-
1
-
-
0030840464
-
STATs and gene regulation
-
DOI 10.1126/science.277.5332.1630
-
Darnell JE Jr. STATs and gene regulation. Science 1997;277:1630-5. (Pubitemid 27446219)
-
(1997)
Science
, vol.277
, Issue.5332
, pp. 1630-1635
-
-
Darnell Jr., J.E.1
-
3
-
-
0037138370
-
Signaling through the JAK/STAT pathway, recent advances and future challenges
-
DOI 10.1016/S0378-1119(02)00398-0, PII S0378111902003980
-
Kisseleva T, Bhattacharya S, Braunstein J, et al. Signalling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002;285:1-24. (Pubitemid 34246317)
-
(2002)
Gene
, vol.285
, Issue.1-2
, pp. 1-24
-
-
Kisseleva, T.1
Bhattacharya, S.2
Braunstein, J.3
Schindler, C.W.4
-
4
-
-
0242468041
-
Regulation of JAK-STAT signalling in the immune system
-
Shuai K, Liu B. Regulation of JAK-STAT signaling in the immune system. Nat Rev Immunol 2003;3:900-11. (Pubitemid 37411719)
-
(2003)
Nature Reviews Immunology
, vol.3
, Issue.11
, pp. 900-911
-
-
Shuai, K.1
Liu, B.2
-
5
-
-
0035895089
-
Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon gamma
-
Lemmink HH, Tuyt L, Knol G, et al. Identification of LIL-STAT in monocytic leukemia cells and monocytes after stimulation with interleukin-6 or interferon gamma. Blood 2001;98:3849-52.
-
(2001)
Blood
, vol.98
, pp. 3849-3852
-
-
Lemmink, H.H.1
Tuyt, L.2
Knol, G.3
-
6
-
-
0024989359
-
Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes
-
Firmbach-Kraft I, Byers M, Shows T, et al. Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene 1990;5:1329-36.
-
(1990)
Oncogene
, vol.5
, pp. 1329-1336
-
-
Firmbach-Kraft, I.1
Byers, M.2
Shows, T.3
-
7
-
-
0242285719
-
STAT proteins: From normal control of cellular events to tumorigenesis
-
DOI 10.1002/jcp.10364
-
Calò V, Migliavacca M, Bazan V, et al. STAT proteins: from normal control of cellular events to tumorigenesis. J Cell Physiol 2003;197:157-68. (Pubitemid 37485244)
-
(2003)
Journal of Cellular Physiology
, vol.197
, Issue.2
, pp. 157-168
-
-
Calo, V.1
Migliavacca, M.2
Bazan, V.3
Macaluso, M.4
Buscemi, M.5
Gebbia, N.6
Russo, A.7
-
8
-
-
59449109107
-
Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting
-
Koppikar P, Lui VW, Man D, et al. Constitutive activation of signal transducer and activator of transcription 5 contributes to tumor growth, epithelial-mesenchymal transition, and resistance to epidermal growth factor receptor targeting. Clin Cancer Res 2008;14:7682-7690.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7682-7690
-
-
Koppikar, P.1
Lui, V.W.2
Man, D.3
-
9
-
-
0034306290
-
STAT proteins and transcriptional responses to extracellular signals
-
Horvath CM. STAT proteins and transcriptional responses to extracellular signals. Trends Biochem Sci 2000;25:496-502.
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 496-502
-
-
Horvath, C.M.1
-
11
-
-
0032832056
-
Interferons as a paradigm for cytokine signal transduction
-
DOI 10.1007/s000180050391
-
Schindler C, Brutsaert S. Interferons as a paradigm for cytokine signal transduction. Cell Mol Life Sci 1999;55:1509-22. (Pubitemid 29445817)
-
(1999)
Cellular and Molecular Life Sciences
, vol.55
, Issue.12
, pp. 1509-1522
-
-
Schindler, C.1
Brutsaert, S.2
-
12
-
-
0036256836
-
JAK-STAT signaling in human disease
-
DOI 10.1172/JCI200215644
-
Schindler C. Series introduction. JAK-STAT signaling in human disease. J Clin Invest 2002;109:1133-7. (Pubitemid 34496589)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.9
, pp. 1133-1137
-
-
Schindler, C.W.1
-
13
-
-
0034777482
-
Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival
-
Brabender J, Danenberg KD, Metzger R, et al. Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival. Clin Cancer Res 2001;7:1850-5. (Pubitemid 32994816)
-
(2001)
Clinical Cancer Research
, vol.7
, Issue.7
, pp. 1850-1855
-
-
Brabender, J.1
Danenberg, K.D.2
Metzger, R.3
Schneider, P.M.4
Park, J.5
Salonga, D.6
Holscher, A.H.7
Danenberg, P.V.8
-
14
-
-
0034658698
-
STATs in oncogenesis
-
Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene 2000;19:2474-88. (Pubitemid 30339203)
-
(2000)
Oncogene
, vol.19
, Issue.21
, pp. 2474-2488
-
-
Bowman, T.1
Garcia, R.2
Turkson, J.3
Jove, R.4
-
15
-
-
0037071409
-
JAKs, STATs and Src kinases in hematopoiesis
-
DOI 10.1038/sj.onc.1205398
-
Rane SG, Reddy EP. JAKs, STATs and Src kinases in hematopoiesis. Oncogene 2002;21:3334-58. (Pubitemid 34587707)
-
(2002)
Oncogene
, vol.21
, Issue.21
, pp. 3334-3358
-
-
Rane, S.G.1
Reddy, E.P.2
-
16
-
-
0034693871
-
Janus kinases: Components of multiple signaling pathways
-
Rane SG, Reddy EP. Janus kinases: components of multiple signaling pathways. Oncogene 2000;19:5662-79.
-
(2000)
Oncogene
, vol.19
, pp. 5662-5679
-
-
Rane, S.G.1
Reddy, E.P.2
-
17
-
-
79953881238
-
Signal transducers and activators of transcription-from cytokine signaling to cancer biology
-
Santos CI, Costa-Pereira AP. Signal transducers and activators of transcription-from cytokine signaling to cancer biology. Biochim Biophys Acta 2011;1816:38-49.
-
(2011)
Biochim Biophys Acta
, vol.1816
, pp. 38-49
-
-
Santos, C.I.1
Costa-Pereira, A.P.2
-
18
-
-
35348850734
-
Hematopoietic cytokine receptor signaling
-
DOI 10.1038/sj.onc.1210757, PII 1210757
-
Baker SJ, Rane SG, Reddy EP. Hematopoietic cytokine receptor signaling. Oncogene 2007;26:6724-37. (Pubitemid 47585098)
-
(2007)
Oncogene
, vol.26
, Issue.47
, pp. 6724-6737
-
-
Baker, S.J.1
Rane, S.G.2
Reddy, E.P.3
-
19
-
-
0033019051
-
The significance of tetramerization in promoter recruitment by Stat5
-
John S, Vinkemeier U, Soldaini E, et al. The significance of tetramerization in promoter recruitment by Stat5. Mol Cell Biol 1999;19:1910-8. (Pubitemid 29098249)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.3
, pp. 1910-1918
-
-
John, S.1
Vinkemeier, U.2
Soldaini, E.3
Darnell Jr., J.E.4
Leonard, W.J.5
-
20
-
-
0042206459
-
A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation
-
DOI 10.1074/jbc.M304196200
-
Ma J, Zhang T, Novotny-Diermayr V, et al. A novel sequence in the coiled-coil domain of Stat3 essential for its nuclear translocation. J Biol Chem 2003;278:29252-60. (Pubitemid 36935841)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.31
, pp. 29252-29260
-
-
Ma, J.1
Zhang, T.2
Novotny-Diermayr, V.3
Tan, A.L.C.4
Cao, X.5
-
21
-
-
0032577678
-
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
-
DOI 10.1016/S0092-8674(00)81443-9
-
Chen X, Vinkemeier U, Zhao Y, et al. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 1998;93:827-39. (Pubitemid 28257588)
-
(1998)
Cell
, vol.93
, Issue.5
, pp. 827-839
-
-
Chen, X.1
Vinkemeier, U.2
Zhao, Y.3
Jeruzalmi, D.4
Darnell Jr., J.E.5
Kuriyan, J.6
-
22
-
-
0032921172
-
The STAT family of proteins in cytokine signaling
-
DOI 10.1016/S0079-6107(98)00051-0, PII S0079610798000510
-
Shuai K. The STAT family of proteins in cytokine signaling. Prog Biophys Mol Biol 1999;71:405-422. (Pubitemid 29156310)
-
(1999)
Progress in Biophysics and Molecular Biology
, vol.71
, Issue.3-4
, pp. 405-422
-
-
Shuai, K.1
-
23
-
-
0034159937
-
Association of STATs with relatives and friends
-
DOI 10.1016/S0962-8924(99)01709-2, PII S0962892499017092
-
Chatterjee-Kishore M, Van Den Akker F, Stark GR. Association of STATs with relatives and friends. Trends Cell Biol 2000;10:106-11. (Pubitemid 30110693)
-
(2000)
Trends in Cell Biology
, vol.10
, Issue.3
, pp. 106-111
-
-
Chatterjee-Kishore, M.1
Akker, F.V.D.2
Stark, G.R.3
-
24
-
-
0034023759
-
The Jak-STAT pathway
-
DOI 10.1016/S0161-5890(00)00018-3, PII S0161589000000183
-
Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol 2000;37:1-11. (Pubitemid 30316189)
-
(2000)
Molecular Immunology
, vol.37
, Issue.1-2
, pp. 1-11
-
-
Imada, K.1
Leonard, W.J.2
-
25
-
-
0035866398
-
A novel serine-dependent proteolytic activity is responsible for truncated signal transducer and activator of transcription proteins in acute myeloid leukemia blasts
-
Xia Z, Salzler RR, Kunz DP, et al. A novel serine-dependent proteolytic activity is responsible for truncated signal transducer and activator of transcription proteins in acute myeloid leukemia blasts Cancer Res 2001;61:1747-53. (Pubitemid 34292614)
-
(2001)
Cancer Research
, vol.61
, Issue.4
, pp. 1747-1753
-
-
Xia, Z.1
Salzler, R.R.2
Kunz, D.P.3
Baer, M.R.4
Kazim, L.5
Baumann, H.6
Wetzler, M.7
-
26
-
-
30044437825
-
Nuclear export determines the cytokine sensitivity of STAT transcription factors
-
DOI 10.1074/jbc.M509180200
-
Lödige I, Marg A, Wiesner B, et al. Nuclear export determines the cytokine sensitivity of STAT transcription factors. J Biol Chem 2005;280:43087-99. (Pubitemid 43049275)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.52
, pp. 43087-43099
-
-
Lodige, I.1
Marg, A.2
Wiesner, B.3
Malecova, B.4
Oelgeschlager, T.5
Vinkemeier, U.6
-
27
-
-
36849026590
-
Stat3 isoforms, α and β, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3β mapping to its unique C-terminal end
-
DOI 10.1074/jbc.M704548200
-
Huang Y, Qiu J, Dong S, Redell MS, et al. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique Cterminal end. J Biol Chem 2007;82:34958-67. (Pubitemid 350232477)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.48
, pp. 34958-34967
-
-
Huang, Y.1
Qiu, J.2
Dong, S.3
Redell, M.S.4
Poli, V.5
Mancini, M.A.6
Tweardy, D.J.7
-
28
-
-
0027735135
-
Nomenclature of the human interferon genes
-
Diaz MO, Bohlander S, Allen G. Nomenclature of the human interferon genes. J Interferon Res 1993;13:443. (Pubitemid 24291187)
-
(1993)
Journal of Interferon Research
, vol.13
, Issue.6
, pp. 443
-
-
Diaz, M.O.1
Bohlander, S.2
Allen, G.3
Adolf, G.R.4
Pestka, S.5
Zoon, K.C.6
Doly, J.7
Revel, M.8
Finter, N.B.9
Testa, D.10
-
29
-
-
0030889207
-
The IFNγ receptor: A paradigm for cytokine receptor signaling
-
DOI 10.1146/annurev.immunol.15.1.563
-
Bach EA, Aguet M, Schreiber RD. The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol 1997;15:563-91. (Pubitemid 27169292)
-
(1997)
Annual Review of Immunology
, vol.15
, pp. 563-591
-
-
Bach, E.A.1
Aguet, M.2
Schreiber, R.D.3
-
30
-
-
0034089107
-
Limitin: An interferon-like cytokine that preferentially influences B- lymphocyte precursors
-
DOI 10.1038/76233
-
Oritani K, Medina KL, Tomiyama Y, et al. Limitin: An interferonlike cytokine that preferentially influences B-lymphocyte precursors. Nat Med 2000;6:659-66. (Pubitemid 30398789)
-
(2000)
Nature Medicine
, vol.6
, Issue.6
, pp. 659-666
-
-
Oritani, K.1
Medina, K.L.2
Tomiyama, Y.3
Ishikawa, J.4
Okajima, Y.5
Ogawa, M.6
Yokota, T.7
Aoyama, K.8
Takahashi, I.9
Kincade, P.W.10
Matsuzawa, Y.11
-
31
-
-
0032493299
-
Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice
-
Lu B, Ebensperger C, Dembic Z, et al. Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice. Proc Natl Acad Sci U S A 1998;95:8233-8.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 8233-8238
-
-
Lu, B.1
Ebensperger, C.2
Dembic, Z.3
-
32
-
-
13344282731
-
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
-
DOI 10.1016/S0092-8674(00)81288-X
-
Meraz MA, White JM, Sheehan KC, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 1996;84:431-42. (Pubitemid 26058568)
-
(1996)
Cell
, vol.84
, Issue.3
, pp. 431-442
-
-
Meraz, M.A.1
White, J.M.2
Sheehan, K.C.F.3
Bach, E.A.4
Rodig, S.J.5
Dighe, A.S.6
Kaplan, D.H.7
Riley, J.K.8
Greenlund, A.C.9
Campbell, D.10
Carver-Moore, K.11
DuBois, R.N.12
Clark, R.13
Aguet, M.14
Schreiber, R.D.15
-
33
-
-
0029909271
-
Interactions between STAT and non-STAT proteins in the interferon- stimulated gene factor 3 transcription complex
-
Horvath CM, Stark GR, Kerr IM, et al. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol Cell Biol 1996;16:6957-64. (Pubitemid 26389755)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.12
, pp. 6957-6964
-
-
Horvath, C.M.1
Stark, G.R.2
Kerr, I.M.3
Darnell Jr., J.E.4
-
34
-
-
0032131227
-
Cooperative binding of stat1-2 heterodimers and ISGF3 to tandem DNA elements
-
DOI 10.1016/S0300-9084(99)80023-6
-
Li X, Leung S, Burns C, et al. Cooperative binding of Stat1-2 heterodimers and ISGF3 to tandem DNA elements. Biochimie 1998;80:703-10. (Pubitemid 29497587)
-
(1998)
Biochimie
, vol.80
, Issue.8-9
, pp. 703-710
-
-
Li, X.1
Leung, S.2
Burns, C.3
Stark, G.R.4
-
35
-
-
0037448456
-
Control mechanism of JAK/STAT signal transduction pathway
-
DOI 10.1016/S0014-5793(02)03842-5
-
Yamada S, Shiono S, Joo A, et al. Control mechanism of JAK/STAT signal transduction pathway. FEBS Lett 2003;534:190-6. (Pubitemid 36084541)
-
(2003)
FEBS Letters
, vol.534
, Issue.1-3
, pp. 190-196
-
-
Yamada, S.1
Shiono, S.2
Joo, A.3
Yoshimura, A.4
-
36
-
-
0034801684
-
SOCS proteins: Negative regulators of cytokine signaling
-
Krebs DL, Hilton DJ. SOCS proteins: negative regulators of cytokine signaling. Stem Cells 2001;19:378-87. (Pubitemid 32900080)
-
(2001)
Stem Cells
, vol.19
, Issue.5
, pp. 378-387
-
-
Krebs, D.L.1
Hilton, D.J.2
-
37
-
-
13744255376
-
Stat acetylation - A key facet of cytokine signaling?
-
DOI 10.1126/science.1108164
-
O'Shea JJ, Kanno Y, Chen X, et al. Cell signaling. Stat acetylation-a key facet of cytokine signaling? Science 2005;307:217-8. (Pubitemid 40116227)
-
(2005)
Science
, vol.307
, Issue.5707
, pp. 217-218
-
-
O'Shea, J.J.1
Kanno, Y.2
Chen, X.3
Levy, D.E.4
-
38
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman MH, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002;82:373-428. (Pubitemid 34654457)
-
(2002)
Physiological Reviews
, vol.82
, Issue.2
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
39
-
-
84867171910
-
The suppressors of cytokine signalling (SOCS)
-
Kile BT, Alexander WS. The suppressors of cytokine signalling (SOCS). Cell Mol Life Sci 2001;581:627-35.
-
(2001)
Cell Mol Life Sci
, vol.581
, pp. 627-635
-
-
Kile, B.T.1
Alexander, W.S.2
-
40
-
-
0035168683
-
JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling
-
DOI 10.1182/blood.V97.1.221
-
Sporri B, Kovanen PE, Sasaki A, et al. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling. Blood 2001;97:221-6. (Pubitemid 32061264)
-
(2001)
Blood
, vol.97
, Issue.1
, pp. 221-226
-
-
Sporri, B.1
Kovanen, P.E.2
Sasaki, A.3
Yoshimura, A.4
Leonard, W.J.5
-
41
-
-
0032169599
-
Inhibition of Stat1-mediated gene activation by PIAS1
-
DOI 10.1073/pnas.95.18.10626
-
Liu B, Liao J, Rao X, et al. Inhibition of Stat1-mediated gene activation by PIAS1. Proc Natl Acad Sci U S A 1998;95:10626-31. (Pubitemid 28413118)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.18
, pp. 10626-10631
-
-
Liu, B.1
Liao, J.2
Rao, X.3
Kushner, S.A.4
Chung, C.D.5
Chang, D.D.6
Shuai, K.E.7
-
42
-
-
0030725378
-
Specific inhibition of Stat3 signal transduction by PIAS3
-
DOI 10.1126/science.278.5344.1803
-
Chung CD, Liao J, Liu B, et al. Specific inhibition of Stat3 signal transduction by PIAS3. Science 1997;278:1803-1805. (Pubitemid 27527648)
-
(1997)
Science
, vol.278
, Issue.5344
, pp. 1803-1805
-
-
Chung, C.D.1
Liao, J.2
Liu, B.3
Rao, X.4
Jay, P.5
Berta, P.6
Shuai, K.7
-
43
-
-
77954096689
-
IL-6: Regulator of Treg/Th17 balance
-
Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol 2010;40:1830-5.
-
(2010)
Eur J Immunol
, vol.40
, pp. 1830-1835
-
-
Kimura, A.1
Kishimoto, T.2
-
44
-
-
79957673711
-
IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
-
Neurath MF, Finotto S. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 2011;22:83-9.
-
(2011)
Cytokine Growth Factor Rev
, vol.22
, pp. 83-89
-
-
Neurath, M.F.1
Finotto, S.2
-
45
-
-
41549107522
-
Cytokine signaling modules in inflammatory responses
-
DOI 10.1016/j.immuni.2008.03.002, PII S1074761308001179
-
O'Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity 2008;28:477-87. (Pubitemid 351467044)
-
(2008)
Immunity
, vol.28
, Issue.4
, pp. 477-487
-
-
O'Shea, J.J.1
Murray, P.J.2
-
46
-
-
0141720769
-
Class II cytokine receptors and their ligands: Key antiviral and inflammatory modulators
-
Renauld, J. C. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat Rev Immunol 2003;3:667-76.
-
(2003)
Nat Rev Immunol
, vol.3
, pp. 667-676
-
-
Renauld, J.C.1
-
47
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
-
DOI 10.1038/75068
-
Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med 2000;6:583-8. (Pubitemid 30305911)
-
(2000)
Nature Medicine
, vol.6
, Issue.5
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Mullberg, J.4
Jostock, T.5
Wirtz, S.6
Schutz, M.7
Bartsch, B.8
Holtmann, M.9
Becker, C.10
Strand, D.11
Czaja, J.12
Schlaak, J.F.13
Lehr, H.A.14
Autschbach, F.15
Schurmann, G.16
Nishimoto, N.17
Yoshizaki, K.18
Ito, H.19
Kishimoto, T.20
Galle, P.R.21
Rose-John, S.22
Neurath, M.F.23
more..
-
49
-
-
22144492213
-
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
-
DOI 10.1073/pnas.0501794102
-
McLoughlin RM, Jenkins BJ, Grail D, et al. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proc Natl Acad Sci U S A 2005;102:9589-94. (Pubitemid 40981725)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.27
, pp. 9589-9594
-
-
McLoughlin, R.M.1
Jenkins, B.J.2
Grail, D.3
Williams, A.S.4
Fielding, C.A.5
Parker, C.R.6
Ernst, M.7
Topley, N.8
Jones, S.A.9
-
50
-
-
0032213273
-
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: Generation and characterization of T cell- specific stat3-deficient mice
-
Takeda K, Kaisho T, Yoshida N, et al. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cellspecific Stat3-deficient mice. J Immunol 1998;16:4652-60. (Pubitemid 28492039)
-
(1998)
Journal of Immunology
, vol.161
, Issue.9
, pp. 4652-4660
-
-
Takeda, K.1
Kaisho, T.2
Yoshida, N.3
Takeda, J.4
Kishimoto, T.5
Akira, S.6
-
51
-
-
0033034365
-
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils
-
DOI 10.1016/S1074-7613(00)80005-9
-
Takeda K, Clausen BE, Kaisho T, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999;10:39-49. (Pubitemid 29077382)
-
(1999)
Immunity
, vol.10
, Issue.1
, pp. 39-49
-
-
Takeda, K.1
Clausen, B.E.2
Kaisho, T.3
Tsujimura, T.4
Terada, N.5
Forster, I.6
Akira, S.7
-
52
-
-
0033451992
-
Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis
-
Shirogane T, Fukada T, Muller JM, et al. Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity 1999;11:709-19. (Pubitemid 30030710)
-
(1999)
Immunity
, vol.11
, Issue.6
, pp. 709-719
-
-
Shirogane, T.1
Fukada, T.2
Muller, J.M.M.3
Shima, D.T.4
Hibi, M.5
Hirano, T.6
-
53
-
-
0032934156
-
Functional roles of STAT family proteins: Lessons from knockout mice
-
Akira S. Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 1999;17:138-46. (Pubitemid 29226664)
-
(1999)
Stem Cells
, vol.17
, Issue.3
, pp. 138-146
-
-
Akira, S.1
-
55
-
-
68949094114
-
Role of CD44 in the differentiation of Th1 and Th2 cells: CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin
-
Guan H, Nagarkatti PS, Nagarkatti M. Role of CD44 in the differentiation of Th1 and Th2 cells: CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin. J Immunol 2009;183:172-80.
-
(2009)
J Immunol
, vol.183
, pp. 172-180
-
-
Guan, H.1
Nagarkatti, P.S.2
Nagarkatti, M.3
-
56
-
-
0033558364
-
+ T cells that respond to bacterial antigens
-
Wirtz S, Finotto S, Kanzler S, et al. Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF-plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens. J Immunol 1999;162:1884-8. (Pubitemid 29288801)
-
(1999)
Journal of Immunology
, vol.162
, Issue.4
, pp. 1884-1888
-
-
Wirtz, S.1
Finotto, S.2
Kanzler, S.3
Lohse, A.W.4
Blessing, M.5
Lehr, H.A.6
Galle, P.R.7
Neurath, M.F.8
-
57
-
-
0029057858
-
Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis
-
Quelle FW, Shimoda K, Thierfelder W, et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol Cell Biol 1995;15:3336-43.
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3336-3343
-
-
Quelle, F.W.1
Shimoda, K.2
Thierfelder, W.3
-
58
-
-
0029876629
-
Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
-
DOI 10.1016/S1074-7613(00)80439-2
-
Kaplan MH, Schindler U, Smiley ST, et al. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996;4:313-9. (Pubitemid 26132509)
-
(1996)
Immunity
, vol.4
, Issue.3
, pp. 313-319
-
-
Kaplan, M.H.1
Schindler, U.2
Smiley, S.T.3
Grusby, M.J.4
-
59
-
-
84867168791
-
Peripheral deficiency of Foxp3+ Regulatory T cells in SOCS-1 knockout mice associated with peri-lethal death
-
Collins E, Jager L, Benitez P, et al. Peripheral deficiency of Foxp3+ Regulatory T cells in SOCS-1 knockout mice associated with peri-lethal death. J Immunol 2010;184:143-33.
-
(2010)
J Immunol
, vol.184
, pp. 143-133
-
-
Collins, E.1
Jager, L.2
Benitez, P.3
-
60
-
-
13044290651
-
Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mrna expression in human neutrophils: Evidence for an IL-10-induced pathway that is independent of STAT protein activation
-
Cassatella MA, Gasperini S, Bovolenta C, et al. Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation. Blood 1999;94:2880-9. (Pubitemid 29477317)
-
(1999)
Blood
, vol.94
, Issue.8
, pp. 2880-2889
-
-
Cassatella, M.A.1
Gasperini, S.2
Bovolenta, C.3
Calzetti, F.4
Vollebregt, M.5
Scapini, P.6
Marchi, M.7
Suzuki, R.8
Suzuki, A.9
Yoshimura, A.10
-
61
-
-
0034635550
-
Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1β on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells
-
DOI 10.1074/jbc.275.6.3841
-
Boisclair YR, Wang J, Shi J, et al. Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. J Biol Chem 2000;275:3841-7. (Pubitemid 30094607)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.6
, pp. 3841-3847
-
-
Boisclair, Y.R.1
Wang, J.2
Shi, J.3
Hurst, K.R.4
Ooi, G.T.5
-
62
-
-
0035979275
-
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
-
DOI 10.1073/pnas.161271798
-
Roberts AW, Robb L, Rakar S, et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc Natl Acad Sci U S A 2001;98:9324-9. (Pubitemid 32743915)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.16
, pp. 9324-9329
-
-
Roberts, A.W.1
Robb, L.2
Rakar, S.3
Hartley, L.4
Cluse, L.5
Nicola, N.A.6
Metcalf, D.7
Hilton, D.J.8
Alexander, W.S.9
-
63
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
DOI 10.1084/jem.193.4.471
-
Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T, Kubo M, Yamashita A, Okabe M, Takeda K, Akira S, Matsumoto S, Toyonaga A, Sata M, Yoshimura A. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001;193:471-81. (Pubitemid 32524478)
-
(2001)
Journal of Experimental Medicine
, vol.193
, Issue.4
, pp. 471-481
-
-
Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
Yoshida, T.4
Kamizono, S.5
Hoshino, T.6
Kubo, M.7
Yamashita, A.8
Okabe, M.9
Takeda, K.10
Akira, S.11
Matsumoto, S.12
Toyonaga, A.13
Sata, M.14
Yoshimura, A.15
-
64
-
-
0035667907
-
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
-
DOI 10.1172/JCI200113568
-
Shouda T, Yoshida T, Hanada T, et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest 2001;108:1781-8. (Pubitemid 34015123)
-
(2001)
Journal of Clinical Investigation
, vol.108
, Issue.12
, pp. 1781-1788
-
-
Shouda, T.1
Yoshida, T.2
Hanada, T.3
Wakioka, T.4
Oishi, M.5
Miyoshi, K.6
Komiya, S.7
Kosai, K.-I.8
Hanakawa, Y.9
Hashimoto, K.10
Nagata, K.11
Yoshimura, A.12
-
65
-
-
77149155643
-
Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis
-
Li Y, De Haar C, Chen M, et al. Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut 2010;59:227-35.
-
(2010)
Gut
, vol.59
, pp. 227-235
-
-
Li, Y.1
De Haar, C.2
Chen, M.3
-
66
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov S, Karin E, Terzic J, et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009;15:103-13.
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
-
67
-
-
0031573141
-
Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
-
Chai SK, Nichols GL, Rothman P. Constitutive activation of Jaks and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol 1997;159:4720-8. (Pubitemid 127471006)
-
(1997)
Journal of Immunology
, vol.159
, Issue.10
, pp. 4720-4728
-
-
Chai, S.K.1
Nichols, G.L.2
Rothman, P.3
-
68
-
-
77956082214
-
STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer
-
Armanious H, Gelebart P, Mackey J, et al. STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer. Int J Clin Exp Pathol 2010;3:654-64.
-
(2010)
Int J Clin Exp Pathol
, vol.3
, pp. 654-664
-
-
Armanious, H.1
Gelebart, P.2
Mackey, J.3
-
69
-
-
0036093058
-
Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival
-
Benekli M, Xia Z, Donohue KA, et al. Constitutive activity of signal transducer and activator of transcription 3 protein in acute myeloid leukemia blasts is associated with short disease-free survival. Blood 2002;99:252-7.
-
(2002)
Blood
, vol.99
, pp. 252-257
-
-
Benekli, M.1
Xia, Z.2
Donohue, K.A.3
-
70
-
-
0034658024
-
Serine phosphorylation of STATs
-
Decker T, Kovarik P. Serine phosphorylation of STATs. Oncogene 2000;19:2628-37. (Pubitemid 30339219)
-
(2000)
Oncogene
, vol.19
, Issue.21
, pp. 2628-2637
-
-
Decker, T.1
Kovarik, P.2
-
71
-
-
0034284088
-
Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity
-
Visconti R, Gadina M, Chiariello M, et al. Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity. Blood 2000;96:1844-52. (Pubitemid 30662111)
-
(2000)
Blood
, vol.96
, Issue.5
, pp. 1844-1852
-
-
Visconti, R.1
Gadina, M.2
Chiariello, M.3
Chen, E.H.4
Stancato, L.F.5
Gutkind, J.S.6
O'Shea, J.J.7
-
72
-
-
0034615929
-
Stat5a serine phosphorylation. Serine 779 is constitutively phosphorylated in the mammary gland, and serine 725 phosphorylation influences prolactin-stimulated in vitro DNA binding activity
-
DOI 10.1074/jbc.275.14.10247
-
Beuvink I, Hess D, Flotow H, et al. Stat5 a serine phosphorylation. Serine 779 is constitutively phosphorylated in the mammary gland, and serine 725 phosphorylation influences prolactin-stimulated in vitro DNA binding activity. J Biol Chem 2000;275:10247-55. (Pubitemid 30202081)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.14
, pp. 10247-10255
-
-
Beuvink, I.1
Hess, D.2
Flotow, H.3
Hofsteenge, J.4
Groner, B.5
Hynes, N.E.6
-
73
-
-
0030795313
-
Mutational analysis of acute-phase response factor/Stat3 activation and dimerization
-
Sasse J, Hemmann U, Schwartz C, et al. Mutational analysis of acute-phase response factor/Stat3 activation and dimerization. Mol Cell Biol 1997;17:4677-86. (Pubitemid 27318143)
-
(1997)
Molecular and Cellular Biology
, vol.17
, Issue.8
, pp. 4677-4686
-
-
Sasse, J.1
Hemmann, U.2
Schwartz, C.3
Schniertshauer, U.4
Heesel, B.5
Landgraf, C.6
Schneider-Mergener, J.7
Heinrich, P.C.8
Horn, F.9
-
74
-
-
4944261760
-
Differential roles of STAT1α and STAT1β in fludarabine-induced cell cycle arrest and apoptosis in human B cells
-
DOI 10.1182/blood-2003-10-3508
-
Baran-Marszak F, Feuillard J, Najjar I, et al. Differential roles of STAT1alpha and STAT1beta in fludarabine-induced cell cycle arrest and apoptosis in human B cells. Blood 2004;104:2475-83. (Pubitemid 39331850)
-
(2004)
Blood
, vol.104
, Issue.8
, pp. 2475-2483
-
-
Baran-Marszak, F.1
Feuillard, J.2
Najjar, I.3
Le Clorennec, C.4
Bechet, J.-M.5
Dusanter-Fourt, I.6
Bornkamm, G.W.7
Raphael, M.8
Fagard, R.9
-
75
-
-
0034663045
-
Myeloid differentiation of FdCP1 cells is dependent on Stat5 processing
-
Piazza F, Valens J, et al. Myeloid differentiation of FdCP1 cells is dependent on Stat5 processing. Blood 2000;96:1358-65. (Pubitemid 30658464)
-
(2000)
Blood
, vol.96
, Issue.4
, pp. 1358-1365
-
-
Piazza, F.1
Valens, J.2
Lagasse, E.3
Schindler, C.4
-
76
-
-
67650956808
-
-
Stephanou A, Ed, Texas: Landes Bioscience Books
-
Pensa S, Regis G, Boselli D, et al. In: Stephanou A, Ed. JAKSTAT pathway in disease. Texas: Landes Bioscience Books 2009; pp. 100-121.
-
(2009)
JAKSTAT Pathway in Disease
, pp. 100-121
-
-
Pensa, S.1
Regis, G.2
Boselli, D.3
-
77
-
-
0035029336
-
STAT isoforms: Mediators of STAT specificity or leukemogenesis?
-
DOI 10.1016/S0145-2126(01)00003-0, PII S0145212601000030
-
Ilaria RL Jr. STAT isoforms: mediators of STAT specificity or leukemogenesis? Leuk Res 2001;25:483-4. (Pubitemid 32401565)
-
(2001)
Leukemia Research
, vol.25
, Issue.6
, pp. 483-484
-
-
Ilaria Jr., R.L.1
-
79
-
-
0036554816
-
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
-
Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res 2002;8:945-54. (Pubitemid 35177340)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.4
, pp. 945-954
-
-
Buettner, R.1
Mora, L.B.2
Jove, R.3
-
80
-
-
0035216135
-
Interferon-γ receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death
-
Bernabei P, Coccia EM, Rigamonti L, et al. Interferon-gamma receptor 2 expression as the deciding factor in human TB and myeloid cell proliferation or death. J Leukoc Biol 2001;70:950-60. (Pubitemid 33151134)
-
(2001)
Journal of Leukocyte Biology
, vol.70
, Issue.6
, pp. 950-960
-
-
Bernabei, P.1
Coccia, E.M.2
Rigamonti, L.3
Bosticardo, M.4
Forni, G.5
Pestka, S.6
Krause, C.D.7
Battistini, A.8
Novelli, F.9
-
81
-
-
33947265626
-
In the absence of IGF-1 signaling, IFN-γ suppresses human malignant T-cell growth
-
DOI 10.1182/blood-2006-07-034231
-
Conti L, Regis G, Longo A, et al. In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth. Blood 2007;109:2496-504. (Pubitemid 46425894)
-
(2007)
Blood
, vol.109
, Issue.6
, pp. 2496-2504
-
-
Conti, L.1
Regis, G.2
Longo, A.3
Bernabei, P.4
Chiarle, R.5
Giovarelli, M.6
Novelli, F.7
-
82
-
-
0033578049
-
STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation
-
DOI 10.1038/sj.onc.1202694
-
Sachsenmaier C, Sadowski HB, Cooper JA. STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation. Oncogene 1999;18:3583-92. (Pubitemid 29322383)
-
(1999)
Oncogene
, vol.18
, Issue.24
, pp. 3583-3592
-
-
Sachsenmaier, C.1
Sadowski, H.B.2
Cooper, J.A.3
-
83
-
-
1042301419
-
STAT1-induced apoptosis is mediated by caspases 2, 3, and 7
-
DOI 10.1074/jbc.M307774200
-
Sironi JJ, Ouchi T. STAT1-induced apoptosis is mediated by caspases 2, 3, and 7. J Biol Chem 2004;279:4066-74. (Pubitemid 38198990)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.6
, pp. 4066-4074
-
-
Sironi, J.J.1
Ouchi, T.2
-
84
-
-
84889271499
-
IFNγ sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway
-
DOI 10.1038/sj/onc/1205255
-
Fulda S, Debatin KM. IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway. Oncogene 2002;21:2295-308. (Pubitemid 34407289)
-
(2002)
Oncogene
, vol.21
, Issue.15
, pp. 2295-2308
-
-
Fulda, S.1
Debatin, K.-M.2
-
85
-
-
0030659512
-
Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
-
DOI 10.1126/science.278.5343.1630
-
Kumar A, Commane M, Flickinger TW, et al. Defective TNFalphainduced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 1997;278:1630-2. (Pubitemid 27516283)
-
(1997)
Science
, vol.278
, Issue.5343
, pp. 1630-1632
-
-
Kumar, A.1
Commane, M.2
Flickinger, T.W.3
Horvath, C.M.4
Stark, G.R.5
-
86
-
-
33645731313
-
Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis
-
Battle TE, Lynch RA, Frank DA. Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res 2006;66:3649-57.
-
(2006)
Cancer Res
, vol.66
, pp. 3649-3657
-
-
Battle, T.E.1
Lynch, R.A.2
Frank, D.A.3
-
87
-
-
0032560475
-
Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice
-
DOI 10.1073/pnas.95.13.7556
-
Kaplan DH, Shankaran V, Dighe AS, et al. Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice. Proc Natl Acad Sci USA 1998;95:7556-61. (Pubitemid 28293291)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.13
, pp. 7556-7561
-
-
Kaplan, D.H.1
Shankaran, V.2
Dighe, A.S.3
Stockert, E.4
Aguet, M.5
Old, L.J.6
Schreiber, R.D.7
-
88
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 2000;19:2468-73. (Pubitemid 30339202)
-
(2000)
Oncogene
, vol.19
, Issue.21
, pp. 2468-2473
-
-
Bromberg, J.1
Darnell Jr., J.E.2
-
89
-
-
0031953831
-
Stat3 activation by Src induces specific gene regulation and is required for cell transformation
-
Turkson J, Bowman T, Garcia R, et al. Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol 1998;18:2545-52. (Pubitemid 28183424)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.5
, pp. 2545-2552
-
-
Turkson, J.1
Bowman, T.2
Garcia, R.3
Caldenhoven, E.4
De Groot, R.P.5
Jove, R.6
-
90
-
-
0028923658
-
Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts
-
Watson CJ, Miller WR. Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br J Cancer 1995;71:840-4.
-
(1995)
Br J Cancer
, vol.71
, pp. 840-844
-
-
Watson, C.J.1
Miller, W.R.2
-
91
-
-
77953019852
-
Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: Implications for future therapeutic approaches
-
Lai SY, Johnson FM. Defining the role of the JAK-STAT pathway in head and neck and thoracic malignancies: implications for future therapeutic approaches. Drug Resist Updat 2010;13:67-78.
-
(2010)
Drug Resist Updat
, vol.13
, pp. 67-78
-
-
Lai, S.Y.1
Johnson, F.M.2
-
92
-
-
84893670317
-
Correlation analysis of JAK-STAT pathway components on prognosis of patients with prostate cancer
-
Epub ahead of print
-
Liu X, He Z, Li CH, et al. Correlation analysis of JAK-STAT pathway components on prognosis of patients with prostate cancer. Pathol Oncol Res 2011; Epub ahead of print.
-
(2011)
Pathol Oncol Res
-
-
Liu, X.1
He, Z.2
Li, C.H.3
-
93
-
-
77951632024
-
Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis
-
Sobti RC, Singh N, Hussain S, et al. Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis. J Recept Signal Transduct Res 2010;30:178-88.
-
(2010)
J Recept Signal Transduct Res
, vol.30
, pp. 178-188
-
-
Sobti, R.C.1
Singh, N.2
Hussain, S.3
-
94
-
-
0032984589
-
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
Catlett-Falcone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 1999;10:105-10.
-
(1999)
Immunity
, vol.10
, pp. 105-110
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
-
95
-
-
21544473172
-
Targeting STAT3 affects melanoma on multiple fronts
-
DOI 10.1007/s10555-005-1580-1
-
Kortylewski M, Jove R, Yu H. Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev 2005;24:315-27. (Pubitemid 40922802)
-
(2005)
Cancer and Metastasis Reviews
, vol.24
, Issue.2
, pp. 315-327
-
-
Kortylewski, M.1
Jove, R.2
Yu, H.3
-
96
-
-
70349323403
-
Targeting signal transducer and activator of transcription signaling pathway in leukemias
-
Benekli M, Baumann H, Wetzler M. Targeting signal transducer and activator of transcription signaling pathway in leukemias. J Clin Oncol 2009;7:4422-32.
-
(2009)
J Clin Oncol
, vol.7
, pp. 4422-4432
-
-
Benekli, M.1
Baumann, H.2
Wetzler, M.3
-
97
-
-
20844444135
-
Targeting Stat3 in cancer therapy
-
DOI 10.1097/00001813-200507000-00002
-
Jing N, Tweardy DJ. Targeting Stat3 in cancer therapy. Anticancer Drugs 2005;16:601-7. (Pubitemid 40863092)
-
(2005)
Anti-Cancer Drugs
, vol.16
, Issue.6
, pp. 601-607
-
-
Jing, N.1
Tweardy, D.J.2
-
98
-
-
33845865825
-
Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
-
DOI 10.1038/nri1995, PII NRI1995
-
Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat Rev Immunol 2007;7:41-51. (Pubitemid 46020826)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.1
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
99
-
-
23844503025
-
Role of Stat3 in regulating p53 expression and function
-
DOI 10.1128/MCB.25.17.7432-7440.2005
-
Niu G, Wright KL, Ma Y, et al. Role of Stat3 in regulating p53 expression and function. Mol Cell Biol 2005;25:7432-40. (Pubitemid 41170107)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.17
, pp. 7432-7440
-
-
Niu, G.1
Wright, K.L.2
Ma, Y.3
Wright, G.M.4
Huang, M.5
Irby, R.6
Briggs, J.7
Karras, J.8
Cress, W.D.9
Pardoll, D.10
Jove, R.11
Chen, J.12
Yu, H.13
-
100
-
-
0033198793
-
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
-
DOI 10.1093/emboj/18.17.4657
-
Sano S, Itami S, Takeda K, et al. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J 1999;18:4657-68. (Pubitemid 29415520)
-
(1999)
EMBO Journal
, vol.18
, Issue.17
, pp. 4657-4668
-
-
Sano, S.1
Itami, S.2
Takeda, K.3
Tarutani, M.4
Yamaguchi, Y.5
Miura, H.6
Yoshikawa, K.7
Akira, S.8
Takeda, J.9
-
101
-
-
3242676769
-
Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C
-
DOI 10.1073/pnas.0404100101
-
Dechow TN, Pedranzini L, Leitch A, et al. Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C. Proc Natl Acad Sci U S A 2004;101:10602-7. (Pubitemid 38955788)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.29
, pp. 10602-10607
-
-
Dechow, T.N.1
Pedranzini, L.2
Leitch, A.3
Leslie, K.4
Gerald, W.L.5
Linkov, I.6
Bromberg, J.F.7
-
102
-
-
33644526633
-
Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells
-
Itoh M, Murata T, Suzuki T, et al. Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells. Oncogene 2006;25:1195-204.
-
(2006)
Oncogene
, vol.25
, pp. 1195-1204
-
-
Itoh, M.1
Murata, T.2
Suzuki, T.3
-
103
-
-
33746764457
-
β4 integrin amplifies erbb2 signaling to promote mammary tumorigenesis
-
DOI 10.1016/j.cell.2006.05.047, PII S009286740600907X
-
Guo W, Pylayeva Y, Pepe A, et al. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006;126:489-502. (Pubitemid 44163602)
-
(2006)
Cell
, vol.126
, Issue.3
, pp. 489-502
-
-
Guo, W.1
Pylayeva, Y.2
Pepe, A.3
Yoshioka, T.4
Muller, W.J.5
Inghirami, G.6
Giancotti, F.G.7
-
104
-
-
0031443156
-
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells
-
Garcia R, Yu CL, Hudnall A, et al. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ 1997;8:1267-76. (Pubitemid 28008723)
-
(1997)
Cell Growth and Differentiation
, vol.8
, Issue.12
, pp. 1267-1276
-
-
Garcia, R.1
Yu, C.-L.2
Hudnall, A.3
Catlett, R.4
Nelson, K.L.5
Smithgall, T.6
Fujita, D.J.7
Ethier, S.P.8
Jove, R.9
-
105
-
-
28544438023
-
Activated epidermal growth factor receptor-stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer
-
DOI 10.1158/1078-0432.CCR-05-0827
-
Haura EB, Zheng Z, Song L, et al. Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clin Cancer Res 2005;11:8288-94. (Pubitemid 41746939)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.23
, pp. 8288-8294
-
-
Haura, E.B.1
Zheng, Z.2
Song, L.3
Cantor, A.4
Bepler, G.5
-
106
-
-
36849012237
-
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
-
DOI 10.1172/JCI31871
-
Gao SP, Mark KG, Leslie K, et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007;117:3846-56. (Pubitemid 350224094)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.12
, pp. 3846-3856
-
-
Gao, S.P.1
Mark, K.G.2
Leslie, K.3
Pao, W.4
Motoi, N.5
Gerald, W.L.6
Travis, W.D.7
Bornmann, W.8
Veach, D.9
Clarkson, B.10
Bromberg, J.F.11
-
107
-
-
13444309088
-
Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation
-
Yang J, Chatterjee-Kishore M, Staugaitis SM, et al. Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation. Cancer Res 2005;65:939-47. (Pubitemid 40216455)
-
(2005)
Cancer Research
, vol.65
, Issue.3
, pp. 939-947
-
-
Yang, J.1
Chatterjee-Kishore, M.2
Staugaitis, S.M.3
Nguyen, H.4
Schlessinger, K.5
Levy, D.E.6
Stark, G.R.7
-
108
-
-
0035943676
-
Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3
-
Wang LH, Yang XY, Mihalic K, et al. Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3. J Biol Chem 2001;276:31839-44.
-
(2001)
J Biol Chem
, vol.276
, pp. 31839-31844
-
-
Wang, L.H.1
Yang, X.Y.2
Mihalic, K.3
-
109
-
-
53249127054
-
β-catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma
-
Yan S, Zhou C, Zhang W, et al. β-catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma. Cancer Lett 2008;271:85-97.
-
(2008)
Cancer Lett
, vol.271
, pp. 85-97
-
-
Yan, S.1
Zhou, C.2
Zhang, W.3
-
110
-
-
33645513412
-
Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer
-
Kawada M, Seno H, Uenoyama Y, et al. Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer. Cancer Res 2006;66:2913-7.
-
(2006)
Cancer Res
, vol.66
, pp. 2913-2917
-
-
Kawada, M.1
Seno, H.2
Uenoyama, Y.3
-
111
-
-
34247480458
-
Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: The role of STAT1
-
DOI 10.1124/mol.106.032284
-
Lui V W, Boehm AL, Koppikar P, et al. Antiproliferative mechanisms of a transcription factor decoy targeting signal transducer and activator of transcription (STAT) 3: the role of STAT1. Mol Pharmacol 2007;71:1435-1443. (Pubitemid 46658696)
-
(2007)
Molecular Pharmacology
, vol.71
, Issue.5
, pp. 1435-1443
-
-
Lui, V.W.Y.1
Boehm, A.L.2
Koppikar, P.3
Leeman, R.J.4
Johnson, D.5
Ogagan, M.6
Childs, E.7
Freilino, M.8
Grandis, J.R.9
-
112
-
-
0036338213
-
STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation
-
DOI 10.1016/S1074-7613(02)00336-9
-
Lee CK, Raz R, Gimeno R, et al. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity 2002;17:63-72. (Pubitemid 34874619)
-
(2002)
Immunity
, vol.17
, Issue.1
, pp. 63-72
-
-
Lee, C.-K.1
Raz, R.2
Gimeno, R.3
Gertner, R.4
Wistinghausen, B.5
Takeshita, K.6
DePinho, R.A.7
Levy, D.E.8
-
113
-
-
0035811006
-
Biologic consequences of Stat1-independent IFN signaling
-
DOI 10.1073/pnas.111163898
-
Gil MP, Bohn E, O'Guin AK, et al. Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci USA 2001;98:6680-6685. (Pubitemid 32538276)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.12
, pp. 6680-6685
-
-
Gil, M.P.1
Bohn, E.2
O'Guin, A.K.3
Ramana, C.V.4
Levine, B.5
Stark, G.R.6
Virgin, H.W.7
Schreiber, R.D.8
-
114
-
-
33744548730
-
Signal transduction of inflammatory cytokines and tumor development
-
DOI 10.1111/j.1349-7006.2006.00197.x
-
Yoshimura A. Signal transduction of inflammatory cytokines and tumor development. Cancer Sci 2006;97:439-447. (Pubitemid 43811583)
-
(2006)
Cancer Science
, vol.97
, Issue.6
, pp. 439-447
-
-
Yoshimura, A.1
-
115
-
-
0029975904
-
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line
-
DOI 10.1073/pnas.93.9.3963
-
Minami M, Inoue M, Wei S, et al. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc Natl Acad Sci U S A 1996;93:3963-6. (Pubitemid 26144231)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.9
, pp. 3963-3966
-
-
Minami, M.1
Inoue, M.2
Wei, S.3
Takeda, K.4
Matsumoto, M.5
Kishimoto, T.6
Akira, S.7
-
116
-
-
17344372977
-
Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition
-
DOI 10.1038/ncb1242
-
Abell K, Bilancio A, Clarkson RW, et al. Stat3-induced apoptosis requires a molecular switch in PI (3) K subunit composition. Nat Cell Biol 2005;7:392-8. (Pubitemid 40533129)
-
(2005)
Nature Cell Biology
, vol.7
, Issue.4
, pp. 392-398
-
-
Abell, K.1
Bilancio, A.2
Clarkson, R.W.E.3
Tiffen, P.G.4
Altaparmakov, A.I.5
Burdon, T.G.6
Asano, T.7
Vanhaesebroeck, B.8
Watson, C.J.9
-
117
-
-
33749004556
-
Regulation of transforming growth factor-β1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3
-
DOI 10.1158/0008-5472.CAN-06-1308
-
Yang Y, Pan X, Lei W, et al. Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer Res 2006;66:8617-24. (Pubitemid 44449176)
-
(2006)
Cancer Research
, vol.66
, Issue.17
, pp. 8617-8624
-
-
Yang, Y.1
Pan, X.2
Lei, W.3
Wang, J.4
Shi, J.5
Li, F.6
Song, J.7
-
118
-
-
19444385692
-
Stat3 regulates genes common to both wound healing and cancer
-
DOI 10.1038/sj.onc.1208469
-
Dauer DJ, Ferraro B, Song L, et al. Stat3 regulates genes common to both wound healing and cancer. Oncogene 2005;24:3397-408. (Pubitemid 40756241)
-
(2005)
Oncogene
, vol.24
, Issue.21
, pp. 3397-3408
-
-
Dauer, D.J.1
Ferraro, B.2
Song, L.3
Yu, B.4
Mora, L.5
Buettner, R.6
Enkemann, S.7
Jove, R.8
Haura, E.B.9
-
119
-
-
33645532055
-
Activation of stat3 in human melanoma promotes brain metastasis
-
Xie TX, Huang FJ, Aldape KD, et al. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res 2006;66:3188-196.
-
(2006)
Cancer Res
, vol.66
, pp. 3188-3196
-
-
Xie, T.X.1
Huang, F.J.2
Aldape, K.D.3
-
120
-
-
33845771270
-
Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
-
Li WC, Ye SL, Sun RX, et al. Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3. Clin Cancer Res 2006;12:7140-48.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7140-7148
-
-
Li, W.C.1
Ye, S.L.2
Sun, R.X.3
-
121
-
-
85047695527
-
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
DOI 10.1038/sj/onc/1205260
-
Niu G, Wright KL, Huang M, et al. Constitutive Stat3 activity upregulates VEGF expression and tumor angiogenesis. Oncogene 2002;21:2000-8. (Pubitemid 34270888)
-
(2002)
Oncogene
, vol.21
, Issue.13
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
Song, L.4
Haura, E.5
Turkson, J.6
Zhang, S.7
Wang, T.8
Sinibaldi, D.9
Coppola, D.10
Heller, R.11
Ellis, L.M.12
Karras, J.13
Bromberg, J.14
Pardoll, D.15
Jove, R.16
Yu, H.17
-
122
-
-
4043181214
-
Cancer genes and the pathways they control
-
DOI 10.1038/nm1087
-
Vogelstein B, Kinzler KW, Cancer genes and the pathways they control. Nat Med 2004:10; 789-99. (Pubitemid 39070849)
-
(2004)
Nature Medicine
, vol.10
, Issue.8
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
123
-
-
33745827054
-
A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: Insights from gene expression profiling
-
DOI 10.1016/j.cyto.2006.04.003, PII S104346660600144X
-
Gatzka M, Piekorz R, Moriggl, et al. A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling. Cytokine 2006;34:143-54. (Pubitemid 44038569)
-
(2006)
Cytokine
, vol.34
, Issue.3-4
, pp. 143-154
-
-
Gatzka, M.1
Piekorz, R.2
Moriggl, R.3
Rawlings, J.4
Ihle, J.N.5
-
124
-
-
77953436551
-
Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1
-
Creamer BA, Sakamoto K, Schmidt JW, et al. Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1. Mol Cell Biol 2010;30:2957-70.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 2957-2970
-
-
Creamer, B.A.1
Sakamoto, K.2
Schmidt, J.W.3
-
125
-
-
33846927933
-
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
-
DOI 10.1182/blood-2006-01-029918
-
Harir N, Pecquet C, Kerenyi M, et al. Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood 2007;109:1678-86. (Pubitemid 46239602)
-
(2007)
Blood
, vol.109
, Issue.4
, pp. 1678-1686
-
-
Harir, N.1
Pecquet, C.2
Kerenyi, M.3
Sonneck, K.4
Kovacic, B.5
Nyga, R.6
Brevet, M.7
Dhennin, I.8
Gouilleux-Gruart, V.9
Beug, H.10
Valent, P.11
Lassoued, K.12
Moriggl, R.13
Gouilleux, F.14
-
126
-
-
77952937102
-
Dispersed chromosomal Stat5b-binding elements mediate growth hormone-activated insulin-like growth factor-I gene transcription
-
Chia DJ. Varco-Merth, Rotwein P. Dispersed chromosomal Stat5b-binding elements mediate growth hormone-activated insulin-like growth factor-I gene transcription, J Biol Chem 2010;285:17636-47.
-
(2010)
J Biol Chem
, vol.285
, pp. 17636-17647
-
-
Chia, D.J.1
Varco-Merth2
Rotwein, P.3
-
127
-
-
12144287247
-
Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth
-
DOI 10.1101/gad.284704
-
Tronche F, Opherk C, Moriggl R, et al. Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev 2004;18:492-7. (Pubitemid 38372806)
-
(2004)
Genes and Development
, vol.18
, Issue.5
, pp. 492-497
-
-
Tronche, F.1
Opherk, C.2
Moriggl, R.3
Kellendonk, C.4
Reimann, A.5
Schwake, L.6
Reichardt, H.M.7
Stangl, K.8
Gau, D.9
Hoeflich, A.10
Beug, H.11
Schmid, W.12
Schutz, G.13
-
128
-
-
77953578552
-
Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo
-
Gu L, Vogiatzi P, Puhr M, et al. Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo. Endocr Relat Cancer 2010;17:481-93.
-
(2010)
Endocr Relat Cancer
, vol.17
, pp. 481-493
-
-
Gu, L.1
Vogiatzi, P.2
Puhr, M.3
-
129
-
-
84867159620
-
The effect of STAT5 silenced by siRNA on proliferation, apoptosis and invasion of esophageal carcinoma cell line EC9706
-
Jin D, Zang W, Wang T, et al. The effect of STAT5 silenced by siRNA on proliferation, apoptosis and invasion of esophageal carcinoma cell line EC9706. Chinese-German J Clin Oncol 2010;9:692-6.
-
(2010)
Chinese-German J Clin Oncol
, vol.9
, pp. 692-696
-
-
Jin, D.1
Zang, W.2
Wang, T.3
-
130
-
-
33846128155
-
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
-
DOI 10.1101/gad.1487307
-
Mallette FA, Gaumont-Leclerc MF, Ferbeyre G. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev 2007;21:43-8. (Pubitemid 46089705)
-
(2007)
Genes and Development
, vol.21
, Issue.1
, pp. 43-48
-
-
Mallette, F.A.1
Gaumont-Leclerc, M.-F.2
Ferbeyre, G.3
-
131
-
-
78650528780
-
The role of Stat5 transcription factors as tumor suppressors or oncogenes
-
Ferbeyre G, Moriggl R. The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 2011;1815:104-14.
-
(2011)
Biochim Biophys Acta
, vol.1815
, pp. 104-114
-
-
Ferbeyre, G.1
Moriggl, R.2
-
132
-
-
46349102713
-
In vivo identification of novel STAT5 target genes
-
DOI 10.1093/nar/gkn271
-
Basham B, Sathe M, Grein J, et al. In vivo identification of novel STAT5 target genes. Nucleic Acids Res 2008;36:3802-18. (Pubitemid 351917541)
-
(2008)
Nucleic Acids Research
, vol.36
, Issue.11
, pp. 3802-3818
-
-
Basham, B.1
Sathe, M.2
Grein, J.3
McClanahan, T.4
D'Andrea, A.5
Lees, E.6
Rascle, A.7
-
133
-
-
0029916933
-
Activation and association of Stat3 with Src in v-Src-transformed cell lines
-
Cao X, Tay A, Guy GR, et al. Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol 1996;16:1595-603. (Pubitemid 26095631)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.4
, pp. 1595-1603
-
-
Cao, X.1
Tay, A.2
Guy, G.R.3
Tan, Y.H.4
-
134
-
-
5444237088
-
STAT proteins as novel targets for cancer drug discovery
-
DOI 10.1517/14728222.8.5.409
-
Turkson J. STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets 2004;8:409-22. (Pubitemid 39359648)
-
(2004)
Expert Opinion on Therapeutic Targets
, vol.8
, Issue.5
, pp. 409-422
-
-
Turkson, J.1
-
135
-
-
4444268818
-
Inactivation of stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
-
DOI 10.1128/MCB.24.18.8037-8047.2004
-
Cui Y, Riedlinger G, Miyoshi K, et al. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 2004;24:8037-47. (Pubitemid 39167454)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.18
, pp. 8037-8047
-
-
Cui, Y.1
Riedlinger, G.2
Miyoshi, K.3
Tang, W.4
Li, C.5
Deng, C.-X.6
Robinson, G.W.7
Hennighausen, L.8
-
136
-
-
0034658551
-
The role of STATs in myeloid differentiation and leukemia
-
Coffer PJ, Koenderman L, De Groot RP. The role of Stats in myeloid differentiation and leukemia. Oncogene 2000;19:2511-22. (Pubitemid 30339207)
-
(2000)
Oncogene
, vol.19
, Issue.21
, pp. 2511-2522
-
-
Coffer, P.J.1
Koenderman, L.2
De Groot, R.P.3
-
137
-
-
0346024125
-
Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers
-
DOI 10.1002/ijc.11619
-
Cotarla I, Ren S, Zhang Y, Gehan E, Singh B, Furth PA. Stat5a is tyrosine phosphorylated and nuclear localized in a high proportion of human breast cancers. Int J Cancer 2004;108:665-71. (Pubitemid 38076397)
-
(2004)
International Journal of Cancer
, vol.108
, Issue.5
, pp. 665-671
-
-
Cotarla, I.1
Ren, S.2
Zhang, Y.3
Gehan, E.4
Singh, B.5
Furth, P.A.6
-
138
-
-
0034657917
-
Modulation of STAT signaling by STAT-interacting proteins
-
Shuai K. Modulation of STAT signaling by STAT-interacting proteins. Oncogene 2000;19:2638-2644. (Pubitemid 30339220)
-
(2000)
Oncogene
, vol.19
, Issue.21
, pp. 2638-2644
-
-
Shuai, K.1
-
139
-
-
0035831040
-
Arginine methylation of STAT1 modulates IFNα/β-induced transcription
-
Mowen KA, Tang J, Zhu W, et al. Arginine methylation of STAT1 modulates IFN alpha/beta-induced transcription. Cell 2001;104:731-41. (Pubitemid 32241023)
-
(2001)
Cell
, vol.104
, Issue.5
, pp. 731-741
-
-
Mowen, K.A.1
Tang, J.2
Zhu, W.3
Schurter, B.T.4
Shuai, K.5
Herschman, H.R.6
David, M.7
-
140
-
-
79952591142
-
Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley
-
Hussain S, Singh N, Salam I, et al. Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley. J Recept Signal Transduct Res 2011;31:147-56.
-
(2011)
J Recept Signal Transduct Res
, vol.31
, pp. 147-156
-
-
Hussain, S.1
Singh, N.2
Salam, I.3
-
141
-
-
33747154401
-
Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development
-
DOI 10.1002/med.20070
-
Kamath S, Buolamwini JK. Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development. Med Res Rev 2006;26:569-94. (Pubitemid 44230413)
-
(2006)
Medicinal Research Reviews
, vol.26
, Issue.5
, pp. 569-594
-
-
Kamath, S.1
Buolamwini, J.K.2
-
142
-
-
12944272024
-
Constitutive activation of stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
-
DOI 10.1073/pnas.97.8.4227
-
Grandis JR, Drenning SD, Zeng Q, et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci USA 2000;97:4227-4232. (Pubitemid 30226115)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.8
, pp. 4227-4232
-
-
Grandis, J.R.1
Drenning, S.D.2
Zeng, Q.3
Watkins, S.C.4
Melhem, M.F.5
Endo, S.6
Johnson, D.E.7
Huang, L.8
He, Y.9
Kim, J.D.10
-
143
-
-
8644234228
-
Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer
-
Han SW, Hwang PG, Chung DH, et al. Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer. Int J Cancer 2005;113:109-15.
-
(2005)
Int J Cancer
, vol.113
, pp. 109-115
-
-
Han, S.W.1
Hwang, P.G.2
Chung, D.H.3
-
144
-
-
0037699512
-
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
-
DOI 10.1038/sj.onc.1206479
-
Song L, Turkson J, Karras JG, Jove R, Haura EB. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene 2003;22:4150-65. (Pubitemid 36876236)
-
(2003)
Oncogene
, vol.22
, Issue.27
, pp. 4150-4165
-
-
Song, L.1
Turkson, J.2
Karras, J.G.3
Jove, R.4
Haura, E.B.5
-
145
-
-
33745243692
-
Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
-
DOI 10.1158/0008-5472.CAN-05-4620
-
Song L, Morris M, Bagui T, Lee FY, Jove R, Haura EB. Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res 2006;66:5542-48. (Pubitemid 43927102)
-
(2006)
Cancer Research
, vol.66
, Issue.11
, pp. 5542-5548
-
-
Song, L.1
Morris, M.2
Bagui, T.3
Lee, F.Y.4
Jove, R.5
Haura, E.B.6
-
146
-
-
33144461661
-
Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group Study
-
DOI 10.1200/JCO.2005.02.4646
-
Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA. Group ECO. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol 2005;23:8646-54. (Pubitemid 46211507)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.34
, pp. 8646-8654
-
-
Burtness, B.1
Goldwasser, M.A.2
Flood, W.3
Mattar, B.4
Forastiere, A.A.5
-
147
-
-
23844498514
-
The role of cetuximab in the treatment of squamous cell cancer of the head and neck
-
DOI 10.1517/14712598.5.8.1085
-
Burtness B. The role of cetuximab in the treatment of squamous cell cancer of the head and neck. Expert Opin Biol Ther 2005;5:1085-1093. (Pubitemid 41170037)
-
(2005)
Expert Opinion on Biological Therapy
, vol.5
, Issue.8
, pp. 1085-1093
-
-
Burtness, B.1
-
148
-
-
0344984245
-
Targeting stat3 with G-quartet oligodeoxynucleotides in human cancer cells
-
DOI 10.1089/104454903770946665
-
Jing N, Li Y, Xu X, et al. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol 2003;22:685-96. (Pubitemid 37468167)
-
(2003)
DNA and Cell Biology
, vol.22
, Issue.11
, pp. 685-696
-
-
Jing, N.1
Li, Y.2
Xu, X.3
Sha, W.4
Li, P.5
Feng, L.6
Tweardy, D.J.7
-
149
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
DOI 10.1038/nrc1609
-
Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer. 2005;5:341-54. (Pubitemid 40637826)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
150
-
-
36048936272
-
Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line
-
DOI 10.1016/j.canlet.2007.08.019, PII S0304383507004016
-
Gariboldi MB, Ravizza R, Molteni R, et al. Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line. Cancer Lett 2007;258:181-8. (Pubitemid 350101017)
-
(2007)
Cancer Letters
, vol.258
, Issue.2
, pp. 181-188
-
-
Gariboldi, M.B.1
Ravizza, R.2
Molteni, R.3
Osella, D.4
Gabano, E.5
Monti, E.6
-
151
-
-
27744507520
-
Les régulations négatives de la voie JAK/STAT: Implication dans la tumorigenèse
-
Espert L, Dusanter-Fourt I, Chelbi-Alix MK. Negative regulation of the JAK/STAT: pathway implication in tumorigenesis. Bull Cancer 2005;92:845-57. (Pubitemid 41604953)
-
(2005)
Bulletin du Cancer
, vol.92
, Issue.10
, pp. 845-857
-
-
Espert, L.1
Dusanter-Fourt, I.2
Chelbi-Alix, M.K.3
-
152
-
-
0032966863
-
Negative regulation of the JAK/STAT pathway
-
DOI 10.1002/(SICI)1521-1878(199901)21:1<47::AID-BIES6>3.0.CO;2-N
-
Starr R, Hilton DJ. Negative regulation of the JAK/STAT pathway. Bioessays 1999;21:47-52. (Pubitemid 29073018)
-
(1999)
BioEssays
, vol.21
, Issue.1
, pp. 47-52
-
-
Starr, R.1
Hilton, D.J.2
-
153
-
-
0346121599
-
Suppressors of cytokine signaling and immunity
-
DOI 10.1038/ni1012
-
Kubo M, Hanada T, Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol 2003;4:1169-76. (Pubitemid 37540685)
-
(2003)
Nature Immunology
, vol.4
, Issue.12
, pp. 1169-1176
-
-
Kubo, M.1
Hanada, T.2
Yoshimura, A.3
-
154
-
-
0034530046
-
ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation
-
DOI 10.1210/me.14.12.1986
-
Kotaja N, Aittomäki S, Silvennoinen O, et al. ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation. Mol Endocrinol 2000;14:1986-2000. (Pubitemid 32055532)
-
(2000)
Molecular Endocrinology
, vol.14
, Issue.12
, pp. 1986-2000
-
-
Kotaja, N.1
Aittomaki, S.2
Silvennoinen, O.3
Palvimo, J.J.4
Janne, O.A.5
-
155
-
-
79251572997
-
STAT-related profiles are associated with patient response to targeted treatments in locally advanced SCCHN
-
Kotoula V, Lambaki S, Televantou D, et al. STAT-related profiles are associated with patient response to targeted treatments in locally advanced SCCHN. Transl Oncol 2011;4:47-58.
-
(2011)
Transl Oncol
, vol.4
, pp. 47-58
-
-
Kotoula, V.1
Lambaki, S.2
Televantou, D.3
-
156
-
-
79955780881
-
JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling
-
Song L, Rawal B, Nemeth JA, et al. JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling. Mol Cancer Ther 2011;10:481-94.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 481-494
-
-
Song, L.1
Rawal, B.2
Nemeth, J.A.3
-
157
-
-
0035393595
-
Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cytotoxic drugs
-
Alas S, Bonavida B. Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/sensitization to cytotoxic drugs. Cancer Res 2001;61:5137-44. (Pubitemid 32681546)
-
(2001)
Cancer Research
, vol.61
, Issue.13
, pp. 5137-5144
-
-
Alas, S.1
Bonavida, B.2
-
158
-
-
79952824314
-
JAK/STAT pathways in cytokine signaling and myeloproliferative disorders: Approaches for targeted therapies
-
Jatiani SS, Baker SJ, Silverman LR, et al. JAK/STAT pathways in cytokine signaling and myeloproliferative disorders: approaches for targeted therapies. Genes Cancer 2010;1:979-93.
-
(2010)
Genes Cancer
, vol.1
, pp. 979-993
-
-
Jatiani, S.S.1
Baker, S.J.2
Silverman, L.R.3
-
159
-
-
77957599590
-
Preclinical and clinical activity of ATP mimetic JAK2 inhibitors
-
Wadleigh M, Tefferi A. Preclinical and clinical activity of ATP mimetic JAK2 inhibitors. Clin Adv Hematol Oncol 2010;8:557-63.
-
(2010)
Clin Adv Hematol Oncol
, vol.8
, pp. 557-563
-
-
Wadleigh, M.1
Tefferi, A.2
-
160
-
-
77949904181
-
Recent developments on JAK2 inhibitors: A patent review
-
Kiss R, Sayeski PP, Keseru GM. Recent developments on JAK2 inhibitors: a patent review. Expert Opin Ther Pat 2010;20:471-95.
-
(2010)
Expert Opin Ther Pat
, vol.20
, pp. 471-495
-
-
Kiss, R.1
Sayeski, P.P.2
Keseru, G.M.3
-
161
-
-
2042503119
-
Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells
-
Kirken RA, Erwin RA, Taub D, Murphy WJ, Behbod F, Wang L, Pericle F, Farrar WL. Tyrphostin AG-490 inhibits cytokinemediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. J Leukoc Biol 1999;65:891-9. (Pubitemid 29279542)
-
(1999)
Journal of Leukocyte Biology
, vol.65
, Issue.6
, pp. 891-899
-
-
Kirken, R.A.1
Erwin, R.A.2
Taub, D.3
Murphy, W.J.4
Behbod, F.5
Wang, L.6
Pericle, F.7
Farrar, W.L.8
-
162
-
-
55249113477
-
A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490
-
Caceres-Cortes JR. A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490. Anticancer Agents Med Chem 2008;8:717-22.
-
(2008)
Anticancer Agents Med Chem
, vol.8
, pp. 717-722
-
-
Caceres-Cortes, J.R.1
-
163
-
-
67749088364
-
Effects of a JAK inhibitor, AG490, on proliferation and apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z
-
Wu MH, Chen XY, Cai KR. Effects of a JAK inhibitor, AG490, on proliferation and apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z. Chinese J Cancer 2009;28:24-8.
-
(2009)
Chinese J Cancer
, vol.28
, pp. 24-28
-
-
Wu, M.H.1
Chen, X.Y.2
Cai, K.R.3
-
164
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal
-
Blaskovich MA, Sun J, Cantor A, et al. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003;63:1270-9. (Pubitemid 36348705)
-
(2003)
Cancer Research
, vol.63
, Issue.6
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
Turkson, J.4
Jove, R.5
Sebti, S.M.6
-
165
-
-
79954423352
-
Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1
-
Yamada O, Ozaki K, Furukawa T, et al. Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1. Cell Signal 2011;23:1119-27.
-
(2011)
Cell Signal
, vol.23
, pp. 1119-1127
-
-
Yamada, O.1
Ozaki, K.2
Furukawa, T.3
-
166
-
-
0035977055
-
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
-
Turkson J, Ryan D, Kim JS, et al. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J Biol Chem 2001;76:45443-55.
-
(2001)
J Biol Chem
, vol.76
, pp. 45443-45455
-
-
Turkson, J.1
Ryan, D.2
Kim, J.S.3
-
167
-
-
22944438395
-
Oligonucleotides as anticancer agents: From the benchside to the clinic and beyond
-
DOI 10.2174/1381612054546752
-
Coppelli FM, Grandis JR. Oligonucleotides as anticancer agents: from the benchside to the clinic and beyond. Curr Pharm Des 2005;11:2825-40. (Pubitemid 41051869)
-
(2005)
Current Pharmaceutical Design
, vol.11
, Issue.22
, pp. 2825-2840
-
-
Coppelli, F.M.1
Grandis, J.R.2
-
169
-
-
77951588976
-
Higher expression levels of SOCS 1, 3, 4, 7 are associated with earlier tumour stage and better clinical outcome in human breast cancer
-
Sasi W, Jiang WG, Sharma A, et al. Higher expression levels of SOCS 1, 3, 4, 7 are associated with earlier tumour stage and better clinical outcome in human breast cancer. BMC Cancer 2010;10:178.
-
(2010)
BMC Cancer
, vol.10
, pp. 178
-
-
Sasi, W.1
Jiang, W.G.2
Sharma, A.3
-
170
-
-
77956060906
-
Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma
-
Ying M, Li D, Yang L, et al. Loss of SOCS3 expression is associated with an increased risk of recurrent disease in breast carcinoma. J Cancer Res Clin Oncol 2010;136:1617-26.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 1617-1626
-
-
Ying, M.1
Li, D.2
Yang, L.3
|