Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of I Ks channels

Journal of Physiology

Volumn 586, Issue 17, 2008, Pages 4179-4191

  Restier, Lioara ^a   Cheng, Lan ^a   Sanguinetti, Michael C ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DELAYED RECTIFIER POTASSIUM CHANNEL; GLUTAMIC ACID; GLYCINE; METHIONINE; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNQ1; SERINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; GENE ACTIVATION; GENE INACTIVATION; GENE MUTATION; GENETIC ASSOCIATION; HEART ATRIUM FIBRILLATION; HETEROLOGOUS EXPRESSION; MICROELECTRODE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP; WILD TYPE; XENOPUS; ANIMAL CELL; ANIMAL EXPERIMENT; ATRIAL FIBRILLATION; GAIN OF FUNCTION MUTATION; MEMBRANE DEPOLARIZATION; OOCYTE; VOLTAGE CLAMP TECHNIQUE; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ANIMALS; ATRIAL FIBRILLATION; HUMANS; ION CHANNEL GATING; KCNQ1 POTASSIUM CHANNEL; MODELS, MOLECULAR; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; XENOPUS LAEVIS;

EID: 51749114470     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.157511     Document Type: Article

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