Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning

Behavioural Brain Research

Volumn 186, Issue 1, 2008, Pages 126-132

  Senechal, Yann ^a   Kelly, Peter H ^a   Dev, Kumlesh K ^a,b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Amyloid precursor protein; Knockout mice; Locomotor activity; Long term memory; Passive avoidance; Spontaneous alternation

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

AGE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AVERSIVE BEHAVIOR; BRAIN TISSUE; COGNITION; CONTROLLED STUDY; GRIP STRENGTH; HIPPOCAMPUS; IN VIVO STUDY; KNOCKOUT MOUSE; LEARNING DISORDER; LOCOMOTION; LONG TERM MEMORY; MALE; MAZE TEST; MEMORY DISORDER; MOUSE; NERVE CELL NETWORK; NEUROMUSCULAR FUNCTION; NONHUMAN; PASSIVE AVOIDANCE; PATHOGENESIS; PRIORITY JOURNAL; WESTERN BLOTTING; WILD TYPE;

AGE FACTORS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AVOIDANCE LEARNING; MALE; MATCHED-PAIR ANALYSIS; MAZE LEARNING; MEMORY, SHORT-TERM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MUSCLE STRENGTH; SPATIAL BEHAVIOR;

EID: 36048938990     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2007.08.003     Document Type: Article

References (33)

1. Akaaboune M., Allinquant B., Farza H., Roy K., Magoul R., Fiszman M., et al. Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle. Mol Cell Neurosci 15 (2000) 355-367
2. Beglopoulos V., and Shen J. Gene-targeting technologies for the study of neurological disorders. Neuromol Med 6 (2004) 13-30
3. Dawson G.R., Seabrook G.R., Zheng H., Smith D.W., Graham S., O'Dowd G., et al. Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience 90 (1999) 1-13
4. Dember W.N., and Fowler H. Spontaneous alteration after free and forced trials. Can J Psychol 13 (1959) 151-154
5. Dev K.K., Nakajima Y., Kitano J., Braithwaite S.P., Henley J.M., and Nakanishi S. PICK1 interacts with and regulates PKC phosphorylation of mGluR7. J Neurosci 20 (2000) 7252-7257
6. Doyle E., Bruce M.T., Breen K.C., Smith D.C., Anderton B., and Regan C.M. Intraventricular infusions of antibodies to amyloid-beta-protein precursor impair the acquisition of a passive avoidance response in the rat. Neurosci Lett 115 (1990) 97-102
7. Dudchenko P.A. An overview of the tasks used to test working memory in rodents. Neurosci Biobehav Rev 28 (2004) 699-709
8. Fitzjohn S.M., Morton R.A., Kuenzi F., Davies C.H., Seabrook G.R., and Collingridge G.L. Similar levels of longterm potentiation in amyloid precursor protein-null and wild-type mice in the CA1 region of picrotoxin treated slices. Neurosci Lett 288 (2000) 9-12
9. Gerlai R. Behavioral tests of hippocampal function: simple paradigms complex problems. Behav Brain Res 125 (2001) 269-277
10. Hirokawa N., and Takemura R. Molecular motors and mechanisms of directional transport in neurons. Nat Rev Neurosci 6 (2005) 201-214
11. Huber G., Martin J.R., Loffler J., and Moreau J.L. Involvement of amyloid precursor protein in memory formation in the rat: an indirect antibody approach. Brain Res 603 (1993) 348-352
12. Hughes R.N. The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci Biobehav Rev 28 (2004) 497-505
13. B(1) receptor isoforms in cognition. Behav Brain Res 181 (2007) 158-162
14. Kelly P.H., Bondolfi L., Hunziker D., Schlecht H.P., Carver K., Maguire E., et al. Progressive age-related impairment of cognitive behaviour in APP23 transgenic mice. Neurobiol Aging 24 (2003) 365-378
15. Lalonde R. The neurobiological basis of spontaneous alternation. Neurosci Biobehav Rev 26 (2002) 91-104
16. Ledermann B., and Burki K. Establishment of a germ-line competent C57BL/6 embryonic stem cell line. Exp Cell Res 197 (1991) 254-258
17. Lorenzo A., Yuan M., Zhang Z., Paganetti P.A., Sturchler-Pierrat C., Staufenbiel M., et al. Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci 3 (2000) 460-464
18. Luo L., Tully T., and White K. Human amyloid precursor protein ameliorates behavioural deficit of flies deleted for Appl gene. Neuron 9 (1992) 595-605
19. Müller U., Cristina N., Li Z.W., Wolfer D.P., Lipp H.P., Rulicke T., et al. Behavioural and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell 79 (1994) 755-765
20. Palacios G., Palacios J.M., Mengod G., and Frey P. Beta-amyloid precursor protein localization in the Golgi apparatus in neurons and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons. Brain Res Mol Brain Res 15 (1992) 195-206
21. Phinney A.L., Calhoun M.E., Wolfer D.P., Lipp H.P., Zheng H., and Jucker M. No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice. Neuroscience 90 (1999) 1207-1216
22. Reinhard C., Hebert S.S., and De Strooper B. The amyloid-beta precursor protein: integrating structure with biological function. EMBO J 24 (2005) 3996-4006
23. Sarter M., Bodewitz G., and Stephens D.N. Attenuation of scopolamine-induced impairment of spontaneous alteration behaviour by antagonist but not inverse agonist and agonist beta-carbolines. Psychopharmacology 94 (1988) 491-495
24. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81 (2001) 741-766
25. Seabrook G.R., Smith D.W., Bowery B.J., Easter A., Reynolds T., Fitzjohn S.M., et al. Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology 38 (1999) 349-359
26. Tanzi R.E., and Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120 (2005) 545-555
27. Torroja L., Packard M., Gorczyca M., White K., and Budnik V. The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction. J Neurosci 19 (1999) 7793-7803
28. Tremml P., Lipp H.P., Müller U., Ricceri L., and Wolfer D.P. Neurobehavioural development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene. Behav Brain Res 95 (1998) 65-76
29. Tremml P., Lipp H.P., Müller U., and Wolfer D.P. Enriched early experiences of mice underexpressing the beta-amyloid precursor protein restore spatial learning capabilities but not normal openfield behaviour of adult animals. Genes Brain Behav 1 (2002) 230-241
30. Turner P.R., O'Connor K., Tate W.P., and Abraham W.C. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70 (2003) 1-32
31. Venable N., and Kelly P.H. Effects of NMDA receptor antagonists on passive avoidance learning and retrieval in rats and mice. Psychopharmacology 100 (1990) 215-221
32. Wang P., Yang G., Mosier D.R., Chang P., Zaidi T., Gong Y.D., et al. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2. J Neurosci 25 (2005) 1219-1225
33. Zheng H., Jiang M., Trumbauer M.E., Sirinathsinghji D.J., Hopkins R., Smith D.W., et al. Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81 (1995) 525-531