KCNE4 can co-associate with the IKs (KCNQ1-KCNE1) channel complex

FEBS Journal

Volumn 275, Issue 6, 2008, Pages 1336-1349

  Manderfield, Lauren J ^a   George, Alfred L ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Accessory subunits; KV7.1; KCNE4; KCNQ1; Potassium channel

Indexed keywords

POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNE4; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BRAIN; CELL MEMBRANE; CELL STRAIN COS1; CHANNEL GATING; COMPLEX FORMATION; HUMAN; HUMAN TISSUE; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TESTIS; TISSUE DISTRIBUTION;

EID: 40349091672     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06294.x     Document Type: Article

References (46)

1. Rettig J, Heinemann SH, Wunder F, Lorra C, Parcej DN, Dolly JO & Pongs O (1994) Inactivation properties of voltage-gated K+ channels altered by presence of b-subunit. Nature 369, 289-294.
2. V channel alpha ⁄ beta subunit interactions. Trends Cardiovasc Med 9, 253-258.
3. Pongs O, Leicher T, Berger M, Roeper J, Bahring R, Wray D, Giese KP, Silva AJ & Storm JF (1999) Functional and molecular aspects of voltage-gated K+ channel beta subunits. Ann NY Acad Sci 868, 344-355.
4. Trimmer JS (1998) Regulation of ion channel expression by cytoplasmic subunits. Curr Opin Neurobiol 8, 370-374.
5. Pourrier M, Schram G & Nattel S (2003) Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP. J Membr Biol 194, 141-152.
6. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS et al. (2000) Modulation of A-type potassium channels by a family of calcium sensors. Nature 403, 553-556.
7. Wible BA, Yang Q, Kuryshev YA, Accili EA & Brown AM (1998) Cloning and expression of a novel K+ channel regulatory protein, KChAP. J Biol Chem 273, 11745-11751.
8. Abbott GW & Goldstein SA (1998) A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Q Rev Biophys 31, 357-398.
9. Takumi T, Ohkubo H & Nakanishi S (1988) Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science 242, 1042-1045.
10. Folander K, Smith JS, Antanavage J, Bennett C, Stein RB & Swanson R (1990) Cloning and expression of the delayed-rectifier IsK channel from neonatal rat heart and diethylstilbestrol-primed rat uterus. Proc Natl Acad Sci USA 87, 2975-2979.
11. Sugimoto T, Tanabe Y, Shigemoto R, Iwai M, Takumi T, Ohkubo H & Nakanishi S (1990) Immunohistochemical study of a rat membrane protein which induces a selective potassium permeation: its localization in the apical membrane portion of epithelial cells. J Membr Biol 113, 39-47.
12. VLQT1 and its regulator IsK in mouse epithelia. Am J Physiol Cell Physiol 280, C359-C372.
13. Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT & Goldstein SA (1999) MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97, 175-187.
14. Piccini M, Vitelli F, Seri M, Galietta LJ, Moran O, Bulfone A, Banfi S, Pober B & Renieri A (1999) KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs. Genomics 60, 251-257.
15. VLQT1 and minK (IsK) proteins to form cardiac IKs potassium channel. Nature 384, 80-83.
16. VLQT1 and IsK (minK) proteins associate to form the IKs cardiac potassium current. Nature 384, 78-80.
17. Tinel N, Diochot S, Borsotto M, Lazdunski M & Barhanin J (2000) KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J 19, 6326-6330.
18. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R & Jentsch TJ (2000) A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403, 196-199.
19. Grunnet M, Jespersen T, Rasmussen HB, Ljungstrom T, Jorgensen NK, Olesen SP & Klaerke DA (2002) KCNE4 is an inhibitory subunit to the KCNQ1 channel. J Physiol (London) 542, 119-130.
20. Angelo K, Jespersen T, Grunnet M, Nielsen MS, Klaerke DA & Olesen SP (2002) KCNE5 induces timeand voltage-dependent modulation of the KCNQ1 current. Biophys J 83, 1997-2006.
21. Chen H, Kim LA, Rajan S, Xu S & Goldstein SAN (2003) Charybdotoxin binding in the IKs pore demonstrates two MinK subunits in each channel complex. Neuron 40, 15-23.
22. Lundquist AL, Turner CL, Ballester LY & George AL Jr (2006) Expression and transcriptional control of human KCNE genes. Genomics 87, 119-128.
23. V1.3 potassium channels. Biophys J 85, 1525-1537.
24. Lundquist AL, Manderfield LJ, Vanoye CG, Rogers CS, Donahue BS, Chang PA, Drinkwater DC, Murray KT & George AL Jr (2005) Expression of multiple KCNE genes in human heart may enable variable modulation of IKs. J Mol Cell Cardiol 38, 277-287.
25. Radicke S, Cotella D, Graf EM, Banse U, Jost N, Varro A, Tseng GN, Ravens U & Wettwer E (2006) Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovasc Res 71, 695-703.
26. Alves VS, Pimenta DC, Sattlegger E & Castilho BA (2004) Biophysical characterization of Gir2, a highly acidic protein of Saccharomyces cerevisiae with anomalous electrophoretic behavior. Biochem Biophys Res Commun 314, 229-234.
27. Garcia-Ortega L, De Los Rios V, Martinez-Ruiz A, Onaderra M, Lacadena J, del Martinez PA & Gavilanes JG (2005) Anomalous electrophoretic behavior of a very acidic protein: ribonuclease U2. Electrophoresis 26, 3407-3413.
28. Luo X, Xiao J, Lin H, Li B, Lu Y, Yang B & Wang Z (2007) Transcriptional activation by stimulating protein 1 and post-transcriptional repression by muscle-specific microRNAs of IKs-encoding genes and potential implications in regional heterogeneity of their expressions. J Cell Physiol 212, 358-367.
29. Chandrasekhar KD, Bas T & Kobertz WR (2006) KCNE1 subunits require co-assembly with K+ channels for efficient trafficking and cell surface expression. J Biol Chem 281, 40015-40023.
30. Takumi T, Moriyoshi K, Aramori I, Ishii T, Oiki S, Okada Y, Ohkubo H & Nakanishi S (1991) Alteration of channel activities and gating by mutations of slow IsK. J Biol Chem 266, 22192-22198.
31. Ma KJ, Li N, Teng SY, Zhang YH, Sun Q, Gu DF & Pu JL (2007) Modulation of KCNQ1 current by atrial fibrillation-associated KCNE4 (145E ⁄ D) gene polymorphism. Chin Med J (Engl) 120, 150-154.
32. Kim SJ & Greger R (1999) Voltage-dependent, slowly activating K+ current (IKs) and its augmentation by carbachol in rat pancreatic acini. Pflugers Arch 438, 604-611.
33. Kottgen M, Hoefer A, Kim SJ, Beschorner U, Schreiber R, Hug MJ & Greger R (1999) Carbachol activates a K+ channel of very small conductance in the basolateral membrane of rat pancreatic acinar cells. Pflugers Arch 438, 597-603.
34. VLQT1 and epithelial function. Pflugers Arch 440, 202-206.
35. Vallon V, Grahammer F, Richter K, Bleich M, Lang F, Barhanin J, Volkl H & Warth R (2001) Role of KCNE1-dependent K+ fluxes in mouse proximal tubule. J Am Soc Nephrol 12, 2003-2011.
36. Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K & Lang F (2005) KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci USA 102, 17864-17869.
37. Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE & McKinnon D (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282, 1890-1893.
38. Toyoda F, Ueyama H, Ding WG & Matsuura H (2006) Modulation of functional properties of KCNQ1 channel by association of KCNE1 and KCNE2. Biochem Biophys Res Commun 344, 814-820.
39. Wu DM, Jiang M, Zhang M, Liu XS, Korolkova YV & Tseng GN (2006) KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart. Heart Rhythm 3, 1469-1480.
40. Park KH, Hernandez L, Cai SQ, Wang Y & Sesti F (2005) A family of K+ channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans. J Biol Chem 280, 21893-21899.
41. Shi G, Nakahira K, Hammond S, Rhodes KJ, Schechter LE & Trimmer JS (1996) Beta subunits promote K+ channel surface expression through effects early in biosynthesis. Neuron 16, 843-852.
42. V1 potassium channel trafficking. J Biol Chem 277, 8298-8305.
43. Bianchi L, Shen Z, Dennis AT, Priori SG, Napolitano C, Ronchetti E, Bryskin R, Schwartz PJ & Brown AM (1999) Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome. Hum Mol Genet 8, 1499-1507.
44. VLQT1 trafficking. Am J Physiol Cell Physiol 286, C1453-C1463.
45. V beta 1 subunit binding specific for shaker-related potassium channel alpha subunits. Neuron 16, 455-463.
46. Heinemann S, Rettig J, Scott V, Parcej DN, Lorra C, Dolly J & Pongs O (1994) The inactivation behaviour of voltage-gated K-channels may be determined by association of alpha-and beta-subunits. J Physiol Paris 88, 173-180.