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Volumn 34, Issue 4, 2010, Pages 487-499

APP transgenic mice: The effect of active and passive immunotherapy in cognitive tasks

Author keywords

Amyloid; Alzheimer's disease; Amyloid precursor protein; Animal model; Behavior; Cognition; Immunization; Transgenic mice

Indexed keywords

ACI 01; ACI 24; ADENOVIRUS VECTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN ANTIBODY 10D5; AMYLOID BETA PROTEIN[1-15]; AMYLOID BETA PROTEIN[1-16]; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[1-4]; AMYLOID BETA PROTEIN[28-30] ANTIBODY; AMYLOID BETA PROTEIN[33-40] ANTIBODY; AMYLOID PRECURSOR PROTEIN; EPITOPE; ESCHERICHIA COLI ENTEROTOXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HERPES SIMPLEX VACCINE; IMMUNOGLOBULIN G; INTERLEUKIN 4; K6 AMYLOID BETA PROTEIN[1-30]; LIPOSOME; M 266; MACROGOL; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 20.1; MONOCLONAL ANTIBODY BAM 10; NAB 61; PEPTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 77649189880     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2009.10.006     Document Type: Review
Times cited : (20)

References (88)
  • 1
    • 0001408917 scopus 로고
    • One-trial object recognition by rats
    • Aggleton J.P. One-trial object recognition by rats. Q. J. Exp. Psychol. 1985, 37:279-294.
    • (1985) Q. J. Exp. Psychol. , vol.37 , pp. 279-294
    • Aggleton, J.P.1
  • 2
    • 0032801549 scopus 로고    scopus 로고
    • Episodic memory, amnesia, and the hippocampal-anterior thalamic axis
    • discussion 444-489
    • Aggleton J.P., Brown M.W. Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behav. Brain Sci. 1999, 22:425-444. discussion 444-489.
    • (1999) Behav. Brain Sci. , vol.22 , pp. 425-444
    • Aggleton, J.P.1    Brown, M.W.2
  • 4
    • 0035830686 scopus 로고    scopus 로고
    • Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    • Arendash G.W., King D.L., Gordon M.N., Morgan D., Hatcher J.M., Hope C.E., Diamond D.M. Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res. 2001, 891:42-53.
    • (2001) Brain Res. , vol.891 , pp. 42-53
    • Arendash, G.W.1    King, D.L.2    Gordon, M.N.3    Morgan, D.4    Hatcher, J.M.5    Hope, C.E.6    Diamond, D.M.7
  • 5
    • 0035689651 scopus 로고    scopus 로고
    • Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory
    • Arendash G.W., Gordon M.N., Diamond D.M., Austin L.A., Hatcher J.M., Jantzen P., DiCarlo G., Wilcock D., Morgan D. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. DNA Cell Biol. 2001, 20:737-744.
    • (2001) DNA Cell Biol. , vol.20 , pp. 737-744
    • Arendash, G.W.1    Gordon, M.N.2    Diamond, D.M.3    Austin, L.A.4    Hatcher, J.M.5    Jantzen, P.6    DiCarlo, G.7    Wilcock, D.8    Morgan, D.9
  • 6
    • 67349213205 scopus 로고    scopus 로고
    • Synaptic degeneration in Alzheimer's disease
    • Arendt T. Synaptic degeneration in Alzheimer's disease. Acta Neuropathol. 2009, 118:167-179.
    • (2009) Acta Neuropathol. , vol.118 , pp. 167-179
    • Arendt, T.1
  • 10
    • 0018344553 scopus 로고
    • Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat
    • Barnes C.A. Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J. Comp. Physiol. Psychol. 1979, 93:74-104.
    • (1979) J. Comp. Physiol. Psychol. , vol.93 , pp. 74-104
    • Barnes, C.A.1
  • 11
    • 58149307496 scopus 로고    scopus 로고
    • Combinatorial treatments including vaccines, chemotherapy and monoclonal antibodies for cancer therapy
    • Baxevanis C.N., Perez S.A., Papamichail M. Combinatorial treatments including vaccines, chemotherapy and monoclonal antibodies for cancer therapy. Cancer Immunol. Immunother. 2009, 58:317-324.
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 317-324
    • Baxevanis, C.N.1    Perez, S.A.2    Papamichail, M.3
  • 12
    • 33747886054 scopus 로고    scopus 로고
    • The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity
    • Bertaina-Anglade V., Enjuanes E., Morillon D., Drieu L.R. The object recognition task in rats and mice: a simple and rapid model in safety pharmacology to detect amnesic properties of a new chemical entity. J. Pharmacol. Toxicol. Methods 2006, 54(2):99-105.
    • (2006) J. Pharmacol. Toxicol. Methods , vol.54 , Issue.2 , pp. 99-105
    • Bertaina-Anglade, V.1    Enjuanes, E.2    Morillon, D.3    Drieu, L.R.4
  • 13
    • 34347215149 scopus 로고    scopus 로고
    • Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
    • Bevins R.A., Besheer J. Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'. Nat. Protoc. 2006, 1:1306-1311.
    • (2006) Nat. Protoc. , vol.1 , pp. 1306-1311
    • Bevins, R.A.1    Besheer, J.2
  • 14
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings L.M., Oddo S., Green K.N., McGaugh J.L., LaFerla F.M. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 2005, 45:675-688.
    • (2005) Neuron , vol.45 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    LaFerla, F.M.5
  • 15
    • 47949132196 scopus 로고    scopus 로고
    • Active and passive immunotherapy for neurodegenerative disorders
    • Brody D.L., Holtzman D.M. Active and passive immunotherapy for neurodegenerative disorders. Annu. Rev. Neurosci. 2008.
    • (2008) Annu. Rev. Neurosci.
    • Brody, D.L.1    Holtzman, D.M.2
  • 16
    • 33847776041 scopus 로고    scopus 로고
    • Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid
    • Chen G., Chen K.S., Kobayashi D., Barbour R., Motter R., Games D., Martin S.J., Morris R.G. Active beta-amyloid immunization restores spatial learning in PDAPP mice displaying very low levels of beta-amyloid. J. Neurosci. 2007, 27:2654-2662.
    • (2007) J. Neurosci. , vol.27 , pp. 2654-2662
    • Chen, G.1    Chen, K.S.2    Kobayashi, D.3    Barbour, R.4    Motter, R.5    Games, D.6    Martin, S.J.7    Morris, R.G.8
  • 17
    • 9144272296 scopus 로고    scopus 로고
    • Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation
    • Cheng I.H., Palop J.J., Esposito L.A., Bien-Ly N., Yan F., Mucke L. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat. Med. 2004, 10:1190-1192.
    • (2004) Nat. Med. , vol.10 , pp. 1190-1192
    • Cheng, I.H.1    Palop, J.J.2    Esposito, L.A.3    Bien-Ly, N.4    Yan, F.5    Mucke, L.6
  • 20
    • 35848962080 scopus 로고    scopus 로고
    • Disease-modifying therapies for Alzheimer disease: challenges to early intervention
    • Cummings J.L., Doody R., Clark C. Disease-modifying therapies for Alzheimer disease: challenges to early intervention. Neurology 2007, 69:1622-1634.
    • (2007) Neurology , vol.69 , pp. 1622-1634
    • Cummings, J.L.1    Doody, R.2    Clark, C.3
  • 21
    • 34250630141 scopus 로고    scopus 로고
    • Appetitive position discrimination in the T-maze
    • Deacon R.M. Appetitive position discrimination in the T-maze. Nat. Protoc. 2006, 1:13-15.
    • (2006) Nat. Protoc. , vol.1 , pp. 13-15
    • Deacon, R.M.1
  • 23
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos R.B., Bales K.R., Cummins D.J., Dodart J.C., Paul S.M., Holtzman D.M. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:8850-8855.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 24
    • 34247574175 scopus 로고    scopus 로고
    • The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
    • Dere E., Huston J.P., Souza Silva M.A. The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents. Neurosci. Biobehav. Rev. 2007, 31:673-704.
    • (2007) Neurosci. Biobehav. Rev. , vol.31 , pp. 673-704
    • Dere, E.1    Huston, J.P.2    Souza Silva, M.A.3
  • 25
    • 0030660554 scopus 로고    scopus 로고
    • Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies
    • Dickson D.W. Neuropathological diagnosis of Alzheimer's disease: a perspective from longitudinal clinicopathological studies. Neurobiol. Aging 1997, 18:S21-S26.
    • (1997) Neurobiol. Aging , vol.18
    • Dickson, D.W.1
  • 27
    • 0023691166 scopus 로고
    • A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
    • Ennaceur A., Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data. Behav. Brain Res. 1988, 31:47-59.
    • (1988) Behav. Brain Res. , vol.31 , pp. 47-59
    • Ennaceur, A.1    Delacour, J.2
  • 28
    • 33846466652 scopus 로고    scopus 로고
    • Plaques, tangles, and memory loss in mouse models of neurodegeneration
    • Eriksen J.L., Janus C.G. Plaques, tangles, and memory loss in mouse models of neurodegeneration. Behav. Genet. 2007, 37:79-100.
    • (2007) Behav. Genet. , vol.37 , pp. 79-100
    • Eriksen, J.L.1    Janus, C.G.2
  • 29
    • 0032976615 scopus 로고    scopus 로고
    • The neuroanatomical and neurochemical basis of conditioned fear
    • Fendt M., Fanselow M.S. The neuroanatomical and neurochemical basis of conditioned fear. Neurosci. Biobehav. Rev. 1999, 23:743-760.
    • (1999) Neurosci. Biobehav. Rev. , vol.23 , pp. 743-760
    • Fendt, M.1    Fanselow, M.S.2
  • 30
    • 42549089024 scopus 로고    scopus 로고
    • Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4
    • Frazer M.E., Hughes J.E., Mastrangelo M.A., Tibbens J.L., Federoff H.J., Bowers W.J. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol. Ther. 2008, 16:845-853.
    • (2008) Mol. Ther. , vol.16 , pp. 845-853
    • Frazer, M.E.1    Hughes, J.E.2    Mastrangelo, M.A.3    Tibbens, J.L.4    Federoff, H.J.5    Bowers, W.J.6
  • 33
    • 45749151056 scopus 로고    scopus 로고
    • Animal models of Alzheimer's disease and frontotemporal dementia
    • Götz J., Ittner L.M. Animal models of Alzheimer's disease and frontotemporal dementia. Nat. Rev. Neurosci. 2008, 9:532-544.
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 532-544
    • Götz, J.1    Ittner, L.M.2
  • 34
    • 48749101427 scopus 로고    scopus 로고
    • Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease
    • Gulinello M., Chen F., Dobrenis K. Early deficits in motor coordination and cognitive dysfunction in a mouse model of the neurodegenerative lysosomal storage disorder, Sandhoff disease. Behav. Brain Res. 2008, 193(2):315-319.
    • (2008) Behav. Brain Res. , vol.193 , Issue.2 , pp. 315-319
    • Gulinello, M.1    Chen, F.2    Dobrenis, K.3
  • 35
    • 0033009194 scopus 로고    scopus 로고
    • Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation
    • Guo Q., Sebastian L., Sopher B.L., Miller M.W., Ware C.B., Martin G.M., Mattson M.P. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J. Neurochem. 1999, 72:1019-1029.
    • (1999) J. Neurochem. , vol.72 , pp. 1019-1029
    • Guo, Q.1    Sebastian, L.2    Sopher, B.L.3    Miller, M.W.4    Ware, C.B.5    Martin, G.M.6    Mattson, M.P.7
  • 36
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 2007, 8:101-112.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 38
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • Hardy J., Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol. Sci. 1991, 12:383-388.
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 39
    • 21544468846 scopus 로고    scopus 로고
    • Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease
    • Hartman R.E., Izumi Y., Bales K.R., Paul S.M., Wozniak D.F., Holtzman D.M. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J. Neurosci. 2005, 25:6213-6220.
    • (2005) J. Neurosci. , vol.25 , pp. 6213-6220
    • Hartman, R.E.1    Izumi, Y.2    Bales, K.R.3    Paul, S.M.4    Wozniak, D.F.5    Holtzman, D.M.6
  • 41
    • 4744367412 scopus 로고    scopus 로고
    • The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory
    • Hughes R.N. The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci. Biobehav. Rev. 2004, 28:497-505.
    • (2004) Neurosci. Biobehav. Rev. , vol.28 , pp. 497-505
    • Hughes, R.N.1
  • 42
    • 0022724941 scopus 로고
    • Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease
    • Ihara Y., Nukina N., Miura R., Ogawara M. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease. J. Biochem. 1986, 99:1807-1810.
    • (1986) J. Biochem. , vol.99 , pp. 1807-1810
    • Ihara, Y.1    Nukina, N.2    Miura, R.3    Ogawara, M.4
  • 43
    • 2542622162 scopus 로고    scopus 로고
    • Search strategies used by APP transgenic mice during navigation in the Morris water maze
    • Janus C. Search strategies used by APP transgenic mice during navigation in the Morris water maze. Learn. Mem. 2004, 11:337-346.
    • (2004) Learn. Mem. , vol.11 , pp. 337-346
    • Janus, C.1
  • 46
    • 10044297055 scopus 로고    scopus 로고
    • Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging
    • Jensen M.T., Mottin M.D., Cracchiolo J.R., Leighty R.E., Arendash G.W. Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging. Neuroscience 2005, 130:667-684.
    • (2005) Neuroscience , vol.130 , pp. 667-684
    • Jensen, M.T.1    Mottin, M.D.2    Cracchiolo, J.R.3    Leighty, R.E.4    Arendash, G.W.5
  • 51
    • 0002173325 scopus 로고    scopus 로고
    • Cognitive-emotional interactions: listen to the Brain
    • Oxford University Press, New York, Oxford, R.J. Davidson, P. Ekman, K. Scherer (Eds.)
    • LeDoux J.E., Lane R.D., Nadel L. Cognitive-emotional interactions: listen to the Brain. Cognitive Neuroscience of Emotion 2000, 129-155. Oxford University Press, New York, Oxford. R.J. Davidson, P. Ekman, K. Scherer (Eds.).
    • (2000) Cognitive Neuroscience of Emotion , pp. 129-155
    • LeDoux, J.E.1    Lane, R.D.2    Nadel, L.3
  • 52
    • 33645220400 scopus 로고    scopus 로고
    • Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice
    • Lee E.B., Leng L.Z., Zhang B., Kwong L., Trojanowski J.Q., Abel T., Lee V.M. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. J. Biol. Chem. 2006, 281:4292-4299.
    • (2006) J. Biol. Chem. , vol.281 , pp. 4292-4299
    • Lee, E.B.1    Leng, L.Z.2    Zhang, B.3    Kwong, L.4    Trojanowski, J.Q.5    Abel, T.6    Lee, V.M.7
  • 55
    • 33646938005 scopus 로고    scopus 로고
    • Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response
    • Maier M., Seabrook T.J., Lazo N.D., Jiang L., Das P., Janus C., Lemere C.A. Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. J. Neurosci. 2006, 26:4717-4728.
    • (2006) J. Neurosci. , vol.26 , pp. 4717-4728
    • Maier, M.1    Seabrook, T.J.2    Lazo, N.D.3    Jiang, L.4    Das, P.5    Janus, C.6    Lemere, C.A.7
  • 56
    • 33847239940 scopus 로고    scopus 로고
    • Structural principles of tau and the paired helical filaments of Alzheimer's disease
    • Mandelkow E., von Bergen M., Biernat J., Mandelkow E.M. Structural principles of tau and the paired helical filaments of Alzheimer's disease. Brain Pathol. 2007, 17:83-90.
    • (2007) Brain Pathol. , vol.17 , pp. 83-90
    • Mandelkow, E.1    von Bergen, M.2    Biernat, J.3    Mandelkow, E.M.4
  • 57
    • 0034927082 scopus 로고    scopus 로고
    • Neurobiology of Pavlovian fear conditioning
    • Maren S. Neurobiology of Pavlovian fear conditioning. Annu. Rev. Neurosci. 2001, 24:897-931.
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 897-931
    • Maren, S.1
  • 61
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 1984, 11:47-60.
    • (1984) J. Neurosci. Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 62
    • 34347399599 scopus 로고    scopus 로고
    • Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model
    • Mouri A., Noda Y., Hara H., Mizoguchi H., Tabira T., Nabeshima T. Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model. FASEB J. 2007, 21:2135-2148.
    • (2007) FASEB J. , vol.21 , pp. 2135-2148
    • Mouri, A.1    Noda, Y.2    Hara, H.3    Mizoguchi, H.4    Tabira, T.5    Nabeshima, T.6
  • 66
    • 51749097108 scopus 로고    scopus 로고
    • Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders
    • Neff F., Wei X., Nolker C., Bacher M., Du Y., Dodel R. Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders. Autoimmun. Rev. 2008, 7:501-507.
    • (2008) Autoimmun. Rev. , vol.7 , pp. 501-507
    • Neff, F.1    Wei, X.2    Nolker, C.3    Bacher, M.4    Du, Y.5    Dodel, R.6
  • 67
    • 0034672421 scopus 로고    scopus 로고
    • Alzheimer's disease: a dysfunction of the amyloid precursor protein(1)
    • Neve R.L., McPhie D.L., Chen Y. Alzheimer's disease: a dysfunction of the amyloid precursor protein(1). Brain Res. 2000, 886:54-66.
    • (2000) Brain Res. , vol.886 , pp. 54-66
    • Neve, R.L.1    McPhie, D.L.2    Chen, Y.3
  • 68
    • 33847049400 scopus 로고    scopus 로고
    • Alzheimer disease: amyloidogenesis, the presenilins and animal models
    • Newman M., Musgrave I.F., Lardelli M. Alzheimer disease: amyloidogenesis, the presenilins and animal models. Biochim. Biophys. Acta 2007, 1772:285-297.
    • (2007) Biochim. Biophys. Acta , vol.1772 , pp. 285-297
    • Newman, M.1    Musgrave, I.F.2    Lardelli, M.3
  • 69
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
    • Nicoll J.A., Wilkinson D., Holmes C., Steart P., Markham H., Weller R.O. Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med. 2003, 9:448-452.
    • (2003) Nat. Med. , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 70
    • 33846015514 scopus 로고    scopus 로고
    • Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    • Oddo S., Vasilevko V., Caccamo A., Kitazawa M., Cribbs D.H., LaFerla F.M. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J. Biol. Chem. 2006, 281:39413-39423.
    • (2006) J. Biol. Chem. , vol.281 , pp. 39413-39423
    • Oddo, S.1    Vasilevko, V.2    Caccamo, A.3    Kitazawa, M.4    Cribbs, D.H.5    LaFerla, F.M.6
  • 72
    • 0031871740 scopus 로고    scopus 로고
    • Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy
    • Pitschke M., Prior R., Haupt M., Riesner D. Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nat. Med. 1998, 4:832-834.
    • (1998) Nat. Med. , vol.4 , pp. 832-834
    • Pitschke, M.1    Prior, R.2    Haupt, M.3    Riesner, D.4
  • 75
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 2001, 81:741-766.
    • (2001) Physiol. Rev. , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 76
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
    • Selkoe D.J. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav. Brain Res. 2008, 192(1):106-113.
    • (2008) Behav. Brain Res. , vol.192 , Issue.1 , pp. 106-113
    • Selkoe, D.J.1
  • 78
    • 0034884382 scopus 로고    scopus 로고
    • Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice
    • Sigurdsson E.M., Scholtzova H., Mehta P.D., Frangione B., Wisniewski T. Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice. Am. J. Pathol. 2001, 159:439-447.
    • (2001) Am. J. Pathol. , vol.159 , pp. 439-447
    • Sigurdsson, E.M.1    Scholtzova, H.2    Mehta, P.D.3    Frangione, B.4    Wisniewski, T.5
  • 79
    • 3242694207 scopus 로고    scopus 로고
    • An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives
    • Sigurdsson E.M., Knudsen E., Asuni A., Fitzer-Attas C., Sage D., Quartermain D., Goni F., Frangione B., Wisniewski T. An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives. J. Neurosci. 2004, 24:6277-6282.
    • (2004) J. Neurosci. , vol.24 , pp. 6277-6282
    • Sigurdsson, E.M.1    Knudsen, E.2    Asuni, A.3    Fitzer-Attas, C.4    Sage, D.5    Quartermain, D.6    Goni, F.7    Frangione, B.8    Wisniewski, T.9
  • 80
    • 33947596205 scopus 로고    scopus 로고
    • Active immunization against Alzheimer's beta-amyloid peptide using phage display technology
    • Solomon B. Active immunization against Alzheimer's beta-amyloid peptide using phage display technology. Vaccine 2007, 25:3053-3056.
    • (2007) Vaccine , vol.25 , pp. 3053-3056
    • Solomon, B.1
  • 82
    • 33750503415 scopus 로고    scopus 로고
    • Drug discovery in dementia: the role of rodent models
    • Van Dam D., De Deyn P.P. Drug discovery in dementia: the role of rodent models. Nat. Rev. Drug Discov. 2006, 5:956-970.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 956-970
    • Van Dam, D.1    De Deyn, P.P.2
  • 83
    • 32644474211 scopus 로고    scopus 로고
    • Effect of Morris water maze diameter on visual-spatial learning in different mouse strains
    • Van Dam D., Lenders G., De Deyn P.P. Effect of Morris water maze diameter on visual-spatial learning in different mouse strains. Neurobiol. Learn. Mem. 2006, 85:164-172.
    • (2006) Neurobiol. Learn. Mem. , vol.85 , pp. 164-172
    • Van Dam, D.1    Lenders, G.2    De Deyn, P.P.3
  • 84
    • 5344277556 scopus 로고    scopus 로고
    • Deciphering the molecular basis of memory failure in Alzheimer's disease
    • Walsh D.M., Selkoe D.J. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004, 44:181-193.
    • (2004) Neuron , vol.44 , pp. 181-193
    • Walsh, D.M.1    Selkoe, D.J.2
  • 85
    • 14244255355 scopus 로고    scopus 로고
    • Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage
    • Wilcock D.M., Rojiani A., Rosenthal A., Subbarao S., Freeman M.J., Gordon M.N., Morgan D. Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. J. Neuroinflammation 2004, 1:24.
    • (2004) J. Neuroinflammation , vol.1 , pp. 24
    • Wilcock, D.M.1    Rojiani, A.2    Rosenthal, A.3    Subbarao, S.4    Freeman, M.J.5    Gordon, M.N.6    Morgan, D.7
  • 86
    • 33745001453 scopus 로고    scopus 로고
    • Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice
    • Wilcock D.M., Alamed J., Gottschall P.E., Grimm J., Rosenthal A., Pons J., Ronan V., Symmonds K., Gordon M.N., Morgan D. Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice. J. Neurosci. 2006, 26:5340-5346.
    • (2006) J. Neurosci. , vol.26 , pp. 5340-5346
    • Wilcock, D.M.1    Alamed, J.2    Gottschall, P.E.3    Grimm, J.4    Rosenthal, A.5    Pons, J.6    Ronan, V.7    Symmonds, K.8    Gordon, M.N.9    Morgan, D.10
  • 87
    • 10744225891 scopus 로고    scopus 로고
    • A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer's disease
    • Zhang J., Wu X., Qin C., Qi J., Ma S., Zhang H., Kong Q., Chen D., Ba D., He W. A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and beta-amyloid plaques in a mouse model of Alzheimer's disease. Neurobiol. Dis. 2003, 14:365-379.
    • (2003) Neurobiol. Dis. , vol.14 , pp. 365-379
    • Zhang, J.1    Wu, X.2    Qin, C.3    Qi, J.4    Ma, S.5    Zhang, H.6    Kong, Q.7    Chen, D.8    Ba, D.9    He, W.10
  • 88
    • 48349117119 scopus 로고    scopus 로고
    • Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Abeta(1-15) reduces Abeta burden and behavioral impairment without Abeta-specific T cell response
    • Zou J., Yao Z., Zhang G., Wang H., Xu J., Yew D.T., Forster E.L. Vaccination of Alzheimer's model mice with adenovirus vector containing quadrivalent foldable Abeta(1-15) reduces Abeta burden and behavioral impairment without Abeta-specific T cell response. J. Neurol. Sci. 2008, 272:87-98.
    • (2008) J. Neurol. Sci. , vol.272 , pp. 87-98
    • Zou, J.1    Yao, Z.2    Zhang, G.3    Wang, H.4    Xu, J.5    Yew, D.T.6    Forster, E.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.