Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice

Neurobiology of Disease

Volumn 20, Issue 3, 2005, Pages 814-822

  Ribé, Elena M ^a   Pérez, Mar ^b   Puig, Berta ^c   Gich, Ignasi ^d   Lim, Filip ^b   Cuadrado, Mar ^a   Sesma, Teresa ^a   Catena, Silvia ^a   Sánchez, Belén ^a   Nieto, María ^a   Gómez Ramos, Pilar ^b   Morán, M Asunción ^b   Cabodevilla, Felipe ^a   Samaranch, Lluis ^a   Ortiz, Lourdes ^a   Pérez, Alberto ^a   Ferrer, Isidro ^c,e   Avila, Jesús ^b   Gómez Isla, Teresa ^a,d  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^c Institut de Neuropatologia   (Spain)

^d HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

Author keywords

amyloid; Alzheimer's disease; APP; Lysosomes; Neuronal loss; Stereology; Tau; Transgenic mice

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; MUTANT PROTEIN; TAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; LEARNING; LIMBIC CORTEX; MEMORY; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CELL DEATH; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; NEURONS; SENILE PLAQUES; TAU PROTEINS;

EID: 27744435409     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.05.027     Document Type: Article

References (24)

1. M.J. Callahan, W.J. Lipinski, F. Bian, R.A. Durham, A. Pack, and L.C. Walker Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice Am. J. Pathol. 158 2001 1173 1177
2. A.M. Cataldo, D.J. Hamilton, and R.A. Nixon Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaques in Alzheimer's disease Brain Res. 640 1994 68 80
3. A.M. Cataldo, D.J. Hamilton, J.L. Barnett, P.A. Paskevich, and R.A. Nixon Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease J. Neurosci. 16 1996 186 199
4. C. Duyckaerts, and D.W. Dickson Neuropathology of Alzheimer's disease D.W. Dickson Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders 2003 ISN Neuropath Basel 47 65
5. I. Ferrer, M. Boada-Rovira, M.L. Sanchez-Guerra, M.J. Rey, and F. Costa-Jussa Neuropathology and pathogenesis of encephalitis following immunization in Alzheimer's disease Brain Pathol. 14 2004 11 20
6. R. Gerlai Behavioral tests of hippocampal function: simple paradigms complex problems Behav. Brain Res. 125 2001 269 277
7. T. Gomez-Isla, H.L. West, G.W. Rebeck, S.D. Harr, J.H. Growdon, J.J. Locascio, T.T. Perls, L.A. Lipsitz, and B.T. Hyman Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease Ann. Neurol. 39 1996 62 70
8. T. Gómez-Isla, M.C. Irizarry, A. Mariash, B. Cheung, O. Soto, S. Schrump, J. Sondel, L. Kotilinek, J. Day, M.A. Schwarzschild, J.H. Cha, K. Newell, D.W. Miller, K. Ueda, A.B. Young, B.T. Hyman, and K.H. Ashe Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice Neurobiol. Aging 24 2003 245 258
9. J. Gotz, F. Chen, J. van Dorpe, and R.M. Nitsch Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils Science 293 2001 1491 1495
10. J.A. Hardy, and G.A. Higgins Alzheimer's disease: the amyloid cascade hypothesis Science 256 1992 184 185
11. J.A. Hardy, and D.J. Selkoe The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics Science 297 2002 353 356
12. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang, and G. Cole Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102
13. M.C. Irizarry, M. McNamara, K. Fedorchak, K. Hsiao, and B.T. Hyman APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1 J. Neuropathol. Exp. Neurol. 56 1997 965 973
14. J. Lewis, D.W. Dickson, W.L. Lin, L. Chisholm, A. Corral, G. Jones, S.H. Yen, N. Sahara, L. Skipper, D. Yager, C. Eckman, J. Hardy, M. Hutton, and E. McGowan Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP Science 293 2001 1487 1491
15. F. Lim, F. Hernandez, J.J. Lucas, P. Gomez-Ramos, M.A. Moran, and J. Avila FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and tau filaments in forebrain Mol. Cell. Neurosci. 18 2001 702 714
16. J.A.R. Nicoll, D. Wilkinson, C. Holmes, P. Steart, H. Markham, and R.O. Weller Neuropathology of human Alzheimer disease after immunization with amyloid-peptide: a case report Nat. Med. 9 2003 448 452
17. S. Oddo, A. Caccamo, J.D. Shepherd, M.P. Murphy, T.E. Golde, R. Kayed, R. Metherate, M.P. Mattson, Y. Akbari, and F.M. LaFerla Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction Neuron 39 2003 409 421
18. M. Perez, E. Ribe, A. Rubio, F. Lim, M.A. Moran, P.G. Ramos, I. Ferrer, M.T. Isla, and J. Avila Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation Neuroscience 130 2005 339 347
19. D. Schenk Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning Nat. Rev., Neurosci. 3 2002 824 828
20. D.J. Selkoe The molecular pathology of Alzheimer's disease Neuron 6 1991 487 498
21. D.J. Selkoe Alzheimer's disease: genotypes, phenotypes, and treatments Science 275 1997 630 631
22. A. Vitali, A. Piccini, R. Borghi, P. Fornaro, S.L. Siedlak, M.A. Smith, P. Gambetti, B. Ghetti, and M. Tabaton Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations J. Alzheimer's Dis. 6 2004 45 51
23. T. Wang, H. Tanila, J. Puolivali, I. Kadish, and T. van Groen Gender differences in the amount and deposition of amyloid beta in APPswe and PS1 double transgenic mice Neurobiol. Dis. 14 2003 318 327
24. M.J. West, and H.J. Gundersen Unbiased stereological estimation of the number of neurons in the human hippocampus J. Comp. Neurol. 296 1990 1 22