Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 45443-45455

  Turkson, James ^a,b   Ryan, Declan ^c   Kim, Joon S ^c   Zhang, Yi ^a   Chen, Zhi ^a,b   Haura, Eric ^a   Laudano, Andy ^d   Sebti, Said ^a,b   Hamilton, Andrew D ^c   Jove, Richard ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c YALE UNIVERSITY   (United States)

^d UNIVERSITY OF NEW HAMPSHIRE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIMERS; GENES; MONOMERS; SCANNING;

GENE REGULATION;

DNA;

CYTOKINE; CYTOPLASM PROTEIN; GROWTH FACTOR; LEUCINE; LIGAND; PHOSPHOPEPTIDE; PROTEIN TYROSINE PHOSPHATASE; STAT1 PROTEIN; STAT3 PROTEIN; ALANINE; DNA; DNA BINDING PROTEIN; DNA BINDING PROTEINS; GROWTH PROMOTOR; LUCIFERASE; PEPTIDE; PHOSPHOTYROSINE; TRANS ACTIVATORS; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; CANCER THERAPY; CARCINOGENESIS; CELL TRANSFORMATION; DNA BINDING; GENE; GENE ACTIVATION; GENE CONTROL; GENE DELETION; GENE DISRUPTION; GENE MAPPING; MOUSE; MUTAGENESIS; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN DOMAIN; PY LKTK GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; ANIMAL; BACULOVIRUS; BIOLOGICAL MODEL; CELL LINE; CELL NUCLEUS; CELL STRAIN 3T3; CHEMISTRY; CYTOSOL; DIMERIZATION; DOSE RESPONSE; DRUG DESIGN; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; INSECT; METABOLISM; MUTATION; PLASMID; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SRC HOMOLOGY DOMAIN; TIME;

ANIMALIA;

3T3 CELLS; ALANINE; ANIMAL; BACULOVIRIDAE; CELL LINE; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; CYTOKINES; CYTOSOL; DIMERIZATION; DNA; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; INSECTS; LUCIFERASE; MICE; MODELS, BIOLOGICAL; MUTATION; PEPTIDES; PHOSPHOPEPTIDES; PHOSPHOTYROSINE; PLASMIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0035977055     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107527200     Document Type: Article

References (65)

1. Darnell, J. E., Jr. (1997) Science 277, 1630-1635
2. Darnell, J. E., Jr., Kerr, I. M., and Stark, G. R. (1994) Science 264, 1415-1421
3. Schindler, C., and Darnell, J. E., Jr. (1995) Annu. Rev. Biochem. 64, 621-651
4. Ihle, J. N., and Kerr, I. M. (1995) Trends Genet. 11, 69-74
5. Horvath, C. M., and Darnell, J. E., Jr. (1997) Curr. Opin. Cell Biol. 9, 233-239
6. Stark, G. R., Kerr, I. M., Williams, B. R., Silverman, R. H., and Schreiber, R. D. (1998) Annu. Rev. Biochem. 67, 227-264
7. Smithgall, T. E., Briggs, S. D., Schreiner, S., Lerner, E. C., Cheng, H., and Wilson, M. B. (2000) Oncogene 19, 2612-2618
8. Akira, S. (2000) Oncogene 19, 2607-2611
9. Hirano, T., Ishihara, K., and Hibi, M. (2000) Oncogene 19, 2548-2556
10. Bromberg, J. F., Horvath, C. M., Wen, Z., Schreiber, R. D., and Darnell, J. E., Jr. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 7673-7678
11. Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., and Taub, R. (1996) Science 274, 1379-1383
12. Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., and Hirano, T. (1996) Immunity 5, 449-460
13. Kaplan, M. H., Sun, Y. L., Hoey, T., and Grusby, M. J. (1996) Nature 382, 174-177
14. Stephens, J. M., Morrison, R. F., and Pilch, P. F. (1996) J. Biol. Chem. 271, 10441-10444
15. Planas, A. M., Berruezo, M., Justicia, C., Barron, S., and Ferrer, I. (1997) J. Neurochem. 68, 1345-1351
16. Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., and Akira, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3801-3804
17. Kotenko, S. V., and Pestka, S. (2000) Oncogene 19, 2557-2565
18. Durbin, J. E., Hackenmiller, R., Simon, M. C., and Levy, D. E. (1996) Cell 84, 443-450
19. Bowman, T., Garcia, R., Turkson, J., and Jove, R. (2000) Oncogene 19, 2474-2488
20. Catlett-Falcone, R., Dalton, W. S., and Jove, R. (1999) Curr. Opin. Oncol. 11, 490-496
21. Garcia, R., and Jove, R. (1998) J. Biomed. Sci. 5, 79-85
22. Bromberg, J. F., Horvath, C. M., Besser, D., Lathem, W. W., and Darnell, J. E., Jr. (1998) Mol. Cell. Biol. 18, 2553-2558
23. Turkson, J., Bowman, T., Garcia, R., Caldenhoven, E., De Groot, R. P., and Jove, R. (1998) Mol. Cell. Biol. 18, 2545-2552
24. Bromberg, J. F., Wrzeszczynska, M. H., Devgan, G., Zhao, Y., Pestell, R. G., Albanese, C., and Darnell, J. E., Jr. (1999) Cell 98, 295-303
25. Turkson, J., and Jove, R. (2000) Oncogene 19, 6613-6626
26. Song, J. I., and Grandis, J. R. (2000) Oncogene 19, 2489-2495
27. Coffer, P. J., Koenderman, L., and de Groot, R. P. (2000) Oncogene 19, 2511-2522
28. Lin, T. S., Mahajan, S., and Frank, D. A. (2000) Oncogene 19, 2496-2504
29. Garcia, R., Bowman, T. L., Niu, G., Yu, H., Minton, S., Muro-Cacho, C. A., Cox, C. E., Falcone, R., Fairclough, R., Parson, S., Laudano, A., Gazit, A., Levitzki, A., Kraker, A., and Jove, R. (2001) Oncogene 20, 2499-2513
30. Catlett-Falcone, R., Landowski, T. H., Oshiro, M. M., Turkson, J., Levitzki, A., Savino, R., Ciliberto, G., Moscinski, L., Fernandez-Luna, J. L., Nuñez, G., Dalton, W. S., and Jove, R. (1999) Immunity 10, 105-115
31. Grandis, J. R., Drenning, S. D., Zeng, Q., Watkins, S. C., Melhem, M. F., Endo, S., Johnson, D. E., Huang, L., He, Y., and Kim, J. D. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4227-4232
32. Grandis, J. R., Drenning, S. D., Chakraborty, A., Zhou, M. Y., Zeng, Q., Pitt, A. S., and Tweardy, D. J. (1998) J. Clin. Invest. 102, 1385-1392
33. Nielsen, M., Kaltoft, K., Nordahl, M., Ropke, C., Geisler, C., Mustelin, T., Dobson, P., Svejgaard, A., and Odum, N. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6764-6769
34. Nielsen, M., Kaestel, C. G., Eriksen, K. W., Woetmann, A., Stokkedal, T., Kaltoft, K., Geisler, C., Ropke, C., and Odum, N. (1999) Leukemia (Baltimore) 13, 735-738
35. Epling-Burnette, P. K., Lui, J. H., Catlette-Falcone, R., Turkson, J., Oshiro, M., Kothapalli, R., Li, Y., Wang, J.-M., Yang-Yen, H.-F., Karras, J., Jove, R., and Loughran, T. P., Jr. (2001) J. Clin. Invest. 107, 351-362
36. Campbell, K. S., Ogris, E., Burke, B., Su, W., Auger, K. R., Druker, B. J., Schaffhausen, B. S., Roberts, T. M., and Pallas, D. C. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 6344-6348
37. Niu, G., Heller, R., Catlett-Falcone, R., Coppola, D., Jaroszeski, M., Dalton, W., Jove, R., and Yu, H. (1999) Cancer Res. 59, 5059-5063
38. Levitzki, A. (1999) Pharmacol. Ther. 82, 231-239
39. Ben-Bassat, H., and Klein, B. (2000) Curr. Pharm. Des. 6, 933-942
40. Fry, D. W. (2000) Anti-Cancer Drug Des. 15, 3-16
41. Miknyoczki, S. J., Chang, H., Klein-Szanto, A., Dionne, C. A., and Ruggeri, B. A. (1999) Clin. Cancer Res. 5, 2205-2212
42. Tian, S. S., Lamb, P., King, A. G., Miller, S. G., Kessler, L., Luengo, J. I., Averill, L., Johnson, R. K., Gleason, J. G., Pelus, L. M., Dillon, S. B., and Rosen, J. (1998) Science 281, 257-259
43. Shuai, K., Stark, G. R., Kerr, I. M., and Darnell, J. E., Jr. (1993) Science 261, 1744-1746
44. Shuai, K., Horvath, C. M., Huang, L. H., Qureshi, S. A., Cowburn, D., and Darnell, J. E., Jr. (1994) Cell 76, 821-828
45. Schaefer, T. S., Sanders, L. K., Park, O. K., and Nathans, D. (1997) Mol. Cell. Biol. 17, 5307-5316
46. Sasse, J., Hemmann, U., Schwartz, C., Schniertshauer, U., Heesel, B., Landgraf, C., Schneider-Mergener, J., Heinrich, P. C., and Horn, F. (1997) Mol. Cell. Biol. 17, 4677-4686
47. Yu, C. L., Meyer, D. J., Campbell, G. S., Larner, A. C., Carter-Su, C., Schwartz, J., and Jove, R. (1995) Science 269, 81-83
48. Johnson, P. J., Coussens, P. M., Danko, A. V., and Shalloway, D. (1985) Mol. Cell. Biol. 5, 1073-1083
49. Turkson, J., Bowman, T., Adnane, J., Zhang, Y., Djeu, J. Y., Sekharam, M., Frank, D. A., Holzman, L. B., Wu, J., Sebti, S., and Jove, R. (1999) Mol. Cell. Biol. 19, 7519-7528
50. Zhang, D., Sun, M., Samols, D., and Kushner, I. (1996) J. Biol. Chem. 271, 9503-9509
51. Yamauchi, K., Holt, K., and Pessin, J. E. (1993) J. Biol. Chem. 268, 14597-14600
52. Zhang, Y., Turkson, J., Carter-Su, C., Smithgall, T., Levitzki, A., Kraker, A., Krolewski, J. J., Medveczky, P., and Jove, R. (2000) J. Biol. Chem. 275, 24935-24944
53. Garcia, R., Yu, C. L., Hudnall, A., Catlett, R., Nelson, K. L., Smithgall, T., Fujita, D. J., Ethier, S. P., and Jove, R. (1997) Cell Growth Differ. 8, 1267-1276
54. Wagner, B. J., Hayes, T. E., Hoban, C. J., and Cochran, B. H. (1990) EMBO J. 9, 4477-4484
55. Gouilleux, F., Moritz, D., Humar, M., Moriggl, R., Berchtold, S., and Groner, B. (1995) Endocrinology 136, 5700-5708
56. Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E., Jr., Stein, R. B., and Rosen, J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 3041-3045
57. Rojas, M., Donahue, J. P., Tan, Z., and Lin, Y. Z. (1998) Nat. Biotechnol. 16, 370-375
58. Zvelebil, M. J., Panayotou, G., Linacre, J., and Waterfield, M. D. (1995) Protein Eng. 8, 527-533
59. Mikita, T., Daniel, C., Wu, P., and Schindler, U. (1998) J. Biol. Chem. 273, 17634-17642
60. Heim, M. H., Kerr, I. M., Stark, G. R., and Darnell, J. E., Jr. (1995) Science 267, 1347-1349
61. Inoue, M., Minami, M., Matsumoto, M., Kishimoto, T., and Akira, S. (1997) J. Biol. Chem. 272, 9550-9555
62. Weber-Nordt, R. M., Riley, J. K., Greenlund, A. C., Moore, K. W., Darnell, J. E., Jr., and Schreiber, R. D. (1996) J. Biol. Chem. 271, 27954-27961
63. Bromberg, J., and Darnell, J. E., Jr. (2000) Oncogene 19, 2468-2473
64. Chakraborty, A., Dyer, K. F., and Tweardy, D. J. (2000) Blood Cells Mol. Dis. 26, 320-330
65. Batzer, A. G., Blaikie, P., Nelson, K., Schlessinger, J., and Margolis, B. (1995) Mol. Cell. Biol. 15, 4403-4409