JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling

Blood

Volumn 97, Issue 1, 2001, Pages 221-226

  Sporri, Bernhard ^b   Kovanen, Panu E ^b   Sasaki, Atsuo ^b   Yoshimura, Akihiko ^b   Leonard, Warren J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; STAT PROTEIN;

ARTICLE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOREGULATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0035168683     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.1.221     Document Type: Article

References (55)

1. Cytokine signaling through nonreceptor protein tyrosine kinases
2. Signaling from the IL-2 receptor to the nucleus
3. Interleukin-2 deficient mice: A new model to study autoimmunity and self-tolerance
4. Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor
5. Heterodimerization of the IL-2 receptor beta- and gamma-chain cytoplasmic domains is required for signalling
6. Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation
7. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
8. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
9. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor
10. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
11. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID and XCID
12. Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3: Jak1-independent functional recruitment of Jak3 to Il-2Rbeta
13. Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes
14. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15
15. Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway
16. Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
17. Jaks and STATs: Biological implications
18. STATs and gene regulation
19. Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor: Loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells
20. Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain
21. Specific inhibition of Stat3 signal transduction by PIAS3
22. Inhibition of Stat1-mediated gene activation by PIAS1
23. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors
24. A family of cytokine-inducible inhibitors of signalling
25. A new protein containing an SH2 domain that inhibits JAK kinases
26. Structure and function of a new STAT-induced STAT inhibitor
27. Twenty proteins containing a C-terminal SOCS box form five structural classes
28. The CIS family: Negative regulators of JAK-STAT signaling
29. The SOCS proteins: A new family of negative regulators of signal transduction
30. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
31. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation
32. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
33. CIS associates with the interleukin-2 receptor beta chain and inhibits IL-2-dependent signaling
34. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice
35. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
36. Control of hsp70 RNA levels in human lymphocytes
37. Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
38. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling
39. Cloning of human Stat5B: Reconstitution of interleukin-2-induecd Stat5A and Stat5B DNA binding activity in COS-7 cells
40. Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation
41. Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
42. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
43. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
44. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain
45. Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain
46. The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis
47. Cutting edge: SOCS1 is a potent inhibitor of IL-4 signal transduction
48. Repression of IL-4-induced gene expression by IFN-gamma requires Stat1 activation
49. Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression
50. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
51. SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase
52. Three distinct domains of SSI-1/SOCS1/JAB protein are required for its suppression of interleukin 6 signaling
53. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
54. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
55. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families