Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1

Cellular Signalling

Volumn 23, Issue 7, 2011, Pages 1119-1127

  Yamada, Osamu ^a   Ozaki, Kohji ^a,c   Furukawa, Thoru ^a   Machida, Mitsuyo ^a   Wang, Yan Hua ^a   Motoji, Toshiko ^a   Mitsuishi, Tsuyoshi ^b   Akiyama, Masaharu ^c   Yamada, Hisashi ^c   Kawauchi, Kiyotaka ^d   Matsuoka, Rumiko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

CML; Drug resistance; P glycoprotein; STAT5; Telomerase

Indexed keywords

BCR ABL PROTEIN; IMATINIB; JANUS KINASE 2; MULTIDRUG RESISTANCE PROTEIN 1; STAT5 PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BLAST CRISIS; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; P-GLYCOPROTEIN; PIPERAZINES; PYRIMIDINES; STAT5 TRANSCRIPTION FACTOR; TELOMERASE; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 79954423352     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2011.02.005     Document Type: Article

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