STAT isoforms: Mediators of STAT specificity or leukemogenesis?

Leukemia Research

Volumn 25, Issue 6, 2001, Pages 483-484

  Ilaria Jr , Robert L ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; STAT PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STAT5B PROTEIN;

HUMAN; LEUKEMOGENESIS; MEDIATOR; NONHUMAN; NOTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

DNA-BINDING PROTEINS; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MILK PROTEINS; PROTEIN ISOFORMS; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0035029336     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(01)00003-0     Document Type: Note

References (22)

1. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
2. p91 STAT1 activation in interleukin-3-stimulated primary acute myeloid leukemia cells
3. Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
4. Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia
5. Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts
6. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl
7. P210 and P190 (BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
8. BCR/abl leads to the constitutive activation of Stat protiens, and shares an epitope with tyrosine phosphorylated Stats
9. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
10. STATs in oncogenesis
11. Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3
12. STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
13. Granulocyte colony-stimulating factor activates a 72-kDa isoform of STAT3 in human neutrophils
14. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
15. Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells
16. Involvement of STAT3 in the granulocyte colony-stimulating factor-induced differentiation of myeloid cells
17. Functional differences between Stat3alpha and Stat3beta
18. Interleukin-3 signals through multiple isoforms of Stat5
19. Identification of an additional isoform of STAT5 expressed in immature macrophages
20. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation
21. Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation