메뉴 건너뛰기




Volumn 19, Issue 9, 2012, Pages 1405-1420

Update on the slow delayed rectifier potassium current (I Ks): Role in modulating cardiac function

Author keywords

antiarrhythmic agents; cardiac arrhythmia; Chromanol293B; HMR1556; I Ks; I Ks activator; KCNE1; KCNQ1; KvLQT1; L 768; The slow delayed rectifier potassium current

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; 1,3 DIHYDRO 5 (2 FLUOROPHENYL) 3 (1H INDOL 3 YLMETHYL) 1 METHYL 2H 1,4 BENZODIAZEPIN 2 ONE; AZIMILIDE; BEPRIDIL; CETIRIZINE; CHLORTALIDONE; CHROMANOL 293B; CLOTRIMAZOLE; DOXORUBICIN; DRONEDARONE; EBASTINE; FLUNARIZINE; L 768763; MEFENAMIC ACID; MEFLOQUINE; N [3 HYDROXY 2,2 DIMETHYL 6 (4,4,4 TRIFLUOROBUTOXY)CHROMAN 4 YL] N METHYLMETHANESULFONAMIDE; NIFLUMIC ACID; NIP 142; PENTOBARBITAL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; PROPOFOL; QUINIDINE; RILMAKALIM; SEVOFLURANE; SIPATRIGINE; SPIRONOLACTONE; TERFENADINE; THIOPENTAL; UNCLASSIFIED DRUG;

EID: 84863270462     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712799462595     Document Type: Review
Times cited : (13)

References (206)
  • 3
    • 30444441408 scopus 로고    scopus 로고
    • Antiarrhythmic drug research
    • DOI 10.1038/sj.bjp.0706500, PII 0706500
    • Walker, M., Antiarrhythmic drug research. Br. J. Pharmacol., 2006, 147, (S1), S222-S231. (Pubitemid 43077280)
    • (2006) British Journal of Pharmacology , vol.147 , Issue.SUPPL. 1
    • Walker, M.J.A.1
  • 6
    • 0014438985 scopus 로고
    • Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres
    • Noble, D.; Tsien, R.W., Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres. J. Physiol., 1969, 200, (1), 205-231.
    • (1969) J. Physiol. , vol.200 , Issue.1 , pp. 205-231
    • Noble, D.1    Tsien, R.W.2
  • 8
    • 0025351245 scopus 로고
    • + current. Differential sensitivity to block by class III antiarrhythmic agent
    • DOI 10.1085/jgp.96.1.195
    • Sanguinetti, M.C.; Jurkiewicz, N.K., Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol., 1990, 96, (1), 195-215. (Pubitemid 20227082)
    • (1990) Journal of General Physiology , vol.96 , Issue.1 , pp. 195-215
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2
  • 9
    • 0035110307 scopus 로고    scopus 로고
    • The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes
    • DOI 10.1016/S0008-6363(00)00306-0, PII S0008636300003060
    • Virag, L.; Iost, N.; Opincariu, M.; Szolnoky, J.; Szecsi, J.; Bogats, G.; Szenohradszky, P.; Varro, A.; Papp, J.G., The slow component of the delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc. Res., 2001, 49, (4), 790-797. (Pubitemid 32178382)
    • (2001) Cardiovascular Research , vol.49 , Issue.4 , pp. 790-797
    • Virag, L.1    Iost, N.2    Opincariu, M.3    Szolnoky, J.4    Szecsi, J.5    Bogats, G.6    Szenohradszky, P.7    Varro, A.8    Papp, J.Gy.9
  • 13
    • 0025963987 scopus 로고
    • Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action
    • Sanguinetti, M.C.; Jurkiewicz, N.K.; Scott, A.; Siegl, P.K., Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action. Circul. Res., 1991, 68, (1), 77-84.
    • (1991) Circul. Res. , vol.68 , Issue.1 , pp. 77-84
    • Sanguinetti, M.C.1    Jurkiewicz, N.K.2    Scott, A.3    Siegl, P.K.4
  • 14
    • 0030831504 scopus 로고    scopus 로고
    • Proarrhythmia with class III antiarrhythmic drugs: Types, risks, and management
    • PII S002914997007170
    • Hohnloser, S.H., Proarrhythmia with class III antiarrhythmic drugs: types, risks, and management. Am. J. Cardiol., 1997, 80, (8A), 82G-89G. (Pubitemid 27469748)
    • (1997) American Journal of Cardiology , vol.80 , Issue.8 A
    • Hohnloser, S.H.1
  • 15
    • 0025164907 scopus 로고
    • Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence
    • Hondeghem, L.; Snyders, D., Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use dependence. Circulation, 1990, 81, (2), 686-690. (Pubitemid 20055978)
    • (1990) Circulation , vol.81 , Issue.2 , pp. 686-690
    • Hondeghem, L.M.1    Snyders, D.J.2
  • 16
    • 8944234858 scopus 로고    scopus 로고
    • Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction
    • DOI 10.1016/S0140-6736(96)02149-6
    • Waldo, A.L.; Camm, A.J.; deRuyter, H.; Friedman, P.L.; MacNeil, D.J.; Pauls, J.F.; Pitt, B.; Pratt, C.M.; Schwartz, P.J.; Veltri, E.P., Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol. Lancet, 1996, 348, (9019), 7-12. (Pubitemid 26237238)
    • (1996) Lancet , vol.348 , Issue.9019 , pp. 7-12
    • Waldo, A.L.1    Camm, A.J.2    DeRuyter, H.3    Friedman, P.L.4    MacNeil, D.J.5    Pauls, J.F.6    Pitt, B.7    Pratt, C.M.8    Schwartz, P.J.9    Veltri, E.P.10
  • 18
    • 0030056967 scopus 로고    scopus 로고
    • Ks Play a Role in the Reverse Rate Dependence of ClassIII Agents?
    • Ks Play a Role in the Reverse Rate Dependence of ClassIII Agents? Circul. Res., 1996, 78, (1), 26-37.
    • (1996) Circul. Res. , vol.78 , Issue.1 , pp. 26-37
    • Gintant, G.A.1
  • 19
    • 76249099757 scopus 로고    scopus 로고
    • Repolarization of the cardiac action potential. Does an increase in repolarization capacity constitute a new anti-arrhythmic principle?
    • Grunnet, M., Repolarization of the cardiac action potential. Does an increase in repolarization capacity constitute a new anti-arrhythmic principle? Acta physiologica (Oxford, England), 2010, 198 Suppl 676, 1-48.
    • (2010) Acta Physiologica (Oxford, England) , vol.198 , Issue.SUPPL. 676 , pp. 1-48
    • Grunnet, M.1
  • 21
    • 29144529013 scopus 로고    scopus 로고
    • The KCNQ1 potassium channel: From gene to physiological function
    • Jespersen, T.; Grunnet, M.; Olesen, S.P., The KCNQ1 potassium channel: from gene to physiological function. Physiology, 2005, 20, (6), 408-416.
    • (2005) Physiology , vol.20 , Issue.6 , pp. 408-416
    • Jespersen, T.1    Grunnet, M.2    Olesen, S.P.3
  • 22
    • 77950978559 scopus 로고    scopus 로고
    • Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death
    • Goldman, A.; Glasscock, E.; Yoo, J.; Chen, T.; Klassen, T.; Noebels, J., Arrhythmia in heart and brain: KCNQ1 mutations link epilepsy and sudden unexplained death. Sci. Transl. Med., 2009, 1, (2), 2ra6.
    • (2009) Sci. Transl. Med. , vol.1 , Issue.2
    • Goldman, A.1    Glasscock, E.2    Yoo, J.3    Chen, T.4    Klassen, T.5    Noebels, J.6
  • 23
    • 33645317063 scopus 로고    scopus 로고
    • HERG potassium channels and cardiac arrhythmia
    • Sanguinetti, M.C.; Tristani-Firouzi, M., hERG potassium channels and cardiac arrhythmia. Nature, 2006, 440, (7083), 463-469.
    • (2006) Nature , vol.440 , Issue.7083 , pp. 463-469
    • Sanguinetti, M.C.1    Tristani-Firouzi, M.2
  • 24
    • 1542298958 scopus 로고    scopus 로고
    • Pharmacology of cardiac potassium channels
    • DOI 10.1016/j.cardiores.2003.12.026, PII S0008636304000021
    • Tamargo, J.; Caballero, R.; Gómez, R.; Valenzuela, C.; Delpón, E., Pharmacology of cardiac potassium channels. Cardiovasc. Res., 2004, 62, (1), 9-33. (Pubitemid 38326808)
    • (2004) Cardiovascular Research , vol.62 , Issue.1 , pp. 9-33
    • Tamargo, J.1    Caballero, R.2    Gomez, R.3    Valenzuela, C.4    Delpon, E.5
  • 26
    • 0035928757 scopus 로고    scopus 로고
    • Ks blockade at high heart rate in guinea pig and rabbit: Implications for arrhythmogenesis in humans
    • Ks blockade at high heart rate in guinea pig and rabbit: implications for arrhythmogenesis in humans. Circulation, 2001, 104, (8), 951-956.
    • (2001) Circulation , vol.104 , Issue.8 , pp. 951-956
    • Lu, Z.1    Kamiya, K.2    Opthof, T.3    Yasui, K.4    Kodama, I.5
  • 28
    • 0028881535 scopus 로고
    • Ks contributes to the longer action potential of the M cell
    • Ks contributes to the longer action potential of the M cell. Circul. Res., 1995, 76, (3), 351-365.
    • (1995) Circul. Res. , vol.76 , Issue.3 , pp. 351-365
    • Liu, D.W.1    Antzelevitch, C.2
  • 29
    • 0035916884 scopus 로고    scopus 로고
    • Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits
    • Xu, X.; Rials, S.J.; Wu, Y.; Salata, J.J.; Liu, T.; Bharucha, D.B.; Marinchak, R.A.; Kowey, P.R., Left ventricular hypertrophy decreases slowly but not rapidly activating delayed rectifier potassium currents of epicardial and endocardial myocytes in rabbits. Circulation, 2001, 103, (11), 1585-1590. (Pubitemid 32226269)
    • (2001) Circulation , vol.103 , Issue.11 , pp. 1585-1590
    • Xu, X.1    Rials, S.J.2    Wu, Y.3    Salata, J.J.4    Liu, T.5    Bharucha, D.B.6    Marinchak, R.A.7    Kowey, P.R.8
  • 30
    • 0032211575 scopus 로고    scopus 로고
    • Ks) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig
    • Ks) contribute to the differences in action potential duration in basal left ventricular myocytes in guinea-pig. Cardiovasc. Res., 1998, 40, (2), 322-331.
    • (1998) Cardiovasc. Res. , vol.40 , Issue.2 , pp. 322-331
    • Bryant, S.M.1    Wan, X.2    Shipsey, S.J.3    Hart, G.4
  • 31
    • 0032999081 scopus 로고    scopus 로고
    • +current: A potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents
    • +current: a potential mechanism of the proarrhythmic effects of methanesulfonanilideclass III agents. Cardiovasc. Res., 1999, 43, (1), 135-147.
    • (1999) Cardiovasc. Res. , vol.43 , Issue.1 , pp. 135-147
    • Cheng, J.1    Kamiya, K.2    Liu, W.3    Tsuji, Y.4    Toyama, J.5    Kodama, I.6
  • 37
    • 52149123342 scopus 로고    scopus 로고
    • Feedback remodeling of cardiac potassium current expression: A novel potential mechanism for control of repolarization reserve
    • Xiao, L.; Xiao, J.; Luo, X.; Lin, H.; Wang, Z.; Nattel, S., Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve. Circulation, 2008, 118, (10), 983-992.
    • (2008) Circulation , vol.118 , Issue.10 , pp. 983-992
    • Xiao, L.1    Xiao, J.2    Luo, X.3    Lin, H.4    Wang, Z.5    Nattel, S.6
  • 38
    • 0037127028 scopus 로고    scopus 로고
    • Requirement of a macromolecular signaling complex for β adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
    • DOI 10.1126/science.1066843
    • Marx, S.O.; Kurokawa, J.; Reiken, S.; Motoike, H.; D'Armiento, J.; Marks, A.R.; Kass, R.S., Requirement of a Macromolecular Signaling Complex for β Adrenergic Receptor Modulation of the KCNQ1-KCNE1 Potassium Channel. Science, 2002, 295, (5554), 496-499. (Pubitemid 34101639)
    • (2002) Science , vol.295 , Issue.5554 , pp. 496-499
    • Marx, S.O.1    Kurokawa, J.2    Reiken, S.3    Motoike, H.4    D'Armiento, J.5    Marks, A.R.6    Kass, R.S.7
  • 39
    • 63349094727 scopus 로고    scopus 로고
    • PKC activation and PIP2 depletion underlie biphasic regulation of IKs by Gq-coupled receptors
    • Matavel, A.; Lopes, C., PKC activation and PIP2 depletion underlie biphasic regulation of IKs by Gq-coupled receptors. J. Mol. Cell. Cardiol., 2009, 46, (5), 704-712.
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , Issue.5 , pp. 704-712
    • Matavel, A.1    Lopes, C.2
  • 40
    • 77949263580 scopus 로고    scopus 로고
    • Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase
    • Dong, M.Q.; Sun, H.Y.; Tang, Q.; Tse, H.F.; Lau, C.P.; Li, G.R., Regulation of human cardiac KCNQ1/KCNE1 channel by epidermal growth factor receptor kinase. Biochim. Biophys. Acta, 2010, 1798, (5), 995-1001.
    • (2010) Biochim. Biophys. Acta , vol.1798 , Issue.5 , pp. 995-1001
    • Dong, M.Q.1    Sun, H.Y.2    Tang, Q.3    Tse, H.F.4    Lau, C.P.5    Li, G.R.6
  • 42
    • 0038785558 scopus 로고    scopus 로고
    • Ks Channel Complex Inhibits Drug Block
    • Ks Channel Complex Inhibits Drug Block. Circulation, 2003, 108, (2), 132-134.
    • (2003) Circulation , vol.108 , Issue.2 , pp. 132-134
    • Yang, T.1    Kanki, H.2    Roden, D.M.3
  • 44
    • 80955142781 scopus 로고    scopus 로고
    • A-Kinase Anchoring Protein 9 and IKs Channel Regulation
    • Chen, L.; Kass, R.S., A-Kinase Anchoring Protein 9 and IKs Channel Regulation. J. Cardiovasc. Pharmacol., 2011, 58, (5), 459-461.
    • (2011) J. Cardiovasc. Pharmacol. , vol.58 , Issue.5 , pp. 459-461
    • Chen, L.1    Kass, R.S.2
  • 46
    • 0142105405 scopus 로고    scopus 로고
    • 2, controls KCNQ1/KCNE1 voltage-gated potassium channels: A functional homology between voltage-gated and inward rectifier K+ channels
    • 2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels. EMBO J., 2003, 22, (20), 5412-5421.
    • (2003) EMBO J. , vol.22 , Issue.20 , pp. 5412-5421
    • Loussouarn, G.1    Park, K.H.2    Bellocq, C.3    Baro, I.4    Charpentier, F.5    Escande, D.6
  • 47
    • 20444428008 scopus 로고    scopus 로고
    • Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate
    • DOI 10.1016/j.conb.2005.05.005, PII S095943880500070X
    • Suh, B.C.; Hille, B., Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate. Curr. Opin. Neurobiol., 2005, 15, (3), 370-378. (Pubitemid 40806451)
    • (2005) Current Opinion in Neurobiology , vol.15 , Issue.3 SPEC. ISS. , pp. 370-378
    • Suh, B.-C.1    Hille, B.2
  • 48
    • 0007996253 scopus 로고    scopus 로고
    • + current by protein kinase C and protein kinase A
    • + current by protein kinase C and protein kinase A. Circul. Res., 1998, 83, (10), 995-1002.
    • (1998) Circul. Res. , vol.83 , Issue.10 , pp. 995-1002
    • Lo, C.F.1    Numann, R.2
  • 53
    • 65549168650 scopus 로고    scopus 로고
    • Redox-and calmodulin-dependent S-nitrosylation of the KCNQ1 channel
    • Asada, K.; Kurokawa, J.; Furukawa, T., Redox-and calmodulin-dependent S-nitrosylation of the KCNQ1 channel. J. Biol. Chem., 2009, 284, (9), 6014-6020.
    • (2009) J. Biol. Chem. , vol.284 , Issue.9 , pp. 6014-6020
    • Asada, K.1    Kurokawa, J.2    Furukawa, T.3
  • 54
  • 57
    • 33847639227 scopus 로고    scopus 로고
    • The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family
    • DOI 10.1016/j.cardiores.2007.01.008, PII S0008636307000156
    • Jespersen, T.; Membrez, M.; Nicolas, C.S.; Pitard, B.; Staub, O.; Olesen, S.P.; Baro, I.; Abriel, H., The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family. Cardiovasc. Res., 2007, 74, (1), 64-74. (Pubitemid 46366952)
    • (2007) Cardiovascular Research , vol.74 , Issue.1 , pp. 64-74
    • Jespersen, T.1    Membrez, M.2    Nicolas, C.S.3    Pitard, B.4    Staub, O.5    Olesen, S.-P.6    Baro, I.7    Abriel, H.8
  • 59
    • 0023734276 scopus 로고
    • Cloning of a membrane protein that induces a slow voltage-gated potassium current
    • Takumi, T.; Ohkubo, H.; Nakanishi, S., Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science, 1988, 242, (4881), 1042-1045.
    • (1988) Science , vol.242 , Issue.4881 , pp. 1042-1045
    • Takumi, T.1    Ohkubo, H.2    Nakanishi, S.3
  • 60
    • 0027491130 scopus 로고
    • + channel protein in mammalian cells and immunolocalization in guinea pig heart
    • + channel protein in mammalian cells and immunolocalization in guinea pig heart. Circul. Res., 1993, 73, (5), 968-973.
    • (1993) Circul. Res. , vol.73 , Issue.5 , pp. 968-973
    • Freeman, L.C.1    Kass, R.S.2
  • 62
    • 0037215775 scopus 로고    scopus 로고
    • Structural determinants and biophysical properties of HERG and KCNQ1 channel gating
    • DOI 10.1016/S0022-2828(02)00286-9, PII S0022282802002869
    • Tristani-Firouzi, M.; Sanguinetti, M.C., Structural determinants and biophysical properties of HERG and KCNQ1 channel gating. J. Mol. Cell. Cardiol., 2003, 35, (1), 27-35. (Pubitemid 36286965)
    • (2003) Journal of Molecular and Cellular Cardiology , vol.35 , Issue.1 , pp. 27-35
    • Tristani-Firouzi, M.1    Sanguinetti, M.C.2
  • 64
    • 0029854263 scopus 로고    scopus 로고
    • Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
    • DOI 10.1038/384080a0
    • Sanguinetti, M.C.; Curran, M.E.; Zou, A.; Shen, J.; Spector, P.S.; Atkinson, D.L.; Keating, M.T., Coassembly of KvLQT1 and minK (IsK) proteins to form cardiac IKs potassium channel. Nature, 1996, 384, (6604), 80-83. (Pubitemid 26374592)
    • (1996) Nature , vol.384 , Issue.6604 , pp. 80-83
    • Sanguinetti, M.C.1    Curran, M.E.2    Zou, A.3    Shen, J.4    Spector, P.S.5    Atkinson, D.L.6    Keating, M.T.7
  • 66
    • 77953037714 scopus 로고    scopus 로고
    • State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation
    • Wu, D.; Delaloye, K.; Zaydman, M.A.; Nekouzadeh, A.; Rudy, Y.; Cui, J., State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation. J. Gen. Physiol., 2010, 135, (6), 595-606.
    • (2010) J. Gen. Physiol. , vol.135 , Issue.6 , pp. 595-606
    • Wu, D.1    Delaloye, K.2    Zaydman, M.A.3    Nekouzadeh, A.4    Rudy, Y.5    Cui, J.6
  • 69
    • 0034929557 scopus 로고    scopus 로고
    • KCNQ potassium channels: Physiology, pathophysiology, and pharmacology
    • DOI 10.1016/S0163-7258(01)00116-4, PII S0163725801001164
    • Robbins, J., KCNQ potassium channels: physiology, pathophysiology, and pharmacology. Pharmacol. Ther., 2001, 90, (1), 1-19. (Pubitemid 32622837)
    • (2001) Pharmacology and Therapeutics , vol.90 , Issue.1 , pp. 1-19
    • Robbins, J.1
  • 70
    • 78650959213 scopus 로고    scopus 로고
    • The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure
    • Labro, A.J.; Boulet, I.R.; Choveau, F.S.; Mayeur, E.; Bruyns, T.; Loussouarn, G.; Raes, A.L.; Snyders, D.J., The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure. J. Biol. Chem., 2011, 286, (1), 717-725.
    • (2011) J. Biol. Chem. , vol.286 , Issue.1 , pp. 717-725
    • Labro, A.J.1    Boulet, I.R.2    Choveau, F.S.3    Mayeur, E.4    Bruyns, T.5    Loussouarn, G.6    Raes, A.L.7    Snyders, D.J.8
  • 74
    • 33847091589 scopus 로고    scopus 로고
    • Structural Insight into KCNQ (Kv7) Channel Assembly and Channelopathy
    • DOI 10.1016/j.neuron.2007.02.010, PII S0896627307001092
    • Howard, R.J.; Clark, K.A.; Holton, J.M.; Minor Jr, D.L., Structural insight into KCNQ (Kv7) channel assembly and channelopathy. Neuron, 2007, 53, (5), 663-675. (Pubitemid 46283377)
    • (2007) Neuron , vol.53 , Issue.5 , pp. 663-675
    • Howard, R.J.1    Clark, K.A.2    Holton, J.M.3    Minor Jr., D.L.4
  • 75
    • 0037047394 scopus 로고    scopus 로고
    • The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels
    • DOI 10.1074/jbc.M204130200
    • Yus-Najera, E.; Santana-Castro, I.; Villarroel, A., The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. J. Biol. Chem., 2002, 277, (32), 28545-28553. (Pubitemid 41079281)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.32 , pp. 28545-28553
    • Yus-Najera, E.1    Santana-Castro, I.2    Villarroel, A.3
  • 76
    • 33646814436 scopus 로고    scopus 로고
    • KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin
    • Ghosh, S.; Nunziato, D.A.; Pitt, G.S., KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. Circul. Res., 2006, 98, (8), 1048-1054.
    • (2006) Circul. Res. , vol.98 , Issue.8 , pp. 1048-1054
    • Ghosh, S.1    Nunziato, D.A.2    Pitt, G.S.3
  • 77
    • 70349449896 scopus 로고    scopus 로고
    • Crystal structure of a trimeric form of the Kv7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif
    • Xu, Q.; Minor, D.L., Jr., Crystal structure of a trimeric form of the Kv7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motif. Protein Sci., 2009, 18, (10), 2100-2114.
    • (2009) Protein Sci. , vol.18 , Issue.10 , pp. 2100-2114
    • Xu, Q.1    Minor Jr., D.L.2
  • 79
    • 33751513050 scopus 로고    scopus 로고
    • Secondary structure of a KCNE cytoplasmic domain
    • DOI 10.1085/jgp.200609657
    • Rocheleau, J.M.; Gage, S.D.; Kobertz, W.R., Secondary structure of a KCNE cytoplasmic domain. J. Gen. Physiol., 2006, 128, (6), 721-729. (Pubitemid 44833382)
    • (2006) Journal of General Physiology , vol.128 , Issue.6 , pp. 721-729
    • Rocheleau, J.M.1    Gage, S.D.2    Kobertz, W.R.3
  • 81
    • 35348847305 scopus 로고    scopus 로고
    • Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome
    • DOI 10.1021/bi700705j
    • Tian, C.; Vanoye, C.G.; Kang, C.; Welch, R.C.; Kim, H.J.; George Jr, A.L.; Sanders, C.R., Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndrome. Biochemistry (Mosc). 2007, 46, (41), 11459-11472. (Pubitemid 47585492)
    • (2007) Biochemistry , vol.46 , Issue.41 , pp. 11459-11472
    • Tian, C.1    Vanoye, C.G.2    Kang, C.3    Welch, R.C.4    Hak, J.K.5    George Jr., A.L.6    Sanders, C.R.7
  • 82
    • 0035798418 scopus 로고    scopus 로고
    • Specific interaction of the potassium channel β-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system
    • DOI 10.1006/jmbi.2001.5053
    • Furukawa, T.; Ono, Y.; Tsuchiya, H.; Katayama, Y.; Bang, M.-L.; Labeit, D.; Labeit, S.; Inagaki, N.; Gregorio, C.C., Specific interaction of the potassium channel β-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. J. Mol. Biol., 2001, 313, (4), 775-784. (Pubitemid 33063426)
    • (2001) Journal of Molecular Biology , vol.313 , Issue.4 , pp. 775-784
    • Furukawa, T.1    Ono, Y.2    Tsuchiya, H.3    Katayama, Y.4    Bang, M.-L.5    Labeit, D.6    Labeit, S.7    Inagaki, N.8    Gregorio, C.C.9
  • 83
    • 80455156160 scopus 로고    scopus 로고
    • N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes
    • Girmatsion, Z.; Biliczki, P.; Takac, I.; Schwerthelm, C.; Hohnloser, S.H.; Ehrlich, J.R., N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes. PLoS ONE, 2011, 6, (11), e26967.
    • (2011) PLoS ONE , vol.6 , Issue.11
    • Girmatsion, Z.1    Biliczki, P.2    Takac, I.3    Schwerthelm, C.4    Hohnloser, S.H.5    Ehrlich, J.R.6
  • 84
    • 77957274957 scopus 로고    scopus 로고
    • Cardiac arrhythmia and thyroid dysfunction: A novel genetic link
    • Purtell, K.; Roepke, T.K.; Abbott, G.W., Cardiac arrhythmia and thyroid dysfunction: a novel genetic link. Int J Biochem Cell Biol, 2010, 42, (11), 1767-1770.
    • (2010) Int J Biochem Cell Biol , vol.42 , Issue.11 , pp. 1767-1770
    • Purtell, K.1    Roepke, T.K.2    Abbott, G.W.3
  • 86
    • 2942746320 scopus 로고    scopus 로고
    • KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity
    • DOI 10.1016/j.neuron.2004.06.001, PII S0896627304003307
    • Melman, Y.F.; Um, S.Y.; Krumerman, A.; Kagan, A.; McDonald, T.V., KCNE1 binds to the KCNQ1 pore to regulate potassium channel activity. Neuron, 2004, 42, (6), 927-937. (Pubitemid 38798231)
    • (2004) Neuron , vol.42 , Issue.6 , pp. 927-937
    • Melman, Y.F.1    Um, S.Y.2    Krumerman, A.3    Kagan, A.4    McDonald, T.V.5
  • 91
    • 78649867712 scopus 로고    scopus 로고
    • KCNE1 Remodels the Voltage Sensor of Kv7. 1 to Modulate Channel Function
    • Wu, D.; Pan, H.; Delaloye, K.; Cui, J., KCNE1 Remodels the Voltage Sensor of Kv7. 1 to Modulate Channel Function. Biophys. J., 2010, 99, (11), 3599-3608.
    • (2010) Biophys. J. , vol.99 , Issue.11 , pp. 3599-3608
    • Wu, D.1    Pan, H.2    Delaloye, K.3    Cui, J.4
  • 93
    • 77953412214 scopus 로고    scopus 로고
    • Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits
    • Zheng, R.; Thompson, K.; Obeng-Gyimah, E.; Alessi, D.; Chen, J.; Cheng, H.; McDonald, T.V., Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits. Biochem. J, 2010, 428, (1), 75-84.
    • (2010) Biochem. J , vol.428 , Issue.1 , pp. 75-84
    • Zheng, R.1    Thompson, K.2    Obeng-Gyimah, E.3    Alessi, D.4    Chen, J.5    Cheng, H.6    McDonald, T.V.7
  • 94
    • 77953041426 scopus 로고    scopus 로고
    • Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1
    • Lvov, A.; Gage, S.D.; Berrios, V.M.; Kobertz, W.R., Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1. J. Gen. Physiol., 2010, 135, (6), 607-618.
    • (2010) J. Gen. Physiol. , vol.135 , Issue.6 , pp. 607-618
    • Lvov, A.1    Gage, S.D.2    Berrios, V.M.3    Kobertz, W.R.4
  • 96
    • 0031469950 scopus 로고    scopus 로고
    • KvLQT1 potassium channel but not IsK is the molecular target for trans- 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethyl-chromane
    • Loussouarn, G.; Charpentier, F.; Mohammad-Panah, R.; Kunzelmann, K.; Baró, I.; Escande, D., KvLQT1 potassium channel but not IsK is the molecular target for trans-6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy- 2,2-dimethyl-chromane. Mol. Pharmacol., 1997, 52, (6), 1131-1136. (Pubitemid 28013733)
    • (1997) Molecular Pharmacology , vol.52 , Issue.6 , pp. 1131-1136
    • Loussouarn, G.1    Charpentier, F.2    Mohammad-Panah, R.3    Kunzelmann, K.4    Baro, I.5    Escande, D.6
  • 97
    • 79953117902 scopus 로고    scopus 로고
    • Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel
    • Van Horn, W.D.; Vanoye, C.G.; Sanders, C.R., Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel. Curr. Opin. Struct. Biol., 2011, 21, (2), 283-291.
    • (2011) Curr. Opin. Struct. Biol. , vol.21 , Issue.2 , pp. 283-291
    • Van Horn, W.D.1    Vanoye, C.G.2    Sanders, C.R.3
  • 105
    • 0034642569 scopus 로고    scopus 로고
    • A constitutively open potassium channel formed by KCNQ1 and KCNE3
    • DOI 10.1038/35003200
    • Schroeder, B.C.; Waldegger, S.; Fehr, S.; Bleich, M.; Warth, R.; Greger, R.; Jentsch, T.J., A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature, 2000, 403, (6766), 196-199. (Pubitemid 30050962)
    • (2000) Nature , vol.403 , Issue.6766 , pp. 196-199
    • Schroeder, B.C.1    Waldegger, S.2    Fehr, S.3    Bleich, M.4    Warth, R.5    Greger, R.6    Jentsch, T.J.7
  • 106
    • 0034383396 scopus 로고    scopus 로고
    • KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel
    • Tinel, N.; Diochot, S.; Borsotto, M.; Lazdunski, M.; Barhanin, J., KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J., 2000, 19, (23), 6326-6330.
    • (2000) EMBO J. , vol.19 , Issue.23 , pp. 6326-6330
    • Tinel, N.1    Diochot, S.2    Borsotto, M.3    Lazdunski, M.4    Barhanin, J.5
  • 108
  • 112
    • 40349091672 scopus 로고    scopus 로고
    • Ks(KCNQ1-KCNE1) channel complex
    • Ks(KCNQ1-KCNE1) channel complex. FEBS J., 2008, 275, (6), 1336-1349.
    • (2008) FEBS J. , vol.275 , Issue.6 , pp. 1336-1349
    • Manderfield, L.J.1    George, A.L.2
  • 116
    • 4043121130 scopus 로고    scopus 로고
    • Low incidence of cardiac events with β-blocking therapy in children with long QT syndrome
    • DOI 10.1016/j.ehj.2004.06.016, PII S0195668X04004166
    • Villain, E.; Denjoy, I.; Lupoglazoff, J.M.; Guicheney, P.; Hainque, B.; Lucet, V.; Bonnet, D., Low incidence of cardiac events with β-blocking therapy in children with long QT syndrome. Eur. Heart J., 2004, 25, (16), 1405-1411. (Pubitemid 39078249)
    • (2004) European Heart Journal , vol.25 , Issue.16 , pp. 1405-1411
    • Villain, E.1    Denjoy, I.2    Lupoglazoff, J.M.3    Guicheney, P.4    Hainque, B.5    Lucet, V.6    Bonnet, D.7
  • 117
    • 0034141999 scopus 로고    scopus 로고
    • A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly
    • Schmitt, N.; Schwarz, M.; Peretz, A.; Abitbol, I.; Attali, B.; Pongs, O., A recessive C-terminal Jervell and Lange-Nielsen mutation of the KCNQ1 channel impairs subunit assembly. EMBO J., 2000, 19, (3), 332-340. (Pubitemid 30072603)
    • (2000) EMBO Journal , vol.19 , Issue.3 , pp. 332-340
    • Schmitt, N.1    Schwarz, M.2    Peretz, A.3    Abitbol, I.4    Attali, B.5    Pongs, O.6
  • 118
    • 64149122748 scopus 로고    scopus 로고
    • LQT1-associated Mutations Increase KCNQ1 Proteasomal Degradation Independently of Derlin-1
    • Peroz, D.; Dahimène, S.; Baró, I.; Loussouarn, G.; Mérot, J., LQT1-associated Mutations Increase KCNQ1 Proteasomal Degradation Independently of Derlin-1. J. Biol. Chem., 2009, 284, (8), 5250-5256.
    • (2009) J. Biol. Chem. , vol.284 , Issue.8 , pp. 5250-5256
    • Peroz, D.1    Dahimène, S.2    Baró, I.3    Loussouarn, G.4    Mérot, J.5
  • 120
    • 71749097435 scopus 로고    scopus 로고
    • Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome
    • Sato, A.; Arimura, T.; Makita, N.; Ishikawa, T.; Aizawa, Y.; Ushinohama, H.; Kimura, A., Novel mechanisms of trafficking defect caused by KCNQ1 mutations found in long QT syndrome. J. Biol. Chem., 2009, 284, (50), 35122-35133.
    • (2009) J. Biol. Chem. , vol.284 , Issue.50 , pp. 35122-35133
    • Sato, A.1    Arimura, T.2    Makita, N.3    Ishikawa, T.4    Aizawa, Y.5    Ushinohama, H.6    Kimura, A.7
  • 122
    • 0033597857 scopus 로고    scopus 로고
    • Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits
    • Franqueza, L.; Lin, M.; Splawski, I.; Keating, M.T.; Sanguinetti, M.C., Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. J. Biol. Chem., 1999, 274, (30), 21063-21070.
    • (1999) J. Biol. Chem. , vol.274 , Issue.30 , pp. 21063-21070
    • Franqueza, L.1    Lin, M.2    Splawski, I.3    Keating, M.T.4    Sanguinetti, M.C.5
  • 123
    • 14944352048 scopus 로고    scopus 로고
    • + channels
    • DOI 10.1113/jphysiol.2004.080887
    • Seebohm, G.; Westenskow, P.; Lang, F.; Sanguinetti, M.C., Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels. J. Physiol., 2005, 563, (2), 359-368. (Pubitemid 40360897)
    • (2005) Journal of Physiology , vol.563 , Issue.2 , pp. 359-368
    • Seebohm, G.1    Westenskow, P.2    Lang, F.3    Sanguinetti, M.C.4
  • 129
    • 0030723260 scopus 로고    scopus 로고
    • Mutations in the hminK gene cause long QT syndrome and suppress I(Ks) function
    • DOI 10.1038/ng1197-338
    • Splawski, I.; Tristani-Firouzi, M.; Lehmann, M.H.; Sanguinetti, M.C.; Keating, M.T., Mutations in the hminK gene cause long QT syndrome and suppress lKs function. Nat. Genet., 1997, 17, (3), 338-340. (Pubitemid 27476001)
    • (1997) Nature Genetics , vol.17 , Issue.3 , pp. 338-340
    • Splawski, I.1    Tristani-Firouzi, M.2    Lehmann, M.H.3    Sanguinetti, M.C.4    Keating, M.T.5
  • 132
    • 36549055058 scopus 로고    scopus 로고
    • KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval
    • DOI 10.1016/j.hrthm.2007.07.022, PII S154752710700793X
    • Lundby, A.; Ravn, L.S.; Svendsen, J.H.; Olesen, S.P.; Schmitt, N., KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval. Heart Rhythm, 2007, 4, (12), 1532-1541. (Pubitemid 350187683)
    • (2007) Heart Rhythm , vol.4 , Issue.12 , pp. 1532-1541
    • Lundby, A.1    Ravn, L.S.2    Svendsen, J.H.3    Olesen, S.-P.4    Schmitt, N.5
  • 134
    • 79251471132 scopus 로고    scopus 로고
    • KS' profile during both atrial and ventricular action potentials
    • KS' profile during both atrial and ventricular action potentials. J. Physiol. Pharmacol., 2010, 61, (6), 759-764.
    • (2010) J. Physiol. Pharmacol. , vol.61 , Issue.6 , pp. 759-764
    • El Harchi, A.1    Zhang, H.2    Hancox, J.C.3
  • 140
    • 0035052435 scopus 로고    scopus 로고
    • Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes
    • Sun, Z.Q.; Thomas, G.P.; Antzelevitch, C., Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J. Cardiovasc. Electrophysiol., 2001, 12, (4), 472-478. (Pubitemid 32324664)
    • (2001) Journal of Cardiovascular Electrophysiology , vol.12 , Issue.4 , pp. 472-478
    • Sun, Z.-Q.1    Thomas, G.P.2    Antzelevitch, C.3
  • 141
    • 0037350080 scopus 로고    scopus 로고
    • Effects of chromanol 293B on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes
    • Du, X.L.; Lau, C.P.; Chiu, S.W.; Tse, H.F.; Gerlach, U.; Li, G.R., Effects of chromanol 293B on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. J. Mol. Cell. Cardiol., 2003, 35, (3), 293-300.
    • (2003) J. Mol. Cell. Cardiol. , vol.35 , Issue.3 , pp. 293-300
    • Du, X.L.1    Lau, C.P.2    Chiu, S.W.3    Tse, H.F.4    Gerlach, U.5    Li, G.R.6
  • 150
    • 1342324061 scopus 로고    scopus 로고
    • In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: Potential insights into class III actions
    • DOI 10.1016/j.cardiores.2003.12.016
    • Nakashima, H.; Gerlach, U.; Schmidt, D.; Nattel, S., In vivo electrophysiological effects of a selective slow delayed-rectifier potassium channel blocker in anesthetized dogs: potential insights into class III actions. Cardiovasc. Res., 2004, 61, (4), 705-714. (Pubitemid 38249469)
    • (2004) Cardiovascular Research , vol.61 , Issue.4 , pp. 705-714
    • Nakashima, H.1    Gerlach, U.2    Schmidt, D.3    Nattel, S.4
  • 152
    • 34250670677 scopus 로고    scopus 로고
    • Ks Block by HMR 1556 Lowers Ventricular Defibrillation Threshold and Reverses the Repolarization Shortening by Isoproterenol Without Rate-Dependence in Rabbits
    • Ks Block by HMR 1556 Lowers Ventricular Defibrillation Threshold and Reverses the Repolarization Shortening by Isoproterenol Without Rate-Dependence in Rabbits. J. Cardiovasc. Electrophysiol., 2007, 18, (7), 750-756.
    • (2007) J. Cardiovasc. Electrophysiol. , vol.18 , Issue.7 , pp. 750-756
    • So, P.P.-S.1    Backx, P.H.2    Hu, X.-D.3    Dorian, P.4
  • 153
    • 57349099486 scopus 로고    scopus 로고
    • + current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles
    • + current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles. Br. J. Pharmacol., 2008, 155, (8), 1185-1194.
    • (2008) Br. J. Pharmacol. , vol.155 , Issue.8 , pp. 1185-1194
    • So, P.P.S.1    Backx, P.H.2    Dorian, P.3
  • 161
    • 53049101647 scopus 로고    scopus 로고
    • Desensitization of chemical activation by auxiliary subunits: Convergence of molecular determinants critical for augmenting KCNQ1 potassium channels
    • Gao, Z.; Xiong, Q.; Sun, H.; Li, M., Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels. J. Biol. Chem., 2008, 283, (33), 22649-22658.
    • (2008) J. Biol. Chem. , vol.283 , Issue.33 , pp. 22649-22658
    • Gao, Z.1    Xiong, Q.2    Sun, H.3    Li, M.4
  • 165
    • 30544449076 scopus 로고    scopus 로고
    • Resveratrol, a natural ingredient of grape skin: Antiarrhythmic efficacy and ionic mechanisms
    • DOI 10.1016/j.bbrc.2005.12.124, PII S0006291X05028822
    • Zhang, Y.; Liu, Y.; Wang, T.; Li, B.; Li, H.; Wang, Z.; Yang, B., Resveratrol, a natural ingredient of grape skin: antiarrhythmic efficacy and ionic mechanisms. Biochem. Biophys. Res. Commun., 2006, 340, (4), 1192-1199. (Pubitemid 43083404)
    • (2006) Biochemical and Biophysical Research Communications , vol.340 , Issue.4 , pp. 1192-1199
    • Zhang, Y.1    Liu, Y.2    Wang, T.3    Li, B.4    Li, H.5    Wang, Z.6    Yang, B.7
  • 168
    • 0242721858 scopus 로고    scopus 로고
    • Pharmacological Activation of Normal and Arrhythmia-Associated Mutant KCNQ1 Potassium Channels
    • DOI 10.1161/01.RES.0000102866.67863.2B
    • Seebohm, G.; Pusch, M.; Chen, J.; Sanguinetti, M.C., Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circul. Res., 2003, 93, (10), 941-947. (Pubitemid 37433232)
    • (2003) Circulation Research , vol.93 , Issue.10 , pp. 941-947
    • Seebohm, G.1    Pusch, M.2    Chen, J.3    Sanguinetti, M.C.4
  • 170
    • 0032546404 scopus 로고    scopus 로고
    • Azimilide dihydrochloride, a novel antiarrhythmic agent
    • DOI 10.1016/S0002-9149(98)00152-0, PII S002914998001520
    • Karam, R.; Marcello, S.; Brooks, R.R.; Corey, A.E.; Moore, A., Azimilide dihydrochloride, a novel antiarrhythmic agent. Am. J. Cardiol., 1998, 81, (6A), 40D-46D. (Pubitemid 28155909)
    • (1998) American Journal of Cardiology , vol.81 , Issue.6 A
    • Karam, R.1    Marcello, S.2    Brooks, R.R.3    Corey, A.E.4    Moore, A.5
  • 171
    • 0028171307 scopus 로고
    • Block of IKs, the slow component of the delayed rectifier K+ current, by the diuretic agent indapamide in guinea pig myocytes
    • Turgeon, J.; Daleau, P.; Bennett, P.B.; Wiggins, S.S.; Selby, L.; Roden, D.M., Block of IKs, the slow component of the delayed rectifier K+ current, by the diuretic agent indapamide in guinea pig myocytes. Circul. Res., 1994, 75, (5), 879-886.
    • (1994) Circul. Res. , vol.75 , Issue.5 , pp. 879-886
    • Turgeon, J.1    Daleau, P.2    Bennett, P.B.3    Wiggins, S.S.4    Selby, L.5    Roden, D.M.6
  • 172
    • 0029163243 scopus 로고
    • Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: Block of delayed rectifier potassium and L-type calcium currents
    • Fermini, B.; Jurkiewicz, N.K.; Jow, B.; Guinosso Jr, P.J.; Baskin, E.P.; Lynch Jr, J.J.; Salata, J.J., Use-dependent effects of the class III antiarrhythmic agent NE-10064 (azimilide) on cardiac repolarization: block of delayed rectifier potassium and L-type calcium currents. J. Cardiovasc. Pharmacol., 1995, 26, (2), 259-271.
    • (1995) J. Cardiovasc. Pharmacol. , vol.26 , Issue.2 , pp. 259-271
    • Fermini, B.1    Jurkiewicz, N.K.2    Jow, B.3    Guinosso Jr., P.J.4    Baskin, E.P.5    Lynch Jr., J.J.6    Salata, J.J.7
  • 173
    • 13844257154 scopus 로고    scopus 로고
    • Azimilide, a novel oral class III antiarrhythmic for both supraventricular and ventricular arrhythmias
    • DOI 10.2174/1568006053004985
    • VerNooy, R.A.; Mangrum, J.M., Azimilide, a novel oral class III antiarrhythmic for both supraventricular and ventricular arrhythmias. Curr. Drug Targets Cardiovasc. & Haematol. Disord., 2005, 5, (1), 75-84. (Pubitemid 40246726)
    • (2005) Current Drug Targets - Cardiovascular and Haematological Disorders , vol.5 , Issue.1 , pp. 75-84
    • VerNooy, R.A.1    Mangrum, J.M.2
  • 174
    • 51749122387 scopus 로고    scopus 로고
    • New horizons in antiarrhythmic therapy: Will novel agents overcome current deficits?
    • Conway, E.; Musco, S.; Kowey, P.R., New horizons in antiarrhythmic therapy: will novel agents overcome current deficits? Am. J. Cardiol., 2008, 102, (6A), 12H-19H.
    • (2008) Am. J. Cardiol. , vol.102 , Issue.6
    • Conway, E.1    Musco, S.2    Kowey, P.R.3
  • 175
    • 33748775202 scopus 로고    scopus 로고
    • Azimilide vs. placebo and sotalol for persistent atrial fibrillation: The A-COMET-II (Azimilide-CardiOversion MaintEnance Trial-II) trial
    • DOI 10.1093/eurheartj/ehl209
    • Lombardi, F.; Borggrefe, M.; Ruzyllo, W.; Lüderitz, B., Azimilide vs. placebo and sotalol for persistent atrial fibrillation: the A-COMET-II (Azimilide-CardiOversion MaintEnance Trial-II) trial. Eur. Heart J., 2006, 27, (18), 2224-2231. (Pubitemid 44412838)
    • (2006) European Heart Journal , vol.27 , Issue.18 , pp. 2224-2231
    • Lombardi, F.1    Borggrefe, M.2    Ruzyllo, W.3    Luderitz, B.4
  • 177
    • 50049112423 scopus 로고    scopus 로고
    • Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart
    • Guérard, N.; Traebert, M.; Suter, W.; Dumotier, B., Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart. J. Pharmacol. Toxicol. Methods, 2008, 58, (1), 32-40.
    • (2008) J. Pharmacol. Toxicol. Methods , vol.58 , Issue.1 , pp. 32-40
    • Guérard, N.1    Traebert, M.2    Suter, W.3    Dumotier, B.4
  • 178
    • 33744497032 scopus 로고    scopus 로고
    • Ks by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles
    • DOI 10.1038/sj.bjp.0706721
    • So, P.P.-S.; Hu, X.-D.; Backx, P.H.; Puglisi, J.L.; Dorian, P., Blockade of IKs by HMR 1556 increases the reverse rate-dependence of refractoriness prolongation by dofetilide in isolated rabbit ventricles. Br. J. Pharmacol., 2006, 148, (3), 255-263. (Pubitemid 43801172)
    • (2006) British Journal of Pharmacology , vol.148 , Issue.3 , pp. 255-263
    • So, P.P.-S.1    Hu, X.-D.2    Backx, P.H.3    Puglisi, J.L.4    Dorian, P.5
  • 179
    • 1342324066 scopus 로고    scopus 로고
    • Ks a relevant drug target?
    • DOI 10.1016/j.cardiores.2004.01.001
    • Curtis, M.J., Is cardiac IKs a relevant drug target? Cardiovasc. Res., 2004, 61, (4), 651-652. (Pubitemid 38249463)
    • (2004) Cardiovascular Research , vol.61 , Issue.4 , pp. 651-652
    • Curtis, M.J.1
  • 180
    • 30644474297 scopus 로고    scopus 로고
    • Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1 + minK channels
    • DOI 10.1038/sj.bjp.0706302
    • Gómez, R.; Núñez, L.; Caballero, R.; Vaquero, M.; Tamargo, J.; Delpón, E., Spironolactone and its main metabolite canrenoic acid block hKv1.5, Kv4.3 and Kv7.1+minK channels. Br. J. Pharmacol., 2005, 146, (1), 146-161. (Pubitemid 43086104)
    • (2005) British Journal of Pharmacology , vol.146 , Issue.1 , pp. 146-161
    • Gomez, R.1    Nunez, L.2    Caballero, R.3    Vaquero, M.4    Tamargo, J.5    Delpon, E.6
  • 185
    • 32244447329 scopus 로고    scopus 로고
    • Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents
    • Tian, M.; Dong, M.Q.; Chiu, S.W.; Lau, C.P.; Li, G.R., Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents. Br. J. Pharmacol., 2006, 147, (3), 289-297.
    • (2006) Br. J. Pharmacol. , vol.147 , Issue.3 , pp. 289-297
    • Tian, M.1    Dong, M.Q.2    Chiu, S.W.3    Lau, C.P.4    Li, G.R.5
  • 186
    • 0033428669 scopus 로고    scopus 로고
    • Blockade of cardiac potassium and other channels by antihistamines
    • Delpon, E.; Valenzuela, C.; Tamargo, J., Blockade of cardiac potassium and other channels by antihistamines. Drug Saf., 1999, 21, (Supplement 1), 11-18. (Pubitemid 30000235)
    • (1999) Drug Safety , vol.21 , Issue.SUPPL. 1 , pp. 11-18
    • Delpon, E.1    Valenzuela, C.2    Tamargo, J.3
  • 187
    • 0031835115 scopus 로고    scopus 로고
    • + currents in cardiac cells: Comparison with terfenadine
    • + currents in cardiac cells: comparison with terfenadine. Br. J. Pharmacol., 1998, 124, (4), 663-668.
    • (1998) Br. J. Pharmacol. , vol.124 , Issue.4 , pp. 663-668
    • Carmeliet, E.1
  • 189
    • 0028936268 scopus 로고
    • Cardiac Electrophysiological Actions of the Histamine H1-Receptor Antagonists Astemizole and Terfenadine Compared with Chlorpheniramine and Pyrilamine
    • Salata, J.J.; Jurkiewicz, N.K.; Wallace, A.A.; Stupienski, R.F.; Guinosso, P.J.; Lynch, J.J., Cardiac Electrophysiological Actions of the Histamine H1-Receptor Antagonists Astemizole and Terfenadine Compared With Chlorpheniramine and Pyrilamine. Circul. Res., 1995, 76, (1), 110-119.
    • (1995) Circul. Res. , vol.76 , Issue.1 , pp. 110-119
    • Salata, J.J.1    Jurkiewicz, N.K.2    Wallace, A.A.3    Stupienski, R.F.4    Guinosso, P.J.5    Lynch, J.J.6
  • 190
    • 0034812621 scopus 로고    scopus 로고
    • Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG
    • Kang, J.; Chen, X.-L.; Wang, L.; Rampe, D., Interactions of the Antimalarial Drug Mefloquine with the Human Cardiac Potassium Channels KvLQT1/minK and HERG. J. Pharmacol. Exp. Ther., 2001, 299, (1), 290-296. (Pubitemid 32905146)
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.299 , Issue.1 , pp. 290-296
    • Kang, J.1    Chen, X.-L.2    Wang, L.3    Rampe, D.4
  • 192
    • 33746430610 scopus 로고    scopus 로고
    • Flunarizine is a highly potent inhibitor of cardiac hERG potassium current
    • DOI 10.1097/01.fjc.0000200810.18575.80, PII 0000534420060200000008
    • Trepakova, E.S.; Dech, S.J.; Salata, J.J., Flunarizine is a highly potent inhibitor of cardiac hERG potassium current. J. Cardiovasc. Pharmacol., 2006, 47, (2), 211-220. (Pubitemid 44384059)
    • (2006) Journal of Cardiovascular Pharmacology , vol.47 , Issue.2 , pp. 211-220
    • Trepakova, E.S.1    Dech, S.J.2    Salata, J.J.3
  • 193
    • 0028362028 scopus 로고
    • Triamterene inhibits the delayed rectifier potassium current (IK) in guinea pig ventricular myocytes
    • Daleau, P.; Turgeon, J., Triamterene inhibits the delayed rectifier potassium current (IK) in guinea pig ventricular myocytes. Circul. Res., 1994, 74, (6), 1114-1120.
    • (1994) Circul. Res. , vol.74 , Issue.6 , pp. 1114-1120
    • Daleau, P.1    Turgeon, J.2
  • 196
    • 33644554126 scopus 로고    scopus 로고
    • Effects of estradiol on cardiac ion channel currents
    • Moller, C.; Netzer, R., Effects of estradiol on cardiac ion channel currents. Eur. J. Pharmacol., 2006, 532, (1-2), 44-49.
    • (2006) Eur. J. Pharmacol. , vol.532 , Issue.1-2 , pp. 44-49
    • Moller, C.1    Netzer, R.2
  • 199
    • 33644977066 scopus 로고    scopus 로고
    • Effects of dronedarone on HERG and KCNQ1/KCNE1 channels
    • Shimizu, A.; Niwa, R.; Lu, Z.; Honjo, H.; Kamiya, K., Effects of dronedarone on HERG and KCNQ1/KCNE1 channels. Environ. Med., 2003, 47, 48-50.
    • (2003) Environ. Med. , vol.47 , pp. 48-50
    • Shimizu, A.1    Niwa, R.2    Lu, Z.3    Honjo, H.4    Kamiya, K.5
  • 200
    • 33644968894 scopus 로고    scopus 로고
    • The neuroprotective agent sipatrigine blocks multiple cardiac ion channels and causes triangulation of the ventricular action potential
    • DOI 10.1111/j.1440-1681.2005.04312.x
    • Gao, Z.; Milnes, J.T.; Choisy, S.; Leach, M.J.; Hancox, J.C.; James, A.F., The neuroprotective agent sipatrigine blocks multiple cardiac ion channels and causes triangulation of the ventricular action potential. Clin. Exp. Pharmacol. Physiol., 2005, 32, (12), 1088-1096. (Pubitemid 43906819)
    • (2005) Clinical and Experimental Pharmacology and Physiology , vol.32 , Issue.12 , pp. 1088-1096
    • Gao, Z.1    Milnes, J.T.2    Choisy, S.C.M.3    Leach, M.J.4    Hancox, J.C.5    James, A.F.6
  • 201
    • 46149098871 scopus 로고    scopus 로고
    • 2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea pig ventricular myocytes
    • 2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea pig ventricular myocytes. J. Membr. Biol., 2008, 222, (3), 151-166.
    • (2008) J. Membr. Biol. , vol.222 , Issue.3 , pp. 151-166
    • Yamada, M.1    Ohta, K.2    Niwa, A.3    Tsujino, N.4    Nakada, T.5    Hirose, M.6
  • 202
    • 33750419028 scopus 로고    scopus 로고
    • Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel
    • DOI 10.1113/jphysiol.2006.116012
    • Bett, G.C.L.; Morales, M.J.; Beahm, D.L.; Duffey, M.E.; Rasmusson, R.L., Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel. J. Physiol., 2006, 576, (3), 755-767. (Pubitemid 44637881)
    • (2006) Journal of Physiology , vol.576 , Issue.3 , pp. 755-767
    • Bett, G.C.L.1    Morales, M.J.2    Beahm, D.L.3    Duffey, M.E.4    Rasmusson, R.L.5
  • 203
    • 34347335754 scopus 로고    scopus 로고
    • Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter
    • DOI 10.1124/mol.106.031682
    • Lerche, C.; Bruhova, I.; Lerche, H.; Steinmeyer, K.; Wei, A.D.; Strutz-Seebohm, N.; Lang, F.; Busch, A.E.; Zhorov, B.S.; Seebohm, G., Chromanol 293B binding in KCNQ1 (Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter. Mol. Pharmacol., 2007, 71, (6), 1503-1511. (Pubitemid 47010903)
    • (2007) Molecular Pharmacology , vol.71 , Issue.6 , pp. 1503-1511
    • Lerche, C.1    Bruhova, I.2    Lerche, H.3    Steinmeyer, K.4    Wei, A.D.5    Strutz-Seebohm, N.6    Lang, F.7    Busch, A.E.8    Zhorov, B.S.9    Seebohm, G.10
  • 205
    • 19744368459 scopus 로고    scopus 로고
    • Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification
    • DOI 10.1016/j.bbrc.2005.04.165, PII S0006291X05009538
    • Du, L.P.; Li, M.Y.; Tsai, K.C.; You, Q.D.; Xia, L., Characterization of binding site of closed-state KCNQ1 potassium channel by homology modeling, molecular docking, and pharmacophore identification. Biochem. Biophys. Res. Commun., 2005, 332, (3), 677-687. (Pubitemid 40745168)
    • (2005) Biochemical and Biophysical Research Communications , vol.332 , Issue.3 , pp. 677-687
    • Du, L.-P.1    Li, M.-Y.2    Tsai, K.-C.3    You, Q.-D.4    Xia, L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.