurons in the aging brain. Science, 1997;278:412-419
    • (1997) Science , vol.278 , pp. 412-419
    • Morrison, J.H.1    Hof, P.R.2
  • 107
    • 84861523642 scopus 로고    scopus 로고
    • Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease
    • Neumeister K. L., Riepe M. W.: Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease. J. Alzheimers Dis., 2012;30(2):245-51
    • (2012) J. Alzheimers Dis. , vol.30 , Issue.2 , pp. 245-251
    • Neumeister, K.L.1    Riepe, M.W.2
  • 109
    • 4043167747 scopus 로고    scopus 로고
    • Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo S., Billings L., Kesslak J. P., Cribbs D. H., La Ferla F. M.: Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron, 2004;43:321-332
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    La Ferla, F.M.5
  • 110
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • Oddo S., Caccamo A., Kitazawa M., Tseng B. P., La Ferla F. M.: Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol. Aging, 2003;24:1063-1070
    • (2003) Neurobiol. Aging , vol.24 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3    Tseng, B.P.4    La Ferla, F.M.5
  • 112
    • 33144487701 scopus 로고    scopus 로고
    • Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease. A link between Aβ and tau pathology
    • Oddo S., Caccamo A., Tran L., Lambert M. P., Glabe C. G., Klein W. L., La Ferla F. M.: Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease. A link between Aβ and tau pathology. J. Biol. Chem., 2006;281:1599-1604
    • (2006) J. Biol. Chem. , vol.281 , pp. 1599-1604
    • Oddo, S.1    Caccamo, A.2    Tran, L.3    Lambert, M.P.4    Glabe, C.G.5    Klein, W.L.6    La Ferla, F.M.7
  • 113
    • 0042924399 scopus 로고    scopus 로고
    • Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
    • Palop J. J., Jones B., Kekonius L., Chin J., Yu G. Q., Raber J., Masliah E., Mucke L.: Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc. Natl. Acad. Sci. USA, 2003;100:9572-9577
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9572-9577
    • Palop, J.J.1    Jones, B.2    Kekonius, L.3    Chin, J.4    Yu, G.Q.5    Raber, J.6    Masliah, E.7    Mucke, L.8
  • 114
    • 0031944692 scopus 로고    scopus 로고
    • Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo
    • Pappolla M. A., Chyan Y. J., Omar R. A., Hsiao K., Perry G., Smith M. A., Bozner P.: Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo. Am. J. Pathol., 1998;152:871-877
    • (1998) Am. J. Pathol. , vol.152 , pp. 871-877
    • Pappolla, M.A.1    Chyan, Y.J.2    Omar, R.A.3    Hsiao, K.4    Perry, G.5    Smith, M.A.6    Bozner, P.7
  • 116
    • 1842431831 scopus 로고    scopus 로고
    • Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice
    • Pennanen L., Welzl H., D'Adamo P., Nitsch R. M., Götz J.: Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice. Neurobiol. Dis., 2004;15:500-509
    • (2004) Neurobiol. Dis. , vol.15 , pp. 500-509
    • Pennanen, L.1    Welzl, H.2    D'Adamo, P.3    Nitsch, R.M.4    Götz, J.5
  • 118
    • 69449093036 scopus 로고    scopus 로고
    • Agedependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
    • Polydoro M., Acker C. M., Duff K., Castillo P. E., Davies P.: Agedependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J. Neurosci., 2009;29:10741-10749
    • (2009) J. Neurosci. , vol.29 , pp. 10741-10749
    • Polydoro, M.1    Acker, C.M.2    Duff, K.3    Castillo, P.E.4    Davies, P.5
  • 119
    • 78751562521 scopus 로고    scopus 로고
    • A novel role for γ-secretase: Selective regulation of spontaneous neurotransmitter release from hippocampal neurons
    • Pratt K. G., Zhu P., Watari H., Cook D. G., Sullivan J. M.: A novel role for γ-secretase: selective regulation of spontaneous neurotransmitter release from hippocampal neurons. J. Neurosci., 2011;31:899-906
    • (2011) J. Neurosci. , vol.31 , pp. 899-906
    • Pratt, K.G.1    Zhu, P.2    Watari, H.3    Cook, D.G.4    Sullivan, J.M.5
  • 122
    • 0037417899 scopus 로고    scopus 로고
    • Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis
    • Redwine J. M., Kosofsky B., Jacobs R. E., Games D., Reilly J. F., Morrison J. H., Young W. G., Bloom F. E.: Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc. Natl. Acad. Sci. USA, 2003;100:1381-1386
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1381-1386
    • Redwine, J.M.1    Kosofsky, B.2    Jacobs, R.E.3    Games, D.4    Reilly, J.F.5    Morrison, J.H.6    Young, W.G.7    Bloom, F.E.8
  • 125
    • 0034642288 scopus 로고    scopus 로고
    • Mutation-dependent aggregation of tau protein and its selective depletion from the soluble fraction in brain of P301L FTDP-17 patients
    • Rizzu P., Joosse M., Ravid R., Hoogeveen A., Kamphorst W., van Swieten J. C., Willemsen R., Heutink P.: Mutation-dependent aggregation of tau protein and its selective depletion from the soluble fraction in brain of P301L FTDP-17 patients. Hum. Mol. Genet., 2000;9:3075-3082
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 3075-3082
    • Rizzu, P.1    Joosse, M.2    Ravid, R.3    Hoogeveen, A.4    Kamphorst, W.5    Van Swieten, J.C.6    Willemsen, R.7    Heutink, P.8
  • 126
    • 0031255352 scopus 로고    scopus 로고
    • Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment
    • Rogers D. C., Fisher E. M., Brown S. D., Peters J., Hunter A. J., Martin J. E.: Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment. Mamm. Genome, 1997;8:711-713
    • (1997) Mamm. Genome , vol.8 , pp. 711-713
    • Rogers, D.C.1    Fisher, E.M.2    Brown, S.D.3    Peters, J.4    Hunter, A.J.5    Martin, J.E.6
  • 127
    • 79952260574 scopus 로고    scopus 로고
    • Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: Rescue by donepezil (Aricept)
    • Romberg C., Mattson M. P., Mughal M. R., Bussey T. J., Saksida L. M.: Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept). J. Neurosci., 2011;31:3500-3507
    • (2011) J. Neurosci. , vol.31 , pp. 3500-3507
    • Romberg, C.1    Mattson, M.P.2    Mughal, M.R.3    Bussey, T.J.4    Saksida, L.M.5
  • 130
    • 77649189880 scopus 로고    scopus 로고
    • APP transgenic mice: The effect of active and passive immunotherapy in cognitive tasks
    • Röskam S., Neff F., Schwarting R., Bacher M., Dodel R.: APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks. Neurosci. Biobehav. Rev., 2010;34:487-499
    • (2010) Neurosci. Biobehav. Rev. , vol.34 , pp. 487-499
    • Röskam, S.1    Neff, F.2    Schwarting, R.3    Bacher, M.4    Dodel, R.5
  • 134
    • 36048938990 scopus 로고    scopus 로고
    • Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning
    • Senechal Y., Kelly P. H., Dev K. K.: Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning. Behav. Brain Res., 2008;186:126-132
    • (2008) Behav. Brain Res. , vol.186 , pp. 126-132
    • Senechal, Y.1    Kelly, P.H.2    Dev, K.K.3
  • 144
    • 0031054505 scopus 로고    scopus 로고
    • Formation of stable complexes between two Alzheimer's disease gene products: Presenilin 2 and β-amyloid precursor protein
    • Weidemann A., Paliga K., Dürrwang U., Czech C., Evin G., Masters C. L., Beyreuther K.: Formation of stable complexes between two Alzheimer's disease gene products: presenilin 2 and β-amyloid precursor protein. Nat. Med., 1997;3:328-332
    • (1997) Nat. Med. , vol.3 , pp. 328-332
    • Weidemann, A.1    Paliga, K.2    Dürrwang, U.3    Czech, C.4    Evin, G.5    Masters, C.L.6    Beyreuther, K.7
  • 146
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse P. J., Price D. L., Struble R. G., Clark A. W., Coyle J. T., Delon M. R.: Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science, 1982;215:1237-1239
    • (1982) Science , vol.215 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3    Clark, A.W.4    Coyle, J.T.5    Delon, M.R.6
  • 147
    • 0027125338 scopus 로고
    • Genetic counselling. Alzheimer's disease: Advances in genetics
    • Wilde M.: Genetic counselling. Alzheimer's disease: advances in genetics. Nurs. Stand., 1992;6:29-31
    • (1992) Nurs. Stand. , vol.6 , pp. 29-31
    • Wilde, M.1
  • 148
    • 0001216824 scopus 로고    scopus 로고
    • Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes
    • Wong T. P., Debeir T., Duff K., Cuello A. C.: Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes. J. Neurosci., 1999;19:2706-2716
    • (1999) J. Neurosci. , vol.19 , pp. 2706-2716
    • Wong, T.P.1    Debeir, T.2    Duff, K.3    Cuello, A.C.4
  • 149
    • 25844462819 scopus 로고    scopus 로고
    • Transgenic C. elegans as a model in Alzheimer's research
    • Wu Y., Luo Y.: Transgenic C. elegans as a model in Alzheimer's research. Curr. Alzheimer Res., 2005;2:37-45
    • (2005) Curr. Alzheimer Res. , vol.2 , pp. 37-45
    • Wu, Y.1    Luo, Y.2
  • 150
    • 58149459581 scopus 로고    scopus 로고
    • Acetyl-Ile-Gly-Leu protects neurons from Aβ1-42 induced toxicity in vitro and in V337M human tau-expressing mice
    • Xiong Z. M., Kitagawa K., Nishiuchi Y., Kimura T., Nakamura T., Inagaki C.: Acetyl-Ile-Gly-Leu protects neurons from Aβ1-42 induced toxicity in vitro and in V337M human tau-expressing mice. Life Sci., 2009;84:132-138
    • (2009) Life Sci. , vol.84 , pp. 132-138
    • Xiong, Z.M.1    Kitagawa, K.2    Nishiuchi, Y.3    Kimura, T.4    Nakamura, T.5    Inagaki, C.6
  • 152
    • 79953060064 scopus 로고    scopus 로고
    • Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy
    • Yue M., Hanna A., Wilson J., Roder H., Janus C.: Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy. Neurobiol. Aging, 2011;32:590-603
    • (2011) Neurobiol. Aging , vol.32 , pp. 590-603
    • Yue, M.1    Hanna, A.2    Wilson, J.3    Roder, H.4    Janus, C.5
  • 153
    • 70350324313 scopus 로고    scopus 로고
    • Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience
    • Zhang J., Gorostiza O. F., Tang H., Bredesen D. E., Galvan V.: Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience. Behav. Brain Res., 2010;206:202-207
    • (2010) Behav. Brain Res. , vol.206 , pp. 202-207
    • Zhang, J.1    Gorostiza, O.F.2    Tang, H.3    Bredesen, D.E.4    Galvan, V.5
  • 155


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.